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MMP
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN26232 | UK 356618 | 230961-08-7 | UK-356618 is a matrix metalloproteinase-3 (MMP-3) inhibitor with an IC50 of 5.9 nM. It displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively). |
| CSN24080 | T-26c | 869296-13-9 | T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes[1]. |
| CSN16901 | Salvianolic acid A | 96574-01-5 | Salvianolic acid A, a natural product isolated and purified from the root of Salvia miltiorrhiza Bge. with antioxidant and protective activity, significantly improves glucose metabolism and inhibit oxidative injury as well as protect against impaired vascular responsiveness in STZ-induced diabetic rats, inhibits platelet activation via the inhibition of PI3K, and attenuates arterial thrombus formation in vivo, suggesting that it may be developed as a therapeutic agent for the prevention of thrombotic disorders. Salvianolic acid A is also a matrix metalloproteinase-9 inhibitor, can prevents cardiac remodeling in spontaneously hypertensive rats, and inhibits PDGF-BB-activated HSC proliferation, partially through apoptosis induction while exerting no direct cytotoxicity on primary hepatocytes and HSC-T6 cells under experimental concentrations. |
| CSN21234 | S-methyl-KE-298 | 143584-75-2 | S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells. |
| CSN22013 | Prinomastat | 192329-42-3 | Prinomastat is a spectrum inhibitor of MMP with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9 respectively. |
| CSN19193 | Phosphoramidon Disodium | 164204-38-0 | Phosphoramidon disodium is a metalloendopeptidase inhibitor, widely used as a biochemical tool. |
| CSN15948 | Morroniside | 25406-64-8 | Morroniside is a naturally occuring iridoid which can regulate hair growth and cycle transition via activation of the Wnt-catenin signaling pathway. |
| CSN25314 | MMP-9-IN-1 | 502887-71-0 | MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor that selectively targets the hemopexin (PEX) domain of MMP-9. |
| CSN32640 | Tiludronate disodium | 149845-07-8 | MMP-2 (Gelatinase A) Inhibitors, Parathyroid Hormone Receptor Antagonists, Signal Transduction Modulators |
| CSN12943 | Marimastat | 154039-60-8 | Marimastat is a competitive and broad-spectrum MMP inhibitor with IC50 values of 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7, respectively. |
| CSN25429 | JNJ0966 | 315705-75-0 | JNJ0966 is a selective inhibitor of MMP-9 zymogen (IC50 = 440nM) that inhibits subsequent generation of the catalytically active enzyme. It showed no effect on the catalytic activity of MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14, and did not inhibit the activation of MMP-2 zymogen. |
| CSN11187 | Ilomastat | 142880-36-2 | GM6001 is a broad spectrum MMPs inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively. |
| CSN11187 | Ilomastat | 142880-36-2 | GM6001 is a broad spectrum MMPs inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively. |
| CSN10218 | Ethyl gallate | 831-61-8 | Ethyl gallate is a natural product isolated and purifeid from the herbs of Coriaria nepalensis, and it can inhibit the abilities of invasion of breast cancer in vitro by inhibiting the mRNA levels of MMP-9MMP-2, phosphorylation of Akt and protein expression of NF-B. |
| CSN32654 | PKF-241-466 | 205807-58-5 | Disintegrin and Metalloproteinase Domain-Containing Protein 17 (ADAM17; TACE) Inhibitors, MMP-1 (Interstitial Collagenase) Inhibitors, MMP-13 (Collagenase 3) Inhibitors, MMP-2 (Gelatinase A) Inhibitors, MMP-9 (Gelatinase B) Inhibitors, Signal Transduction Modulators |
| CSN32653 | TMI-1 | 287403-39-8 | Disintegrin and Metalloproteinase Domain-Containing Protein 17 (ADAM17; TACE) Inhibitors, MMP-1 (Interstitial Collagenase) Inhibitors, MMP-13 (Collagenase 3) Inhibitors, MMP-2 (Gelatinase A) Inhibitors, MMP-7 (Matrilysin) Inhibitors, MMP-9 (Gelatinase B) Inhibitors, Signal Transduction Modulators |
| CSN32655 | PKF-242-484 | 205807-59-6 | Disintegrin and Metalloproteinase Domain-Containing Protein 17 (ADAM17; TACE) Inhibitors, MMP-1 (Interstitial Collagenase) Inhibitors, MMP-13 (Collagenase 3) Inhibitors, MMP-2 (Gelatinase A) Inhibitors, MMP-3 (Stromelysin 1) Inhibitors, MMP-9 (Gelatinase B) Inhibitors, Signal Transduction Modulators |
| CSN18069 | CTS-1027 | 193022-04-7 | CTS-1027 is a potent small molecule inhibitor of MMPs (IC500.4 nM0.6 nM for MMP2MMP13), displaying 1,000 fold selectivity over MMP1. |
| CSN17670 | Batimastat sodium salt | 130464-84-5 | Batimastat sodium is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively. |
| CSN26236 | ARP-100 | 704888-90-4 | ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). |
| CSN32647 | 4-(Dodecylamino)phenol | 25848-37-7 | Antioxidants, Apoptosis Inducers, Free Radical Scavengers, Lipid Peroxidation Inhibitors, MMP-2 (Gelatinase A) Inhibitors, MMP-9 (Gelatinase B) Inhibitors |
| CSN32641 | Incyclinide | 15866-90-7 | Angiogenesis Inhibitors, MMP-2 (Gelatinase A) Inhibitors, MMP-9 (Gelatinase B) Inhibitors, Signal Transduction Modulators, Vascular Endothelial Growth Factor (VEGF) Inhibitors |
| CSN32643 | ABT-518 | 286845-00-9 | Angiogenesis Inhibitors, MMP-2 (Gelatinase A) Inhibitors, MMP-9 (Gelatinase B) Inhibitors |
| CSN32645 | Tanomastat | 179545-77-8 | Angiogenesis Inhibitors, MMP-2 (Gelatinase A) Inhibitors, MMP-3 (Stromelysin 1) Inhibitors, MMP-9 (Gelatinase B) Inhibitors |
| CSN24958 | Abametapir | 1762-34-1 | Abametapir is the active ingredient of Xeglyze Lotion. Abametapir inhibits metalloproteinases; enzymes that are essential to physiological processes critical for egg development and the survival of nymph and adult lice. In vitro and ex vivo research has demonstrated that abametapir not only kills the lice, but also prevents hatching of their eggs. Xeglyze Lotion is emerging as a differentiated development candidate to treat head lice infestations. |
| CSN29447 | PD-166793 | 199850-67-4 | Broad spectrum MMP inhibitor |
| CSN33198 | GW280264X | 866924-39-2 | |
| CSN39987 | Apratastat | 287405-51-0 | |
| CSN42022 | ADAMTS-5 Inhibitor | 929634-33-3 | |
| CSN39089 | ZLDI-8 | 667880-38-8 | |
| CSN68121 | Aldumastat | 1957278-93-1 | |
| CSN75578 | WAY-170523 | 307002-73-9 | |
| CSN80889 | TAPI-0 | 163958-73-4 |
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