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LXR

LXR

Cat. No. Product Name CAS No. Information
CSN17950 SR-9243 1613028-81-1 SR9243 is a LXR inverse agonist that induces LXR-corepressor interaction and shows anticancer activity and selectively targets the warburg effect and lipogenesis
CSN23133 SR 9238 1416153-62-2 SR9238 is a potent synthetic LXR antagonist with IC50s of 214 nM and 43 nM for LXR and LXR respectively
CSN21423 Rovazolac 1454288-88-0 Rovazolac is a modulator of liver x receptor (LXR).
CSN23678 RGX104 Free Acid 610318-54-2 RGX104 free acid is an agonist of liver-X nuclear hormone receptor LXR it can regulate the immune process by activating the ApoE gene
CSN22495 RGX-104 610318-03-1 RGX-104 is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene.
CSN14796 Nagilactone B 19891-51-1 Nagilactone B, a natural product isolated and purified from the herbs of Podocarpus neriifolius, selectively activates LXR in macrophages and induces ABCA1- and ABCG1-mediated cholesterol efflux while exerting minimal effects on lipogenesis and lipid accumulation in liver, resulting in regression of atherosclerosis, and therefore might be a promising strategy for therapeutics.
CSN16661 LXR-623   875787-07-8 LXR-623 is a novel and brain-penetrant LXR agonist with IC50 values of 179 and 24 nM for LXR and LXR respectively
CSN15972 GW3965 405911-09-3 GW3965 is a potent selective LXR agonist for hLXR and hLXR with EC50 of 190 and 30 nM respectively
CSN12844 GW3965 HCl   405911-17-3 GW3965 HCl is a selective and non-steroidal LXR agonist with EC50 values of 190 and 30 nM for hLXR and hLXR respectively
CSN22840 GSK 2033 1221277-90-2 GSK 2033 is a potent LXR antagonist with pIC50 of 7.5.
CSN19056 AZ876 898800-26-5 AZ876 is a high-affinity LXR agonist
CSN20272 27-Hydroxycholesterol 20380-11-4 27-Hydroxycholesterol is an endogenous oxysterol with multiple biological functions, including activity as a selective estrogen receptor modulator (SERM) (a mixed, tissue-specific agonist-antagonist of the estrogen receptor (ER)) and as an agonist of the liver X receptor (LXR). It is a metabolite of cholesterol that is produced by the enzyme CYP27A1.
CSN21924 24-Hydroxycholesterol 474-73-7 24-Hydroxycholesterol is an endogenous agonist of the nuclear receptor LXR and has also been found to be a high affinity ligand for RORα and RORγ (Ki = 25 nM).
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