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MMP

MMP

Cat. No. Product Name CAS No. Information
CSN26232 UK 356618 230961-08-7 UK-356618 is a matrix metalloproteinase-3 (MMP-3) inhibitor with an IC50 of 5.9 nM. It displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively).
CSN24080 T-26c 869296-13-9 T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes[1].
CSN16901 Salvianolic acid A 96574-01-5 Salvianolic acid A, a natural product isolated and purified from the root of Salvia miltiorrhiza Bge. with antioxidant and protective activity, significantly improves glucose metabolism and inhibit oxidative injury as well as protect against impaired vascular responsiveness in STZ-induced diabetic rats, inhibits platelet activation via the inhibition of PI3K, and attenuates arterial thrombus formation in vivo, suggesting that it may be developed as a therapeutic agent for the prevention of thrombotic disorders. Salvianolic acid A is also a matrix metalloproteinase-9 inhibitor, can prevents cardiac remodeling in spontaneously hypertensive rats, and inhibits PDGF-BB-activated HSC proliferation, partially through apoptosis induction while exerting no direct cytotoxicity on primary hepatocytes and HSC-T6 cells under experimental concentrations.
CSN21234 S-methyl-KE-298 143584-75-2 S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.
CSN22013 Prinomastat 192329-42-3 Prinomastat is a spectrum inhibitor of MMP with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9 respectively.
CSN19193 Phosphoramidon Disodium 164204-38-0 Phosphoramidon disodium is a metalloendopeptidase inhibitor, widely used as a biochemical tool.
CSN15948 Morroniside 25406-64-8 Morroniside is a naturally occuring iridoid which can regulate hair growth and cycle transition via activation of the Wnt-catenin signaling pathway.
CSN25314 MMP-9-IN-1 502887-71-0 MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor that selectively targets the hemopexin (PEX) domain of MMP-9.
CSN32640 Tiludronate disodium 149845-07-8 MMP-2 (Gelatinase A) Inhibitors, Parathyroid Hormone Receptor Antagonists, Signal Transduction Modulators
CSN12943 Marimastat   154039-60-8 Marimastat is a competitive and broad-spectrum MMP inhibitor with IC50 values of 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7, respectively.
CSN25429 JNJ0966 315705-75-0 JNJ0966 is a selective inhibitor of MMP-9 zymogen (IC50 = 440nM) that inhibits subsequent generation of the catalytically active enzyme. It showed no effect on the catalytic activity of MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14, and did not inhibit the activation of MMP-2 zymogen.
CSN11187 Ilomastat     142880-36-2 GM6001 is a broad spectrum MMPs inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively.
CSN11187 Ilomastat   142880-36-2 GM6001 is a broad spectrum MMPs inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively.
CSN10218 Ethyl gallate   831-61-8 Ethyl gallate is a natural product isolated and purifeid from the herbs of Coriaria nepalensis, and it can inhibit the abilities of invasion of breast cancer in vitro by inhibiting the mRNA levels of MMP-9MMP-2, phosphorylation of Akt and protein expression of NF-B.
CSN32654 PKF-241-466 205807-58-5 Disintegrin and Metalloproteinase Domain-Containing Protein 17 (ADAM17; TACE) Inhibitors, MMP-1 (Interstitial Collagenase) Inhibitors, MMP-13 (Collagenase 3) Inhibitors, MMP-2 (Gelatinase A) Inhibitors, MMP-9 (Gelatinase B) Inhibitors, Signal Transduction Modulators
CSN32653 TMI-1 287403-39-8 Disintegrin and Metalloproteinase Domain-Containing Protein 17 (ADAM17; TACE) Inhibitors, MMP-1 (Interstitial Collagenase) Inhibitors, MMP-13 (Collagenase 3) Inhibitors, MMP-2 (Gelatinase A) Inhibitors, MMP-7 (Matrilysin) Inhibitors, MMP-9 (Gelatinase B) Inhibitors, Signal Transduction Modulators
CSN32655 PKF-242-484 205807-59-6 Disintegrin and Metalloproteinase Domain-Containing Protein 17 (ADAM17; TACE) Inhibitors, MMP-1 (Interstitial Collagenase) Inhibitors, MMP-13 (Collagenase 3) Inhibitors, MMP-2 (Gelatinase A) Inhibitors, MMP-3 (Stromelysin 1) Inhibitors, MMP-9 (Gelatinase B) Inhibitors, Signal Transduction Modulators
CSN18069 CTS-1027 193022-04-7 CTS-1027 is a potent small molecule inhibitor of MMPs (IC500.4 nM0.6 nM for MMP2MMP13), displaying 1,000 fold selectivity over MMP1.
CSN17670 Batimastat sodium salt 130464-84-5 Batimastat sodium is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively.
CSN26236 ARP-100 704888-90-4 ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM).
CSN32647 4-(Dodecylamino)phenol 25848-37-7 Antioxidants, Apoptosis Inducers, Free Radical Scavengers, Lipid Peroxidation Inhibitors, MMP-2 (Gelatinase A) Inhibitors, MMP-9 (Gelatinase B) Inhibitors
CSN32641 Incyclinide 15866-90-7 Angiogenesis Inhibitors, MMP-2 (Gelatinase A) Inhibitors, MMP-9 (Gelatinase B) Inhibitors, Signal Transduction Modulators, Vascular Endothelial Growth Factor (VEGF) Inhibitors
CSN32643 ABT-518 286845-00-9 Angiogenesis Inhibitors, MMP-2 (Gelatinase A) Inhibitors, MMP-9 (Gelatinase B) Inhibitors
CSN32645 Tanomastat 179545-77-8 Angiogenesis Inhibitors, MMP-2 (Gelatinase A) Inhibitors, MMP-3 (Stromelysin 1) Inhibitors, MMP-9 (Gelatinase B) Inhibitors
CSN24958 Abametapir 1762-34-1 Abametapir is the active ingredient of Xeglyze Lotion. Abametapir inhibits metalloproteinases; enzymes that are essential to physiological processes critical for egg development and the survival of nymph and adult lice. In vitro and ex vivo research has demonstrated that abametapir not only kills the lice, but also prevents hatching of their eggs. Xeglyze Lotion is emerging as a differentiated development candidate to treat head lice infestations.
CSN29447 PD-166793 199850-67-4 Broad spectrum MMP inhibitor
CSN33198 GW280264X 866924-39-2
CSN39987 Apratastat 287405-51-0
CSN42022 ADAMTS-5 Inhibitor 929634-33-3
CSN39089 ZLDI-8 667880-38-8
CSN68121 Aldumastat 1957278-93-1
CSN75578 WAY-170523 307002-73-9
CSN80889 TAPI-0 163958-73-4
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