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MEK
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN11663 | PD98059 | 167869-21-8 | PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 M specifically inhibits MEK-1-mediated activation of MAPK and does not directly inhibit ERK1 or ERK2 |
| CSN12677 | Isorhamnetin | 480-19-3 | Isorhamnetin, a natural flavonol aglycone, can inhibit xanthine oxidase with IC50 of 400nM and stabilize -catenin as well as up-regulate the Wnt signaling pathway. Isorhamnetin could also be act as an apoptosia inducer with antitumor activities. |
| CSN24827 | 6,7-Dimethoxy-N-(3-phenoxyphenyl)quinolin-4-amine hydrochloride | 179246-08-3 | GW284543 HCl is a selective MEK5 inhibitor. It reduces pERK5 and decreases endogenous MYC protein. |
| CSN24751 | GW284543 | 790186-68-4 | GW284543 is a selective MEK5 inhibitor. It reduces pERK5 and decreases endogenous MYC protein. |
| CSN13423 | CI-1040 | 212631-79-3 | CI-1040 is an ATP non-competitive MEK12 inhibitor with IC50 of 17 nM being 100-fold selective for MEK12 than MEK5 |
| CSN12415 | BIX-02188 | 334949-59-6 | BIX-02188 is a selective inhibitor of MEK5 with IC50 of 43 nM also inhibits ERK5 catalytic activity with IC50 of 810 nM and does not inhibit closely related kinases MEK1 MEK2 ERK2 and JNK2 |
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