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| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN13148 | Turofexorate isopropyl | 629664-81-9 | WAY-362450 is an agonist of farnesoid X receptor (FXR) with EC50 of 4 nM. WAY-362450 is used to the treatment of dyslipidemia. |
| CSN17240 | Bempedoic acid | 738606-46-7 | ETC-1002 is an AMPK activator and increase the level of AMPK phosphorylation. |
| CSN16982 | Tiplaxtinin | 393105-53-8 | Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 M. |
| CSN16507 | Orlistat | 96829-58-2 | Orlistat is an approved reversible general lipase inhibitor with IC50 of 122 ngmL, used to treat obesity. |
| CSN20554 | Seladelpar | 851528-79-5 | Seladelpar is selectively exhibits activation of peroxisome proliferator-activated receptor (PPAR) which may has therapeutic activity against dyslipidemia, metabolic syndrome, type 2 diabetes, and non-alcoholic steatohepatitis. |
| CSN11101 | Glipizide | 29094-61-9 | Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes. |
| CSN11584 | Repaglinide | 135062-02-1 | Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes. |
| CSN13516 | Ranitidine hydrochloride | 66357-59-3 | Ranitidine HCl is an antagonist of histamine H2-receptor that can inhibit stomach acid production. |
| CSN17332 | Teneligliptin hydrobromide | 906093-29-6 | Teneligliptin Hydrobromide is a DPP4 inhibitor with IC50 value of <1 nM. It is commonly used as an add on treatment when meformin is not achieving the expected glycemic goals. |
| CSN11539 | Neostigmine Bromide | 114-80-7 | Neostigmine bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis. Neostigmine bromide is a reversible AchR inhibitor but can not cross the blood-brain barrier. |
| CSN10130 | Miglitol | 72432-03-2 | Miglitol is a desoxynojirimycin-derived inhibitor of alpha-glucosidase with antihyperglycemic activity. |
| CSN16237 | Canagliflozin hemihydrate | 928672-86-0 | Canagliflozin selectively inhibits SGLT2 with IC50 of 2.2 nM. |
| CSN12116 | Torsemide | 56211-40-6 | Torsemide is a medication mainly used in the management of fluid overload and peripheral edema associated with congestive heart failure. |
| CSN12556 | Mitiglinide calcium | 145525-41-3 | Mitiglinide calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K channels in pancreatic beta-cells. |
| CSN11335 | Lovastatin | 75330-75-5 | Lovastatin is a HMG-CoA reductase used to treat high blood cholesterol and reduce the risk of cardiovascular disease, a naturally occuring fungal metabolite. |
| CSN11927 | Simvastatin | 79902-63-9 | Simvastatin a specific and a lovastatin similar HMG-CoA reductase inhibitor with Ki value of 0.1-0.2 nM, used to treat hypercholesterolemia. |
| CSN10987 | Febuxostat | 144060-53-7 | Febuxostat is an inhibitor of xanthine oxidase with Ki of 0.6 nM and can affect the progression of renal disease. |
| CSN17291 | Nitisinone | 104206-65-7 | Nitisinone is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase. |
| CSN10050 | Folic acid | 59-30-3 | Folic acid, a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA. |
| CSN12287 | Vildagliptin | 274901-16-5 | Vildagliptin is an inhibitor of DPP-4 with IC50 of 2.3 nM that is used in the treatment of type 2 diabetes mellitus. |
| CSN11697 | Phloretin | 60-82-2 | Phloretin, a dihydrochalcone flavonoid, can inhibit the active transport of glucose into cells by SGLT1 and SGLT2. It is mainly found in fruit and roots of apple tree. |
| CSN12570 | Rosiglitazone maleate | 155141-29-0 | Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated receptor- (PPAR) with Kd of 40 nM and it also acts as a modulator of TRP channels. |
