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MEK

MEK

Cat. No. Product Name CAS No. Information
CSN16379 U0126 109511-58-2 U0126 is a highly selective inhibitor of both MEK1 and MEK2 a type of MAPKERK kinase
CSN15896 PF-3644022 1276121-88-0 PF-3644022 is a potent ATP-competitive inhibitor of mitogen-activated protein kinase MAPK-activated protein kinase-2 MK2 IC50 52 nM and Ki 3 nM It inhibits tumor necrosis factor TNF production in U937 monocytic cells and peripheral blood mononuclear cells PBMCs IC50 160 nM and exhibits oral efficacy in acute and chronic inflammatory models
CSN11663 PD98059   167869-21-8 PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 M specifically inhibits MEK-1-mediated activation of MAPK and does not directly inhibit ERK1 or ERK2
CSN12886 PD0325901   391210-10-9 PD0325901 is selective and non ATP-competitive MEK inhibitor with IC50 of 033 nM
CSN19736 MEK1 Inhibitor CL2 40784-65-4 MEK1 inhibitor CL2 exhibits MEK1 binding affinity with IC50 71 nM which is so far the best result for metal complexes and more potent than U0126702 M and AZD6244220 M
CSN12677 Isorhamnetin 480-19-3 Isorhamnetin, a natural flavonol aglycone, can inhibit xanthine oxidase with IC50 of 400nM and stabilize -catenin as well as up-regulate the Wnt signaling pathway. Isorhamnetin could also be act as an apoptosia inducer with antitumor activities.
CSN24827 6,7-Dimethoxy-N-(3-phenoxyphenyl)quinolin-4-amine hydrochloride 179246-08-3 GW284543 HCl is a selective MEK5 inhibitor. It reduces pERK5 and decreases endogenous MYC protein.
CSN24751 GW284543 790186-68-4 GW284543 is a selective MEK5 inhibitor. It reduces pERK5 and decreases endogenous MYC protein.
CSN13423 CI-1040 212631-79-3 CI-1040 is an ATP non-competitive MEK12 inhibitor with IC50 of 17 nM being 100-fold selective for MEK12 than MEK5
CSN12415 BIX-02188 334949-59-6 BIX-02188 is a selective inhibitor of MEK5 with IC50 of 43 nM also inhibits ERK5 catalytic activity with IC50 of 810 nM and does not inhibit closely related kinases MEK1 MEK2 ERK2 and JNK2
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