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mTOR

mTOR

Cat. No. Product Name CAS No. Information
CSN17119 XL388 1251156-08-7 XL388 is a potent and selective ATP-competitive mTOR inhibitor with IC50 value of 99 nM
CSN16762 WYE-687 1062161-90-3 WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM showing 100 fold selectivity for mTOR than PI3K
CSN16829 WYE-354 1062169-56-5 WYE-354 is a potent specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM blocks mTORC1P-S6K T389 and mTORC2P-AKT S473 not P-AKT T308 selective for mTOR than PI3K 100-fold and PI3K 500-fold
CSN15879 WYE-125132 1144068-46-1 WYE-125132 is a highly potent ATP-competitive and specific mTOR kinase inhibitor with an IC50 of 019 nM highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR
CSN16670 WAY-600 1062159-35-6 WAY-600 is a potent ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM and blocks mTORC1P-S6K T389 and mTORC2P-AKT S473 but not P-AKT T308 It is selective for mTOR than PI3K 100-fold and PI3K 500-fold
CSN15687 Torin 2 1223001-51-1 Torin 2 is a potent and selective mTOR inhibitor with IC50 of 025 nM showing 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties and inhibition of ATMATRDNA-PK with EC50 of 28 nM35 nM118 nM respectively
CSN17146 Torin 1   1222998-36-8 Torin 1 is a potent inhibitor of mTORC12 with IC50 of 2 nM10 nM exhibiting 1000-fold selectivity for mTOR than PI3K
CSN17210 Salidroside   10338-51-9 Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola crenulata.
CSN26152 SAFit2 1643125-33-0 SAFit2 is a novel selective antagonist of the FK506-binding protein 51 with Ki value of 6nM.
CSN21086 RapaLink-1 1887095-82-0 RapaLink-1 is the third-generation mTOR inhibitor exploiting the unique juxtaposition of two drug (first- and second-generation mTOR kinase inhibitors) –binding pockets to create a bivalent interaction that allows inhibition of the mutants which has resistance to the previous TORKi (mTOR kinase inhibitors).
CSN17584 QL-IX-55 1223002-54-7 QL-IX-55 is a selective ATP-competitive inhibitor of mTORC12 with IC50s of 505010-50 nM for Human mTORC1Yeast mTORC1Yeast mTORC2 respectively
CSN19143 PQR620 1927857-56-4 PRQ620 is a highly potent and selective mTORC1/2 inhibitor, shows anti-tumor effects in vitro and in vivo.
CSN12732 PP242   1092351-67-1 PP 242 is the first selective and ATP competitive mTOR inhibitor with IC50 of 8 nM
CSN13796 Palomid 529 914913-88-5 Palomid 529 is a novel dual mTORC12 inhibitor.
CSN16065 OSI-027 936890-98-1 OSI-027 shows the selective and ATP competitive inhibition activities against mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively.
CSN11574 Nordihydroguaiaretic Acid 500-38-9 Nordihydroguaiaretic Acid is a naturally occuring mTORC1 inhibitor
CSN27361 Niclosamide olamine 1420-04-8 Niclosamide olamine is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models. Niclosamide olamine inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mammalian target of Rapamycin complex 1 (mTORC1) signaling.
CSN17562 mTOR-IN-1 1207358-59-5 mTOR-IN-1 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 15 nM
CSN27773 mTOR inhibitor-1   468747-17-3 mTOR inhibitor-1 is an ATP-competitive inhibitor of mTOR. It suppressed A549 cell proliferation and induced autophagy.
CSN16980 MHY1485   326914-06-1 MHY1485 is a mTOR activator and inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes
CSN19147 LY303511 HCl 2070014-90-1 LY303511 HCl is an analogue of LY294002 which can inhibit mTOR-dependent phosphorylation of S6K but not PI3K-dependent phosphorylation of Akt It also blocks voltage-gated potassium Kv channels with IC50 value of 646 M
CSN25185 L-Leucine 61-90-5 Leucine is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. It contributes to regulation of blood-sugar levels growth and repair of muscle and bone tissue growth hormone production and wound healing.
CSN12392 KU-0063794 938440-64-3 KU-0063794 is a selective inhibitor of mammalian target of rapamycin mTOR IC50 10 nM for mTORC1 and mTORC2 respectively with no effect on PI3Ks
CSN15888 INK-128   1224844-38-5 INK 128 is a potent and selective mTOR inhibitor with IC50 of 1 nM and is 200-fold less potent to class I PI3K isoforms.
CSN17116 GDC-0349 1207360-89-1 GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 38 nM showing 700-fold selectivity over PI3K and other 266 kinases
CSN22228 FT-1518 1313026-58-2 FT-1518 is a new generation selective potent and oral bioavailable mTORC1 and mTORC2 inhibitor and exhibits antitumor activity
CSN16716 Everolimus   159351-69-6 Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.
CSN16716 Everolimus   159351-69-6 Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.
CSN15905 ETP-46464 1345675-02-6 ETP-46464 is a cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR ATR DNA-PK PI 3-K and ATM IC50 06 14 36 170 and 545 nM respectively
CSN19142 CZ415   1429639-50-8 CZ415 is a potent and highly selective ATP-competitive mTOR inhibitor with pKdsupappsup value of 82
CSN17593 CC-223 1228013-30-6 CC-223 is a potent mTOR kinase inhibitor IC5016 nM with 150-fold sensitivity over the related lipid kinase PI3K IC504 M
CSN26528 BGT226 free base 915020-55-2 BGT226 is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BGT226 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the proapoptotic Bcl2 family of proteins.
CSN12949 AZD8055 1009298-09-2 AZD8055 is an ATP-competitive mTOR inhibitor with IC50 of 0.8 nM with excellent selectivity (~1,000-fold) against PI3K isoforms and ATM/DNA-PK.
CSN13850 AZD2014   1009298-59-2 AZD2014 is an mTOR inhibitor with IC50 of 2.8 nM and is highly selective against multiple PI3K isoforms (α/β/γ/δ).
CSN18073 AP1903 195514-63-7 AP1903 is a homodimer binding to FKBP and elicites potent and dosedependent apoptotic death of engineered cell line HT1080 in culture with an EC50 of 01 nM
CSN23318 3BDO 890405-51-3 3BDO is a new mTOR activator which can also inhibit autophagy.
CSN12442 (+)-Usniacin 7562-61-0 ()-Usniacin, a naturally occurring dibenzofuran derivative isolated and purified from the Usnea diffracta Vain. with antitumoral, antiviral, antibiotic, acaricidal, antipyretic, analgesic, antioxidative and anti-inflammatory activities.
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