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Lignans

Lignans

Cat. No. Product Name CAS No. Information
CSN14378 Yangambin 13060-14-5 Yangambin, a natural product isolated and purified from the leaves of Ocotea duckei Vattimo., is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF) and therefore constitutes a potential therapeutic agent in different shock states where abnormal PAF release is supposed to play an important role.
CSN14378 Yangambin 13060-14-5 Yangambin, a natural product isolated and purified from the leaves of Ocotea duckei Vattimo., is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF) and therefore constitutes a potential therapeutic agent in different shock states where abnormal PAF release is supposed to play an important role.
CSN14640 Wallichinine 125292-97-9 Wallichinine, a natural product isolated and purified from the stems of Piper wightii, shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF), significantly potentiates the effects of two ABCB1 substrates vincristine and doxorubicin on inhibition of growth, arrest of cell cycle and induction of apoptosis in ABCB1 overexpressing cancer cells, and the overexpression of ABCB1 in cancer cells is one of the main reasons of cancer multidrug resistance (MDR), suggesting that wallichinine with ABCB1 presents valuable clues for the development of MDR reversal reagents from natural products.
CSN13531 Syringaresinol-Di-O-Glucoside 66791-77-3 Syringaresinol-Di-O-Glucoside is a natural product which exhibits an antidiabetic and antioxidative effect on a streptozotocininduced mouse model of diabetes.
CSN14357 Sequirin C 18194-29-1 Sequirin C, a natural product isolated and purified from the herbs of Cryptomeria japonica, can inhibit feeding behavior.
CSN14645 Schizandriside 71222-06-5 Schizandriside, a natural product isolated and purified from the leaves of Miconia rubiginosa with anti-inflammatory effect, shows significant cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with inhibitory concentration (IC50) values of 3.26-8.89 uM, and has inhibitory activities against nitric oxide and prostaglandin E(2) production in IFN-γ- and lipopolysaccharide-stimulated RAW 264.7 cells.
CSN19434 Schizandrin   7432-28-2 Schizandrin is a natural product possessing antioxidant and anti-inflammatory activities.
CSN18769 Schizantherin B 58546-55-7 Schisantherin B is a natural product isolated and purified from the seeds of Schisandra chinensis (Turcz.) Baill. showing good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis.
CSN16630 Schisantherin A 58546-56-8 Schisantherin A is a natural product isolated and purified from the herbs of Chelidonium majus with anti-microbial, anti-oxidant and anti-inflammatory properties, and is a specific inhibitor of Rac1b.
CSN13949 Schisanhenol 69363-14-0 Schisanhenol, a natural compound solated from the fruits of Schisandra rubriflora, is a UGT2B7 UDP-glucuronosyltransferases inhibitor.
CSN16432 Schisandrin B   61281-37-6 Schisandrin B is a naturally occuring anti-inflammatory and antioxidant agent which can inhibit ROS production in microglia.
CSN16433 Schisandrin A   61281-38-7 Schisandrin A is a naturally occuring agonist of the adiponectin receptor 2 with an IC50 value of 3.5 M.
CSN14350 Savinin 493-95-8 Savinin, a natural product isolated and purified from the heartwood of Pterocarpus santalinus with antiinflammatory effect, can significantly inhibit tumor necrosis factor (TNF)-a production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, and T cell proliferation elicited by concanavalin (Con A), without displaying cytotoxicity, and also exhibits potent spermicidal activity and significant insecticidal activity.
CSN14360 Randaiol 87562-14-9 Randaiol is a natural product isolated and purified from the barks of Magnolia hypoleuca.
CSN14359 Piperitol 52151-92-5 Piperitol is a natural product isolated and purified from the fruits of Myristica fragrans.
CSN12281 Pinoresinol 487-36-5 Pinoresinol, a natural product isolated and purified from the bark of Eucommia ulmoides Oliver, may exert pharmacologically interesting effects via modulation of the insulin-like signalling pathway in C.
CSN14349 Paulownin 13040-46-5 Paulownin, a natural product isolated and purified from the barks of Paulownia tomentosa, is active against the MCF-7 breast cancer cell line with IC50 values of 14.0 uM, and has the action of anti-inflammation, analgesia, immunity, hypoglycemia and has little toxicity.
