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OX Receptor

OX Receptor

Cat. No. Product Name CAS No. Information
CSN27292 YNT-185 1804978-81-1 YNT 185 is potent and selective orexin OX2 receptor agonist with EC50 of 28 nM at human OX2 expressed in CHO cells. YNT 185 displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells).
CSN18978 TCS-OX2-29   372523-75-6 TCS-OX2-29 is a potent and selective orexin 2 OX2 receptor antagonist with IC50 of 40 nM
CSN16236 TCS 1102 916141-36-1 TCS 1102 is a potent dual orexin receptor antagonist Ki values are 02 and 3 nM for OX2 and OX1 receptors respectively
CSN20432 Seltorexant 1293281-49-8 Seltorexant is a selective orexin-2 receptor antagonist that has been shown to promote sleep in various species.
CSN16826 SB-674042 483313-22-0 SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist Kd 376 nM exhibiting 100-fold selectivity for OX1 over OX2 receptors
CSN20633 SB-649868 380899-24-1 SB-649868 is a potent and selective orally active orexin OX 1 and OX2 receptor antagonist pKi 94 and 95 at the OX1 and OX2 receptor respectively
CSN16521 SB-408124 288150-92-5 SB-408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane respectively and exhibits 50-fold selectivity over OX2 receptor
CSN17847 SB-408124 Hydrochloride 1431697-90-3 SB-408124 HCl is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively and exhibits 50-fold selectivity over OX2 receptor.
CSN11490 SB-334867 249889-64-3 SB-334867 is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2.
CSN11489 SB-334867 free base   792173-99-0 SB-334867 free base is a selective non-peptide orexin OX1 receptor antagonist with pKb of 72
CSN50652 ORN-0829 hydrate 1793073-93-4 ORN-0829 is a potent dual orexin 1/2 receptor antagonist.
CSN18036 Orexin 2 Receptor Agonist 1796565-52-0 Orexin 2 receptor agonist is a potent and selective OX2R agonist with EC50 of 23 nM
CSN13779 Filorexant 1088991-73-4 MK-6096 is an orally bioavailable potent and selective reversible antagonist of OX1 and OX2 receptor 3 nM in binding
CSN16552 MK-3697 1224846-01-8 MK-3697 is an isonicotinamide small molecule acting as a potent and selective Orexin 2 receptor antagonist with Ki 095 nM
CSN18852 MK-1064 1207253-08-4 MK-1064 is a selective orexin 2 receptor antagonist2-SORA for the research of insomnia
CSN26720 YNT-185 dihydrochloride 1804978-82-2 for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models[1][2].
CSN26371 EMPA 680590-49-2 EMPA is highly potent, selective OX2 receptor antagonist with IC50 values of 2.3 nM and 1900 nM for OX2 and OX1 respectively.
CSN17023 Almorexant 871224-64-5 Almorexant is a potent and competitive dual orexin 1 receptor OX1orexin 2 receptor OX2 antagonist with Ki values of 13 and 017 nM for OX1 and OX2 respectively
CSN13780 Almorexant hydrochloride 913358-93-7 Almorexant HCl is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
CSN20430 ACT-462206 1361321-96-1 ACT-462206 is a potent and brain-penetrant dual orexin receptor antagonist IC50 values are 11 and 60 nM for OX2 and OX1 receptors respectively and it exhibits anxiolytic-like properties in vivo
CSN33694 GSK1059865 1191044-58-2
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