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Neurological Disease

Cat. No. Product Name CAS No. Information
CSN13896 DAPT 208255-80-5 DAPT is an inhibitor of -secretase and it can reduce the expression of A40 and A42 with IC50 values of 115 nM and 200 nM.
CSN11878 SA4503 2HCl 165377-44-6 SA4503 2HCl is the 2HCl form of SA4503 which is an agonist of opioid sigma1 receptor (σ1R) with IC50 of 17.4 nM.
CSN13513 Alvimopan 156053-89-3 Alvimopan is a peripherally selective opioid mu receptor antagonist.
CSN11872 Rufinamide 106308-44-5 Rufinamide, an antiepileptic agent, is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS).
CSN16070 Reboxetine Mesylate 98769-84-7 Reboxetine Mesylate is a norepinephrine reuptake inhibitor (NRI) used in the treatment of unipolar depression.
CSN12584 Riluzole 1744-22-5 Riluzole is an antagonist of glutamate that used as an anticonvulsant. It can prolong the survival of patients with amyotrophic lateral sclerosis.
CSN17988 SA4503 165377-43-5 SA4503 is an agonist of opioid sigma1 receptor (1R) with IC50 of 17.4 nM.
CSN12336 Fosaprepitant Dimeglumine 265121-04-8 Fosaprepitant Dimeglumine is a prodrug for aprepitant which is a selective and high-affinity antagonist of NK1 receptor.
CSN17246 Azeliragon 603148-36-3 Azeliragon is an orally bioavailable inhibitor of the receptor for advanced glycation endproducts (RAGE) with Kd of 12.7 nM for human recombinant sRAGE. While RAGE transports amyloid- (A) from plasma into the CNS, Azeliragon is evaluated as a potential treatment for patients with mild-to-moderate Alzheimers disease (AD).
CSN16369 Imperatorin 482-44-0 Imperatorin is a naturally occuring multiple-target inhibitor of NOS with IC50 value of 9.2 M, BChE with IC50 value of 31.4 M, a potent calcium antagonist on vascular smooth muscle. It is also a weak agonist of TRPV1 with EC50 of 12.63.2 M.
CSN12115 Topiramate 97240-79-4 Topiramate is a selective GluK1 kainate receptors (GluR5) antagonist with IC50 value of 0.46 M which can act as a positive allosteric modulator of GABAA receptor-mediated currents, inhibit Nav channels and L-type Ca2 channels.
CSN11859 Rolipram 61413-54-5 Rolipram is a selective inhibitor of phosphodiesterases PDE 4, especially the PDE 4B with IC50 of 130 nM while IC50 for PDE4D is 240 nM, its an anti-inflammatory agent.
CSN16213 Nonivamide 2444-46-4 Nonivamide, an analog of capsaicin, is agonist of transient receptor potential vanilloid type 1 (TRPV1). It can be extracted from the fruits of Capsicum annuum L..
CSN10324 Aprepitant 170729-80-3 Aprepitant is a selective and high-affinity neurokinin-1 receptor antagonist with IC50 of 0.1 nM.
CSN12946 Paroxetine HCl 78246-49-8 Paroxetine HCl is a selective serotonin-reuptake inhibitor (SSRI) with antidepressant activity.
CSN11379 Mephenesin 59-47-2 Mephenesin is a centrally acting muscle relaxant which may work as an NMDA receptor antagonist.
CSN17228 (1S-cis)-Milnacipran HCl 175131-60-9 (1S-cis)-Milnacipran HCl inhibits serotonin-norepinephrine reuptake and is used for the treatment of fibromyalgia.
CSN10736 Desvenlafaxine 93413-62-8 Desvenlafaxine inhibits serotonin(5-HT) and norepinephrine (NE) reuptake with Ki of 40.2 nM and 558.4 nM, respectively.
CSN12817 Fluoxetine HCl 56296-78-7 Fluoxetine HCl, an antidepressant, is an inhibitor of the selective serotonin reuptake with Kd of 0.81 nM against serotonin transporter.
CSN11774 Procaine 59-46-1 Procaine, a benzoic acid derivative, is an anesthetic drug through targeting multiple proteins.
CSN16283 Carbamazepine 298-46-4 Carbamazepine is a blocker of sodium channel with IC50 of 131 M in rat brain synaptosomes. It is an anticonvulsant drug.
CSN12526 Ropivacaine HCl H2O 132112-35-7 Ropivacaine HCl, a local anaesthetic, can reversibly inhibit sodium ion influx and block impulse propagation along nerve fibres.