CSN13651 Nortrachelogenin 34444-37-6 Nortrachelogenin, a natural product isolated and purified from the herbs of Trachelospermum jasminoides, shows effects on the central nervous system producing depression in rabbits and is an agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors (GFRs), thereby efficiently synergizing with TRAIL exposure.
CSN14342 Niranthin 50656-77-4 Niranthin, a natural product isolated and purified from the herbs of Phyllanthus amarus, exhibits anti-hepatitis B virus activity both in vitro and in vivo, and antiinflammatory and antiallodynic actions which are probably mediated through its direct antagonistic action on the PAF receptor binding sites.
CSN14342 Niranthin 50656-77-4 Niranthin, a natural product isolated and purified from the herbs of Phyllanthus amarus, exhibits anti-hepatitis B virus activity both in vitro and in vivo, and antiinflammatory and antiallodynic actions which are probably mediated through its direct antagonistic action on the PAF receptor binding sites.
CSN10752 Matairesinol 580-72-3 Matairesinol, a natural product isolated and purified from the roots of Wikstroemia indica, has anti-angiogenic activity and anti-osteoporotic activity.
CSN11353 Magnolin 31008-18-1 Magnolin, a natural product isolated and purified from the flowers of Magnolia biondii Pamp., reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro.
CSN14355 Lyoniside 34425-25-7 Lyoniside is a natural product isolated and purified from the stem barks of Canarium bengalense with antioxidant, allelopathic and antifungal activities.
CSN14026 Lariciresinol 27003-73-2 Lariciresinol, a natural product isolated and purified from the herbs of Phyllanthus niruri, possesses fungicidal activities by disrupting the fungal plasma membrane. (-)-Lariciresinol and its 7S,8S,8R stereoisomer can inhibit the root growth of Italian ryegrass to 51-55 relative to the negative control.
CSN14356 Isotaxiresinol 26194-57-0 Isotaxiresinol, a natural product isolated and purified from the branch of Taxus wallichiana, may be useful for treatment of postmenopausal osteoporosis, especially for prevention of bone fracture induced by estrogen deficiency, and prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha.
CSN14061 Isolariciresinol 548-29-8 Isolariciresinol, a natural product isolated and purified from the herbs of Phyllanthus niruri, has antioxidant and anti-inflammatory activities during an in vitro gastro-intestinal digestion of the Radix Isatidis extract (RIE).
CSN11113 Gomisin N 69176-52-9 Gomisin N, a natural product isolated and purified from the fruits of Schizandra chinensis with anti-hepatotoxic, anticancer, anti-oxidative and anti-inflammatory activities.
CSN14375 Gomisin J 66280-25-9 Gomisin J is a natural product isolated and purified from the fruits of Schizandra chinensis with vasodilatory activity that mediates mainly by calcium-dependent activation of eNOS with subsequent production of endothelial NO, and inhibits LPO in rat liver mitochondria and protects cultured myocardial cells from being injured by calcium paradox.
CSN14121 Gomisin D 60546-10-3 Gomisin D is a natural product isolated and purified from the fruits of Schizandra chinensis.
CSN14362 Futoquinol 28178-92-9 Futoquinol, a natural product isolated and purified from the herbs of Piper kadsura with anti-neuroinflammatory activity, can potently inhibit NO production with an IC(50) value of 16.8 mM in microglia cells, and shows potent inhibition of PMA-induced ROS production in human polymorphonuclear neutrophils with IC(50) values 13.1 +/- 5.3 mM.
CSN14364 Eudesmin 526-06-7 Eudesmin, a natural product isolated and purified from the dry leaves of Haplophyllum perforatum Kar.et Kir.
CSN15668 DL-Syringaresinol 1177-14-6 DL-Syringaresinol, a natural product isolated and purified from the herbs of Liriodendron tulipifera, shows inhibitory activity of Helicobacter pylori motility with the IC50 value is 50 mg/mL, potently inhibit the proliferation of human promyelocytic HL-60 cells through G1 arrest and induction of apoptosis, induces vasorelaxation by enhancing NO production in endothelial cells via two distinct mechanisms, phosphatidylinositol 3-kinase/Akt- and (PLC)/Ca2+/CaMKKβ -dependent eNOS phosphorylation and Ca(2+)-dependent eNOS dimerization, and protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism.
