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NLR

NLR

Cat. No. Product Name CAS No. Information
CSN18850 NOD-IN-1 132819-92-2 NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 M and 6.45 M, respectively.
CSN16516 ML130 799264-47-4 ML130 is a selective and potent NOD1 inhibitor with IC50 of 560 nM. It inhibits NOD1-induced NF-B activation.
CSN18163 MCC950 Sodium 256373-96-3 MCC950 Sodium is a potent and highly specific small molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 nM in BMDMs.
CSN18104 MCC950 210826-40-7 MCC950 is a potent, selective, small-molecule inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs.
CSN22257 INF39   866028-26-4 INF39 is an irreversible NLRP3 inhibitor with IC50 value of 100 M for inhibiton of NLRP3 ATPase which can inhibit IL-1 release caspase activation and pyroptosis in THP-1 cells
CSN21903 NLRP3i 16673-34-0 Glibenclamide impurity A is an inhibitor of the formation of the NLRP3 inflammasome in cardiomyocytes.
CSN21218 CY-09   1073612-91-5 CY-09 can inhibit NLRP3 with Kd value of 500 nM through directly bounding to the ATP-binding site of the NLRP3 NACHT domain.
CSN25202 Chalcone, 2′,4′-dihydroxy-6′-methoxy- 18956-16-6 Cardamonin (Cardamomin), a natural flavone isolated from Alpinia katsumadai Hayata, acts as an aryl hydrocarbon receptor (AhR) activator. Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway .
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