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NOS
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN19029 | ZL006 | 1181226-02-7 | ZL006 is a potent inhibitor of nNOSPSD-95 interaction and inhibits NMDA receptor-mediated NO synthesis |
| CSN14855 | Verminoside | 50932-19-9 | Verminoside, a natural product isolated and purified from the barks of Kigelia pinnata with anti-inflammatory effect, inhibits both iNOS expression and NO release in the LPS-induced J774.A1 macrophage cell line. |
| CSN14690 | Triptoquinone A | 142950-86-5 | Triptoquinone A, a natural product isolated and purified from the roots of Tripterygium wilfordii Hook.f. |
| CSN23846 | Tetrahydrobiopterin | 17528-72-2 | Tetrahydrobiopterin is a cofactor of the aromatic amino acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase (NOS) isoforms. |
| CSN25207 | SDMA | 30344-00-4 | SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity. |
| CSN22638 | (S)-Methylisothiourea Sulfate | 867-44-7 | S-Methylisothiourea Sulfate is a highly selective potent and competitive inhibitor of iNOS |
| CSN26150 | S-Methyl-L-thiocitrulline | 209589-59-3 | S-Methyl-L-thiocitrulline (Me-TC) is a potent NOS inhibitor. It inhibited the oxidation of L-arginine and the L-arginine-independent oxidation of NADPH by nNOS from human brain. |
| CSN10641 | prim-O-Glucosylcimifugin | 80681-45-4 | Prim-O-glucosylcimifugin is a natural product isolated and purified from the root of Saposhnikovia divaricata (Turcz.) Schischk., which can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0G1 phase. |
| CSN22647 | Piperidin-2-imine HCl | 16011-96-4 | Piperidin-2-imine HCl is a selective iNOS inhibitor. |
| CSN25404 | L-NNA | 2149-70-4 | Nitroarginine, or Nω-nitro-L-arginine, is a nitro derivative of the amino acid arginine. It is an inhibitor of nitric oxide synthase and hence a vaso-constrictor and coronary constrictor. As such, it finds widespread use as a biochemical tool in the study of nitric oxide and its biological effects. Nitroarginine has been used in research studying coronary constriction, in the presence of midazolam vasodilatation was unaffected by nitroarginine. Nitroarginine is currently in clinical trials for treating patients with advanced solid tumors. |
| CSN21155 | L-NMMA Acetate | 53308-83-1 | L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 M, respectively. |
| CSN22944 | L-NIO 2HCl | 159190-44-0 | L-NIO 2HCl is an inhibitor of nitric oxide (NO) synthase, including iNOS, eNOS and nNOS. |
| CSN22943 | L-NIL HCl | 150403-89-7 | L-NIL HCl is a selective inhibitor of inducible nitric oxide synthase with IC50 of 3.3 μM. |
| CSN16603 | L-NAME HCl | 51298-62-5 | L-NAME HCl is a non-selective NOS inhibitor with Ki values of 15 nM 39 nM and 44 M for nNOS bovine eNOS human and iNOS murine respectively |
| CSN22880 | L-Canavanine Sulfate | 2219-31-0 | L-Canavanine Sulfate is a NO synthase inhibitor. |
| CSN15716 | L-Arginine HCl | 1119-34-2 | L-Arginine HCl is a substrate of NOS and a nonessential amino acid in human. |
| CSN22080 | Kuwanon A | 62949-77-3 | Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.) and inhibits nitric oxide production with IC50 of 10.5 μM. |
| CSN16369 | Imperatorin | 482-44-0 | Imperatorin is a naturally occuring multiple-target inhibitor of NOS with IC50 value of 9.2 M, BChE with IC50 value of 31.4 M, a potent calcium antagonist on vascular smooth muscle. It is also a weak agonist of TRPV1 with EC50 of 12.63.2 M. |
| CSN19030 | IC-87201 | 866927-10-8 | IC87201 an inhibitor of PSD95-nNOS protein-protein interactions suppresses NMDAR-dependent NO and cGMP formation |
| CSN18103 | GW274150 | 210354-22-6 | GW274150 is an arginine-competitive, NADPH-dependent iNOS inhibitor that has been identified from a series of acetamide amino acids that have a high selectivity for iNOS vs both eNOS ( 260-fold) and nNOS ( 219-fold) and high bioavailability ( 90) after oral administration. |
| CSN22803 | EIT Hydrobromide | 1071-37-0 | EIT Hydrobromide is a potent, selective and reversible inhibitor of isoform II NO synthase with IC50 of 13 nM. |
| CSN12661 | Dehydroevodiamine | 67909-49-3 | Dehydroevodiamine is an alkaloid isolated from E. rutaecarpa and possesses anti-inflammatory, antiarrhythmic, hypotensive, and anti-amnesic biological activities. |
| CSN10310 | Dehydroandrographolide | 134418-28-3 | Dehydroandrographolide is extracted from herbal medicine Andrographis paniculata (Burm f) Nees and alleviates oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS. |
| CSN22730 | BYK 191023 2HCl | 1216722-25-6 | BYK 191023 2HCl is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS) with IC50 of 86 nM. |
| CSN27536 | Asymmetric dimethylarginine | 30315-93-6 | Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states. |
| CSN22685 | AR-C 102222 | 1781934-50-6 | AR-C 102222 is a selective iNOS inhibitor with IC50 of 0.037 μM. |
| CSN19966 | Apiin | 26544-34-3 | Apiin can inhibit iNOS expression and nitrite production in J774.A1 cells. It is a flavonoid isolated from the herbs of petroselinum crispum. |
| CSN22682 | AMT HCl | 21463-31-0 | AMT HCl is a potent, selective and reversible inhibitor of iNOS with IC50 of 3.6 nM. |
| CSN10284 | Aminoguanidine HCl | 1937-19-5 | Aminoguanidine HCl is a selective and irreversible iNOS inhibitor. |
| CSN23420 | Agmatine sulfate | 2482-00-0 | Agmatine sulfate is a competitive NOS inhibitor |
| CSN23606 | 7-Nitroindazole | 2942-42-9 | 7-Nitroindazole is a competitive reversible and non-selective NOS inhibitor |
| CSN25443 | 3-Bromo-7-nitroindazole | 74209-34-0 | 3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or inducible nitric oxide synthase (iNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain. |
| CSN12781 | 2-(2-Aminoethyl)isothiourea dihydrobromide | 56-10-0 | 2-2-Aminoethylisothiourea dihydrobromide inhibits nitric oxide synthase NOS |
| CSN14783 | 15-Methoxypinusolidic Acid | 769928-72-5 | 15-Methoxypinusolidic acid, a natural product isolated and purified from the leaves of Biota orientalis, induces apoptosis in murine microglial cells, presumably via inhibition of the cell cycle progression, inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB, suppresses adipocyte differentiation through the inhibition of PPARgamma-dependent adipogenic gene expression, and attenuates glutamate-induced excitotoxicity via stabilization of [Ca2+]i homeostasis and suppression of oxidative stress possibly through the actions on the NMDA receptors. |
| CSN16858 | 1400W 2HCl | 214358-33-5 | 1400W 2HCl is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase (iNOS). |
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