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Metabolic Disease

Cat. No. Product Name CAS No. Information
CSN13148 WAY-362450 629664-81-9 WAY-362450 is an agonist of farnesoid X receptor (FXR) with EC50 of 4 nM. WAY-362450 is used to the treatment of dyslipidemia.
CSN17240 ETC-1002 738606-46-7 ETC-1002 is an AMPK activator and increase the level of AMPK phosphorylation.
CSN16982 Tiplaxtinin 393105-53-8 Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 M.
CSN16507 Orlistat 96829-58-2 Orlistat is an approved reversible general lipase inhibitor with IC50 of 122 ngmL, used to treat obesity.
CSN20554 Seladelpar 851528-79-5 Seladelpar is selectively exhibits activation of peroxisome proliferator-activated receptor (PPAR) which may has therapeutic activity against dyslipidemia, metabolic syndrome, type 2 diabetes, and non-alcoholic steatohepatitis.
CSN11101 Glipizide 29094-61-9 Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes.
CSN11584 Repaglinide 135062-02-1 Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes.
CSN13516 Ranitidine HCl 66357-59-3 Ranitidine HCl is an antagonist of histamine H2-receptor that can inhibit stomach acid production.
CSN17332 Teneligliptin Hydrobromide 906093-29-6 Teneligliptin Hydrobromide is a DPP4 inhibitor with IC50 value of <1 nM. It is commonly used as an add on treatment when meformin is not achieving the expected glycemic goals.
CSN11539 Neostigmine Bromide 114-80-7 Neostigmine bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis. Neostigmine bromide is a reversible AchR inhibitor but can not cross the blood-brain barrier.
CSN10130 Miglitol 72432-03-2 Miglitol is a desoxynojirimycin-derived inhibitor of alpha-glucosidase with antihyperglycemic activity.
CSN16237 Canagliflozin Hemihydrate 928672-86-0 Canagliflozin selectively inhibits SGLT2 with IC50 of 2.2 nM.
CSN12116 Torsemide 56211-40-6 Torsemide is a medication mainly used in the management of fluid overload and peripheral edema associated with congestive heart failure.
CSN12556 Mitiglinide Calcium 145525-41-3 Mitiglinide calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K channels in pancreatic beta-cells.
CSN11927 Simvastatin 79902-63-9 Simvastatin a specific and a lovastatin similar HMG-CoA reductase inhibitor with Ki value of 0.1-0.2 nM, used to treat hypercholesterolemia.
CSN10987 Febuxostat 144060-53-7 Febuxostat is an inhibitor of xanthine oxidase with Ki of 0.6 nM and can affect the progression of renal disease.
CSN17291 Nitisinone 104206-65-7 Nitisinone is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase.
CSN10050 Folic Acid 59-30-3 Folic acid, a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.
CSN12287 Vildagliptin 274901-16-5 Vildagliptin is an inhibitor of DPP-4 with IC50 of 2.3 nM that is used in the treatment of type 2 diabetes mellitus.
CSN11697 Phloretin 60-82-2 Phloretin, a dihydrochalcone flavonoid, can inhibit the active transport of glucose into cells by SGLT1 and SGLT2. It is mainly found in fruit and roots of apple tree.
CSN12570 Rosiglitazone Maleate 155141-29-0 Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated receptor- (PPAR) with Kd of 40 nM and it also acts as a modulator of TRP channels.
CSN12489 Pioglitazone HCl 112529-15-4 Pioglitazone HCl is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes.
CSN11988 Strontium Ranelate 135459-87-9 Strontium ranelate stimulates the calcium sensing receptors (CaSR) and leads to the differentiation of pre-osteoblast to osteoblast which increases the bone formation.
CSN10464 Bisindolylmaleimide I 133052-90-1 GF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKC, PKCI, PKCII, and PKC in cell-free assays, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.
CSN11339 Lubiprostone 136790-76-6 Lubiprostone is an ClC-2 chloride channel activator used in the treatment of idiopathic chronic constipation.
CSN12976 Epalrestat 82159-09-9 Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM, and used for the treatment of diabetic neuropathy.
CSN15683 LX4211 1018899-04-1 LX4211 is an inhibitor of SGLT2 and SGLT1 with antidiabetic activity.
CSN16739 Calcitriol 32222-06-3 Calcitriol is a vitamin D receptor agonist with IC50 of 0.4 nM.
CSN17473 Bexagliflozin 1118567-05-7 Bexagliflozin is an inhibitor of SGLT2 with IC50 value of 2 nM.
CSN21260 Vildagliptin Dihydrate 2133364-01-7 Vildagliptin (LAF237 dihydrateNVP-LAF 237 dihydrate) is a dipeptidyl peptidase 4 (DPP4) inhibitor that delays the degradation of glucagon-like peptide-1 (GLP-1).
CSN12209 Doxercalciferol 54573-75-0 Doxercalciferol is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease.
CSN10236 Alfacalcidol 41294-56-8 Alfacalcidol is a non-selective VDR activator medication.
CSN11492 Camostat Mesilate 59721-29-8 Camostat mesylate is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trypsin, prostasin and matriptase.
CSN11585 NPS-2143 284035-33-2 NPS-2143 is a selective potent calcium ion-sensing receptor antagonist with IC50 of 43 and 41 nM for cytoplasmic Ca2 concentrations and parathyroid hormone secretion, respectively.
CSN12991 LY333531 HCl 169939-93-9 LY333531 is a -specific protein kinase C inhibitor. It competitively and reversibly inhibits PKC1 and PKC2 with IC50 values of 4.7 and 5.9 nM respectively.
CSN19830 Luseogliflozin 898537-18-3 Luseogliflozin is a potent and competitive inhibitor of sodium-dependent glucose cotransporter 2 (SGLT2 inhibitor).
CSN19257 LMPTP inhibitor-Compound 23 1908414-82-3 LMPTP inhibitor 1 is a potent molecule for diabetes which can increase liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes by inhibiting the IR phosphatase LMPTP.
CSN18081 Balaglitazone 199113-98-9 Balaglitazone is a partial agonist of PPAR-.
CSN10234 Aleglitazar 475479-34-6 Aleglitazar is a dual PPAR- agonist with IC50 of 2.8 nM4.6 nM.
CSN18404 Calcitetrol 72203-93-1 Calcitetrol is the hormonally active form of vitamin D with three hydroxyl groups.
CSN18265 Grapiprant 415903-37-6 Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2).
CSN18790 Mitiglinide Calcium Hydrate 207844-01-7 Mitiglinide calcium is a drug for the treatment of type 2 diabetes and it is a highly selective KATP channel antagonist.
CSN12954 Canagliflozin 842133-18-0
CSN22510 Sograzepide 155488-25-8 Sograzepide is a gastrincholecystokinin 2 receptor (CCK2) antagonist.
CSN22122 Monacolin J 79952-42-4 Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.
CSN22185 Elobixibat 439087-18-0 Elobixibat is a potent ileal bile acid transporter (IBAT) inhibitor with IC50 values of 0.53 0.17 nM, 0.13 0.03 nM, and 5.8 1.6 nM for human IBAT, mouse IBAT, and canine IBAT.
CSN23794 LGD6972 1207989-09-0
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