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mGluR
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN23268 | Ym 202074 | 299900-83-7 | YM-202074 is a high affinity, selective metabotropic glutamate receptor type 1 (mGlu1) antagonist. YM-202074 binds an allosteric site of the rat mGlu1 receptor with a Ki of 4.8 nM. It inhibits mGlu1-mediated inositol phosphates production (IC50 = 8.6 nM in rat cerebellar granule cells). |
| CSN23198 | XAP044 | 196928-50-4 | XAP044 is a potent and selective mGlu7 antagonist (IC50 = 88 nM). It inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. XAP044 displays no effects on the LTP of mGlu7 deficient mice. |
| CSN26264 | Xanthurenic acid | 59-00-7 | Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus, which activates mGlu2/3 metabotropic glutamate receptors (mGlu2 and mGlu3). |
| CSN23892 | VU6012962 | 2313526-86-0 | VU6012962 is a CNS-penetrant metabotropic glutamate receptor 7 (mGlu7) negative allosteric modulator (NAM) with an IC50 of 347 nM. |
| CSN24066 | VU6005649 | 2137047-43-7 | VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively. |
| CSN20205 | Auglurant | 1396337-04-4 | VU0424238 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 selected for clinical evaluation of psychiatric and neurodegenerative disorders. |
| CSN23184 | VU0422288 | 1630936-95-6 | VU0422288, also known as ML 396, is a positive allosteric modulator (EC50 values are 108, 125 and 146 nM for mGlu4, mGlu8 and mGlu7 respectively). |
| CSN23183 | VU0409106 | 1276617-62-9 | VU0409106 is a potent and selective inhibitor of mGlu5. |
| CSN23186 | VU0469650 | 1443748-47-7 | VU 0469650 hydrochloride is a potent and selective negative allosteric modulator of mGlu1 (IC50 = 99 nM). VU 0469650 hydrochloride exhibits >100-fold selectivity for mGlu1 over mGlu2-8 and 68 other GPCRs, ion channels, kinases and transporters. |
| CSN23267 | VU 0469650 HCl | N/A | VU 0469650 hydrochloride is a potent and selective negative allosteric modulator of mGlu1 (IC50 = 99 nM). VU 0469650 hydrochloride exhibits >100-fold selectivity for mGlu1 over mGlu2-8 and 68 other GPCRs, ion channels, kinases and transporters. |
| CSN23181 | VU0155041 | 1093757-42-6 | UV0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). |
| CSN12115 | Topiramate | 97240-79-4 | Topiramate is a selective GluK1 kainate receptors (GluR5) antagonist with IC50 value of 0.46 M which can act as a positive allosteric modulator of GABAA receptor-mediated currents, inhibit Nav channels and L-type Ca2 channels. |
| CSN26379 | TCN238 | 125404-04-8 | TCN238 is a orally available and brain penetrant positive allosteric mGlu4 receptor modulator with an EC50 of 1 μM. |
| CSN23124 | Spaglumic Acid | 3106-85-2 | Spaglumic Acid is a neuropeptide found in millimolar concentrations in brain. |
| CSN23116 | SIB-1757 | 31993-01-8 | SIB-1757 is a highly selective antagonist for the mGlu5 metabotropic glutamate receptor subtype. SIB-1757 displays an IC50 value of 0.4 μM at hmGlu5 compared with > 30 μM at hmGlu1b, hmGlu2, hmGlu4, hmGlu6, hmGlu7 and hmGlu8. |
| CSN23070 | Ro 64-5229 | 246852-46-0 | Ro64-5229 is a selective, non-competitive mGlu2 antagonist. Ro64-5229 inhibits GTPγ35S binding to mGlu2-containing membranes (IC50 = 0.11 μM). |
| CSN15700 | Basimglurant | 802906-73-6 | RG7090 is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM. |
| CSN23187 | VU-29 | 890764-36-0 | Potent positive allosteric modulator of mGlu5 receptors |
| CSN23182 | VU0155041 sodium | 1259372-69-4 | Potent positive allosteric modulator of mGlu4 receptors; sodium salt of VU 0155041 (Cat. No. 3248) |
| CSN23155 | TC-N 22A | 1314140-00-5 | Potent and selective positive allosteric modulator of mGlu4 receptors |
| CSN18031 | PHCCC | 179068-02-1 | PHCCC is a Group I metabotropic glutamate receptor antagonist with EC 50 of 6 M and a positive allosteric modulator of mGluR4. |
