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Metabolic Disease

Cat. No. Product Name CAS No. Information
CSN13148 WAY-362450 629664-81-9 WAY-362450 is an agonist of farnesoid X receptor (FXR) with EC50 of 4 nM. WAY-362450 is used to the treatment of dyslipidemia.
CSN17240 ETC-1002 738606-46-7 ETC-1002 is an AMPK activator and increase the level of AMPK phosphorylation.
CSN16982 Tiplaxtinin 393105-53-8 Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 M.
CSN16507 Orlistat 96829-58-2 Orlistat is an approved reversible general lipase inhibitor with IC50 of 122 ngmL, used to treat obesity.
CSN20554 Seladelpar 851528-79-5 Seladelpar is selectively exhibits activation of peroxisome proliferator-activated receptor (PPAR) which may has therapeutic activity against dyslipidemia, metabolic syndrome, type 2 diabetes, and non-alcoholic steatohepatitis.
CSN11101 Glipizide 29094-61-9 Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes.
CSN11584 Repaglinide 135062-02-1 Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes.
CSN13516 Ranitidine HCl 66357-59-3 Ranitidine HCl is an antagonist of histamine H2-receptor that can inhibit stomach acid production.
CSN17332 Teneligliptin Hydrobromide 906093-29-6 Teneligliptin Hydrobromide is a DPP4 inhibitor with IC50 value of <1 nM. It is commonly used as an add on treatment when meformin is not achieving the expected glycemic goals.
CSN11539 Neostigmine Bromide 114-80-7 Neostigmine bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis. Neostigmine bromide is a reversible AchR inhibitor but can not cross the blood-brain barrier.
CSN10130 Miglitol 72432-03-2 Miglitol is a desoxynojirimycin-derived inhibitor of alpha-glucosidase with antihyperglycemic activity.
CSN16237 Canagliflozin Hemihydrate 928672-86-0 Canagliflozin selectively inhibits SGLT2 with IC50 of 2.2 nM.
CSN12116 Torsemide 56211-40-6 Torsemide is a medication mainly used in the management of fluid overload and peripheral edema associated with congestive heart failure.
CSN12556 Mitiglinide Calcium 145525-41-3 Mitiglinide calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K channels in pancreatic beta-cells.
CSN11335 Lovastatin 75330-75-5 Lovastatin is a HMG-CoA reductase used to treat high blood cholesterol and reduce the risk of cardiovascular disease, a naturally occuring fungal metabolite.
CSN11927 Simvastatin 79902-63-9 Simvastatin a specific and a lovastatin similar HMG-CoA reductase inhibitor with Ki value of 0.1-0.2 nM, used to treat hypercholesterolemia.
CSN10987 Febuxostat 144060-53-7 Febuxostat is an inhibitor of xanthine oxidase with Ki of 0.6 nM and can affect the progression of renal disease.
CSN17291 Nitisinone 104206-65-7 Nitisinone is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase.
CSN10050 Folic Acid 59-30-3 Folic acid, a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.
CSN12287 Vildagliptin 274901-16-5 Vildagliptin is an inhibitor of DPP-4 with IC50 of 2.3 nM that is used in the treatment of type 2 diabetes mellitus.
CSN11697 Phloretin 60-82-2 Phloretin, a dihydrochalcone flavonoid, can inhibit the active transport of glucose into cells by SGLT1 and SGLT2. It is mainly found in fruit and roots of apple tree.
CSN12570 Rosiglitazone Maleate 155141-29-0 Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated receptor- (PPAR) with Kd of 40 nM and it also acts as a modulator of TRP channels.
CSN12489 Pioglitazone HCl 112529-15-4 Pioglitazone HCl is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes.
CSN11988 Strontium Ranelate 135459-87-9 Strontium ranelate stimulates the calcium sensing receptors (CaSR) and leads to the differentiation of pre-osteoblast to osteoblast which increases the bone formation.
CSN10464 Bisindolylmaleimide I 133052-90-1 GF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKC, PKCI, PKCII, and PKC in cell-free assays, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.
CSN11339 Lubiprostone 136790-76-6 Lubiprostone is an ClC-2 chloride channel activator used in the treatment of idiopathic chronic constipation.
CSN12217 Wy-14643 50892-23-4 Wy-14643 is an agonist of PPAR with EC50 of 0.63 M that can decrease the inflammatory response. It has other functions including lipid metabolism, cell proliferation, differentiation, adipogenesis etc..
CSN12976 Epalrestat 82159-09-9 Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM, and used for the treatment of diabetic neuropathy.
CSN15683 LX4211 1018899-04-1 LX4211 is an inhibitor of SGLT2 and SGLT1 with antidiabetic activity.
CSN16739 Calcitriol 32222-06-3 Calcitriol is a vitamin D receptor agonist with IC50 of 0.4 nM.
CSN17473 Bexagliflozin 1118567-05-7 Bexagliflozin is an inhibitor of SGLT2 with IC50 value of 2 nM.
CSN21260 Vildagliptin Dihydrate 2133364-01-7 Vildagliptin (LAF237 dihydrateNVP-LAF 237 dihydrate) is a dipeptidyl peptidase 4 (DPP4) inhibitor that delays the degradation of glucagon-like peptide-1 (GLP-1).
CSN12209 Doxercalciferol 54573-75-0 Doxercalciferol is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease.
CSN10236 Alfacalcidol 41294-56-8 Alfacalcidol is a non-selective VDR activator medication.
CSN11492 Camostat Mesilate 59721-29-8 Camostat mesylate is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trypsin, prostasin and matriptase.
CSN11585 NPS-2143 284035-33-2 NPS-2143 is a selective potent calcium ion-sensing receptor antagonist with IC50 of 43 and 41 nM for cytoplasmic Ca2 concentrations and parathyroid hormone secretion, respectively.
CSN12991 LY333531 HCl 169939-93-9 LY333531 is a -specific protein kinase C inhibitor. It competitively and reversibly inhibits PKC1 and PKC2 with IC50 values of 4.7 and 5.9 nM respectively.
CSN19830 Luseogliflozin 898537-18-3 Luseogliflozin is a potent and competitive inhibitor of sodium-dependent glucose cotransporter 2 (SGLT2 inhibitor).
CSN19257 LMPTP inhibitor-Compound 23 1908414-82-3 LMPTP inhibitor 1 is a potent molecule for diabetes which can increase liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes by inhibiting the IR phosphatase LMPTP.
CSN18081 Balaglitazone 199113-98-9 Balaglitazone is a partial agonist of PPAR-.
CSN10234 Aleglitazar 475479-34-6 Aleglitazar is a dual PPAR- agonist with IC50 of 2.8 nM4.6 nM.
CSN18404 Calcitetrol 72203-93-1 Calcitetrol is the hormonally active form of vitamin D with three hydroxyl groups.
CSN18265 Grapiprant 415903-37-6 Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2).
CSN18790 Mitiglinide Calcium Hydrate 207844-01-7 Mitiglinide calcium is a drug for the treatment of type 2 diabetes and it is a highly selective KATP channel antagonist.
CSN22510 Sograzepide 155488-25-8 Sograzepide is a gastrincholecystokinin 2 receptor (CCK2) antagonist.
CSN22122 Monacolin J 79952-42-4 Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.
CSN22185 Elobixibat 439087-18-0 Elobixibat is a potent ileal bile acid transporter (IBAT) inhibitor with IC50 values of 0.53 0.17 nM, 0.13 0.03 nM, and 5.8 1.6 nM for human IBAT, mouse IBAT, and canine IBAT.
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