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Neurological Disease

Cat. No. Product Name CAS No. Information
CSN13896 DAPT 208255-80-5 DAPT is an inhibitor of -secretase and it can reduce the expression of A40 and A42 with IC50 values of 115 nM and 200 nM.
CSN11878 SA4503 2HCl 165377-44-6 SA4503 2HCl is the 2HCl form of SA4503 which is an agonist of opioid sigma1 receptor (σ1R) with IC50 of 17.4 nM.
CSN13513 Alvimopan 156053-89-3 Alvimopan is a peripherally selective opioid mu receptor antagonist.
CSN11872 Rufinamide 106308-44-5 Rufinamide, an antiepileptic agent, is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS).
CSN16070 Reboxetine Mesylate 98769-84-7 Reboxetine Mesylate is a norepinephrine reuptake inhibitor (NRI) used in the treatment of unipolar depression.
CSN12584 Riluzole 1744-22-5 Riluzole is an antagonist of glutamate that used as an anticonvulsant. It can prolong the survival of patients with amyotrophic lateral sclerosis.
CSN17988 SA4503 165377-43-5 SA4503 is an agonist of opioid sigma1 receptor (1R) with IC50 of 17.4 nM.
CSN12336 Fosaprepitant Dimeglumine 265121-04-8 Fosaprepitant Dimeglumine is a prodrug for aprepitant which is a selective and high-affinity antagonist of NK1 receptor.
CSN17246 Azeliragon 603148-36-3 Azeliragon is an orally bioavailable inhibitor of the receptor for advanced glycation endproducts (RAGE) with Kd of 12.7 nM for human recombinant sRAGE. While RAGE transports amyloid- (A) from plasma into the CNS, Azeliragon is evaluated as a potential treatment for patients with mild-to-moderate Alzheimers disease (AD).
CSN16369 Imperatorin 482-44-0 Imperatorin is a naturally occuring multiple-target inhibitor of NOS with IC50 value of 9.2 M, BChE with IC50 value of 31.4 M, a potent calcium antagonist on vascular smooth muscle. It is also a weak agonist of TRPV1 with EC50 of 12.63.2 M.
CSN12115 Topiramate 97240-79-4 Topiramate is a selective GluK1 kainate receptors (GluR5) antagonist with IC50 value of 0.46 M which can act as a positive allosteric modulator of GABAA receptor-mediated currents, inhibit Nav channels and L-type Ca2 channels.
CSN11859 Rolipram 61413-54-5 Rolipram is a selective inhibitor of phosphodiesterases PDE 4, especially the PDE 4B with IC50 of 130 nM while IC50 for PDE4D is 240 nM, its an anti-inflammatory agent.
CSN16213 Nonivamide 2444-46-4 Nonivamide, an analog of capsaicin, is agonist of transient receptor potential vanilloid type 1 (TRPV1). It can be extracted from the fruits of Capsicum annuum L..
CSN10324 Aprepitant 170729-80-3 Aprepitant is a selective and high-affinity neurokinin-1 receptor antagonist with IC50 of 0.1 nM.
CSN12946 Paroxetine HCl 78246-49-8 Paroxetine HCl is a selective serotonin-reuptake inhibitor (SSRI) with antidepressant activity.
CSN11379 Mephenesin 59-47-2 Mephenesin is a centrally acting muscle relaxant which may work as an NMDA receptor antagonist.
CSN17228 (1S-cis)-Milnacipran HCl 175131-60-9 (1S-cis)-Milnacipran HCl inhibits serotonin-norepinephrine reuptake and is used for the treatment of fibromyalgia.
CSN11774 Procaine 59-46-1 Procaine, a benzoic acid derivative, is an anesthetic drug through targeting multiple proteins.
CSN16283 Carbamazepine 298-46-4 Carbamazepine is a blocker of sodium channel with IC50 of 131 M in rat brain synaptosomes. It is an anticonvulsant drug.
CSN12998 Lamotrigine 84057-84-1 Lamotrigine is a member of the sodium channel blocking class of antiepileptic drugs which can block L-, N-, and P-type calcium channels and has weak 5-HT3 receptor inhibition.
CSN16436 Acetylcysteine 616-91-1 Acetylcysteine is an inhibitor of ROS and the production of TNF. It is a pharmaceutical drug and nutritional supplement used as mucolytic agent.
CSN15719 CNV1014802 HCl 934240-31-0 CNV1014802 HCl is a blocker of Nav1.7 sodium channel with analgesic effects.
CSN11657 Paroxetine HCl Hemihydrate 110429-35-1 Paroxetine HCl is an antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs).
CSN13883 (+)-MK 801 Maleate 77086-22-7 ()-MK 801 Maleate is a highly potent, selective and non-competitive NMDA receptor antagonist with Ki of 30.5 nM.
CSN18136 Emapunil 226954-04-7 Emapunil is a ligand of translocator protein TSPO (18 kDa) with Ki of 0.297 nM. It can enhance GABA-mediated neurotransmission via induction of neurosteroidogenesis and has antidepressant effect.
CSN16659 CTEP 871362-31-1 CTEP is a selective allosteric mGluR5 antagonist with IC50 value of 2.2 nM.
CSN13878 CNV1014802 934240-30-9 CNV1014802 is a blocker of Nav1.7 sodium channel.
CSN19815 Tradipitant 622370-35-8 Tradipitant is the 2nd generation neurokinin-1 receptor antagonist, which showed activity in preclinical anxiety models.
CSN13650 Alvimopan Dihydrate 170098-38-1 Alvimopan is a peripherally acting mu-opioid receptor (PAM-OR, IC50 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery.
CSN20601 LY2456302 1174130-61-0 LY-2456302 is a potent and centrally-penetrant kappa opioid receptor antagonist with a Ki of 0.807 nM.
CSN15700 RG7090 802906-73-6 RG7090 is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM.
CSN22504 Serlopitant 860642-69-9 Serlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist.
CSN11490 SB-334867 249889-64-3 SB-334867 is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2.
CSN18608 gamma-Secretase Modulators 937812-80-1 gamma-Secretase modulators is an Amyloid- production inhibitor, useful for Alzheimers disease.
CSN20432 Seltorexant 1293281-49-8 Seltorexant is a selective orexin-2 receptor antagonist that has been shown to promote sleep in various species.
CSN20205 VU0424238 1396337-04-4 VU0424238 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 selected for clinical evaluation of psychiatric and neurodegenerative disorders.
CSN22349 Apimostinel 1421866-48-9 Apimostinel is an oral NMDA receptor partial agonist.
CSN22355 Balovaptan 1228088-30-9 Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.
CSN22403 Fonadelpar 515138-06-4 Fonadelpar is a PPAR agonist, used in the research of neuroparalytic keratopathy.
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