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mTOR

mTOR

Cat. No. Product Name CAS No. Information
CSN17119 XL388 1251156-08-7 XL388 is a potent and selective ATP-competitive mTOR inhibitor with IC50 value of 99 nM
CSN16829 WYE-354 1062169-56-5 WYE-354 is a potent specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM blocks mTORC1P-S6K T389 and mTORC2P-AKT S473 not P-AKT T308 selective for mTOR than PI3K 100-fold and PI3K 500-fold
CSN16670 WAY-600 1062159-35-6 WAY-600 is a potent ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM and blocks mTORC1P-S6K T389 and mTORC2P-AKT S473 but not P-AKT T308 It is selective for mTOR than PI3K 100-fold and PI3K 500-fold
CSN12047 Temsirolimus 162635-04-3 Temsirolimus directly inhibits mTOR kinase activity with IC50 values of 176 015 M
CSN17210 Salidroside   10338-51-9 Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola crenulata.
CSN16385 Rapamycin   53123-88-9 Rapamycin is a specific mTOR inhibitor with IC50 of 0.1 nM.
CSN12732 PP242   1092351-67-1 PP 242 is the first selective and ATP competitive mTOR inhibitor with IC50 of 8 nM
CSN13796 Palomid 529 914913-88-5 Palomid 529 is a novel dual mTORC12 inhibitor.
CSN11574 Nordihydroguaiaretic Acid 500-38-9 Nordihydroguaiaretic Acid is a naturally occuring mTORC1 inhibitor
CSN27361 Niclosamide olamine 1420-04-8 Niclosamide olamine is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models. Niclosamide olamine inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mammalian target of Rapamycin complex 1 (mTORC1) signaling.
CSN27773 mTOR inhibitor-1   468747-17-3 mTOR inhibitor-1 is an ATP-competitive inhibitor of mTOR. It suppressed A549 cell proliferation and induced autophagy.
CSN16980 MHY1485   326914-06-1 MHY1485 is a mTOR activator and inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes
CSN19147 LY303511 HCl 2070014-90-1 LY303511 HCl is an analogue of LY294002 which can inhibit mTOR-dependent phosphorylation of S6K but not PI3K-dependent phosphorylation of Akt It also blocks voltage-gated potassium Kv channels with IC50 value of 646 M
CSN25185 L-Leucine 61-90-5 Leucine is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. It contributes to regulation of blood-sugar levels growth and repair of muscle and bone tissue growth hormone production and wound healing.
CSN16716 Everolimus   159351-69-6 Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.
CSN16716 Everolimus   159351-69-6 Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.
CSN15905 ETP-46464 1345675-02-6 ETP-46464 is a cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR ATR DNA-PK PI 3-K and ATM IC50 06 14 36 170 and 545 nM respectively
CSN12949 AZD8055 1009298-09-2 AZD8055 is an ATP-competitive mTOR inhibitor with IC50 of 0.8 nM with excellent selectivity (~1,000-fold) against PI3K isoforms and ATM/DNA-PK.
CSN18073 AP1903 195514-63-7 AP1903 is a homodimer binding to FKBP and elicites potent and dosedependent apoptotic death of engineered cell line HT1080 in culture with an EC50 of 01 nM
CSN23318 3BDO 890405-51-3 3BDO is a new mTOR activator which can also inhibit autophagy.
CSN12442 (+)-Usniacin 7562-61-0 ()-Usniacin, a naturally occurring dibenzofuran derivative isolated and purified from the Usnea diffracta Vain. with antitumoral, antiviral, antibiotic, acaricidal, antipyretic, analgesic, antioxidative and anti-inflammatory activities.
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