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mGluR

mGluR

Cat. No. Product Name CAS No. Information
CSN23198 XAP 044 196928-50-4 XAP044 is a potent and selective mGlu7 antagonist (IC50 = 88 nM). It inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. XAP044 displays no effects on the LTP of mGlu7 deficient mice.
CSN26264 4,8-Dihydroxyquinoline-2-carboxylic acid 59-00-7 Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus, which activates mGlu2/3 metabotropic glutamate receptors (mGlu2 and mGlu3).
CSN23892 VU6012962 2313526-86-0 VU6012962 is a CNS-penetrant metabotropic glutamate receptor 7 (mGlu7) negative allosteric modulator (NAM) with an IC50 of 347 nM.
CSN24066 VU6005649 2137047-43-7 VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively.
CSN20205 VU0424238 1396337-04-4 VU0424238 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 selected for clinical evaluation of psychiatric and neurodegenerative disorders.
CSN23181 VU 0155041 1093757-42-6 UV0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively).
CSN12115 Topiramate   97240-79-4 Topiramate is a selective GluK1 kainate receptors (GluR5) antagonist with IC50 value of 0.46 M which can act as a positive allosteric modulator of GABAA receptor-mediated currents, inhibit Nav channels and L-type Ca2 channels.
CSN26379 Tcn238 125404-04-8 TCN238 is a orally available and brain penetrant positive allosteric mGlu4 receptor modulator with an EC50 of 1 μM.
CSN23124 Spaglumic Acid 3106-85-2 Spaglumic Acid is a neuropeptide found in millimolar concentrations in brain.
CSN23116 SIB 1757 31993-01-8 SIB-1757 is a highly selective antagonist for the mGlu5 metabotropic glutamate receptor subtype. SIB-1757 displays an IC50 value of 0.4 μM at hmGlu5 compared with > 30 μM at hmGlu1b, hmGlu2, hmGlu4, hmGlu6, hmGlu7 and hmGlu8.
CSN23070 Ro 64-5229 246852-46-0 Ro64-5229 is a selective, non-competitive mGlu2 antagonist. Ro64-5229 inhibits GTPγ35S binding to mGlu2-containing membranes (IC50 = 0.11 μM).
CSN15700 RG7090 802906-73-6 RG7090 is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM.
CSN23187 VU 29 890764-36-0 Potent positive allosteric modulator of mGlu5 receptors
CSN23182 VU 0155041 Sodium Salt 1259372-69-4 Potent positive allosteric modulator of mGlu4 receptors; sodium salt of VU 0155041 (Cat. No. 3248)
CSN23155 TC-N 22A 1314140-00-5 Potent and selective positive allosteric modulator of mGlu4 receptors
CSN23007 NPS 2390 226878-01-9 NPS 2390 is a Group I mGlu antagonist.
CSN26699 NPEC-caged-LY379268 1315379-62-4 NPEC-caged-LY379268 is a type II mGluR agonist[1].
CSN29465 L-Cysteinesulfinic acid 1115-65-7 NMDA and mGlu agonist.
CSN22978 ML 337 1443118-44-2 ML 337 is a selective negative allosteric modulator of mGlu3 with IC50 of 593 nM.
CSN22977 ML 289 1382481-79-9 ML 289 is a selective negative allosteric modulator at mGlu3 receptors with IC50 of 660 nM.
CSN13469 Mavoglurant 543906-09-8 Mavoglurant is a structurally non-competitive mGlu5 receptor antagonist has an IC50 of 30 nM in a functional assay with human mGluR5
CSN18024 LY354740 176199-48-7 LY354740 is a highly potent efficacious and selective group II mGlu23 receptor agonist produces 90 suppression of forskolin-stimulated cAMP formation with an EC50 of 51 03 nM
CSN22065 Lu AF21934 1445605-23-1 Lu AF21934 is a selective and brain-penetrant mGlu4 receptor positive allosteric modulator with IC50 of 500 nM for human mGlu4.
CSN11296 L-Glutamic Acid Monosodium 142-47-2 L-Glutamic Acid Monosodium is an excitatory amino acid neurotransmitter as an agonist at GluR and NMDA receptor.
CSN27529 L-Cysteinesulfinic acid monohydrate 207121-48-0 L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.
CSN24057 JNJ-42153605 1254977-87-1 JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor with EC50 of 17 nM.
CSN18792 IEM 1754 Dihydrobromide 162831-31-4 IEM 1754 dihydrobromide is a selective AMPAkainate receptor blockers for GluR1 and GluR3 with IC50 of 6 M
CSN23016 H-Ser(PO3H2)-OH   407-41-0 H-SerPO3H2-OH is both a Group III metabotropic glutamate receptor mGluR4 mGluR7 and mGluR8 agonist and a competitive NMDA antagonist
CSN24075 Foliglurax 1883329-51-8 Foliglurax (PXT002331) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 79 nM[1]. Antiparkinsonian effect[1].
CSN26363 FITM 932737-65-0 FITM is a negative allosteric modulator of mGlu1 receptor with a Ki of 2.5 nM.
CSN10975 Evans Blue 314-13-6 Evans blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT).
CSN18005 E4CPG 170846-89-6 E4CPG is a group Igroup II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG .
CSN16659 CTEP 871362-31-1 CTEP is a selective allosteric mGluR5 antagonist with IC50 value of 2.2 nM.
CSN27612 CDPPB 781652-57-1 CDPPB is a potent, selective and brain penetrant positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5), with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5.
CSN26700 AZD-8529 mesylate 1314217-69-0 AZD-8529 is a a positive allosteric modulator at the mGluR2 receptor. AZD8529 decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys. AZD8529 potentiated agonist-induced activation of mGluR2 in the membrane-binding assay and in primate cortex, hippocampus, and striatum. In monkeys, AZD8529 decreased nicotine self-administration at doses (.3-3 mg/kg) that did not affect food self-administration. AZD8529 also reduced nicotine priming- and cue-induced reinstatement of nicotine seeking after extinction of the drug-reinforced responding. In rats, AZD8529 decreased nicotine-induced accumbens dopamine release. The positive allosteric modulators of metabotropic glutamate receptor 2 should be considered for relapse prevention.
CSN24484 (S)-4CPG 134052-73-6 (S)-4CPG is a selective competitive group I mGlu antagonist.
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