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mTOR

mTOR

Cat. No. Product Name CAS No. Information
CSN15943 Zotarolimus 221877-54-9 Zotarolimus is an analogue of rapamycin and inhibits FKBP-12 binding with IC50 of 28 nM
CSN17119 XL388 1251156-08-7 XL388 is a potent and selective ATP-competitive mTOR inhibitor with IC50 value of 99 nM
CSN16762 WYE-687 1062161-90-3 WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM showing 100 fold selectivity for mTOR than PI3K
CSN16829 WYE-354 1062169-56-5 WYE-354 is a potent specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM blocks mTORC1P-S6K T389 and mTORC2P-AKT S473 not P-AKT T308 selective for mTOR than PI3K 100-fold and PI3K 500-fold
CSN15879 WYE-125132 1144068-46-1 WYE-125132 is a highly potent ATP-competitive and specific mTOR kinase inhibitor with an IC50 of 019 nM highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR
CSN16670 WAY-600 1062159-35-6 WAY-600 is a potent ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM and blocks mTORC1P-S6K T389 and mTORC2P-AKT S473 but not P-AKT T308 It is selective for mTOR than PI3K 100-fold and PI3K 500-fold
CSN15687 Torin 2 1223001-51-1 Torin 2 is a potent and selective mTOR inhibitor with IC50 of 025 nM showing 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties and inhibition of ATMATRDNA-PK with EC50 of 28 nM35 nM118 nM respectively
CSN17146 Torin 1   1222998-36-8 Torin 1 is a potent inhibitor of mTORC12 with IC50 of 2 nM10 nM exhibiting 1000-fold selectivity for mTOR than PI3K
CSN12047 Temsirolimus 162635-04-3 Temsirolimus directly inhibits mTOR kinase activity with IC50 values of 176 015 M
CSN15684 Tacrolimus 104987-11-3 Tacrolimus is a potent immunosuppressive drug often administered to transplant recipient patients and exhibits a variety of adverse cardiovascular effects. Its mechanism of action involves the formation of a high affinity complex (Ki 0.2 nM) with FK-506 binding protein 12 (FKBP12).
CSN12789 Tacrolimus Monohydrate 109581-93-3 Tacrolimus is a potent immunosuppressive drug often administered to transplant recipient patients and exhibits a variety of adverse cardiovascular effects. Its mechanism of action involves the formation of a high affinity complex (Ki 0.2 nM) with FK-506 binding protein 12 (FKBP12).
CSN16385 Rapamycin   53123-88-9 Rapamycin is a specific mTOR inhibitor with IC50 of 0.1 nM.
CSN17584 QL-IX-55 1223002-54-7 QL-IX-55 is a selective ATP-competitive inhibitor of mTORC12 with IC50s of 505010-50 nM for Human mTORC1Yeast mTORC1Yeast mTORC2 respectively
CSN19143 PQR620 1927857-56-4 PRQ620 is a highly potent and selective mTORC12 inhibitor shows anti-tumor effects in vitro and in vivo
CSN12732 PP242   1092351-67-1 PP 242 is the first selective and ATP competitive mTOR inhibitor with IC50 of 8 nM
CSN13796 Palomid 529 914913-88-5 Palomid 529 is a novel dual mTORC12 inhibitor.
CSN11574 Nordihydroguaiaretic Acid 500-38-9 Nordihydroguaiaretic Acid is a naturally occuring mTORC1 inhibitor
CSN17562 mTOR-IN-1 1207358-59-5 mTOR-IN-1 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 15 nM
CSN16980 MHY1485   326914-06-1 MHY1485 is a mTOR activator and inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes
CSN19147 LY303511 HCl 2070014-90-1 LY303511 HCl is an analogue of LY294002 which can inhibit mTOR-dependent phosphorylation of S6K but not PI3K-dependent phosphorylation of Akt It also blocks voltage-gated potassium Kv channels with IC50 value of 646 M
CSN17919 LY303511 154447-38-8 LY303511 an inactive analogue of LY294002 is a mTOR inhibitor that did not inhibit PI3-K
CSN12392 KU-0063794 938440-64-3 KU-0063794 is a selective inhibitor of mammalian target of rapamycin mTOR IC50 10 nM for mTORC1 and mTORC2 respectively with no effect on PI3Ks
CSN15888 INK-128   1224844-38-5 INK 128 is a potent and selective mTOR inhibitor with IC50 of 1 nM and is 200-fold less potent to class I PI3K isoforms.
CSN17116 GDC-0349 1207360-89-1 GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 38 nM showing 700-fold selectivity over PI3K and other 266 kinases
CSN22228 FT-1518 1313026-58-2 FT-1518 is a new generation selective potent and oral bioavailable mTORC1 and mTORC2 inhibitor and exhibits antitumor activity
CSN16716 Everolimus     159351-69-6 Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.
CSN15905 ETP-46464 1345675-02-6 ETP-46464 is a cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR ATR DNA-PK PI 3-K and ATM IC50 06 14 36 170 and 545 nM respectively
CSN19142 CZ415   1429639-50-8 CZ415 is a potent and highly selective ATP-competitive mTOR inhibitor with pKdsupappsup value of 82
CSN17593 CC-223 1228013-30-6 CC-223 is a potent mTOR kinase inhibitor IC5016 nM with 150-fold sensitivity over the related lipid kinase PI3K IC504 M
CSN12949 AZD8055   1009298-09-2 AZD8055 is an ATP-competitive mTOR inhibitor with IC50 of 0.8 nM with excellent selectivity (~1,000-fold) against PI3K isoforms and ATM/DNA-PK.
CSN13850 AZD2014     1009298-59-2 AZD2014 is an mTOR inhibitor with IC50 of 2.8 nM and is highly selective against multiple PI3K isoforms (α/β/γ/δ).
CSN18074 AP20187 195514-80-8 AP20187 is a synthetic cell-permeable ligand that can be used to induce homodimerization of fusion proteins containing the DmrB domain
CSN18073 AP1903 195514-63-7 AP1903 is a homodimer binding to FKBP and elicites potent and dosedependent apoptotic death of engineered cell line HT1080 in culture with an EC50 of 01 nM
CSN13765 Ridaforolimus 572924-54-0
CSN22703 AZD 3147 1101810-02-9
CSN16065 OSI-027 936890-98-1
CSN21086 RapaLink-1 1887095-82-0
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