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MEK
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN16379 | U0126 | 109511-58-2 | U0126 is a highly selective inhibitor of both MEK1 and MEK2 a type of MAPKERK kinase |
| CSN15896 | PF-3644022 | 1276121-88-0 | PF-3644022 is a potent ATP-competitive inhibitor of mitogen-activated protein kinase MAPK-activated protein kinase-2 MK2 IC50 52 nM and Ki 3 nM It inhibits tumor necrosis factor TNF production in U937 monocytic cells and peripheral blood mononuclear cells PBMCs IC50 160 nM and exhibits oral efficacy in acute and chronic inflammatory models |
| CSN11663 | PD98059 | 167869-21-8 | PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 M specifically inhibits MEK-1-mediated activation of MAPK and does not directly inhibit ERK1 or ERK2 |
| CSN20180 | PD-184161 | 212631-67-9 | PD184161 is an orally-active MEK inhibitor with antitumor effects in HCC in vitro and in vivo that appear to correlate with suppression of MEK activity |
| CSN12886 | PD0325901 | 391210-10-9 | PD0325901 is selective and non ATP-competitive MEK inhibitor with IC50 of 033 nM |
| CSN19736 | MEK1 Inhibitor CL2 | 40784-65-4 | MEK1 inhibitor CL2 exhibits MEK1 binding affinity with IC50 71 nM which is so far the best result for metal complexes and more potent than U0126702 M and AZD6244220 M |
| CSN12677 | Isorhamnetin | 480-19-3 | Isorhamnetin, a natural flavonol aglycone, can inhibit xanthine oxidase with IC50 of 400nM and stabilize -catenin as well as up-regulate the Wnt signaling pathway. Isorhamnetin could also be act as an apoptosia inducer with antitumor activities. |
| CSN24827 | 6,7-Dimethoxy-N-(3-phenoxyphenyl)quinolin-4-amine hydrochloride | 179246-08-3 | GW284543 HCl is a selective MEK5 inhibitor. It reduces pERK5 and decreases endogenous MYC protein. |
| CSN24751 | GW284543 | 790186-68-4 | GW284543 is a selective MEK5 inhibitor. It reduces pERK5 and decreases endogenous MYC protein. |
| CSN13423 | CI-1040 | 212631-79-3 | CI-1040 is an ATP non-competitive MEK12 inhibitor with IC50 of 17 nM being 100-fold selective for MEK12 than MEK5 |
| CSN12415 | BIX-02188 | 334949-59-6 | BIX-02188 is a selective inhibitor of MEK5 with IC50 of 43 nM also inhibits ERK5 catalytic activity with IC50 of 810 nM and does not inhibit closely related kinases MEK1 MEK2 ERK2 and JNK2 |
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