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mTOR

mTOR

Cat. No. Product Name CAS No. Information
CSN16829 WYE-354 1062169-56-5 WYE-354 is a potent specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM blocks mTORC1P-S6K T389 and mTORC2P-AKT S473 not P-AKT T308 selective for mTOR than PI3K 100-fold and PI3K 500-fold
CSN12047 Temsirolimus 162635-04-3 Temsirolimus directly inhibits mTOR kinase activity with IC50 values of 176 015 M
CSN15684 Tacrolimus 104987-11-3 Tacrolimus is a potent immunosuppressive drug often administered to transplant recipient patients and exhibits a variety of adverse cardiovascular effects. Its mechanism of action involves the formation of a high affinity complex (Ki 0.2 nM) with FK-506 binding protein 12 (FKBP12).
CSN16385 Rapamycin   53123-88-9 Rapamycin is a specific mTOR inhibitor with IC50 of 0.1 nM.
CSN11574 Nordihydroguaiaretic Acid 500-38-9 Nordihydroguaiaretic Acid is a naturally occuring mTORC1 inhibitor
CSN27361 Niclosamide olamine 1420-04-8 Niclosamide olamine is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models. Niclosamide olamine inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mammalian target of Rapamycin complex 1 (mTORC1) signaling.
CSN19147 LY303511 HCl 2070014-90-1 LY303511 HCl is an analogue of LY294002 which can inhibit mTOR-dependent phosphorylation of S6K but not PI3K-dependent phosphorylation of Akt It also blocks voltage-gated potassium Kv channels with IC50 value of 646 M
CSN16716 Everolimus   159351-69-6 Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.
CSN16716 Everolimus   159351-69-6 Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.
CSN17593 CC-223 1228013-30-6 CC-223 is a potent mTOR kinase inhibitor IC5016 nM with 150-fold sensitivity over the related lipid kinase PI3K IC504 M
CSN12442 (+)-Usniacin 7562-61-0 ()-Usniacin, a naturally occurring dibenzofuran derivative isolated and purified from the Usnea diffracta Vain. with antitumoral, antiviral, antibiotic, acaricidal, antipyretic, analgesic, antioxidative and anti-inflammatory activities.
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