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OGGs belong to the helix-hairpin-helix (HhH) superfamilly of base excision repair DNA glycosylases. OGGs are not the only enzymes able to cleave 8-oxoG from DNA. OGG members are divided into three subfamilies OGG1, OGG2 and AGOG, which correspond more or less to the three kingdoms of life. Eukaryotic OGG1 cleaves 8-oxoG only when paired with cytosine. Despite the lack of sequence homology. OGG enzymes are all described as bifunctional enzymes, which have both glycosylase and β-lyase activities in vitro.
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN29566 | SU0268 | 2210228-45-6 | SU0268 is a potent and selective OGG1 inhibitor. |
| CSN25635 | OGG1-IN-08 | 350997-39-6 | O8 OGG1 Inhibitor is an inhibitor of OGG1 with IC50 value of 0.35μM in fluorescence-based OGG1 assays. It can inhibit Schiff base formation during OGG1-mediated catalysis but did not reduce DNA binding of OGG1 to a 7,8-dihydro-8-oxoguanine (8-oxo-Gua)-containing substrate. |
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