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| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN22262 | VH032 | 1448188-62-2 | VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHLHIF-1 interaction with Kd of 185 nM. |
| CSN22307 | JQ1-VHL-PROTAC | N/A | JQ1-VHL-PROTAC is a PROTAC synthesis. |
| CSN22306 | IBET151-VHL-PROTAC | N/A | IBET151-VHL-PROTAC is a PROTAC. |
| CSN22297 | Gefitinib-based PROTAC 3 | 2230821-27-7 | Gefitinib-based PROTAC 3 is a VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11.7 nM and 22.3 nM for HCC827 cell (Exon 19 del) and H3255 cell (L858R). |
| CSN23768 | PROTAC ERRα ligand 1 | 1264754-13-3 | E3 ligase Ligand 5 is a ligand of E3 ligase, extracted from patent US 20160058872A1, Paragraph 0515. |
| CSN22288 | CCT367766 | 2229856-58-8 | CCT-367766 (CCT367766) is a heterobifunctional PROTAC that binds and degrades the putative transcription factor regulator Pirin in cells. |
| CSN22291 | BETd-260 Trifluoroacetate | 2140289-21-8 | BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL effectively degrades BRD4 protein at 30 pM in the RS411 leukemia cell line, achieves an IC50 of 51 pM in inhibition of RS411 cell growth and induces rapid tumor regression in vivo against RS411 xenograft tumors. |
| CSN22261 | (S,R,S)-AHPC-Boc | 1448189-98-7 | A VHL ligand for PROTAC. |
| CSN22260 | HOOCCH2O-PEG4-CH2COOH | 77855-75-5 | A PEG linker for PROTAC. |
| CSN22276 | PEG6-(CH2CO2H)2 | 77855-76-6 | A PEG linker for PROTAC. |
| CSN22312 | CM11 | N/A | A homo-PROTAC, bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce self-degradation induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response a chemical probe for selective VHL knockdown. |
| CSN25475 | 5-Ethynyl-2'-deoxyuridine | 61135-33-9 | 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker. |
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