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Cat. No. Product Name CAS No. Information
CSN22263 VHL-Alkyne N/A VHL-alkyne is a VHL ligand for PROTAC synthesis.
CSN22262 VH-032 1448188-62-2 VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHLHIF-1 interaction with Kd of 185 nM.
CSN22281 TL13-12 2229037-04-9 TL13-12 is PROTAC selectively targeting on ALK with DC50 values of 10nM and 180nM in H3122 and Karpas 299 cells, respectively, consist of an ALK-binding TAE684 ligand linked to Pomalidomide.
CSN22280 TL13-112 2229037-19-6 TL13-112 is PROTAC selectively targeting on ALK with DC50 values of 10nM and 40nM in H3122 and Karpas 299 cells, respectively, consist of an ALK-binding LDK378 ligand linked to Pomalidomide.
CSN22269 E3 Ligand-Linker Conjugate 9 1957236-20-2 Thalidomide-O-amido-PEG3-C2-Amine is a PROTAC block consist of Thalidomide and a linker with an Amine functional group for conjugation reactions.
CSN22270 E3 Ligand-Linker Conjugate 8 1957235-74-3 Thalidomide-O-amido-PEG2-C2-Amine is a PROTAC block consist of Thalidomide and a linker with Amine functional group for conjugation reactions.
CSN22271 E3 Ligand-Linker Conjugate 7 2022182-59-6 Thalidomide-O-amido-PEG-C2-Amine is a PROTAC block consist of Thalidomide and a linker with Amine functional group for conjugation reactions.
CSN23772 E3 Ligase Ligand-Linker Conjugates 20 1950635-15-0 Thalidomide-O-amido-C8-Amine is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions.
CSN22274 E3 Ligand-Linker Conjugate 3 1799711-24-2 Thalidomide-O-amido-C4-Amine is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions.
CSN22272 E3 Ligand-Linker Conjugate 6 2022182-57-4 Thalidomide-O-amido-C3-Amine is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions.
CSN21424 E3 ligase Ligand 3 1061605-21-7 TC E3 5031 is a thalidomide derivate for conjugation reactions of PROTAC, which can hijack cereblon as the E3 ubiquitin ligase component.
CSN22296 QCA570 2207569-08-0 QCA570 is a potent PROTAC targeting on BET, consist of an optimized BET ligand QCA276 linked to a CRBN E3 ligand.
CSN22292 MZ1 1797406-69-9 MZ1 is a PROTAC with VHL-ligand and targeting on BRD protein, with preferential selectivity to BRD4 (Kd=149nM) over BRD2 and BRD3.
CSN22283 MS4078 2229036-62-6 MS4078 is a PROTAC targeting on ALK with DC50 value of 11nM, consist of ALK inhibitor ceritinib as a warhead linked to CRBN ligand Pomalidomide.
CSN22282 MS4077 2230077-10-6 MS4077 is a PROTAC targeting on ALK with DC50 value of 3nM, consist of ALK inhibitor ceritinib as a warhead linked to CRBN ligand Pomalidomide.
CSN22273 E3 Ligand-Linker Conjugate 4 2093388-45-3 Lenalidomide-C5-Amine is a PROTAC block consist of Lenalidomide linked to alkyl with Amine functional group for conjugation reactions.
CSN22307 JQ1-VHL-PROTAC N/A JQ1-VHL-PROTAC is a PROTAC synthesis.
CSN22306 IBET151-VHL-PROTAC N/A IBET151-VHL-PROTAC is a PROTAC.
CSN22297 Gefitinib-Based PROTAC 3 2230821-27-7 Gefitinib-based PROTAC 3 is a VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11.7 nM and 22.3 nM for HCC827 cell (Exon 19 del) and H3255 cell (L858R).
CSN22298 Foretinib-Based PROTAC 7 2230821-68-6 Foretinib-Based PROTAC 7 is a VHL-recruiting PROTAC that induces the degradation of c-Met in a dose- and time-dependent fashion in MDA-MB-231 cells.
CSN21420 E3 ligase Ligand 2 5054-59-1 E3 ligase Ligand 2 is a thalidomide derivate for conjugation reactions of PROTAC, which can hijack cereblon as the E3 ubiquitin ligase component.
CSN22285 dTRIM24 2170695-14-2 dTRIM24 is a potent and selective PROTAC targeting on TRIM24 which has been posited as a dependency in numerous cancers, with TRIM24 ligand IACS-9571 conjugated to a VHL ligand.
CSN22289 dBRD9 2170679-45-3 dBRD9 is a potent and selective PROTAC targeting on BRD9, with a PEG-linked pomalidomide
CSN22286 dBET1 1799711-21-9 dBET1 is a PROTAC, consisting of a BRD4-ligand JQ-1 linkerd to a cereblon E3 ligase ligand, targeting on BET bromodomain BRD4
CSN22288 CCT-367766 2229856-58-8 CCT-367766 (CCT367766) is a heterobifunctional PROTAC that binds and degrades the putative transcription factor regulator Pirin in cells.
CSN22291 BETd-260 Trifluoroacetate 2140289-21-8 BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL effectively degrades BRD4 protein at 30 pM in the RS411 leukemia cell line, achieves an IC50 of 51 pM in inhibition of RS411 cell growth and induces rapid tumor regression in vivo against RS411 xenograft tumors.
CSN22293 ARV-771 1949837-12-0 ARV-771 is a PROTAC targeting on pan-BET, containing a BRD4-binding moiety (JQ-1) and a VHL-binding moiety.
CSN22261 VHL Ligand 3 1448189-98-7 A VHL ligand for PROTAC.
CSN22264 VHL Ligand 4 1631137-45-5 A VHL ligand for PROTAC.
CSN22265 VHL-2 1631137-31-9 A VHL ligand for PROTAC.
CSN22260 Bis-PEG5-acid 77855-75-5 A PEG linker for PROTAC.
CSN22276 Bis-PEG6-acid 77855-76-6 A PEG linker for PROTAC.
CSN22277 Bis-PEG4-acid 32775-08-9 A PEG linker for PROTAC.
CSN22312 CM11 N/A A homo-PROTAC, bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce self-degradation induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response a chemical probe for selective VHL knockdown.
CSN23768 E3 ligase Ligand 5 1264754-13-3
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