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mTOR
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN17119 | XL388 | 1251156-08-7 | XL388 is a potent and selective ATP-competitive mTOR inhibitor with IC50 value of 99 nM |
| CSN16762 | WYE-687 | 1062161-90-3 | WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM showing 100 fold selectivity for mTOR than PI3K |
| CSN16829 | WYE-354 | 1062169-56-5 | WYE-354 is a potent specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM blocks mTORC1P-S6K T389 and mTORC2P-AKT S473 not P-AKT T308 selective for mTOR than PI3K 100-fold and PI3K 500-fold |
| CSN15879 | WYE-132 | 1144068-46-1 | WYE-125132 is a highly potent ATP-competitive and specific mTOR kinase inhibitor with an IC50 of 019 nM highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR |
| CSN16670 | WAY-600 | 1062159-35-6 | WAY-600 is a potent ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM and blocks mTORC1P-S6K T389 and mTORC2P-AKT S473 but not P-AKT T308 It is selective for mTOR than PI3K 100-fold and PI3K 500-fold |
| CSN13765 | Ridaforolimus | 572924-54-0 | Treatment of HT-1080 cells with Deforolimus induces a dose-dependent inhibition of phosphorylation of both S6 and 4E-BP1, with IC50 of 0.2 nM and 5.6 nM, respectively, and leads to a decrease in cell size, an increase in the proportion of cells in the G1 phase of the cell cycle, and inhibition of glucose uptake. |
| CSN15687 | Torin 2 | 1223001-51-1 | Torin 2 is a potent and selective mTOR inhibitor with IC50 of 025 nM showing 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties and inhibition of ATMATRDNA-PK with EC50 of 28 nM35 nM118 nM respectively |
| CSN17146 | Torin 1 | 1222998-36-8 | Torin 1 is a potent inhibitor of mTORC12 with IC50 of 2 nM10 nM exhibiting 1000-fold selectivity for mTOR than PI3K |
| CSN17210 | Salidroside | 10338-51-9 | Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola crenulata. |
| CSN26152 | SAFit2 | 1643125-33-0 | SAFit2 is a novel selective antagonist of the FK506-binding protein 51 with Ki value of 6nM. |
| CSN16385 | Rapamycin | 53123-88-9 | Rapamycin is a specific mTOR inhibitor with IC50 of 0.1 nM. |
| CSN21086 | RapaLink-1 | 1887095-82-0 | RapaLink-1 is the third-generation mTOR inhibitor exploiting the unique juxtaposition of two drug (first- and second-generation mTOR kinase inhibitors) –binding pockets to create a bivalent interaction that allows inhibition of the mutants which has resistance to the previous TORKi (mTOR kinase inhibitors). |
| CSN17584 | QL-IX-55 | 1223002-54-7 | QL-IX-55 is a selective ATP-competitive inhibitor of mTORC12 with IC50s of 505010-50 nM for Human mTORC1Yeast mTORC1Yeast mTORC2 respectively |
| CSN23791 | PWT33597 mesylate | 1246203-36-0 | PWT33597 is a dual inhibitor of PI3K alpha and mTOR with selectivity for PI3K alpha (IC50 = 26 nM) over PI3K delta (IC50 = 291 nM) but also displaying activity against mTOR in biochemical assays (IC50 = 21 nM). It had good pharmacokinetic properties in multiple preclinical species. |
| CSN19143 | PQR620 | 1927857-56-4 | PRQ620 is a highly potent and selective mTORC1/2 inhibitor, shows anti-tumor effects in vitro and in vivo. |
| CSN12732 | Torkinib | 1092351-67-1 | PP 242 is the first selective and ATP competitive mTOR inhibitor with IC50 of 8 nM |
| CSN13796 | Palomid 529 | 914913-88-5 | Palomid 529 is a novel dual mTORC12 inhibitor. |
| CSN16065 | OSI-027 | 936890-98-1 | OSI-027 shows the selective and ATP competitive inhibition activities against mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively. |
| CSN11574 | Nordihydroguaiaretic acid | 500-38-9 | Nordihydroguaiaretic Acid is a naturally occuring mTORC1 inhibitor |
| CSN27361 | Niclosamide olamine | 1420-04-8 | Niclosamide olamine is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models. Niclosamide olamine inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mammalian target of Rapamycin complex 1 (mTORC1) signaling. |
