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The linear ubiquitination assembly complex (LUBAC), consisting of HOIL-1L, HOIP, and Sharpin, has been reported to activate NF-κB-mediated transcription in response to receptor signaling by ligating linear ubiquitin chains to Nemo and Rip1.

LUBAC

Cat. No. Product Name CAS No. Information
CSN28419 JTP-0819958 2470242-33-0 JTP-0819958 is a selective and covalent LUBAC (Linear Ubiquitin Chain Assembly Complex) inhibitor.
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