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LRRK2

LRRK2

Cat. No. Product Name CAS No. Information
CSN15765 PF-06447475   1527473-33-1 PF-06447475 is a brain-penetrant potent and selective LRRK2 inhibitor with IC50 values of 3 nM possessing neuroprotective activity
CSN28447 PF-06371900 1622291-81-9 PF-06371900 is a selective LRRK2 inhibitor with IC50 value of 64nM.
CSN17129 JH-II-127 1700693-08-8 JH-II-127 is a brain-penetrant potent and selective LRRK2 inhibitor with IC50 values of 22 66 and 477 nM for G2019S-mutant wild-type and A2016T-mutant LRRK2 respectively
CSN17279 HG-10-102-01 1351758-81-0 HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 IC50233 nM and the G2019S mutant IC5032 nM
CSN15754 GSK2578215A 1285515-21-0 GSK2578215A is a brain-penetrant potent and selective LRRK2 inhibitor with IC50 values of 89 and 101 nM for LRRK2G2019S mutant and wild-type LRRK2 respectively
CSN15912 GNE-0877 1374828-69-9 GNE0877 is a highly potent selective and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 LRRK2 small molecule inhibitor with an IC50 of 3 nM
CSN17916 GNE-9605 1536200-31-3 GNE-9605 is a selective and potent LRRK2 with IC50 value of 187 nM
CSN18902 GNE-7915 Tosylate 2070015-00-6 GNE-7915 tosylate is a potent selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9 nM
CSN17181 GNE-7915 1351761-44-8 GNE-7915 is a brain-penetrant potent and selective LRRK2 inhibitor with IC50 value of 9 nM
CSN16309 CZC-54252 1191911-27-9 CZC-54252 is a potent LRRK2 inhibitor with IC50 values of 128 nM and 185 nM for wild-type and G2019S mutant LRRK2 respecitively possessing neuroprotective effect
CSN17277 CZC-25146 1191911-26-8 CZC-25146 is a potent LRRK2 inhibitor with IC50 values of 476 and 687 nM for for wild-type and G2019S mutant LRRK2 respectively It also inhibits PLK4 GAK TNK1 CAMKK2 and PIP4K2
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