NOT

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Pathway
ADC ADC Linker ADC Linker with Payload ADC Toxin
Anti-infection Antibacterial Antifungal Antiparasitic CMV Filovirus HBV HCV HIV HIV Integrase HIV Protease HRV HSV Influenza Virus NNRTI NRTI Orthopoxvirus Reverse Transcriptase RSV SARS-CoV CCR Dengue Virus HHV LpxC Neuraminidase NS2B-NS3 Protease Prion SQLE Antiviral β-lactamase FCoV 3CLpro M2 proton channel Antiprotozoal Viral MTase PLP GraR
Apoptosis Apoptosis Inducer Bcl-2 Caspase c-Myc c-RET DAPK IAP MDM2 p53 PD-1/PD-L1 PERK PKD Survivin Thymidylate Synthase TNF-alpha G0/G1 switch protein 2 MDM2/PROTAC Mcl-1 (stapled peptide) Bim (stapled peptide) Bcl-2 (stapled peptide) p53/MDM2 (stapled peptide)
Autophagy Autophagy CXCR LRRK2 ULK SPHK PPT mitoNEET TFEB
Cell Cycle APC Aurora Kinase Casein Kinase CDK Chk c-Myc CRISPR/Cas9 CRM1 DHFR DNA/RNA Synthesis DUB DYRK eIF G-quadruplex Haspin Kinase HSP IRE1 Kinesin LIMK Microtubule/Tubulin Mps1 Nucleoside Antimetabolite/Analog p97 PAK PD-1/PD-L1 PERK PLK PPAR PTEN RAD51 Rho ROCK Wee1 BUB HSF Mad2 p21 E1/E2/E3 Enzyme FOXM1 MKLP Cdc25 TACC DOCK Clathrin MARP Lats kinase
Cytoskeleton Akt Bcr-Abl Dynamin FAK Gap Junction Protein HSP Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK Wnt β-catenin Selectin Arp2/3 Complex PKC Spastin Gap Junction MLCK TACC
DNA Damage ATM/ATR DNA/RNA Synthesis DNA Alkylator/Crosslinker DNA-PK HDAC MTH1 PARP Sirtuin Telomerase Topoisomerase OGG ATAD5
Endocrinology/Hormones 5 Alpha Reductase ACE Androgen Receptor Aromatase ERR Glucocorticoid Receptor GPCR Opioid Receptor Progesterone Receptor Renin TPO TRHR Thyroid Hormone Receptor
Epigenetics AMPK Aurora Kinase CECR2 DNA Methyltransferase Epigenetic Reader Domain HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MicroRNA PAD PARP Pim PKC Sirtuin TET MBD-containing protein EZH2 (stapled peptide) HES FTO
GPCR/G Protein Adenosine Receptor Adiponectin Receptor Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRTH2 CXCR Dopamine Receptor Endothelin Receptor GHSR Glucagon Receptor Glucocorticoid Receptor GNRH Receptor Guanylate Cyclase Hedgehog Histamine Receptor Imidazoline Receptor LPA Receptor LTR mGluR Motilin Receptor MT Receptor Neurotensin Receptor NK Receptor NMUR Opioid Receptor OX Receptor OXTR P2Y Receptor PAFR PAR PKA Prostaglandin Receptor Ras RGS SGLT Sigma Receptor SSTR TSH Receptor Urotensin Receptor Vasopressin Receptor HDR More >>
Immunology/Inflammation CCR Complement System COX CRTH2 CXCR FLAP Histamine Receptor IFNAR IL Receptor IRAK LTR MALT1 NADPH Oxidase NLR NOS Nrf2 PD-1/PD-L1 PGE Synthase ROS SIK STING Thrombopoietin Receptor TLR Calcineurin Complement Receptor IL IRF3 MIF S100A9 TSPO cGAS Immunology & Inflammation Related LTA4H MyD88 macrophage/microglia NFAT FPR CYPA CD80 Scavenger receptor NOT CD28-B7 Endorphin LanC-like protein PG Synthase XBP1 S100β
JAK/STAT Signaling EGFR JAK Pim STAT
MAPK/ERK Pathway ERK JNK KLF MEK MLK MNK p38 MAPK Raf RSK Cot/tpl2 MAP3K12 MAP4K4 AP-1
LIF/Stat3 LIF
Membrane Transporter/Ion Channel AMPAR BCRP CFTR Chloride Channel CRAC Channel CRM1 EAAT2 HCN Channel MAT MCT Na+/Ca2+ Exchanger NKCC P2X Receptor P-gp Potassium Channel Proton Pump Sodium Channel TRPV URAT1 VDAC GABA Receptor IBAT Oct SGLT AChR ATPase Calcium Channel EAAT1 GlyT1 Na+/K+ ATPase NBC NMDAR TRP Channel SLC Glutamate transporter UCP ENT GABA transporter Glycine transporter Kainate receptor ABC Transporter ANT AKK1 Efflux pump Clathrin Piezo OCTN
