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JAK

JAK

Cat. No. Product Name CAS No. Information
CSN18177 ZM39923 273727-89-2 ZM39923 is a Janus kinase inhibitor with IC50 of 10 nM
CSN18107 WHI-P97 211555-05-4 WHI-P97 is a rationally designed potent inhibitor of JAK-3
CSN16224 WHI-P154   211555-04-3 WHI-P154 is a specific inhibitor of JAK3 with IC50 value of 18 M almost shows no activity against JAK1 or JAK2
CSN18721 Upadacitinib 1310726-60-3 Upadacitinib is a selective JAK1 inhibitor with an IC50 of 43 nM.
CSN12405 TG 101348   936091-26-8 TG 101348 is an inhibitor of JAK2 with an IC of 6 nM and also inhibits related kinases FLT3, RET, and JAK3 with less potent activity, having IC values of 25, 17 and 169 nM, respectively.
CSN23146 TC JL 37 1258294-34-6 TCJL-37 is a potent TYK2 inhibitor.
CSN15697 Solcitinib 1206163-45-2 Solcitinib is a highly selective JAK1 inhibitor with IC50 value of 9.8 nM, with much less potency against JAK1 and JAK2 with IC50 values 100nM.
CSN24499 SAR-20347   1450881-55-6 SAR-20347 is a TYK2 and JAK inhibitor with IC50 values of 0.6, 23, 26 and 41nM for TYK2, JAK1, JAK2 and JAK3, respectively.
CSN18612 S-Ruxolitinib 941685-37-6 S-Ruxolitinib is the first potent, selective, JAK12 inhibitor to enter the clinic with IC50 of 3.3 nM2.8 nM, 130-fold selectivity for JAK12 versus JAK3.
CSN17456 Ruxolitinib Sulfate 1092939-16-6 Ruxolitinib sulfate is the first potent, selective, JAK12 inhibitor to enter the clinic with IC50 of 3.3 nM2.8 nM, 130-fold selectivity for JAK12 versus JAK3.
CSN13499 Ruxolitinib Phosphate 1092939-17-7 Ruxolitinib phosphate is a potent and selective JAK12 inhibitor to enter the clinic with IC50 of 3.3 nM2.8 nM, 130-fold selectivity for JAK12 versus JAK3.
CSN12394 Ruxolitinib     941678-49-5 Ruxolitinib is the first potent, selective, JAK12 inhibitor to enter the clinic with IC50 of 3.3 nM2.8 nM, 130-fold selectivity for JAK12 versus JAK3.
CSN16800 Pyridone 6 457081-03-7 Pyridone 6 is a potent and selective inhibitor of JAK1 (IC5015 nM, murine JAK1), JAK2 (IC501 nM), JAK3 (Ki5 nM), and Tyk2 (IC501 nM) displaying significantly weaker affinities(130 nM to 10 mM) for other protein tyrosine kinases.
CSN23211 ZM 449829 4452-06-6 Potent, selective JAK3 inhibitor
CSN19685 PF-956980 1262832-74-5 PF-956980 is a FGF1 receptor antagonist, a PDGF receptor modulator, an Flt3 tyrosine kinase modulator, and a VEGF antagonist used as immunosuppressive agent.
CSN23226 PF-06700841 Tosylate Salt 2140301-96-6 PF-06700841 P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. PF-06700841 P-Tosylate also inhibits JAK2 and JAK3 with IC50s of 77 nM and 6.49 μM, respectively[1].
CSN19687 PF-06263276 1421502-62-6 PF-06263276 is a potent and selective pan-JAK inhibitor which is suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
CSN16871 Peficitinib 944118-01-8 Peficitinb is an oral Janus kinase (JAK) inhibitor. Peficitinib inhibits JAK1, JAK2, JAK3 and Tyk2 enzyme activities with IC50s of 3.9, 5.0, 0.71 and 4.8 nM, respectively, and has moderate selectivity for JAK3 inhibition.
CSN19239 Oclacitinib Fumarate   1640292-55-2 Oclacitinib Fumarate is a potent JAK inhibitor with IC50 value ranging in 10-99 nM for JAK family members, most potent against JAK1 with IC50 value of 10 nM.
CSN17137 NVP-BSK805 1092499-93-8 NVP-BSK805 is a selective JAK2 and JAK2V617F mutant inhibitor with IC50 value of 048 nM with 20-fold selectivity over TYK2 JAK3 and JAK1 IC50 values of 108 187 and 316 nM respectively
CSN23010 NSC 33994 82058-16-0 NSC 33994 is a selective inhibitor of JAK2 with IC50 of 60 nM.
CSN23158 TCS 21311 1260181-14-3 NIBR3049, also known as TCS-21311, is a potent and selective JAK3 inhibitor IC50 values of 8 nM..
CSN11462 Mollugin 55481-88-4 Mollugin, a natural product isolated and purified from the roots of Rubia cordifolia L., may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway.
CSN11286 Lestaurtinib 111358-88-4 Lestaurtinib is a tyrosine kinase inhibitor structurally related to staurosporine. This semisynthetic derivative of the indolocarbazole K252a was investigated by Cephalon as a treatment for various types of cancer.
