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MMP
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN19037 | TAPI-2 | 187034-31-7 | TAPI-2 is a broad-spectrum inhibitor of matrix metalloprotease MMP tumour necrosis factor-converting enzyme TACE and a disintegrin and metalloproteinase ADAM with an IC50 of 2010 M for MMP |
| CSN17979 | TAPI-1 | 163847-77-6 | TAPI-1 is a specific TACE TNF--converting enzyme inhibitor |
| CSN16623 | SB-3CT | 292605-14-2 | SB-3CT is a potent competitive and non-selective MMP-2 and MMP-9 inhibitor with Ki values of 139 and 600 nM respectively |
| CSN16901 | Salvianolic Acid A | 96574-01-5 | Salvianolic acid A, a natural product isolated and purified from the root of Salvia miltiorrhiza Bge. with antioxidant and protective activity, significantly improves glucose metabolism and inhibit oxidative injury as well as protect against impaired vascular responsiveness in STZ-induced diabetic rats, inhibits platelet activation via the inhibition of PI3K, and attenuates arterial thrombus formation in vivo, suggesting that it may be developed as a therapeutic agent for the prevention of thrombotic disorders. Salvianolic acid A is also a matrix metalloproteinase-9 inhibitor, can prevents cardiac remodeling in spontaneously hypertensive rats, and inhibits PDGF-BB-activated HSC proliferation, partially through apoptosis induction while exerting no direct cytotoxicity on primary hepatocytes and HSC-T6 cells under experimental concentrations. |
| CSN21234 | S-methyl-KE-298 | 143584-75-2 | S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells. |
| CSN21340 | S 3304 | 203640-27-1 | S 3304 is a novel MMP inhibitor |
| CSN22013 | Prinomastat | 192329-42-3 | Prinomastat is a spectrum inhibitor of MMP with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9 respectively. |
| CSN11720 | Pimaric Acid | 127-27-5 | Pimaric acid is a natural product isolated and purified from the herbs of Aralia cordata having a potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α-induced human aortic smooth muscle cells. |
| CSN16584 | NSC 405020 | 7497-07-6 | NSC 405020 is a non-catalytic Membrane type-1 MMP inhibitor with IC50 100 M |
| CSN15948 | Morroniside | 25406-64-8 | Morroniside is a naturally occuring iridoid which can regulate hair growth and cycle transition via activation of the Wnt-catenin signaling pathway. |
| CSN12943 | Marimastat | 154039-60-8 | Marimastat is a competitive and broad-spectrum MMP inhibitor with IC50 values of 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7, respectively. |
| CSN14005 | Isoginkgetin | 548-19-6 | Isoginkgetin is a MMP-9 inhibitor isolated and purified from the leaves of Ginkgo biloba L also a Pre-mRNA Splicing inhibitor with IC 50 of 30 M |
| CSN11187 | GM6001 | 142880-36-2 | GM6001 is a broad spectrum MMPs inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively. |
| CSN11187 | GM6001 | 142880-36-2 | GM6001 is a broad spectrum MMPs inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively. |
| CSN15653 | Ginsenoside CK | 39262-14-1 | Ginsenoside CK, a natural product isolated and purified from the roots of Panax ginseng C.A.Mey., is a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A. |
| CSN19851 | GI 254023X | 260264-93-5 | GI 254023X is a potent and selective ADAM10 metalloproteinase inhibitor |
| CSN18069 | CTS-1027 | 193022-04-7 | CTS-1027 is a potent small molecule inhibitor of MMPs (IC500.4 nM0.6 nM for MMP2MMP13), displaying 1,000 fold selectivity over MMP1. |
| CSN17670 | Batimastat Sodium | 130464-84-5 | Batimastat sodium is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively. |
| CSN17343 | Batimastat | 130370-60-4 | Batimastat is a potent broad spectrum MMP inhibitor with IC50 of 3 4 4 6 and 20 nM for MMP-1 MMP-2 MMP-9 MMP-7 and MMP-3 respectively |
| CSN24958 | Abametapir | 1762-34-1 | Abametapir is the active ingredient of Xeglyze Lotion. Abametapir inhibits metalloproteinases; enzymes that are essential to physiological processes critical for egg development and the survival of nymph and adult lice. In vitro and ex vivo research has demonstrated that abametapir not only kills the lice, but also prevents hatching of their eggs. Xeglyze Lotion is emerging as a differentiated development candidate to treat head lice infestations. |
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