Metabolic Enzyme 15-PGDH ACC ACE Adenosine Deaminase Adenosine Kinase AhR ALDH Aldose Reductase Aminopeptidase ATP Citrate Lyase Carbonic Anhydrase Cathepsin CETP COMT CPA Decarboxylase Dehydrogenase DGAT DHFR Elastase Enolase FAAH FABP Factor Xa FAS Ferroptosis FXR Glucokinase GLUT1 GSNOR GST Hexokinase HIF HIV Integrase HMGCR HSP Hydroxylase IDH IDO Lipase Lipoxygenase LXR MAO Mineralocorticoid Receptor NAE NAMPT Neprilysin P450 PAI-1 More >>
Neuronal Signaling AChE Adenosine Kinase Adrenergic Receptor AMPAR Amyloid-β CaMK CGRP Receptor COMT COX DAT Dopamine Receptor FAAH GABA Receptor GlyT1 Histamine Receptor Imidazoline Receptor MAO mGluR MT Receptor NK Receptor NMDAR Opioid Receptor OX Receptor P2X Receptor P-gp Secretase SSRIs Substance P Choline Cholinesterase Enkephalinase Glucosylceramide Synthase NET PSD-95 RAGE SERT 5-HT Receptor AChR Proprotein convertases QC AQP4 CHT GABA transporter Glycine transporter Kainate receptor Endorphin S100β
PI3K/Akt/mTOR Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN RSK FOXO PHLPP PDK
Protease Caspase Cysteine Protease DPP4 Glutaminase HIV Protease MMP Proteasome Secretase Ser/Thr Protease NEP PE Aspartic Protease Tyrosinase DPP2
Protein Tyrosine Kinase/RTK Ack1 ALK Bcr-Abl BMX Kinase BTK c-FMS c-Kit c-Met/HGFR c-RET DDR1/DDR2 Receptor DYRK EGFR Ephrin Receptor FAK FGFR FLT3 HER2 IGF-1R Insulin Receptor ITK PDGFR PKA PTK Pyk2 Ros1 Src Syk TAM Receptor Tie-2 Trk Receptor VEGFR BRK MERTK FGF Tec ErbB
Stem Cells/Wnt Casein Kinase ERK Gli GSK-3 Hedgehog JAK MST Notch PKA PORCN ROCK Secretase sFRP-1 Smo STAT Wnt YAP β-catenin BMI-1 TGF-beta Receptor CREB β-catenin (stapled peptide) Notch (stapled peptide) PKA/AKAP (stapled peptide) MARP LIN28 LRH-1
TGF-beta/Smad TGF-beta Receptor Smad TGF-beta MARP
Ubiquitin APC DUB NAE p97 Proteasome E1/E2/E3 Enzyme SUMO FBXO
Phosphatase
NF-κB HDAC IKK MALT1 NF-κB Nrf2 PPAR RIP Kinase TAK1
Biochemical Reagent Intermediate and Others Biochemical Assay Reagent Dye Reagent
PROTAC E1/E2/E3 Enzyme MDM2/PROTAC Others
Stapled Peptide Mcl-1 (stapled peptide) β-catenin (stapled peptide) EZH2 (stapled peptide) SOS1/KRAS (stapled peptide) Notch (stapled peptide) PKA/AKAP (stapled peptide) Beclin 1 (stapled peptide) Bim (stapled peptide) Bcl-2 (stapled peptide) p53/MDM2 (stapled peptide) RAP1/TRF2 (stapled peptide) Rab (stapled peptide) VDR (stapled peptide) β-arrestin/β-adaptin (stapled peptide)
Others Phosphatase SRPK Diuretic DUE-B E2F ECE FANCJ FAP Fer/FerT FPP synthase Fucosyltransferase Galectin-3 GBF1 GCase HIPK2 HPPD Insecticide LAT1 MLKL MPO MPTP MTTP Muscle Relaxant NMD NO Synthesis Nur77 Osteoclasts/Bone/Osteogenesis PAX2 PBR PCA1 PCSK9 PDX1 PFKFB3 Phosphorylase PIN1 PKG Platelet PME-1 Protein Synthesis Rev-ErbA SAP SQS SREBP Sweetener Tgase TIR1 UGT1A1 Urease Vanin More >>

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NOT

NOT1, 2, 3 and 4 proteins are part of a regulatory complex that negatively affects transcription. All four NOT proteins were found to co-immunoprecipitate with CCR4 and CAF1, and NOT1 co-purified with CCR4 and CAF1 through three chromatographic steps in a complex estimated to be 1.2x10(6) Da in size.

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