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NOS

NOS

Cat. No. Product Name CAS No. Information
CSN19029 ZL006 1181226-02-7 ZL006 is a potent inhibitor of nNOSPSD-95 interaction and inhibits NMDA receptor-mediated NO synthesis
CSN14855 Verminoside 50932-19-9 Verminoside, a natural product isolated and purified from the barks of Kigelia pinnata with anti-inflammatory effect, inhibits both iNOS expression and NO release in the LPS-induced J774.A1 macrophage cell line.
CSN14690 Triptoquinone A 142950-86-5 Triptoquinone A, a natural product isolated and purified from the roots of Tripterygium wilfordii Hook.f.
CSN23846 Tetrahydrobiopterin 17528-72-2 Tetrahydrobiopterin is a cofactor of the aromatic amino acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase (NOS) isoforms.
CSN25207 SDMA 30344-00-4 SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity.
CSN22638 (S)-Methylisothiourea Sulfate   867-44-7 S-Methylisothiourea Sulfate is a highly selective potent and competitive inhibitor of iNOS
CSN26150 S-Methyl-L-thiocitrulline 209589-59-3 S-Methyl-L-thiocitrulline (Me-TC) is a potent NOS inhibitor. It inhibited the oxidation of L-arginine and the L-arginine-independent oxidation of NADPH by nNOS from human brain.
CSN10641 prim-O-Glucosylcimifugin 80681-45-4 Prim-O-glucosylcimifugin is a natural product isolated and purified from the root of Saposhnikovia divaricata (Turcz.) Schischk., which can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0G1 phase.
CSN22647 Piperidin-2-imine HCl 16011-96-4 Piperidin-2-imine HCl is a selective iNOS inhibitor.
CSN25404 L-NNA 2149-70-4 Nitroarginine, or Nω-nitro-L-arginine, is a nitro derivative of the amino acid arginine. It is an inhibitor of nitric oxide synthase and hence a vaso-constrictor and coronary constrictor. As such, it finds widespread use as a biochemical tool in the study of nitric oxide and its biological effects. Nitroarginine has been used in research studying coronary constriction, in the presence of midazolam vasodilatation was unaffected by nitroarginine. Nitroarginine is currently in clinical trials for treating patients with advanced solid tumors.
CSN21155 L-NMMA Acetate 53308-83-1 L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 M, respectively.
CSN22944 L-NIO 2HCl 159190-44-0 L-NIO 2HCl is an inhibitor of nitric oxide (NO) synthase, including iNOS, eNOS and nNOS.
CSN22943 L-NIL HCl 150403-89-7 L-NIL HCl is a selective inhibitor of inducible nitric oxide synthase with IC50 of 3.3 μM.
CSN16603 L-NAME HCl   51298-62-5 L-NAME HCl is a non-selective NOS inhibitor with Ki values of 15 nM 39 nM and 44 M for nNOS bovine eNOS human and iNOS murine respectively
CSN22880 L-Canavanine Sulfate 2219-31-0 L-Canavanine Sulfate is a NO synthase inhibitor.
CSN15716 L-Arginine HCl   1119-34-2 L-Arginine HCl is a substrate of NOS and a nonessential amino acid in human.
CSN22080 Kuwanon A 62949-77-3 Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.) and inhibits nitric oxide production with IC50 of 10.5 μM.
CSN16369 Imperatorin   482-44-0 Imperatorin is a naturally occuring multiple-target inhibitor of NOS with IC50 value of 9.2 M, BChE with IC50 value of 31.4 M, a potent calcium antagonist on vascular smooth muscle. It is also a weak agonist of TRPV1 with EC50 of 12.63.2 M.
CSN19030 IC-87201 866927-10-8 IC87201 an inhibitor of PSD95-nNOS protein-protein interactions suppresses NMDAR-dependent NO and cGMP formation
CSN18103 GW274150 210354-22-6 GW274150 is an arginine-competitive, NADPH-dependent iNOS inhibitor that has been identified from a series of acetamide amino acids that have a high selectivity for iNOS vs both eNOS ( 260-fold) and nNOS ( 219-fold) and high bioavailability ( 90) after oral administration.
CSN22803 EIT Hydrobromide 1071-37-0 EIT Hydrobromide is a potent, selective and reversible inhibitor of isoform II NO synthase with IC50 of 13 nM.
CSN12661 Dehydroevodiamine   67909-49-3 Dehydroevodiamine is an alkaloid isolated from E. rutaecarpa and possesses anti-inflammatory, antiarrhythmic, hypotensive, and anti-amnesic biological activities.
CSN10310 Dehydroandrographolide   134418-28-3 Dehydroandrographolide is extracted from herbal medicine Andrographis paniculata (Burm f) Nees and alleviates oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS.
CSN22730 BYK 191023 2HCl 1216722-25-6 BYK 191023 2HCl is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS) with IC50 of 86 nM.
CSN27536 Asymmetric dimethylarginine 30315-93-6 Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states.
CSN22685 AR-C 102222 1781934-50-6 AR-C 102222 is a selective iNOS inhibitor with IC50 of 0.037 μM.
CSN19966 Apiin 26544-34-3 Apiin can inhibit iNOS expression and nitrite production in J774.A1 cells. It is a flavonoid isolated from the herbs of petroselinum crispum.
CSN22682 AMT HCl 21463-31-0 AMT HCl is a potent, selective and reversible inhibitor of iNOS with IC50 of 3.6 nM.
CSN10284 Aminoguanidine HCl   1937-19-5 Aminoguanidine HCl is a selective and irreversible iNOS inhibitor.
CSN23420 Agmatine sulfate   2482-00-0 Agmatine sulfate is a competitive NOS inhibitor
CSN23606 7-Nitroindazole   2942-42-9 7-Nitroindazole is a competitive reversible and non-selective NOS inhibitor
CSN25443 3-Bromo-7-nitroindazole 74209-34-0 3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or inducible nitric oxide synthase (iNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain.
CSN12781 2-(2-Aminoethyl)isothiourea dihydrobromide 56-10-0 2-2-Aminoethylisothiourea dihydrobromide inhibits nitric oxide synthase NOS
CSN14783 15-Methoxypinusolidic Acid 769928-72-5 15-Methoxypinusolidic acid, a natural product isolated and purified from the leaves of Biota orientalis, induces apoptosis in murine microglial cells, presumably via inhibition of the cell cycle progression, inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB, suppresses adipocyte differentiation through the inhibition of PPARgamma-dependent adipogenic gene expression, and attenuates glutamate-induced excitotoxicity via stabilization of [Ca2+]i homeostasis and suppression of oxidative stress possibly through the actions on the NMDA receptors.
CSN16858 1400W 2HCl 214358-33-5 1400W 2HCl is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase (iNOS).
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