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Microtubule/Tubulin
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN26702 | Tubulin inhibitor 8 | 1309925-39-0 | Tubulin inhibitor 8 (Compound 33b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 8 inhibits tubulin polymerization with an IC50 of 0.73 μM. Tubulin inhibitor 8 inhibits K562 cell growth with an IC50 of 14 nM[1]. |
| CSN26701 | Tubulin inhibitor 7 | 1309925-41-4 | Tubulin inhibitor 7 (Compound 33c) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 7 inhibits tubulin polymerization with an IC50 of 0.52 μM. Tubulin inhibitor 7 inhibits K562 cell growth with an IC50 of 11 nM[1]. |
| CSN26703 | Tubulin inhibitor 6 | 105925-39-1 | Tubulin inhibitor 6 (Compound 14b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 6 inhibits tubulin polymerization with an IC50 of 0.87 μM. Tubulin inhibitor 6 inhibits K562 cell growth with an IC50 of 840 nM[1]. |
| CSN16451 | Triclabendazole | 68786-66-3 | Triclabendazole is a benzimidazole carbamate anthelmintic which can bind to beta-tublin and inhibits protein synthesis. |
| CSN33179 | Tau tracer 2 | 2173361-80-1 | Tau tracer 2 can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging. |
| CSN18138 | Taltobulin trifluoroacetate | 228266-41-9 | Taltobulin trifluoroacetat is an analogue of hemiasterlin. It is a potent tubulin inhibitor and an ADCs cytotoxin. |
| CSN18137 | Taltobulin | 228266-40-8 | Taltobulin is an analogue of hemiasterlin. It is a potent tubulin inhibitor and an ADCs cytotoxin. |
| CSN25544 | T-1101 tosylate | 2250404-95-4 | T-1101 tosylate is a Hec1/Nek2 (Highly expressed in cancer 1 / NIMA-related kinase 2) inhibitor with antitumor activity. T-1101 tosylate is inactive toward normal cells, kinases and hERG. |
| CSN26117 | SSE15206 | 1370046-40-4 | SSE15206 is a microtubule depolymerizing agent which inhibits microtubule polymerization both in biochemical and cellular assays by binding to colchicine site in tubulin. It causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation. |
| CSN25753 | SMIFH2 | 340316-62-3 | SMIFH2 is an inhibitor of formin homology 2 (FH2) domains. |
| CSN26496 | S-methyl DM1 | 912569-84-7 | S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin with a Kd of 0.93 μM and inhibts microtubule polymerization. S-methyl DM1 potently suppresses microtubule dynamic instability and has anticancer effects[1][2]. |
| CSN25428 | Parbendazole | 14255-87-9 | Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 8.79 nM, and exhibits a broad-spectrum anthelmintic activity. |
| CSN18161 | Ombrabulin hydrochloride | 253426-24-3 | Ombrabulin HCl is a synthetic derivative of CA-4-P, which inhibits growth in a large number of drug-resistant animal tumors and carcinogen-induced tumors. |
| CSN27661 | Myoseverin | 267402-71-1 | Myoseverin is a microtuble-binding molecule and reversible inhibitor of tubulin polymerization. It binds to tublin leading to multinucleated myotubes fission. |
| CSN18091 | MMAD | 203849-91-6 | MMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate. |
| CSN26704 | Mivobulin | 122332-18-7 | Mivobulin, also known as CI-980, is a synthetic colchicine analogue with potential antineoplastic activity. Mivobulin isethionate binds to tubulin, thereby inhibiting microtubule polymerization and mitosis. |
| CSN17257 | Leucomethylene blue mesylate | 1236208-20-0 | Leucomethylene blue mesylate, a common reduced form of methylene blue, is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimers disease (AD) and frontotemporal dementia. |
| CSN18117 | Ixabepilone | 219989-84-1 | Ixabepilone is a microtubule inhibitor working by binding to tubulin and promoting tubulin polymerization and microtubule stabilization. |
| CSN17468 | Dolastatin 10 | 110417-88-4 | Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly. Dolastatin and Dolastatins analogs are the cytotoxic components in Antibody-drug conjugates design (eg. cAC10-vcMMAE) |
| CSN25687 | CHM-1 | 154554-41-3 | CHM-1 induces apoptosis, and it binds tubulin and inhibits tubulin polymerization. CHM-1 possess antimitotic antitumor activity. It is a potent and selective antitumor agent. |
| CSN27280 | Batabulin sodium | 195533-98-3 | Batabulin sodium can bind covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. It affects cell morphology and leads to cell-cycle arrest. |
| CSN26705 | Batabulin | 195533-53-0 | Batabulin disrupts microtubule polymerization by binding certain beta-tubulin isotypes and is effective against some multidrug-resistant tumors. |
| CSN22155 | Amphethinile | 91531-98-5 | Amphethinile is an anti-tubulin agent and a novel anti-mitotic agent. The affinity constant for the association (Ka) of Amphethinile with tubulin is 1.3 M. |
| CSN27630 | TRx0237 | 951131-15-0 | |
| CSN38348 | Cl-NQTrp | 185351-23-9 | |
| CSN42994 | Rosabulin | 501948-05-6 | |
| CSN50142 | 6-Methoxy-3-(3,4,5-trimethoxybenzylidene)indolin-2-one | 1151995-69-5 | |
| CSN68770 | PBOX-15 | 354759-10-7 | |
| CSN68434 | BSc3094 | 946857-84-7 | |
| CSN68493 | Tau tracer 1 | 2173353-53-0 | |
| CSN79705 | N-(3-fluorobenzyl)-2-(5-(4-morpholinophenyl)pyridin-2-yl)acetamide | 897016-26-1 | |
| CSN85943 | Tubulin polymerization-IN-21 | 2703017-14-3 |
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