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Notch
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN22137 | tCFA15 | 220757-88-0 | tCFA15 is a trimethyl cyclohexenonic long chain fatty alcohol containing 15 carbon atoms on the side chain promotes the differentiation of neurons and may regulates Notchsignaling |
| CSN27582 | RIN1 | 2682114-39-0 | RIN1 is a new class of small molecule inhibitor that disrupts the interaction between NOTCH and RBPJ. It also blocked the functional interaction of RBPJ with SHARP, a scaffold protein that forms a transcriptional repressor complex with RBPJ in the absence of NOTCH signaling. |
| CSN15691 | LY3039478 | 1421438-81-4 | LY3039478 is a novel potent Notch inhibitor with an IC50 of 041 nM |
| CSN18826 | IMR-1A | 331862-41-0 | IMR-1A is the metabolite of IMR-1 a Notch inhibitor targeting the transcriptional activation |
| CSN18825 | IMR-1 | 310456-65-6 | IMR-1 is a cell penetrant and potent inhibitor of Notch transcriptional activation complex with IC50 of 6 M for targeting the transcriptional activation |
| CSN18205 | FLI-06 | 313967-18-9 | FLI-06 is a Notch signaling inhibitor with EC50 of 2.3 μM which can disrupt Notch trafficking and processing. |
| CSN27670 | CB-103 | 218457-67-1 | CB-103 is a first-in-class orally active pan-notch signaling pathway inhibitor extracted from patent US9296682B2 with anti-tumor activity. |
| CSN13458 | Bruceine D | 21499-66-1 | Bruceine D, a natural product isolated and purified from the barks of Ailanthus altissima, may have the potential to be used as a natural viricide, or a lead compound for viricides, inhibits the growth of three pancreatic cancer cell lines, i.e., PANC-1, SW1990 and CAPAN-1, and induces cytotoxicity in Capan-2 cells via the induction of cellular apoptosis involving the mitochondrial pathway. |
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