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Neurological Disease

Cat. No. Product Name CAS No. Information
CSN11878 SA4503 2HCl 165377-44-6 SA4503 2HCl is the 2HCl form of SA4503 which is an agonist of opioid sigma1 receptor (σ1R) with IC50 of 17.4 nM.
CSN13513 Alvimopan 156053-89-3 Alvimopan is a peripherally selective opioid mu receptor antagonist.
CSN16070 Reboxetine Mesylate 98769-84-7 Reboxetine Mesylate is a norepinephrine reuptake inhibitor (NRI) used in the treatment of unipolar depression.
CSN12584 Riluzole 1744-22-5 Riluzole is an antagonist of glutamate that used as an anticonvulsant. It can prolong the survival of patients with amyotrophic lateral sclerosis.
CSN17988 SA4503 165377-43-5 SA4503 is an agonist of opioid sigma1 receptor (1R) with IC50 of 17.4 nM.
CSN12336 Fosaprepitant Dimeglumine 265121-04-8 Fosaprepitant Dimeglumine is a prodrug for aprepitant which is a selective and high-affinity antagonist of NK1 receptor.
CSN16369 Imperatorin 482-44-0 Imperatorin is a naturally occuring multiple-target inhibitor of NOS with IC50 value of 9.2 M, BChE with IC50 value of 31.4 M, a potent calcium antagonist on vascular smooth muscle. It is also a weak agonist of TRPV1 with EC50 of 12.63.2 M.
CSN12115 Topiramate 97240-79-4 Topiramate is a selective GluK1 kainate receptors (GluR5) antagonist with IC50 value of 0.46 M which can act as a positive allosteric modulator of GABAA receptor-mediated currents, inhibit Nav channels and L-type Ca2 channels.
CSN11859 Rolipram 61413-54-5 Rolipram is a selective inhibitor of phosphodiesterases PDE 4, especially the PDE 4B with IC50 of 130 nM while IC50 for PDE4D is 240 nM, its an anti-inflammatory agent.
CSN16213 Nonivamide 2444-46-4 Nonivamide, an analog of capsaicin, is agonist of transient receptor potential vanilloid type 1 (TRPV1). It can be extracted from the fruits of Capsicum annuum L..
CSN10324 Aprepitant 170729-80-3 Aprepitant is a selective and high-affinity neurokinin-1 receptor antagonist with IC50 of 0.1 nM.
CSN12946 Paroxetine HCl 78246-49-8 Paroxetine HCl is a selective serotonin-reuptake inhibitor (SSRI) with antidepressant activity.
CSN11379 Mephenesin 59-47-2 Mephenesin is a centrally acting muscle relaxant which may work as an NMDA receptor antagonist.
CSN10736 Desvenlafaxine 93413-62-8 Desvenlafaxine inhibits serotonin(5-HT) and norepinephrine (NE) reuptake with Ki of 40.2 nM and 558.4 nM, respectively.
CSN12817 Fluoxetine HCl 56296-78-7 Fluoxetine HCl, an antidepressant, is an inhibitor of the selective serotonin reuptake with Kd of 0.81 nM against serotonin transporter.
CSN16283 Carbamazepine 298-46-4 Carbamazepine is a blocker of sodium channel with IC50 of 131 M in rat brain synaptosomes. It is an anticonvulsant drug.
CSN16436 Acetylcysteine 616-91-1 Acetylcysteine is an inhibitor of ROS and the production of TNF. It is a pharmaceutical drug and nutritional supplement used as mucolytic agent.
CSN13883 (+)-MK 801 Maleate 77086-22-7 ()-MK 801 Maleate is a highly potent, selective and non-competitive NMDA receptor antagonist with Ki of 30.5 nM.
CSN12795 Phenytoin 57-41-0 Phenytoin is an inactive voltage-gated sodium channel stabilizer.
CSN18136 Emapunil 226954-04-7 Emapunil is a ligand of translocator protein TSPO (18 kDa) with Ki of 0.297 nM. It can enhance GABA-mediated neurotransmission via induction of neurosteroidogenesis and has antidepressant effect.
CSN13650 Alvimopan Dihydrate 170098-38-1 Alvimopan is a peripherally acting mu-opioid receptor (PAM-OR, IC50 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery.
CSN12199 Vilazodone 163521-12-8 Vilazodone is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.
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