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Microtubule/Tubulin

Microtubule/Tubulin

Cat. No. Product Name CAS No. Information
CSN20039 Tubulysin M 936691-46-2 Tubulysin M is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays with anti-microtubule anti-mitotic an apoptosis inducer anticancer anti-angiogenic and antiproliferative activity
CSN16451 Triclabendazole   68786-66-3 Triclabendazole is a benzimidazole carbamate anthelmintic which can bind to beta-tublin and inhibits protein synthesis.
CSN18137 Taltobulin 228266-40-8 Taltobulin is an analogue of hemiasterlin. It is a potent tubulin inhibitor and an ADCs cytotoxin.
CSN25544 T-1101 tosylate 2250404-95-4 T-1101 tosylate is a Hec1/Nek2 (Highly expressed in cancer 1 / NIMA-related kinase 2) inhibitor with antitumor activity. T-1101 tosylate is inactive toward normal cells, kinases and hERG.
CSN26117 SSE15206 1370046-40-4 SSE15206 is a microtubule depolymerizing agent which inhibits microtubule polymerization both in biochemical and cellular assays by binding to colchicine site in tubulin. It causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation.
CSN25428 Parbendazole 14255-87-9 Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 8.79 nM, and exhibits a broad-spectrum anthelmintic activity.
CSN18161 Ombrabulin HCl 253426-24-3 Ombrabulin HCl is a synthetic derivative of CA-4-P, which inhibits growth in a large number of drug-resistant animal tumors and carcinogen-induced tumors.
CSN11569 Nocodazole 31430-18-9 Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl (E255K) and Abl (T315I) with IC50 of 0.21 M, 0.53 M and 0.64 M, respectively.
CSN18091 MMAD 203849-91-6 MMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.
CSN12992 Maytansinol 57103-68-1 Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro
CSN17257 Leucomethylene Blue Mesylate 1236208-20-0 Leucomethylene blue mesylate, a common reduced form of methylene blue, is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimers disease (AD) and frontotemporal dementia.
CSN18117 Ixabepilone 219989-84-1 Ixabepilone is a microtubule inhibitor working by binding to tubulin and promoting tubulin polymerization and microtubule stabilization.
CSN12790 Fosbretabulin Disodium   168555-66-6 Fosbretabulin disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds -tubulin with Kd of 0.4 M in a cell-free assay. Fosbretabulin disodium inhibits the polymerization of tubulin with IC50 of 2.4 M, and also disrupts tumor vasculature.
CSN17468 Dolastatin 10 110417-88-4 Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly. Dolastatin and Dolastatins analogs are the cytotoxic components in Antibody-drug conjugates design (eg. cAC10-vcMMAE)
CSN20041 DM3 796073-54-6 DM3 is a tubulin inhibitor inhibits the assemblyof microtubules by binding to tubulin with a linker structure can create an antibody-drug conjugate ADC
CSN20054 DM1-SMe 138148-68-2 DM1-SMe is a tubulin inhibitor inhibits the assemblyof microtubules by binding to tubulin with a linker structure can create an antibody-drug conjugate ADC
CSN25687 CHM 1 154554-41-3 CHM-1 induces apoptosis, and it binds tubulin and inhibits tubulin polymerization. CHM-1 possess antimitotic antitumor activity. It is a potent and selective antitumor agent.
CSN12964 Cabazitaxel   183133-96-2 Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide and grow.
CSN20459 BTB1 86030-08-2 BTB1 an ATP-competitive and selective inhibitor of the mitotic motor protein Kif18A with IC50 value of 17 M
CSN18377 Ansamitocin P-3 66584-72-3 Ansamitocin P-3, which is used as an antibody drug conjugate cytotoxin is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29.
CSN22155 Amphethinile 91531-98-5 Amphethinile is an anti-tubulin agent and a novel anti-mitotic agent. The affinity constant for the association (Ka) of Amphethinile with tubulin is 1.3 M.
CSN11119 (+)-Griseofulvin   126-07-8 ()-Griseofulvin is a naturally occuring centrosomal clustering inhibitor and induces keratin cytoskeleton alterations. It is also an antifungal drug.
CSN27661 Myoseverin   267402-71-1
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