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MEK
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN62390 | Zapnometinib | 303175-44-2 | Zapnometinib is a MEK inhibitor, with an IC50 of 5.7 nM. |
| CSN16379 | U0126 | 109511-58-2 | U0126 is a highly selective inhibitor of both MEK1 and MEK2 a type of MAPKERK kinase |
| CSN12171 | U0126-EtOH | 1173097-76-1 | U0126 ethanol is a highly selective inhibitor of MEK1/2 with IC50 of 70/60nM. |
| CSN13667 | Trametinib | 871700-17-3 | Trametinib is a highly specific and potent MEK12 inhibitor with IC50 of 0.92 nM1.8 nM, no inhibition of the kinase activities of c-Raf, B-Raf, ERK12. |
| CSN16943 | Trametinib (DMSO solvate) | 1187431-43-1 | Trametinib DMSO Solvate is a specific MEK12 inhibitor with IC50 of 0.92 nM1.8 nM. |
| CSN16108 | TAK-733 | 1035555-63-5 | TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 32 nM inactive to Abl1 AKT3 c-RAF CamK1 CDK2 c-Met etc |
| CSN11936 | SL327 | 305350-87-2 | SL327 is a cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK-1 and MEK-2 IC50 018 and 022 M respectively |
| CSN12386 | Selumetinib | 606143-52-6 | Selumetinib is a potent, highly selective MEK1 inhibitor with IC50 of 14 nM, also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. |
| CSN32909 | Selonsertib hydrochloride | 1448428-05-4 | Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. |
| CSN16923 | Selonsertib | 1448428-04-3 | Selonsertib is a highly selective and potent ASK1 inhibitor (IC50 3.2 nM) with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. |
| CSN16380 | RO4987655 | 874101-00-5 | RO4987655 is an orally active small molecule targeting mitogen-activated protein kinase kinase 1 MAP2K1MEK1 IC5052 nM with potential antineoplastic activity |
| CSN18581 | Refametinib (R enantiomer) | 923032-38-6 | Refametinib R-enantiomer is the only cyclopropane-1-sulfonamide derivative, and exhibits a highly selective allosteric inhibition of MEK 12. |
| CSN18580 | Refametinib | 923032-37-5 | Refametinib is a specific and non-ATP-competitive MEK 12 inhibitor with IC50 values of 19 and 47 nM, respectively. |
| CSN11663 | PD98059 | 167869-21-8 | PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 M specifically inhibits MEK-1-mediated activation of MAPK and does not directly inhibit ERK1 or ERK2 |
| CSN16824 | PD318088 | 391210-00-7 | PD318088 is a non-ATP competitive allosteric MEK12 inhibitor binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site |
| CSN20180 | PD184161 | 212631-67-9 | PD184161 is an orally-active MEK inhibitor with antitumor effects in HCC in vitro and in vivo that appear to correlate with suppression of MEK activity |
| CSN12886 | Mirdametinib | 391210-10-9 | PD0325901 is selective and non ATP-competitive MEK inhibitor with IC50 of 033 nM |
| CSN23026 | PD-334581 | 548756-68-9 | PD 334581 is an inhibitor of MEK1. |
| CSN17708 | OTS514 | 1338540-63-8 | OTS514 is a highly potent TOPK inhibitor with an IC50 value of 2.6 nM. |
| CSN17709 | OTS964 hydrochloride | 1338545-07-5 | OTS-964 is a TOPK T-LAK cell originated protein kinase inhibitor with IC50 value of 28 nM which can specifically block cytokinesis leading to apoptosis in a broad range of cancer cells |
| CSN18020 | NQDI-1 | 175026-96-7 | NQDI-1 is a selective inhibitor of apoptosis signal-regulating kinase 1 ASK1 with IC50 of 3 M and Ki of 500 nM |
| CSN22992 | MSC 2032964A | 1124381-43-6 | MSC 2032964A is a potent and selective ASK1 inhibitor with IC50 of 93 nM. |
| CSN22161 | Balamapimod | 863029-99-6 | MKI 833 is a small molecule inhibitor of a target signaling molecule of the MEKMAPK pathway. |
| CSN19736 | Bis(N,N '-disalicylidene)-1,2-cyclohexanediamine-cobalt(II) | 40784-65-4 | MEK1 inhibitor CL2 exhibits MEK1 binding affinity with IC50 71 nM which is so far the best result for metal complexes and more potent than U0126702 M and AZD6244220 M |
| CSN18222 | MEK inhibitor | 334951-92-7 | MEK inhibitor is a potent MEK inhibitor antitumor agent |
| CSN12677 | Isorhamnetin | 480-19-3 | Isorhamnetin, a natural flavonol aglycone, can inhibit xanthine oxidase with IC50 of 400nM and stabilize -catenin as well as up-regulate the Wnt signaling pathway. Isorhamnetin could also be act as an apoptosia inducer with antitumor activities. |