CSN14117 Dihydroguaiaretic Acid 66322-34-7 Dihydroguaiaretic acid, a natural product isolated and purified from the aerial parts of Saururus chinensis.
CSN14635 Denudatin B 87402-88-8 Denudatin B, a natural product isolated and purified from the herbs of Kadsura coccinea, inhibits the aggregation and ATP release of washed rabbit platelets caused by platelet-activating factor (PAF) in a concentration-dependent manner, has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin, relaxes vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels and its effect to increase cGMP may enhance the vasorelaxation and shows potent 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging activity.
CSN19920 Dehydrodiisoeugenol 2680-81-1 Dehydrodiisoeugenol, a natural product isolated and purified from the seeds of Myristica fragrans Houtt.
CSN19920 Dehydrodiisoeugenol 2680-81-1 Dehydrodiisoeugenol, a natural product isolated and purified from the seeds of Myristica fragrans Houtt.
CSN14119 Dehydrodiconiferyl Alcohol 4263-87-0 Dehydrodiconiferyl alcohol, a natural product isolated and purified from the stems of Cucurbita moschata., shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts, and can modulate the differentiation of Th17 and Th1 cells and suppress experimental autoimmune encephalomyelitis, it may be a potential candidate as an agent for the control of Th17 and Th1-mediated inflammatory diseases.
CSN14638 Cycloolivil 3064-05-9 Cycloolivil, a natural polyphenolic antioxidant isolated and purified from the herbs of Maytenus hookeri Loes.
CSN14871 Boehmenan 57296-22-7 Boehmenan, a natural product isolated and purified from the herbs of Euphorbia hirta Linn., exhibits cytotoxicity against both Wnt-dependent (HCT116) and Wnt-independent (RKO) cells, and decreases the expression of full, cytosolic and nuclear β-catenin along with c-myc in STF/293 cells, suggesting that boehmenan may have inhibited the Wnt signal by decreasing β-catenin levels.
CSN19867 Asarinin 133-05-1 Asarinin, a natural product isolated and purified from the herbs of Asarum sieboldii Miq.
CSN12574 Arctiin   20362-31-6 Arctiin is a suppressor of cyclin D1 protein expression in multiple types of human tumor cells and also shows antiviral activity against influenza A.
CSN14120 Angeloylgomisin H 66056-22-2 Angeloylgomisin H, a natural product isolated and purified from the fruits of Schizandra chinensis, shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ugmL against MCF7, HEK293 and CAL27 cell lines and may present significant myocardial protective activity.
CSN14358 Agatharesinol 7288-11-1 Agatharesinol, a natural product isolated and purified from the barks of Cryptomeria japonica, is localized in the ray parenchyma cells in Sugi heartwood.
CSN13202 5-Allyl-3-Methoxy-6-Methyl-7-(3,4,5-Trimethoxyphenyl)bicyclo[3.2.1]oct-3-Ene-2,8-Dione 106894-43-3 5-Allyl-3-methoxy-6-methyl-7-(3,4,5-trimethoxyphenyl)bicyclo3.2.1oct-3-ene-2,8-dione is a natural product isolated and purified from the herbs of Cassia fistula.
CSN10826 (-)-Arcitin 25488-59-9 2,3-Bis(3,4-dimethoxybenzyl)butyrolactone is a natural product isolated and purified from the barks of Pseudolarix kaempferi.
CSN13972 (-)-Syringaresinol 6216-81-5 (-)-Syringaresinol, a natural product isolated and purified from the rhizomes of Polygonatum kingianum, inhibits the proliferation of human promyelocytic HL-60 cells through G(1) arrest and induction of apoptosis, may be a potential chemotherapeutic agent for the treatment of cancer.
CSN13989 (-)-Pinoresinol 81446-29-9 (-)-Pinoresinol, a natural product isolated and purified from the bark of Eucommia ulmoides.
CSN13971 (±)-Pinoresinol 4263-88-1 ()-Pinoresinol is a natural product isolated and purified from Eucommia ulmoides Oliv extract.
CSN14367 (+)-Isolariciresinol 9'O-Glucoside 63358-12-3 ()-Isolariciresinol 9O-glucoside()-Isolariciresinol 9O-glucoside is a natural product isolated and purified from plants.
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