| CSN23007 | NPS 2390 | 226878-01-9 | NPS 2390 is a Group I mGlu antagonist. |
| CSN26699 | NPEC-caged-LY379268 | 1315379-62-4 | NPEC-caged-LY379268 is a type II mGluR agonist[1]. |
| CSN29465 | L-Cysteinesulfinic acid | 1115-65-7 | NMDA and mGlu agonist. |
| CSN23218 | MMPIP | 479077-02-6 | MMPIP HCl is an allosteric mGlu7-selective receptor antagonist. |
| CSN13469 | Mavoglurant | 543906-09-8 | Mavoglurant is a structurally non-competitive mGlu5 receptor antagonist has an IC50 of 30 nM in a functional assay with human mGluR5 |
| CSN18024 | Eglumegad | 176199-48-7 | LY354740 is a highly potent efficacious and selective group II mGlu23 receptor agonist produces 90 suppression of forskolin-stimulated cAMP formation with an EC50 of 51 03 nM |
| CSN22065 | Lu AF21934 | 1445605-23-1 | Lu AF21934 is a selective and brain-penetrant mGlu4 receptor positive allosteric modulator with IC50 of 500 nM for human mGlu4. |
| CSN24472 | LSN2814617 | 1313498-08-6 | LSN2814617 is a potent and selective positive allosteric modulator at the mGlu5 receptor with EC50 value fo 52nM. |
| CSN11296 | L-Glutamic acid monosodium salt | 142-47-2 | L-Glutamic Acid Monosodium is an excitatory amino acid neurotransmitter as an agonist at GluR and NMDA receptor. |
| CSN27529 | L-Cysteinesulfinic acid monohydrate | 207121-48-0 | L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively. |
| CSN24057 | JNJ-42153605 | 1254977-87-1 | JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor with EC50 of 17 nM. |
| CSN18792 | IEM-1754 | 162831-31-4 | IEM 1754 dihydrobromide is a selective AMPAkainate receptor blockers for GluR1 and GluR3 with IC50 of 6 M |
| CSN23202 | YM 202074 fumarate salt | 299900-84-8 | High affinity, selective mGlu1 antagonist |
| CSN23016 | O-Phospho-L-serine | 407-41-0 | H-SerPO3H2-OH is both a Group III metabotropic glutamate receptor mGluR4 mGluR7 and mGluR8 agonist and a competitive NMDA antagonist |
| CSN24075 | Foliglurax | 1883329-51-8 | Foliglurax (PXT002331) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 79 nM[1]. Antiparkinsonian effect[1]. |
| CSN26363 | FITM | 932737-65-0 | FITM is a negative allosteric modulator of mGlu1 receptor with a Ki of 2.5 nM. |
| CSN10975 | Evans Blue | 314-13-6 | Evans blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). |
| CSN18005 | E4CPG | 170846-89-6 | E4CPG is a group Igroup II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG . |
| CSN16659 | CTEP | 871362-31-1 | CTEP is a selective allosteric mGluR5 antagonist with IC50 value of 2.2 nM. |
| CSN27612 | CDPPB | 781652-57-1 | CDPPB is a potent, selective and brain penetrant positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5), with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5. |
| CSN26700 | AZD-8529 mesylate | 1314217-69-0 | AZD-8529 is a a positive allosteric modulator at the mGluR2 receptor. AZD8529 decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys. AZD8529 potentiated agonist-induced activation of mGluR2 in the membrane-binding assay and in primate cortex, hippocampus, and striatum. In monkeys, AZD8529 decreased nicotine self-administration at doses (.3-3 mg/kg) that did not affect food self-administration. AZD8529 also reduced nicotine priming- and cue-induced reinstatement of nicotine seeking after extinction of the drug-reinforced responding. In rats, AZD8529 decreased nicotine-induced accumbens dopamine release. The positive allosteric modulators of metabotropic glutamate receptor 2 should be considered for relapse prevention. |
| CSN22665 | ACDPP HCl | N/A | ACDPP HCl is the hydrochloride form of ACDPP. ACDPP is a modest mGlu5 receptor antagonist. |
| CSN24484 | (S)-4CPG | 134052-73-6 | (S)-4CPG is a selective competitive group I mGlu antagonist. |
| CSN32737 | Decoglurant | 911115-16-7 | |
| CSN42041 | UBP316 | 936095-50-0 | |
| CSN43844 | HTL14242 | 1644645-32-8 |
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