| CSN17562 | mTOR inhibitor-3 | 1207358-59-5 | mTOR-IN-1 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 15 nM |
| CSN27773 | mTOR inhibitor-1 | 468747-17-3 | mTOR inhibitor-1 is an ATP-competitive inhibitor of mTOR. It suppressed A549 cell proliferation and induced autophagy. |
| CSN16980 | MHY1485 | 326914-06-1 | MHY1485 is a mTOR activator and inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes |
| CSN19147 | LY 303511 hydrochloride | 2070014-90-1 | LY303511 HCl is an analogue of LY294002 which can inhibit mTOR-dependent phosphorylation of S6K but not PI3K-dependent phosphorylation of Akt It also blocks voltage-gated potassium Kv channels with IC50 value of 646 M |
| CSN17919 | LY 303511 | 154447-38-8 | LY303511 an inactive analogue of LY294002 is a mTOR inhibitor that did not inhibit PI3-K |
| CSN25185 | L-Leucine | 61-90-5 | Leucine is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. It contributes to regulation of blood-sugar levels growth and repair of muscle and bone tissue growth hormone production and wound healing. |
| CSN12392 | KU-0063794 | 938440-64-3 | KU-0063794 is a selective inhibitor of mammalian target of rapamycin mTOR IC50 10 nM for mTORC1 and mTORC2 respectively with no effect on PI3Ks |
| CSN15888 | Sapanisertib | 1224844-38-5 | INK 128 is a potent and selective mTOR inhibitor with IC50 of 1 nM and is 200-fold less potent to class I PI3K isoforms. |
| CSN17116 | GDC-0349 | 1207360-89-1 | GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 38 nM showing 700-fold selectivity over PI3K and other 266 kinases |
| CSN22228 | FT-1518 | 1313026-58-2 | FT-1518 is a new generation selective potent and oral bioavailable mTORC1 and mTORC2 inhibitor and exhibits antitumor activity |
| CSN16716 | Everolimus | 159351-69-6 | Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM. |
| CSN16716 | Everolimus | 159351-69-6 | Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM. |
| CSN15905 | ETP-46464 | 1345675-02-6 | ETP-46464 is a cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR ATR DNA-PK PI 3-K and ATM IC50 06 14 36 170 and 545 nM respectively |
| CSN19142 | CZ415 | 1429639-50-8 | CZ415 is a potent and highly selective ATP-competitive mTOR inhibitor with pKdsupappsup value of 82 |
| CSN17593 | Onatasertib | 1228013-30-6 | CC-223 is a potent mTOR kinase inhibitor IC5016 nM with 150-fold sensitivity over the related lipid kinase PI3K IC504 M |
| CSN26528 | BGT226 | 915020-55-2 | BGT226 is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BGT226 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the proapoptotic Bcl2 family of proteins. |
| CSN12949 | AZD-8055 | 1009298-09-2 | AZD8055 is an ATP-competitive mTOR inhibitor with IC50 of 0.8 nM with excellent selectivity (～1,000-fold) against PI3K isoforms and ATM/DNA-PK. |
| CSN13850 | Vistusertib | 1009298-59-2 | AZD2014 is an mTOR inhibitor with IC50 of 2.8 nM and is highly selective against multiple PI3K isoforms (α/β/γ/δ). |
| CSN22703 | AZD3147 | 1101810-02-9 | AZD 3147 is a potent and selective dual mTORC1 and 2 inhibitor with IC50 of 1.5 nM. |
| CSN18073 | Rimiducid | 195514-63-7 | AP1903 is a homodimer binding to FKBP and elicites potent and dosedependent apoptotic death of engineered cell line HT1080 in culture with an EC50 of 01 nM |
| CSN23318 | 3BDO | 890405-51-3 | 3BDO is a new mTOR activator which can also inhibit autophagy. |
| CSN12442 | (+)-Usnic acid | 7562-61-0 | ()-Usniacin, a naturally occurring dibenzofuran derivative isolated and purified from the Usnea diffracta Vain. with antitumoral, antiviral, antibiotic, acaricidal, antipyretic, analgesic, antioxidative and anti-inflammatory activities. |
| CSN51382 | MTI-31 | 1567915-38-1 |
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