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mGluR

mGluR

Cat. No. Product Name CAS No. Information
CSN20205 VU0424238 1396337-04-4 VU0424238 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 selected for clinical evaluation of psychiatric and neurodegenerative disorders.
CSN17179 VU 0364439 1246086-78-1 VU 0364439 is a mGlu4 positive allosteric modulator PAM with EC50 of 198 nM
CSN15882 VU 0361737   1161205-04-4 VU 0361737 is a brain-penetrant and selective positive allosteric modulator of mGlu4 receptors with EC50 values of 240 nM
CSN16570 VU 0357121   433967-28-3 VU 0357121 is a positive allosteric mGlu5 receptors modulator with EC50 value of 33 nM
CSN22529 UBP 1112 339526-74-8 UBP 1112 is a selective group III mGluR antagonist with a Kd of 51 M 96-fold affinity for group III over group II mGlu receptor Kd 488 M and shows no significant activity at group I mGlu receptor or iGlu receptor
CSN12115 Topiramate   97240-79-4 Topiramate is a selective GluK1 kainate receptors (GluR5) antagonist with IC50 value of 0.46 M which can act as a positive allosteric modulator of GABAA receptor-mediated currents, inhibit Nav channels and L-type Ca2 channels.
CSN17040 (S)-MCPG 150145-89-4 S-MCPG is the active isomer of RS-MCPG non-selective group Igroup II metabotropic glutamate receptor antagonist
CSN17028 (RS)-MCPG 146669-29-6 RS-MCPG is a non-selective group Igroup II metabotropic glutamate receptor antagonist
CSN18975 Ro 67-7476 298690-60-5 Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors
CSN15957 Ro 67-4853 302841-89-0 Ro 67-4853 is a drug used in scientific research which acts as a selective positive allosteric modulator for the metabotropic glutamate receptor subtype mGluR1
CSN15700 RG7090 802906-73-6 RG7090 is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM.
CSN20553 PF-06462894 1622291-66-0 PF-06462894 is an alkyne-lacking metabotropic glutamate receptor 5 negative allosteric modulator
CSN13647 MTEP HCl 1186195-60-7 MTEP hydrochloride is a potent selective and non-competitive mGlu5 antagonist with IC50 and Ki of 5 nM and 16 nM respectively
CSN22469 MSOP 66515-29-5 MSOP is a selective group III metabotropic glutamate receptor antagonist with apparent KD of 51 M for the L-AP4-sensitive presynaptic mGluR
CSN11477 MPEP 96206-92-7 MPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype IC50 36 nM and a positive allosteric modulator at mGlu4 receptors
CSN15940 MPEP HCl 219911-35-0 MPEP hydrochloride is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype with IC50 of 36 nM
CSN18318 Methoxy-PEPy 524924-76-3 Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM
CSN18984 Mavoglurant Racemate 1636881-61-2 Mavoglurant racemate is the racemate of mavoglurant
CSN12419 LY404039 635318-11-5 LY404039 is an inhibitor for mGluR1 Ki149 nM and mGluR2 Ki 92 nM which can also inhibit dopamine receptor
CSN18024 LY354740 176199-48-7 LY354740 is a highly potent efficacious and selective group II mGlu23 receptor agonist produces 90 suppression of forskolin-stimulated cAMP formation with an EC50 of 51 03 nM
CSN11347 LY341495 201943-63-7 LY341495 is a highly potent and selective group II metabotropic glutamate receptor antagonist
CSN16643 LY2979165 1311385-32-6 LY2979165 is a mGlu2 agonist a drug candidate drug used to treat bipolar disorder
CSN19844 LY 456236 HCl 338736-46-2 LY 456236 hydrochloride is a selective mGlu1 receptor antagonist IC50 values are 143 nM and 10 M for mGlu1 and mGlu5 receptors respectively
CSN19861 LSN 2463359 1401031-52-4 LSN 2463359 is a potent and selective positive allosteric modulator at the mGlu5 receptor EC50 24 nM
CSN16403 L-Glutamine   56-85-9 L-Glutamine is an essential amino acid which serves as a substrate for biosynthesis of neurotransmitters glutamate and GABA in neurons
CSN11296 L-Glutamic Acid Monosodium 142-47-2 L-Glutamic Acid Monosodium is an excitatory amino acid neurotransmitter as an agonist at GluR and NMDA receptor.
CSN22445 L-APB 23052-81-5 L-APB is a potent and specific agonist for the group III mGluRs with EC50s of 013002 029007 1003 249107 M for mGlu4 mGlu8 mGlu6 and mGlu7 receptors respectively
CSN19846 Kainic Acid 487-79-6 Kainic acid is a selective agonist at kainate receptors Potent excitant and neurotoxin
CSN18977 JNJ-16259685 409345-29-5 JNJ16259685 is a selective antagonist at the mGlu1 receptors and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM
CSN22437 JNJ-46778212 1363281-27-9 JNJ-46778212 is an mGlu5 positive allosteric modulator with an EC50 of 260 nM
CSN17481 JNJ-40411813 1127498-03-6 JNJ-40411813 is a positive allosteric modulator of the metabotropic Glutamate 2 receptor mGlu2R with EC50 of 147 nM
CSN18792 IEM 1754 Dihydrobromide 162831-31-4 IEM 1754 dihydrobromide is a selective AMPAkainate receptor blockers for GluR1 and GluR3 with IC50 of 6 M
CSN20520 GET-73 202402-01-5 GET-73 is a mGlu5 receptor allosteric modulator potentially for the treatment of alcoholism
CSN18973 FPTQ 864863-72-9 FPTQ is mGluR1 antagonist with IC50 of 6 nM and 14 nM for human and mouse mGluR1 respectively
CSN10975 Evans Blue 314-13-6 Evans blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT).
CSN18512 Dipraglurant 872363-17-2 Dipraglurant is a mGluR5 antagonists with IC50 of 0021 M
CSN13492 D-Glutamine   5959-95-5 D-Glutamine is a non-essential amino acid involved in many metabolic processes such as forming the central metabolite in amino acid transamination
CSN16659 CTEP 871362-31-1 CTEP is a selective allosteric mGluR5 antagonist with IC50 value of 2.2 nM.
CSN13419 CPPHA 693288-97-0 CPPHA is a selective positive allosteric modulator of mGluR5 receptor
CSN18974 CFMTI 864864-17-5 CFMTI is a potent and selective metabotropic glutamate receptor mGluR1 allosteric antagonist with IC50 of 26 nM
CSN22354 AZD-8529 1092453-15-0 AZD-8529 is a potent highly selective and orally bioavailable positive allosteric modulator of mGluR2 with an EC50 of 285 nM and shows no positive allosteric modulator responses at 20-25 M on the mGluR1 3 4 5 6 7 and 8 subtypes
CSN19841 AIDA 168560-79-0 AIDA is a relatively potent and selective antagonist of group I metabotropic glutamate receptors mGlu1a having no effect on group II mGlu2 or group III mGlu4 receptors expressed individually in baby hamster kidney cells
CSN22668 ACPT-I 194918-76-8
CSN22662 ABP 688 924298-51-1
CSN22629 (RS)-3,5-DHPG 146255-66-5
CSN22633 (S)-3,4-DCPG 201730-11-2
CSN22665 ACDPP HCl N/A
CSN22637 (S)-HexylHIBO 334887-48-8
CSN22632 (RS)-PPG 120667-15-4
CSN22634 (S)-3,5-DHPG 117468-89-0
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