K-Ras (G12C)/PROTAC refers to the PROTAC target K-Ras (G12C).
|Cat. No.||Product Name||CAS No.||Information|
|CSN28451||PROTAC K-Ras Degrader-1||2378258-52-5||PROTAC K-Ras Degrader-1 (Compound 518) is a PROTAC targeting on K-Ras and exhibits ≥70% degradation efficacy in SW1573 cells.|
|CSN27182||LC-2||2502156-03-6||LC-2 is the first PROTAC capable of degrading endogenous KRAS(G12C). It covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRASG12C cell lines.|