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Microtubule/Tubulin

Microtubule/Tubulin

Cat. No. Product Name CAS No. Information
CSN26702 Tubulin inhibitor 8 1309925-39-0 Tubulin inhibitor 8 (Compound 33b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 8 inhibits tubulin polymerization with an IC50 of 0.73 μM. Tubulin inhibitor 8 inhibits K562 cell growth with an IC50 of 14 nM[1].
CSN26701 Tubulin inhibitor 7 1309925-41-4 Tubulin inhibitor 7 (Compound 33c) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 7 inhibits tubulin polymerization with an IC50 of 0.52 μM. Tubulin inhibitor 7 inhibits K562 cell growth with an IC50 of 11 nM[1].
CSN26703 Tubulin inhibitor 6 105925-39-1 Tubulin inhibitor 6 (Compound 14b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 6 inhibits tubulin polymerization with an IC50 of 0.87 μM. Tubulin inhibitor 6 inhibits K562 cell growth with an IC50 of 840 nM[1].
CSN16451 Triclabendazole   68786-66-3 Triclabendazole is a benzimidazole carbamate anthelmintic which can bind to beta-tublin and inhibits protein synthesis.
CSN18137 Taltobulin 228266-40-8 Taltobulin is an analogue of hemiasterlin. It is a potent tubulin inhibitor and an ADCs cytotoxin.
CSN25544 T-1101 tosylate 2250404-95-4 T-1101 tosylate is a Hec1/Nek2 (Highly expressed in cancer 1 / NIMA-related kinase 2) inhibitor with antitumor activity. T-1101 tosylate is inactive toward normal cells, kinases and hERG.
CSN26117 SSE15206 1370046-40-4 SSE15206 is a microtubule depolymerizing agent which inhibits microtubule polymerization both in biochemical and cellular assays by binding to colchicine site in tubulin. It causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation.
CSN25753 SMIFH2 340316-62-3 SMIFH2 is an inhibitor of formin homology 2 (FH2) domains.
CSN26496 S-methyl DM1 912569-84-7 S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin with a Kd of 0.93 μM and inhibts microtubule polymerization. S-methyl DM1 potently suppresses microtubule dynamic instability and has anticancer effects[1][2].
CSN25428 Parbendazole 14255-87-9 Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 8.79 nM, and exhibits a broad-spectrum anthelmintic activity.
CSN18161 Ombrabulin HCl 253426-24-3 Ombrabulin HCl is a synthetic derivative of CA-4-P, which inhibits growth in a large number of drug-resistant animal tumors and carcinogen-induced tumors.
CSN11569 Nocodazole 31430-18-9 Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl (E255K) and Abl (T315I) with IC50 of 0.21 M, 0.53 M and 0.64 M, respectively.
CSN27661 Myoseverin   267402-71-1 Myoseverin is a microtuble-binding molecule and reversible inhibitor of tubulin polymerization. It binds to tublin leading to multinucleated myotubes fission.
CSN22985 MPC 6827 HCl 917369-31-4 MPC 6827 HCl is a potent inhibitor of microtubule formation with IC50 of 1.5 - 3.4 nM.
CSN18091 MMAD 203849-91-6 MMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.
CSN26704 Mivobulin 122332-18-7 Mivobulin, also known as CI-980, is a synthetic colchicine analogue with potential antineoplastic activity. Mivobulin isethionate binds to tubulin, thereby inhibiting microtubule polymerization and mitosis.
CSN17257 Leucomethylene Blue Mesylate 1236208-20-0 Leucomethylene blue mesylate, a common reduced form of methylene blue, is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimers disease (AD) and frontotemporal dementia.
CSN18117 Ixabepilone 219989-84-1 Ixabepilone is a microtubule inhibitor working by binding to tubulin and promoting tubulin polymerization and microtubule stabilization.
CSN12790 Fosbretabulin Disodium   168555-66-6 Fosbretabulin disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds -tubulin with Kd of 0.4 M in a cell-free assay. Fosbretabulin disodium inhibits the polymerization of tubulin with IC50 of 2.4 M, and also disrupts tumor vasculature.
CSN17468 Dolastatin 10 110417-88-4 Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly. Dolastatin and Dolastatins analogs are the cytotoxic components in Antibody-drug conjugates design (eg. cAC10-vcMMAE)
CSN25687 CHM 1 154554-41-3 CHM-1 induces apoptosis, and it binds tubulin and inhibits tubulin polymerization. CHM-1 possess antimitotic antitumor activity. It is a potent and selective antitumor agent.
CSN27280 Batabulin sodium 195533-98-3 Batabulin sodium can bind covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. It affects cell morphology and leads to cell-cycle arrest.
CSN26705 Batabulin 195533-53-0 Batabulin disrupts microtubule polymerization by binding certain beta-tubulin isotypes and is effective against some multidrug-resistant tumors.
CSN22155 Amphethinile 91531-98-5 Amphethinile is an anti-tubulin agent and a novel anti-mitotic agent. The affinity constant for the association (Ka) of Amphethinile with tubulin is 1.3 M.
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