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Cat. No. Product Name CAS No. Information
CSN22262 VH032 1448188-62-2 VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHLHIF-1 interaction with Kd of 185 nM.
CSN22307 JQ1-VHL-PROTAC N/A JQ1-VHL-PROTAC is a PROTAC synthesis.
CSN22306 IBET151-VHL-PROTAC N/A IBET151-VHL-PROTAC is a PROTAC.
CSN22297 Gefitinib-based PROTAC 3 2230821-27-7 Gefitinib-based PROTAC 3 is a VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11.7 nM and 22.3 nM for HCC827 cell (Exon 19 del) and H3255 cell (L858R).
CSN22298 N-(3-Fluoro-4-((7-(3-(3-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 2230821-68-6 Foretinib-Based PROTAC 7 is a VHL-recruiting PROTAC that induces the degradation of c-Met in a dose- and time-dependent fashion in MDA-MB-231 cells.
CSN23768 PROTAC ERRα ligand 1 1264754-13-3 E3 ligase Ligand 5 is a ligand of E3 ligase, extracted from patent US 20160058872A1, Paragraph 0515.
CSN22288 CCT367766 2229856-58-8 CCT-367766 (CCT367766) is a heterobifunctional PROTAC that binds and degrades the putative transcription factor regulator Pirin in cells.
CSN22291 BETd-260 Trifluoroacetate 2140289-21-8 BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL effectively degrades BRD4 protein at 30 pM in the RS411 leukemia cell line, achieves an IC50 of 51 pM in inhibition of RS411 cell growth and induces rapid tumor regression in vivo against RS411 xenograft tumors.
CSN22261 (S,R,S)-AHPC-Boc 1448189-98-7 A VHL ligand for PROTAC.
CSN22260 HOOCCH2O-PEG4-CH2COOH 77855-75-5 A PEG linker for PROTAC.
CSN22276 PEG6-(CH2CO2H)2 77855-76-6 A PEG linker for PROTAC.
CSN22312 CM11 N/A A homo-PROTAC, bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce self-degradation induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response a chemical probe for selective VHL knockdown.
CSN25475 5-Ethynyl-2'-deoxyuridine 61135-33-9 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker.
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