CSN12998 Lamotrigine 84057-84-1 Lamotrigine is a member of the sodium channel blocking class of antiepileptic drugs which can block L-, N-, and P-type calcium channels and has weak 5-HT3 receptor inhibition.
CSN16436 Acetylcysteine 616-91-1 Acetylcysteine is an inhibitor of ROS and the production of TNF. It is a pharmaceutical drug and nutritional supplement used as mucolytic agent.
CSN15719 CNV1014802 HCl 934240-31-0 CNV1014802 HCl is a blocker of Nav1.7 sodium channel with analgesic effects.
CSN11657 Paroxetine HCl Hemihydrate 110429-35-1 Paroxetine HCl is an antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs).
CSN13883 (+)-MK 801 Maleate 77086-22-7 ()-MK 801 Maleate is a highly potent, selective and non-competitive NMDA receptor antagonist with Ki of 30.5 nM.
CSN12795 Phenytoin 57-41-0 Phenytoin is an inactive voltage-gated sodium channel stabilizer.
CSN18136 Emapunil 226954-04-7 Emapunil is a ligand of translocator protein TSPO (18 kDa) with Ki of 0.297 nM. It can enhance GABA-mediated neurotransmission via induction of neurosteroidogenesis and has antidepressant effect.
CSN16659 CTEP 871362-31-1 CTEP is a selective allosteric mGluR5 antagonist with IC50 value of 2.2 nM.
CSN18007 NBI-98854 171598-74-6 NBI-98854 is a potent, highly selective, VMAT2 inhibitor that is effective in regulating the levels of dopamine release during nerve communication.
CSN13878 CNV1014802 934240-30-9 CNV1014802 is a blocker of Nav1.7 sodium channel.
CSN19815 Tradipitant 622370-35-8 Tradipitant is the 2nd generation neurokinin-1 receptor antagonist, which showed activity in preclinical anxiety models.
CSN13650 Alvimopan Dihydrate 170098-38-1 Alvimopan is a peripherally acting mu-opioid receptor (PAM-OR, IC50 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery.
CSN20601 LY2456302 1174130-61-0 LY-2456302 is a potent and centrally-penetrant kappa opioid receptor antagonist with a Ki of 0.807 nM.
CSN16531 Desvenlafaxine Succinate Hydrate 386750-22-7 Desvenlafaxine succinate is a serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively.
CSN15700 RG7090 802906-73-6 RG7090 is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM.
CSN16865 NBI-98782 85081-18-1 NBI-98782 is a vesicular monoamine transporter (VMAT2) inhibtior with an Ki value of 0.97 nM.
CSN12199 Vilazodone 163521-12-8 Vilazodone is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.
CSN18094 Talnetant HCl 204519-66-4 Talnetant HCl is a potent and selective NK3 receptor antagonist (ki=1.4 nM, hNK-3-CHO), 100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 μM.
CSN22504 Serlopitant 860642-69-9 Serlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist.
CSN11490 SB-334867 249889-64-3 SB-334867 is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2.
CSN18608 gamma-Secretase Modulators 937812-80-1 gamma-Secretase modulators is an Amyloid- production inhibitor, useful for Alzheimers disease.
CSN22503 Saredutant 142001-63-6 Saredutant is a selective NK2 receptor antagonist.
CSN20432 Seltorexant 1293281-49-8 Seltorexant is a selective orexin-2 receptor antagonist that has been shown to promote sleep in various species.
CSN20205 VU0424238 1396337-04-4 VU0424238 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 selected for clinical evaluation of psychiatric and neurodegenerative disorders.
CSN20616 Cannabidivarin 24274-48-4 Cannabidivarin is a non-psychoactive cannabinoid found in Cannabis that activates CB2 cannabinoid receptors as well as the transient receptor potential channels TRPA1, TRPV1, and TRPV2 (EC50s 0.42, 3.6, and 7.3 M, respectively). It is also reported to antagonize TRPM8 (IC50 0.9 M) and to inhibit diacylglycerol lipase (IC50 16.6 M).
CSN22349 Apimostinel 1421866-48-9 Apimostinel is an oral NMDA receptor partial agonist.
CSN22355 Balovaptan 1228088-30-9 Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.
CSN22403 Fonadelpar 515138-06-4 Fonadelpar is a PPAR agonist, used in the research of neuroparalytic keratopathy.
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