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mGluR

mGluR

Cat. No. Product Name CAS No. Information
CSN23892 VU6012962 2313526-86-0 VU6012962 is a CNS-penetrant metabotropic glutamate receptor 7 (mGlu7) negative allosteric modulator (NAM) with an IC50 of 347 nM.
CSN12115 Topiramate   97240-79-4 Topiramate is a selective GluK1 kainate receptors (GluR5) antagonist with IC50 value of 0.46 M which can act as a positive allosteric modulator of GABAA receptor-mediated currents, inhibit Nav channels and L-type Ca2 channels.
CSN23124 Spaglumic Acid 3106-85-2 Spaglumic Acid is a neuropeptide found in millimolar concentrations in brain.
CSN23116 SIB 1757 31993-01-8 SIB-1757 is a highly selective antagonist for the mGlu5 metabotropic glutamate receptor subtype. SIB-1757 displays an IC50 value of 0.4 μM at hmGlu5 compared with > 30 μM at hmGlu1b, hmGlu2, hmGlu4, hmGlu6, hmGlu7 and hmGlu8.
CSN23070 Ro 64-5229 246852-46-0 Ro64-5229 is a selective, non-competitive mGlu2 antagonist. Ro64-5229 inhibits GTPγ35S binding to mGlu2-containing membranes (IC50 = 0.11 μM).
CSN23187 VU 29 890764-36-0 Potent positive allosteric modulator of mGlu5 receptors
CSN23007 NPS 2390 226878-01-9 NPS 2390 is a Group I mGlu antagonist.
CSN22913 MMPEP   823198-78-3 MMPEP is both a selective non-competitive mGlu5 receptor antagonist with IC50 value of 36 nM and a mGlu4 receptor positive allosteric modulator.
CSN13469 Mavoglurant 543906-09-8 Mavoglurant is a structurally non-competitive mGlu5 receptor antagonist has an IC50 of 30 nM in a functional assay with human mGluR5
CSN22960 MAP4 157381-42-5 MAP4 is a potent group II mGlu agonist and also group III mGlu antagonist.
CSN18024 LY354740 176199-48-7 LY354740 is a highly potent efficacious and selective group II mGlu23 receptor agonist produces 90 suppression of forskolin-stimulated cAMP formation with an EC50 of 51 03 nM
CSN11296 L-Glutamic Acid Monosodium 142-47-2 L-Glutamic Acid Monosodium is an excitatory amino acid neurotransmitter as an agonist at GluR and NMDA receptor.
CSN27529 L-Cysteinesulfinic acid monohydrate 207121-48-0 L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.
CSN18792 IEM 1754 Dihydrobromide 162831-31-4 IEM 1754 dihydrobromide is a selective AMPAkainate receptor blockers for GluR1 and GluR3 with IC50 of 6 M
CSN22849 HexylHIBO 334887-43-3 HexylHIBO is a Group I mGlu receptor antagonist with Kis of 140 and 110 μM at mGlu1a and mGlu5a receptors respectively.
CSN23016 H-Ser(PO3H2)-OH   407-41-0 H-SerPO3H2-OH is both a Group III metabotropic glutamate receptor mGluR4 mGluR7 and mGluR8 agonist and a competitive NMDA antagonist
CSN10975 Evans Blue 314-13-6 Evans blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT).
CSN24484 (S)-4CPG 134052-73-6 (S)-4CPG is a selective competitive group I mGlu antagonist.
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