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MMP

MMP

Cat. No. Product Name CAS No. Information
CSN19037 TAPI-2 187034-31-7 TAPI-2 is a broad-spectrum inhibitor of matrix metalloprotease MMP tumour necrosis factor-converting enzyme TACE and a disintegrin and metalloproteinase ADAM with an IC50 of 2010 M for MMP
CSN17979 TAPI-1 163847-77-6 TAPI-1 is a specific TACE TNF--converting enzyme inhibitor
CSN16623 SB-3CT 292605-14-2 SB-3CT is a potent competitive and non-selective MMP-2 and MMP-9 inhibitor with Ki values of 139 and 600 nM respectively
CSN16901 Salvianolic Acid A 96574-01-5 Salvianolic acid A, a natural product isolated and purified from the root of Salvia miltiorrhiza Bge. with antioxidant and protective activity, significantly improves glucose metabolism and inhibit oxidative injury as well as protect against impaired vascular responsiveness in STZ-induced diabetic rats, inhibits platelet activation via the inhibition of PI3K, and attenuates arterial thrombus formation in vivo, suggesting that it may be developed as a therapeutic agent for the prevention of thrombotic disorders. Salvianolic acid A is also a matrix metalloproteinase-9 inhibitor, can prevents cardiac remodeling in spontaneously hypertensive rats, and inhibits PDGF-BB-activated HSC proliferation, partially through apoptosis induction while exerting no direct cytotoxicity on primary hepatocytes and HSC-T6 cells under experimental concentrations.
CSN21234 S-methyl-KE-298 143584-75-2 S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.
CSN21340 S 3304   203640-27-1 S 3304 is a novel MMP inhibitor
CSN22013 Prinomastat 192329-42-3 Prinomastat is a spectrum inhibitor of MMP with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9 respectively.
CSN11720 Pimaric Acid 127-27-5 Pimaric acid is a natural product isolated and purified from the herbs of Aralia cordata having a potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α-induced human aortic smooth muscle cells.
CSN16584 NSC 405020   7497-07-6 NSC 405020 is a non-catalytic Membrane type-1 MMP inhibitor with IC50 100 M
CSN15948 Morroniside 25406-64-8 Morroniside is a naturally occuring iridoid which can regulate hair growth and cycle transition via activation of the Wnt-catenin signaling pathway.
CSN12943 Marimastat   154039-60-8 Marimastat is a competitive and broad-spectrum MMP inhibitor with IC50 values of 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7, respectively.
CSN14005 Isoginkgetin 548-19-6 Isoginkgetin is a MMP-9 inhibitor isolated and purified from the leaves of Ginkgo biloba L also a Pre-mRNA Splicing inhibitor with IC 50 of 30 M
CSN11187 GM6001     142880-36-2 GM6001 is a broad spectrum MMPs inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively.
CSN11187 GM6001   142880-36-2 GM6001 is a broad spectrum MMPs inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively.
CSN15653 Ginsenoside CK 39262-14-1 Ginsenoside CK, a natural product isolated and purified from the roots of Panax ginseng C.A.Mey., is a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A.
CSN19851 GI 254023X 260264-93-5 GI 254023X is a potent and selective ADAM10 metalloproteinase inhibitor
CSN18069 CTS-1027 193022-04-7 CTS-1027 is a potent small molecule inhibitor of MMPs (IC500.4 nM0.6 nM for MMP2MMP13), displaying 1,000 fold selectivity over MMP1.
CSN17670 Batimastat Sodium 130464-84-5 Batimastat sodium is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively.
CSN17343 Batimastat 130370-60-4 Batimastat is a potent broad spectrum MMP inhibitor with IC50 of 3 4 4 6 and 20 nM for MMP-1 MMP-2 MMP-9 MMP-7 and MMP-3 respectively
CSN24958 Abametapir 1762-34-1 Abametapir is the active ingredient of Xeglyze Lotion. Abametapir inhibits metalloproteinases; enzymes that are essential to physiological processes critical for egg development and the survival of nymph and adult lice. In vitro and ex vivo research has demonstrated that abametapir not only kills the lice, but also prevents hatching of their eggs. Xeglyze Lotion is emerging as a differentiated development candidate to treat head lice infestations.
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