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MEK

MEK

Cat. No. Product Name CAS No. Information
CSN19200 Vacquinol-1 2HCl 1998099-96-9 Vacquinol-1 is an MKK4 activator which rapidly and selectively induces glioma cell death
CSN16379 U0126 109511-58-2 U0126 is a highly selective inhibitor of both MEK1 and MEK2 a type of MAPKERK kinase
CSN12171 U0126 Ethanol     1173097-76-1 U0126 ethanol is a highly selective inhibitor of MEK1/2 with IC50 of 70/60nM.
CSN13667 Trametinib   871700-17-3 Trametinib is a highly specific and potent MEK12 inhibitor with IC50 of 0.92 nM1.8 nM, no inhibition of the kinase activities of c-Raf, B-Raf, ERK12.
CSN16943 Trametinib DMSO Solvate   1187431-43-1 Trametinib DMSO Solvate is a specific MEK12 inhibitor with IC50 of 0.92 nM1.8 nM.
CSN16108 TAK-733 1035555-63-5 TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 32 nM inactive to Abl1 AKT3 c-RAF CamK1 CDK2 c-Met etc
CSN11936 SL327 305350-87-2 SL327 is a cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK-1 and MEK-2 IC50 018 and 022 M respectively
CSN12386 Selumetinib     606143-52-6 Selumetinib is a potent, highly selective MEK1 inhibitor with IC50 of 14 nM, also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc.
CSN16380 RO4987655 874101-00-5 RO4987655 is an orally active small molecule targeting mitogen-activated protein kinase kinase 1 MAP2K1MEK1 IC5052 nM with potential antineoplastic activity
CSN18581 Refametinib R-Enantiomer 923032-38-6 Refametinib R-enantiomer is the only cyclopropane-1-sulfonamide derivative, and exhibits a highly selective allosteric inhibition of MEK 12.
CSN18580 Refametinib 923032-37-5 Refametinib is a specific and non-ATP-competitive MEK 12 inhibitor with IC50 values of 19 and 47 nM, respectively.
CSN15896 PF-3644022 1276121-88-0 PF-3644022 is a potent ATP-competitive inhibitor of mitogen-activated protein kinase MAPK-activated protein kinase-2 MK2 IC50 52 nM and Ki 3 nM It inhibits tumor necrosis factor TNF production in U937 monocytic cells and peripheral blood mononuclear cells PBMCs IC50 160 nM and exhibits oral efficacy in acute and chronic inflammatory models
CSN11663 PD98059   167869-21-8 PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 M specifically inhibits MEK-1-mediated activation of MAPK and does not directly inhibit ERK1 or ERK2
CSN16824 PD318088 391210-00-7 PD318088 is a non-ATP competitive allosteric MEK12 inhibitor binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site
CSN20180 PD-184161 212631-67-9 PD184161 is an orally-active MEK inhibitor with antitumor effects in HCC in vitro and in vivo that appear to correlate with suppression of MEK activity
CSN12886 PD0325901   391210-10-9 PD0325901 is selective and non ATP-competitive MEK inhibitor with IC50 of 033 nM
CSN17709 OTS-964 1338545-07-5 OTS-964 is a TOPK T-LAK cell originated protein kinase inhibitor with IC50 value of 28 nM which can specifically block cytokinesis leading to apoptosis in a broad range of cancer cells
CSN18020 NQDI-1   175026-96-7 NQDI-1 is a selective inhibitor of apoptosis signal-regulating kinase 1 ASK1 with IC50 of 3 M and Ki of 500 nM
CSN22161 MKI 833 863029-99-6 MKI 833 is a small molecule inhibitor of a target signaling molecule of the MEKMAPK pathway.
CSN19736 MEK1 Inhibitor CL2 40784-65-4 MEK1 inhibitor CL2 exhibits MEK1 binding affinity with IC50 71 nM which is so far the best result for metal complexes and more potent than U0126702 M and AZD6244220 M
CSN18222 MEK Inhibitor 334951-92-7 MEK inhibitor is a potent MEK inhibitor antitumor agent
CSN16307 GDC-0623 1168091-68-6 GDC-0623 is a selective and ATP-uncompetitive MEK1 inhibitor with Ki value of 013 nM
CSN17263 DTP3 1809784-29-9 DTP3 is a selective GADD45MKK7 inhibitor which inhibits cancer-selective NF-B survival pathway
CSN18600 Cobimetinib R-Enantiomer 934660-94-3 Cobimetinib R-enantiomer is the R-enantiomer of cobimetinib, which is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase (MEK12).
CSN18601 Cobimetinib Racemate 934662-91-6 Cobimetinib is a potent, highly selective inhibitor of MEK12.
CSN15744 Cobimetinib   934660-93-2 Cobimetinib is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.
CSN13423 CI-1040 212631-79-3 CI-1040 is an ATP non-competitive MEK12 inhibitor with IC50 of 17 nM being 100-fold selective for MEK12 than MEK5
CSN17644 BIX-02189 1265916-41-3 BIX02189 is a selective MEK5ERK5 inhibitor with an IC50 of 59 nM
CSN18791 BIX-02189(Random Configuration)   1094614-85-3 BIX-02189Random Configuration is a selective and potent inhibitor of both MEK5 and ERK5 with IC50 values of 15 and 59 nM respectively
CSN18793 BIX-02188(Random Configuration)   1094614-84-2 BIX-02188Random Configuration is a potent and selective MEK5 inhibitor with IC50 value of 43 nM
CSN12415 BIX-02188 334949-59-6 BIX-02188 is a selective inhibitor of MEK5 with IC50 of 43 nM also inhibits ERK5 catalytic activity with IC50 of 810 nM and does not inhibit closely related kinases MEK1 MEK2 ERK2 and JNK2
CSN17122 AZD8330 869357-68-6 AZD8330 is a selective, non-ATP competitive MEK 12 inhibitor with IC50 of 7 nM.
CSN13700 AS-703026     1236699-92-5 AS7-03026 is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5-2000nM in MM cell lines.
CSN16001 ARRY-162   606143-89-9 ARRY-162 is a potent inhibitor of MEK12 with IC50 of 12 nM in a cell-free assay.
CSN18997 APS-2-79 HCl   2002381-31-7 APS-2-79 HCl is a KSR Kinase suppressor of Ras-dependent MAPK modulator which can stabilize KSR inactive state with an IC50 value of 120 nM resulting in inhibition of oncogenic Ras signaling antagonizing the RasMAPK pathway
CSN22850 HI TOPK 032 487020-03-1
CSN22992 MSC 2032964A 1124381-43-6
CSN23026 PD 334581 548756-68-9
CSN23144 TC ASK 10 1005775-56-3
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