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NF-κB

NF-kB

Cat. No. Product Name CAS No. Information
CSN19410 Tanshinone IIA   568-72-9 Tanshinone IIA is a naturally occuring cardioprotective agent which can inhibit NF-B and AP-1 DNA binding and display antioxidant and anti-inflammatory properties.
CSN12011 Sulfasalazine   599-79-1 Sulfasalazine is a potent and specific NF-B inhibitor and also inhibits system Xsubcsub and induces ferroptosis.
CSN16392 Sodium Salicylate   54-21-7 Sodium Salicylate is anti-inflammatory drugs which can inhibit the activation of NF-kappa B.
CSN19187 SC75741 913822-46-5 SC75741 is a novel NF-kappaB inhibitor.
CSN18329 PNRI-299 550368-41-7 PNRI-299 is a selective AP-1 transcription inhibitor with IC50 of 20 M without affecting NF-kappaB transcription (up to 200 M) or thioredoxin (up to 200 M).
CSN18699 Parthenolide   20554-84-1 Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium) with multiple biological functions. Parthenolide inhibits the growth of the promastigote form of L. amazonensis with IC50 of 3.6 gmL, induces apoptosis in cancer cells and blocks inflammation by inhibiting signaling through NF-B.
CSN20622 NIK Inhibitor C33 1451079-18-7 NIK inhibitor C33 is a high-selective inhibitor of tricyclic NF-B inducing kinase (NIK) over PI3K.
CSN20621 NIK Inhibitor C32 1555655-78-1 NIK inhibitor C32 is a high-selective inhibitor of tricyclic NF-B inducing kinase (NIK) over PI3K.
CSN11532 Neferine 2292-16-2 Neferine, is a major alkaloid present in the green embryos of Nelumbo nucifera Gaertn with anti-arrhythmia, anti-hypertensive and vaso-relaxant properties , and is also a NF-B inhibitor.
CSN12446 Magnolol 528-43-8 Magnolol is a multifunctional compound isolated from the Chinese medicinal plant Magnolia officinalis, with antifungal, antibacterial and antioxidant effects, as well as anti-inflammatory activity by interferring with NF-B signaling and inhibiting IL-6-induced STAT3 activation.
CSN12507 Lipoic Acid   1200-22-2 Lipoic Acid can inhibit TNF-alpha-induced NF-kappaB activation.
CSN16019 JSH-23   749886-87-1 JSH-23 is an inhibitor of NF-B transcriptional activity with IC50 of 7.1 M in RAW 264.7 cell line.
CSN21426 GSK-963 2049868-46-2 GSK963 inhibits RIP1-dependent cell death with an IC50 of between 1 and 4nM in human and murine cells.
CSN23601 Ethyl caffeate   102-37-4 Ethyl caffeate shows suppressesion of NF-B activation and its downstream inflammatory mediators. It can be found in bidens pilosa.
CSN21353 Edasalonexent 1204317-86-1 Edasalonexent is an orally bioavailable NF-B inhibitor.
CSN10802 Diethyl Maleate   141-05-9 Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NFkB.
CSN18398 Didox 69839-83-4 Didox can prevent LPS-induced NF-KB activation and translocation of NF-kappa beta p65 subunits.
CSN10751 Dauricine 524-17-4 Dauricine is a plant metabolite, chemically classified as a phenol, an aromatic ether, and an isoquinoline alkaloid.
CSN15792 CID-2858522 758679-97-9 CID-2858522 selectively inhibits the NF-B pathway (IC50 0.1 M for PMA-stimulated IL-8 production) induced by PKC, operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activation pathways.
CSN22315 CBL0137 HCl   1197397-89-9 CBL0137 HCl is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 M and inhibits NF-B with an EC50 of 0.47 M.
CSN10538 Caffeic Acid Phenethyl Ester   104594-70-9 Caffeic acid phenethyl ester, a natural product isolated and purified from the barks of Cinnamomum cassia Presl, is a potent and specific inhibitor of NF-B activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities.
CSN19420 Andrographolide   5508-58-7 Andrographolide is a naturally occuring NF-B inhibitor.
CSN17286 Ammonium Pyrrolidine-1-Carbodithioate   5108-96-3 Ammonium pyrrolidine-1-carbodithioate is a selective NF-B inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.
CSN18157 Adjudin   252025-52-8 Adjudin exhibits anti-inflammatory properties by suppression of NF-B p65 nuclear translocation and DNA binding activity as well as ERK MAPK phosphorylation.
CSN17995 Adelmidrol   1675-66-7 Adelmidrol is an ethanolamide derivative of azelaic acid with anti-inflammatory properties partly dependent on PPAR, it also markedly reduce pro-inflammatory NF-B pathway.
CSN23578 4'-Hydroxychalcone   2657-25-2 4-Hydroxychalcone has diverse biological activities including inhibiting TNF-induced NF-B pathway activation and activating BMP signaling. It is found in herbs and spices and tea, is a member of the class of compounds known as retrochalcones.
CSN23620 4-Aminosalicylic acid   65-49-6 4-Aminosalicylic acid, known as PAS, is an antibacterial agent used to treat tuberculosis. It works by suppressing NF-B and scavenging free radicals.
CSN14830 11-Hydroxytephrosin 72458-85-6 11-Hydroxytephrosin, a natural product isolated and purified from the herbs of Derris robusta, inhibits NF-kappaB activity.
CSN13425 (-)-DHMEQ 287194-40-5 (-)-DHMEQ, the eutomer of DHMEQ , is a developed NF-kB inhibitor with stronger activity than ()-DHMEQ., inhibits nuclear factor kB activation with IC50 value of 20 ugmL.
CSN19066 (+)-DHMEQ 287194-41-6 ()-DHMEQ, the distomer of DHMEQ, is an inhibitor of NF-B.
CSN22711 Bengamide B 104947-69-5
CSN23067 Ro 106-9920 62645-28-7
CSN23316 Curcumenol 19431-84-6
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