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mGluR

mGluR

Cat. No. Product Name CAS No. Information
CSN23268 YM 202074 299900-83-7 YM-202074 is a high affinity, selective metabotropic glutamate receptor type 1 (mGlu1) antagonist. YM-202074 binds an allosteric site of the rat mGlu1 receptor with a Ki of 4.8 nM. It inhibits mGlu1-mediated inositol phosphates production (IC50 = 8.6 nM in rat cerebellar granule cells).
CSN23198 XAP 044 196928-50-4 XAP044 is a potent and selective mGlu7 antagonist (IC50 = 88 nM). It inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. XAP044 displays no effects on the LTP of mGlu7 deficient mice.
CSN23892 VU6012962 N/A VU6012962 is a CNS-penetrant metabotropic glutamate receptor 7 (mGlu7) negative allosteric modulator (NAM) with an IC50 of 347 nM.
CSN24066 VU6005649 2137047-43-7 VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively.
CSN20205 VU0424238 1396337-04-4 VU0424238 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 selected for clinical evaluation of psychiatric and neurodegenerative disorders.
CSN23184 VU 0422288 1630936-95-6 VU0422288, also known as ML 396, is a positive allosteric modulator (EC50 values are 108, 125 and 146 nM for mGlu4, mGlu8 and mGlu7 respectively).
CSN23183 VU 0409106 1276617-62-9 VU0409106 is a potent and selective inhibitor of mGlu5.
CSN23186 VU 0469650 1443748-47-7 VU 0469650 hydrochloride is a potent and selective negative allosteric modulator of mGlu1 (IC50 = 99 nM). VU 0469650 hydrochloride exhibits >100-fold selectivity for mGlu1 over mGlu2-8 and 68 other GPCRs, ion channels, kinases and transporters.
CSN15882 VU 0361737   1161205-04-4 VU 0361737 is a brain-penetrant and selective positive allosteric modulator of mGlu4 receptors with EC50 values of 240 nM
CSN23181 VU 0155041 1093757-42-6 UV0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively).
CSN22529 UBP 1112 339526-74-8 UBP 1112 is a selective group III mGluR antagonist with a Kd of 51 M 96-fold affinity for group III over group II mGlu receptor Kd 488 M and shows no significant activity at group I mGlu receptor or iGlu receptor
CSN12115 Topiramate   97240-79-4 Topiramate is a selective GluK1 kainate receptors (GluR5) antagonist with IC50 value of 0.46 M which can act as a positive allosteric modulator of GABAA receptor-mediated currents, inhibit Nav channels and L-type Ca2 channels.
CSN23141 TASP 0433864 1431980-60-7 TASP0433864 is a novel positive allosteric modulator of metabotropic glutamate 2 receptor. TASP0433864 exhibited PAM activity at human and rat mGlu2 receptors with EC50 values of 199 and 206 nM, respectively, without exerting agonist activity at rat mGlu2 receptor. TASP0433864 produced a leftward and upward shift in the concentration-response curve of glutamate-increased guanosine 5'-O-(3-[(35)S]thio)triphosphate binding to mGlu2 receptor. The inhibitory effect of TASP0433864 on cortical activation was also observed in the mouse 2-deoxy-glucose uptake study. TASP0433864 is a selective mGlu2 receptor PAM with antipsychotic activity, and the attenuation of excess glutamatergic neurotransmission may be involved in the action of TASP0433864.
CSN23124 Spaglumic Acid 3106-85-2 Spaglumic Acid is a neuropeptide found in millimolar concentrations in brain.
CSN23116 SIB 1757 31993-01-8 SIB-1757 is a highly selective antagonist for the mGlu5 metabotropic glutamate receptor subtype. SIB-1757 displays an IC50 value of 0.4 μM at hmGlu5 compared with > 30 μM at hmGlu1b, hmGlu2, hmGlu4, hmGlu6, hmGlu7 and hmGlu8.
CSN23203 YM 230888 446257-23-4 Selective mGlu1 antagonist
CSN17028 (RS)-MCPG 146669-29-6 RS-MCPG is a non-selective group Igroup II metabotropic glutamate receptor antagonist
CSN23070 Ro 64-5229 246852-46-0 Ro64-5229 is a selective, non-competitive mGlu2 antagonist. Ro64-5229 inhibits GTPγ35S binding to mGlu2-containing membranes (IC50 = 0.11 μM).
CSN15700 RG7090 802906-73-6 RG7090 is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM.