| CSN12489 | Pioglitazone hydrochloride | 112529-15-4 | Pioglitazone HCl is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes. |
| CSN11988 | Strontium Ranelate | 135459-87-9 | Strontium ranelate stimulates the calcium sensing receptors (CaSR) and leads to the differentiation of pre-osteoblast to osteoblast which increases the bone formation. |
| CSN11339 | Lubiprostone | 136790-76-6 | Lubiprostone is an ClC-2 chloride channel activator used in the treatment of idiopathic chronic constipation. |
| CSN12489 | Pioglitazone hydrochloride | 112529-15-4 | Pioglitazone HCl is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes. |
| CSN12570 | Rosiglitazone maleate | 155141-29-0 | Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated receptor- (PPAR) with Kd of 40 nM and it also acts as a modulator of TRP channels. |
| CSN10464 | Bisindolylmaleimide I | 133052-90-1 | GF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKC, PKCI, PKCII, and PKC in cell-free assays, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor. |
| CSN12217 | Pirinixic acid | 50892-23-4 | Wy-14643 is an agonist of PPAR with EC50 of 0.63 M that can decrease the inflammatory response. It has other functions including lipid metabolism, cell proliferation, differentiation, adipogenesis etc.. |
| CSN12976 | Epalrestat | 82159-09-9 | Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM, and used for the treatment of diabetic neuropathy. |
| CSN15683 | Sotagliflozin | 1018899-04-1 | LX4211 is an inhibitor of SGLT2 and SGLT1 with antidiabetic activity. |
| CSN16739 | Calcitriol | 32222-06-3 | Calcitriol is a vitamin D receptor agonist with IC50 of 0.4 nM. |
| CSN17473 | Bexagliflozin (EGT1442) | 1118567-05-7 | Bexagliflozin is an inhibitor of SGLT2 with IC50 value of 2 nM. |
| CSN21260 | Vildagliptin dihydrate | 2133364-01-7 | Vildagliptin (LAF237 dihydrateNVP-LAF 237 dihydrate) is a dipeptidyl peptidase 4 (DPP4) inhibitor that delays the degradation of glucagon-like peptide-1 (GLP-1). |
| CSN12209 | Doxercalciferol | 54573-75-0 | Doxercalciferol is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease. |
| CSN10236 | Alfacalcidol | 41294-56-8 | Alfacalcidol is a non-selective VDR activator medication. |
| CSN11492 | Camostat mesylate | 59721-29-8 | Camostat mesylate is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trypsin, prostasin and matriptase. |
| CSN11585 | NPS-2143 | 284035-33-2 | NPS-2143 is a selective potent calcium ion-sensing receptor antagonist with IC50 of 43 and 41 nM for cytoplasmic Ca2 concentrations and parathyroid hormone secretion, respectively. |
| CSN12991 | Ruboxistaurin hydrochloride | 169939-93-9 | LY333531 is a -specific protein kinase C inhibitor. It competitively and reversibly inhibits PKC1 and PKC2 with IC50 values of 4.7 and 5.9 nM respectively. |
| CSN19257 | LMPTP inhibitor 1 | 1908414-82-3 | LMPTP inhibitor 1 is a potent molecule for diabetes which can increase liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes by inhibiting the IR phosphatase LMPTP. |
| CSN18081 | Balaglitazone | 199113-98-9 | Balaglitazone is a partial agonist of PPAR-. |
| CSN10234 | Aleglitazar | 475479-34-6 | Aleglitazar is a dual PPAR- agonist with IC50 of 2.8 nM4.6 nM. |
| CSN18404 | Calcitetrol | 72203-93-1 | Calcitetrol is the hormonally active form of vitamin D with three hydroxyl groups. |
| CSN18265 | Grapiprant | 415903-37-6 | Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2). |
| CSN18790 | Mitiglinide calcium hydrate | 207844-01-7 | Mitiglinide calcium is a drug for the treatment of type 2 diabetes and it is a highly selective KATP channel antagonist. |
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