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Microtubule/Tubulin

Microtubule/Tubulin

Cat. No. Product Name CAS No. Information
CSN12203 Vinorelbine Ditartrate 125317-39-7 Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals.
CSN12201 Vinflunine 162652-95-1 Vinflunine is a vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity
CSN23847 Vincristine 57-22-7 Vincristine (Leurocristine) is a microtubule-destabilizing agent (MDA). Vincristine (Leurocristine) binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine (Leurocristine) is used to treat hematologic cancers, such as leukemia and lymphoma, and childhood sarcomas[1][2].
CSN20035 Tubulysin B 205304-87-6 Tubulysin B is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays with anti-microtubule anti-mitotic an apoptosis inducer anticancer anti-angiogenic and antiproliferative activity
CSN16451 Triclabendazole   68786-66-3 Triclabendazole is a benzimidazole carbamate anthelmintic which can bind to beta-tublin and inhibits protein synthesis.
CSN18138 Taltobulin Trifluoroacetate 228266-41-9 Taltobulin trifluoroacetat is an analogue of hemiasterlin. It is a potent tubulin inhibitor and an ADCs cytotoxin.
CSN18137 Taltobulin 228266-40-8 Taltobulin is an analogue of hemiasterlin. It is a potent tubulin inhibitor and an ADCs cytotoxin.
CSN25544 T-1101 tosylate 2250404-95-4 T-1101 tosylate is a Hec1/Nek2 (Highly expressed in cancer 1 / NIMA-related kinase 2) inhibitor with antitumor activity. T-1101 tosylate is inactive toward normal cells, kinases and hERG.
CSN13791 Plinabulin 714272-27-2 Plinabulin is a vascular disrupting agent VDA against tubulin-depolymerizing with IC50 of 9818 nM in tumor cells
CSN18161 Ombrabulin HCl 253426-24-3 Ombrabulin HCl is a synthetic derivative of CA-4-P, which inhibits growth in a large number of drug-resistant animal tumors and carcinogen-induced tumors.
CSN11569 Nocodazole 31430-18-9 Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl (E255K) and Abl (T315I) with IC50 of 0.21 M, 0.53 M and 0.64 M, respectively.
CSN11537 Nemorubicin 108852-90-0 Nemorubicin is a 3-deamino-32-(S)-methoxy-4-morpholinylderivative of doxorubicin with anticancer activity on human hepatocellular carcinoma with an IC50 of 80 nM.
CSN13727 MMAF 745017-94-1 MMAF can inhibit tubulin polymerization used in ADCs with lower cytotoxic activity than MMAE
CSN13588 MMAE 474645-27-7 MMAE can inhibit tubulin polymerization used in ADCs.
CSN18091 MMAD 203849-91-6 MMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.
CSN18012 MMAD HCl 173441-26-4 MMAD HCl, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.
CSN18492 Mc-MMAE 863971-24-8 Mc-MMAE is a protective group maleimidocaproyl-conjugated MMAE
CSN12992 Maytansinol 57103-68-1 Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro
CSN19821 Maitansine 35846-53-8 Maitansine is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.
CSN18573 Lexibulin 2HCl 917111-49-0 Lexibulin 2HCl is a potent tubulin polymerisation inhibitor with IC50 of 10-100 nM in cancer cell lines and with potent cytotoxic and vascular disrupting activity in vitro and in vivo.
CSN17257 Leucomethylene Blue Mesylate 1236208-20-0 Leucomethylene blue mesylate, a common reduced form of methylene blue, is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimers disease (AD) and frontotemporal dementia.
CSN18117 Ixabepilone 219989-84-1 Ixabepilone is a microtubule inhibitor working by binding to tubulin and promoting tubulin polymerization and microtubule stabilization.
CSN19198 INH6   1001753-24-7 INH6 can bind to Hec1 and inhibit its association with Nek2 and kinetochores
CSN23867 Indibulin 204205-90-3 Indibulin is a microtubule destabilizer that blocks tubulin polymerization with IC50 of 0.3 μM.
