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Metabolic Disease

Cat. No. Product Name CAS No. Information
CSN11584 Repaglinide 135062-02-1 Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes.
CSN11539 Neostigmine Bromide 114-80-7 Neostigmine bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis. Neostigmine bromide is a reversible AchR inhibitor but can not cross the blood-brain barrier.
CSN10130 Miglitol 72432-03-2 Miglitol is a desoxynojirimycin-derived inhibitor of alpha-glucosidase with antihyperglycemic activity.
CSN12116 Torsemide 56211-40-6 Torsemide is a medication mainly used in the management of fluid overload and peripheral edema associated with congestive heart failure.
CSN11335 Lovastatin 75330-75-5 Lovastatin is a HMG-CoA reductase used to treat high blood cholesterol and reduce the risk of cardiovascular disease, a naturally occuring fungal metabolite.
CSN11927 Simvastatin 79902-63-9 Simvastatin a specific and a lovastatin similar HMG-CoA reductase inhibitor with Ki value of 0.1-0.2 nM, used to treat hypercholesterolemia.
CSN17291 Nitisinone 104206-65-7 Nitisinone is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase.
CSN10050 Folic Acid 59-30-3 Folic acid, a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.
CSN11697 Phloretin 60-82-2 Phloretin, a dihydrochalcone flavonoid, can inhibit the active transport of glucose into cells by SGLT1 and SGLT2. It is mainly found in fruit and roots of apple tree.
CSN12570 Rosiglitazone Maleate 155141-29-0 Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated receptor- (PPAR) with Kd of 40 nM and it also acts as a modulator of TRP channels.
CSN12489 Pioglitazone HCl 112529-15-4 Pioglitazone HCl is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes.
CSN11988 Strontium Ranelate 135459-87-9 Strontium ranelate stimulates the calcium sensing receptors (CaSR) and leads to the differentiation of pre-osteoblast to osteoblast which increases the bone formation.
CSN11339 Lubiprostone 136790-76-6 Lubiprostone is an ClC-2 chloride channel activator used in the treatment of idiopathic chronic constipation.
CSN12489 Pioglitazone HCl 112529-15-4 Pioglitazone HCl is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes.
CSN12570 Rosiglitazone Maleate 155141-29-0 Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated receptor- (PPAR) with Kd of 40 nM and it also acts as a modulator of TRP channels.
CSN10464 Bisindolylmaleimide I 133052-90-1 GF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKC, PKCI, PKCII, and PKC in cell-free assays, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.
CSN12217 Wy-14643 50892-23-4 Wy-14643 is an agonist of PPAR with EC50 of 0.63 M that can decrease the inflammatory response. It has other functions including lipid metabolism, cell proliferation, differentiation, adipogenesis etc..
CSN12976 Epalrestat 82159-09-9 Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM, and used for the treatment of diabetic neuropathy.
CSN16739 Calcitriol 32222-06-3 Calcitriol is a vitamin D receptor agonist with IC50 of 0.4 nM.
CSN12209 Doxercalciferol 54573-75-0 Doxercalciferol is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease.
CSN12991 LY333531 HCl 169939-93-9 LY333531 is a -specific protein kinase C inhibitor. It competitively and reversibly inhibits PKC1 and PKC2 with IC50 values of 4.7 and 5.9 nM respectively.
CSN18081 Balaglitazone 199113-98-9 Balaglitazone is a partial agonist of PPAR-.
CSN18265 Grapiprant 415903-37-6 Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2).
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