CSN23187 VU 29 890764-36-0 Potent positive allosteric modulator of mGlu5 receptors
CSN23182 VU 0155041 Sodium Salt 1259372-69-4 Potent positive allosteric modulator of mGlu4 receptors; sodium salt of VU 0155041 (Cat. No. 3248)
CSN23155 TC-N 22A 1314140-00-5 Potent and selective positive allosteric modulator of mGlu4 receptors
CSN20553 PF-06462894 1622291-66-0 PF-06462894 is an alkyne-lacking metabotropic glutamate receptor 5 negative allosteric modulator
CSN13647 MTEP HCl 1186195-60-7 MTEP HCl is a potent, selective and non-competitive mGlu5 antagonist with IC50 and Ki of 5 nM and 16 nM, respectively.
CSN22469 MSOP 66515-29-5 MSOP is a selective group III metabotropic glutamate receptor antagonist with apparent KD of 51 M for the L-AP4-sensitive presynaptic mGluR
CSN15940 MPEP HCl 219911-35-0 MPEP HCl is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype with IC50 of 36 nM.
CSN23218 MMPIP 479077-02-6 MMPIP HCl is an allosteric mGlu7-selective receptor antagonist.
CSN18318 Methoxy-PEPy 524924-76-3 Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM
CSN16643 LY2979165 1311385-32-6 LY2979165 is a mGlu2 agonist a drug candidate drug used to treat bipolar disorder
CSN22065 Lu AF21934 1445605-23-1 Lu AF21934 is a selective and brain-penetrant mGlu4 receptor positive allosteric modulator with IC50 of 500 nM for human mGlu4.
CSN24472 LSN2814617 1313498-08-6 LSN2814617 is a potent and selective positive allosteric modulator at the mGlu5 receptor with EC50 value fo 52nM.
CSN11296 L-Glutamic Acid Monosodium 142-47-2 L-Glutamic Acid Monosodium is an excitatory amino acid neurotransmitter as an agonist at GluR and NMDA receptor.
CSN22445 L-APB 23052-81-5 L-APB is a potent and specific agonist for the group III mGluRs with EC50s of 013002 029007 1003 249107 M for mGlu4 mGlu8 mGlu6 and mGlu7 receptors respectively
CSN22437 JNJ-46778212 1363281-27-9 JNJ-46778212 is an mGlu5 positive allosteric modulator with an EC50 of 260 nM
CSN24057 JNJ-42153605 1254977-87-1 JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor with EC50 of 17 nM.
CSN18792 IEM 1754 Dihydrobromide 162831-31-4 IEM 1754 dihydrobromide is a selective AMPAkainate receptor blockers for GluR1 and GluR3 with IC50 of 6 M
CSN23202 YM 202074 fumarate salt 299900-84-8 High affinity, selective mGlu1 antagonist
CSN18973 FPTQ 864863-72-9 FPTQ is mGluR1 antagonist with IC50 of 6 nM and 14 nM for human and mouse mGluR1 respectively
CSN24075 Foliglurax 1883329-51-8 Foliglurax (PXT002331) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 79 nM[1]. Antiparkinsonian effect[1].
CSN10975 Evans Blue 314-13-6 Evans blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT).
CSN18005 E4CPG 170846-89-6 E4CPG is a group Igroup II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG .
CSN18512 Dipraglurant 872363-17-2 Dipraglurant is a mGluR5 antagonists with IC50 of 0021 M
CSN16659 CTEP 871362-31-1 CTEP is a selective allosteric mGluR5 antagonist with IC50 value of 2.2 nM.
CSN18974 CFMTI 864864-17-5 CFMTI is a potent and selective metabotropic glutamate receptor mGluR1 allosteric antagonist with IC50 of 26 nM
CSN22354 AZD-8529 1092453-15-0 AZD-8529 is a potent highly selective and orally bioavailable positive allosteric modulator of mGluR2 with an EC50 of 285 nM and shows no positive allosteric modulator responses at 20-25 M on the mGluR1 3 4 5 6 7 and 8 subtypes
CSN16339 ADX-47273   851881-60-2 ADX-47273 is a positive allosteric modulator of mGlu5 receptor with EC50 value of 023 M in primary astrocyte culture
CSN24484 (S)-4CPG 134052-73-6 (S)-4CPG is a selective competitive group I mGlu antagonist.
CSN22630 (RS)-3-Hydroxyphenylglycine 31932-87-3 (RS)-3-Hydroxyphenylglycine is a selective group I metabotropic glutamate receptor agonist.
CSN22629 (RS)-3,5-DHPG 146255-66-5 (RS)-3,5-DHPG is a selective group I metabotropic glutamate receptor agonist which activates both mGlu1 and mGlu5.
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