CSN12790 Fosbretabulin Disodium   168555-66-6 Fosbretabulin disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds -tubulin with Kd of 0.4 M in a cell-free assay. Fosbretabulin disodium inhibits the polymerization of tubulin with IC50 of 2.4 M, and also disrupts tumor vasculature.
CSN25215 Estramustine 2998-57-4 Estramustine is an antimicrotubule chemotherapy agent and arrests prostate cancer cells in the G2/M phase of the cell cycle.
CSN15734 Epothilone D 189453-10-9 Epothilone D is a potent microtubule stabilizer.
CSN18805 Epothilone A 152044-53-6 Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC001 of 2 M
CSN16317 ELR510444   1233948-35-0 ELR510444 is an inhibitor of tubulin polymerization with IC50 value of 10 M
CSN17468 Dolastatin 10 110417-88-4 Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly. Dolastatin and Dolastatins analogs are the cytotoxic components in Antibody-drug conjugates design (eg. cAC10-vcMMAE)
CSN12495 Docetaxel     114977-28-5 Docetaxel, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.
CSN16704 Docetaxel Trihydrate   148408-66-6 Docetaxel Trihydrate can promote the assembly of microtublules.
CSN20044 DM4-SMe 796073-68-2 DM4-Me is a tubulin inhibitor inhibits the assemblyof microtubules by binding to tubulin with a linker structure can create an antibody-drug conjugate ADC
CSN20043 DM3-SMe 796073-70-6 DM3-SMe is a tubulin inhibitor inhibits the assemblyof microtubules by binding to tubulin with a linker structure can create an antibody-drug conjugate ADC
CSN20054 DM1-SMe 138148-68-2 DM1-SMe is a tubulin inhibitor inhibits the assemblyof microtubules by binding to tubulin with a linker structure can create an antibody-drug conjugate ADC
CSN14353 Deoxypodophyllotoxin 19186-35-7 Deoxypodophyllotoxin, a natural microtube inhibitor isolated and purified from the roots of Dysosma versipellis (Hance) M.Cheng ex Ying, is cytotoxic agent, antineoplastic agent and potent antitumor agent and may be beneficial in regulating the immediate-type allergic reaction.
CSN19484 Deacetyltaxol   78432-77-6 Deacetyltaxol is a natural product isolated and purified from the barks of Taxus chinensis (Pilger) Rehd. with cytotoxicity in human glial and neuroblastoma cell-lines.
CSN12500 Combretastatin A4   117048-59-6 Combretastatin A4 is a tubulin polymerization inhibitor with Kd value of 04 M for binding to -tubulin
CSN12964 Cabazitaxel 183133-96-2 Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide and grow.
CSN20542 BRD70326 N/A BRD70326 potentiates IL-10 production by suppressing microtubule polmerization.
CSN18622 BNC105 945771-74-4 BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties
CSN18377 Ansamitocin P-3 66584-72-3 Ansamitocin P-3, which is used as an antibody drug conjugate cytotoxin is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29.
CSN22155 Amphethinile 91531-98-5 Amphethinile is an anti-tubulin agent and a novel anti-mitotic agent. The affinity constant for the association (Ka) of Amphethinile with tubulin is 1.3 M.
CSN11486 Albendazole Oxide   54029-12-8 Albendazole Oxide can selectively inhibit beta-tubulin polymerization used as an anthelmintic medicine
CSN13479 7-Xylosyl-10-Deacetyltaxol 90332-63-1 7-Xylosyl-10-deacetyltaxol is a paclitaxel derivative with improved pharmacological features and higher water solubility
CSN11119 (+)-Griseofulvin   126-07-8 ()-Griseofulvin is a naturally occuring centrosomal clustering inhibitor and induces keratin cytoskeleton alterations. It is also an antifungal drug.
CSN25428 Parbendazole 14255-87-9
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