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Lipoxygenase

Lipoxygenase

Cat. No. Product Name CAS No. Information
CSN17529 Zileuton Sodium 118569-21-4 Zileuton sodium is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.
CSN12237 Zileuton   111406-87-2 Zileuton is a reversible 5-lipoxygenase inhibitor with IC50 value of 0.5 M in rat basophilic leukemia-1 (RBL-1) cells. It also potently inhibited leukotriene B4 production with an IC50 value of 0.6 M in purified human peripheral blood polymorphonuclear leukocytes (PMNL).
CSN23549 Phenidone   92-43-3 Phenidone inhibited both the lipoxygenase and Cox pathways
CSN17912 ML355   1532593-30-8 ML355 is a selective 12-lipoxygenase inhibitor with an IC50 value of 0.34 M, with much less potency against 15-LO-1, 15-LO-2, and 5-LO (IC50s 9.7, 100, and 100 M).
CSN23745 ML351 847163-28-4 ML351 is a novel chemotype and the first reported selective inhibitor of 15-LOX-1 with IC50 value of 200 nM.
CSN11356 Malotilate   59937-28-9 Malotilate is hepatotrophic drug which can selectively inhibit the 5-lipoxygenase, whereas both the 12- and the 15-lipoxygenase pathways were stimulated, with antifibrotic and hepatoprotective properties.
CSN19785 Jujuboside D 194851-84-8 Jujuboside D shows lipoxygenase-inhibiting activity
CSN12630 Esculetin   305-01-1 Esculetin is a naturally occuring 5-lipoxygenase and 12-Lipoxygenase inhibitor with IC50 values of ID50 values of 4 and 25 M respectively
CSN20248 CarbORev-5901 104325-75-9 CarbORev-5901 is a carborane-based inhibitor of the 5-lipoxygenase pathway
CSN22333 A-69412 123606-23-5 A-69412 is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase (5-LO).
CSN13042 5-Hydroxy-3',4',7-Trimethoxyflavone 29080-58-8 5-Hydroxy-347-trimethoxyflavone a natural product isolated and purified fromt Lippia nodiflora L shows prominent inhibitory activity against soybean lipoxygenase
CSN17071 2-(3,4-Dihydroxyphenyl)ethanol   10597-60-1 2-(3,4-Dihydroxyphenyl)ethanol is a potent and specific inhibitor of lipoxygenase activities, inhibits platelet 12-LO activity with IC50 of 4.2 mM and PMNL 5-LO activity with IC50 of 13 mM. Its a natural product isolated and purified from the herbs of Canarium album with antioxidant property.
CSN22648 2-TEDC 132465-10-2
CSN23023 PD 146176 4079-26-9
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