CSN23767 JAK3-IN-6 1443235-95-7 JAK3-IN-6 is an irreversible, potent and highly selective JAK3 inhibitor with IC50 value of 0.15 nM, 4300-fold selective for JAK3 over JAK1 in enzyme assays.
CSN22435 JAK-IN-1 1334673-53-8 JAK-IN-1 is a JAK123 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively. JAK-IN-1 shows improved selectivity for JAK3 over JAK1.
CSN20267 JAK Inhibitor C35 1400687-19-5 JAK inhibitor C6 is a potent dual JAK13 inhibitor providing exceptional biochemical potency against JAK1 and JAK3 while maintaining good selectivity against JAK2 and Tyk2.
CSN22434 JAK Inhibitor 1 2096999-92-5 JAK inhibitor 1 is an inhibitor of JAK extracted from patent US20170121327A1, compound example 283.
CSN17204 Itacitinib 1334298-90-6 Itacitinib is an oral selective JAK1 tyrosine kinase inhibitor, which is potential for the treatment of rheumatoid arthritis, myelofibrosis, rheumatoid arthritis and plaque psoriasis.
CSN13689 GLPG0634 Analog 1206101-20-3 GLPG0634 analog is a pan JAK inhibitor with IC50s of 50-200 nM for JAK1JAK2JAK3.
CSN23319 FM381 2226521-65-7 FM381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909 at the gatekeeper position +7 in JAK3. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.
CSN15694 Filgotinib 1206161-97-8 Filgotinib is a selective JAK12 inhibitor with IC50 values of 1028nM, with less potency against JAK3 and TYK2 with IC50 values of 810 nM and 116 nM, respectively.
CSN21229 Delgocitinib 1263774-59-9 Delgocitinib is a novel and specific JAK inhibitor with IC50s of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, respectively.
CSN14154 Dehydrocrenatidine 65236-62-6 Dehydrocrenatidine, a natural product isolated and purified from the barks of Picrasma quassioides, is a JAK-specific inhibitor, which inhibits JAK2-JH1 kinase activity in vitro , represses constitutively activated JAK2 and STAT3, as well as interleukin-6-, interferon--, and interferon--stimulated JAK activity, and STAT phosphorylation, and suppresses STAT3 and STAT1 downstream gene expression.
CSN13843 Decernotinib 944842-54-0 Decernotinib is a selective JAK3 inhibitor with Ki value of 2.5nM, with 4-fold selectivity over JAK1, JAK2, and TYK2 with Ki values of 11nM, 13nM and 13nM, respectively.
CSN17436 CYT387 Sulfate 1056636-06-6 CYT387 sulfate is an ATP-competitive inhibitor of JAK1JAK2 with IC50 of 11 nM18 nM, 10-fold selectivity versus JAK3.
CSN13153 CYT387   1056634-68-4 CYT387 is a selective and potent ATP-competitive JAK1/2 inhibitor with IC50 values of 11nM and 18nM, respectively, with less potency against JAK3 with IC50 value of 155 nM.
CSN10079 Cucurbitacin I 2222-07-3 Cucurbitacin I is a naturally occurring triterpenoid derived from Cucurbitaceae family plants that exhibits a number of potentially useful pharmacological and biological activities.
CSN16269 CTX-0294885 1439934-41-4 CTX-0294885 is a bisanilino pyrimidine and exhibits inhibitory activity against a broad range of kinases in vitro, further developed into a Sepharose-supported kinase capture reagent.
CSN13905 Cerdulatinib 1198300-79-6 Cerdulatinib is a multiple tyrosine kinase inhibitor with IC50 values of 12 nM6 nM8 nM and 0.5 nM, for JAK1JAK2JAK3 and TYK2, also shows potency against MST1, ARK5, MLK1, Fms. Syk, etc. with IC50 values ranging in 4-51 nM.
CSN19204 Cerdulatinib HCl 1369761-01-2 Cerdulatinib HCl is a dual JAKSYK inhibitor with IC50 of 12 nM6 nM8 nM0.5 nM and 32 nM for JAK1JAK2JAK3TYK2 and Syk, respectively. It also inhibits other kinases with IC50 less than 200 nM.
CSN15836 CEP-33779 1257704-57-6 CEP-33779 is a highly selective JAK2 inhibitor with IC50 value of 1.8 nM, with much less potency against JAK1 and TYK2 with 40- and 800-fold IC50 values.
CSN17535 Baricitinib Phosphate 1187595-84-1 Baricitinib Phosphate can selectively inhibit JAK12 inhibitor with IC50 values of 5.9 nM and 5.7 nM.
CSN13692 Baricitinib   1187594-09-7 Baricitinib can selectively inhibit JAK12 inhibitor with IC50 values of 5.9 nM and 5.7 nM.
CSN17120 AZ 960 905586-69-8 AZ 960 is a potent ATP-competitive JAK inhibitor with IC50 values of 3 nM and 9nM for JAK2 and JAK3 respectively
CSN22692 Atiprimod 2HCl 130065-61-1 Atiprimod 2HCl is an inhibitor JAK2 with IC50 of 397 nM.
CSN24191 Abrocitinib 1622902-68-4 Abrocitinib is a potent and selective JAK1 inhibitor with IC50s of 29 and 803nM for JAK1 and JAK2, respectively.
CSN19970 Curculigoside 85643-19-2
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