| CSN14616 | Isoangustone A | 129280-34-8 | Isoangustone A, a natural product isolated and purified from the roots of Licorice with antitumor activity, induces G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-κB signaling, inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma and shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals. |
| CSN22850 | HI-TOPK-032 | 487020-03-1 | HI TOPK 032 is a T-LAK-cell-originated protein kinase (TOPK) inhibitor. |
| CSN24827 | GW 284543 hydrochloride | 179246-08-3 | GW284543 HCl is a selective MEK5 inhibitor. It reduces pERK5 and decreases endogenous MYC protein. |
| CSN24751 | GW284543 | 790186-68-4 | GW284543, also known as UNC10225170, is a 4-anilinoquin(az)oline chemotype that selectively inhibits MEK5. |
| CSN16307 | GDC-0623 | 1168091-68-6 | GDC-0623 is a selective and ATP-uncompetitive MEK1 inhibitor with Ki value of 013 nM |
| CSN17263 | DTP3 | 1809784-29-9 | DTP3 is a selective GADD45MKK7 inhibitor which inhibits cancer-selective NF-B survival pathway |
| CSN26697 | Cobimetinib hemifumarate | 1369665-02-0 | Cobimetinib, also known as GDC-0973 and XL-518, RG 7420, is an orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. MEK inhibitor GDC-0973 specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation. Preclinical studies have demonstrated that this agent is effective in inhibiting the growth of tumor cells bearing a B-RAF mutation, which has been found to be associated with many tumor types. |
| CSN18600 | Cobimetinib (R-enantiomer) | 934660-94-3 | Cobimetinib R-enantiomer is the R-enantiomer of cobimetinib, which is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase (MEK12). |
| CSN18601 | Cobimetinib racemate | 934662-91-6 | Cobimetinib is a potent, highly selective inhibitor of MEK12. |
| CSN15744 | Cobimetinib | 934660-93-2 | Cobimetinib is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. |
| CSN13423 | CI-1040 | 212631-79-3 | CI-1040 is an ATP non-competitive MEK12 inhibitor with IC50 of 17 nM being 100-fold selective for MEK12 than MEK5 |
| CSN17644 | BIX02189 | 1265916-41-3 | BIX02189 is a selective MEK5ERK5 inhibitor with an IC50 of 59 nM |
| CSN18791 | BIX 02189 | 1094614-85-3 | BIX-02189Random Configuration is a selective and potent inhibitor of both MEK5 and ERK5 with IC50 values of 15 and 59 nM respectively |
| CSN18793 | BIX-02188(Random Configuration) | 1094614-84-2 | BIX-02188Random Configuration is a potent and selective MEK5 inhibitor with IC50 value of 43 nM |
| CSN12415 | BIX02188 | 334949-59-6 | BIX-02188 is a selective inhibitor of MEK5 with IC50 of 43 nM also inhibits ERK5 catalytic activity with IC50 of 810 nM and does not inhibit closely related kinases MEK1 MEK2 ERK2 and JNK2 |
| CSN17122 | AZD8330 | 869357-68-6 | AZD8330 is a selective, non-ATP competitive MEK 12 inhibitor with IC50 of 7 nM. |
| CSN18896 | GS-444217 | 1262041-49-5 | ASK1-IN-1 is an apoptosis signal regulating kinase 1 (ASK1) inhibitor. |
| CSN26475 | ASK1-IN-1 | 2411382-24-4 | ASK1-IN-1 is a CNS-penetrant ASK1 (apoptosis signal-regulating kinase 1) inhibitor, with good potency (cell IC50=138 nM; Biochemical IC50=21 nM)[1]. |
| CSN23144 | TC ASK 10 | 1005775-56-3 | ASK1 Inhibitor 10 is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1). It is selective for ASK1 over ASK2 as well as MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, and B-RAF. It inhibits streptozotocin-induced increases in JNK and p38 phosphorylation in INS-1 pancreatic β cells in a concentration-dependent manner. |
| CSN13700 | Pimasertib | 1236699-92-5 | AS7-03026 is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5-2000nM in MM cell lines. |
| CSN16001 | Binimetinib | 606143-89-9 | ARRY-162 is a potent inhibitor of MEK12 with IC50 of 12 nM in a cell-free assay. |
| CSN18997 | APS-2-79 hydrochloride | 2002381-31-7 | APS-2-79 HCl is a KSR Kinase suppressor of Ras-dependent MAPK modulator which can stabilize KSR inactive state with an IC50 value of 120 nM resulting in inhibition of oncogenic Ras signaling antagonizing the RasMAPK pathway |
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