Welcome to CSNpharm! For Research Use Only!
Home +1-708-781-1677 sales@csnpharm.com    

JAK

JAK

Cat. No. Product Name CAS No. Information
CSN18177 ZM39923 273727-89-2 ZM39923 is a Janus kinase inhibitor with IC50 of 10 nM
CSN13641 XL019   945755-56-6 XL019 is a selective and potent JAK2 inhibitor with IC50 value of 22 nM with less potency to JAK1 JAK3 FLT3 and PDGFR with IC50 values of 1343 nM 2142 nM 1397 nM and 1254 nM respectively
CSN13436 WP1066 857064-38-1 WP1066 is a dual inhibitor for both JAK2 and STAT3 with IC50 value of 230 M and 243 M respectively
CSN18107 WHI-P97 211555-05-4 WHI-P97 is a rationally designed potent inhibitor of JAK-3
CSN16224 WHI-P154   211555-04-3 WHI-P154 is a specific inhibitor of JAK3 with IC50 value of 18 M almost shows no activity against JAK1 or JAK2
CSN18721 Upadacitinib 1310726-60-3 Upadacitinib is a selective JAK1 inhibitor with an IC50 of 43 nM.
CSN12405 TG 101348   936091-26-8 TG 101348 is an inhibitor of JAK2 with an IC of 6 nM and also inhibits related kinases FLT3, RET, and JAK3 with less potent activity, having IC values of 25, 17 and 169 nM, respectively.
CSN15697 Solcitinib 1206163-45-2 Solcitinib is a highly selective JAK1 inhibitor with IC50 value of 9.8 nM, with much less potency against JAK1 and JAK2 with IC50 values 100nM.
CSN20642 SD1029 118372-34-2 SD1029 is a cell-permeable xanthenedione compound that acts as a JAK2-selective inhibitor
CSN18612 S-Ruxolitinib 941685-37-6 S-Ruxolitinib is the first potent, selective, JAK12 inhibitor to enter the clinic with IC50 of 3.3 nM2.8 nM, 130-fold selectivity for JAK12 versus JAK3.
CSN17456 Ruxolitinib Sulfate 1092939-16-6 Ruxolitinib sulfate is the first potent, selective, JAK12 inhibitor to enter the clinic with IC50 of 3.3 nM2.8 nM, 130-fold selectivity for JAK12 versus JAK3.
CSN13499 Ruxolitinib Phosphate 1092939-17-7 Ruxolitinib phosphate is a potent and selective JAK12 inhibitor to enter the clinic with IC50 of 3.3 nM2.8 nM, 130-fold selectivity for JAK12 versus JAK3.
CSN12394 Ruxolitinib       941678-49-5 Ruxolitinib is the first potent, selective, JAK12 inhibitor to enter the clinic with IC50 of 3.3 nM2.8 nM, 130-fold selectivity for JAK12 versus JAK3.
CSN16800 Pyridone 6 457081-03-7 Pyridone 6 is a potent and selective inhibitor of JAK1 (IC5015 nM, murine JAK1), JAK2 (IC501 nM), JAK3 (Ki5 nM), and Tyk2 (IC501 nM) displaying significantly weaker affinities(130 nM to 10 mM) for other protein tyrosine kinases.
CSN19685 PF-956980 1262832-74-5 PF-956980 is a FGF1 receptor antagonist, a PDGF receptor modulator, an Flt3 tyrosine kinase modulator, and a VEGF antagonist used as immunosuppressive agent.
CSN19687 PF-06263276 1421502-62-6 PF-06263276 is a potent and selective pan-JAK inhibitor which is suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
CSN16871 Peficitinib 944118-01-8 Peficitinb is an oral Janus kinase (JAK) inhibitor. Peficitinib inhibits JAK1, JAK2, JAK3 and Tyk2 enzyme activities with IC50s of 3.9, 5.0, 0.71 and 4.8 nM, respectively, and has moderate selectivity for JAK3 inhibition.
CSN13490 Pacritinib 937272-79-2 Pacritinib is a macrocyclic multiple inhibitor of JAK2 V617F JAK2 FLT3 D835Y and FLT3 with IC50 values of 19 nM 23 nM 6 nM and 22 nM respectively
CSN19239 Oclacitinib   1640292-55-2 Oclacitinib is a potent JAK inhibitor with IC50 value ranging in 10-99 nM for JAK family members, most potent against JAK1 with IC50 value of 10 nM.
CSN17137 NVP-BSK805 1092499-93-8 NVP-BSK805 is a selective JAK2 and JAK2V617F mutant inhibitor with IC50 value of 048 nM with 20-fold selectivity over TYK2 JAK3 and JAK1 IC50 values of 108 187 and 316 nM respectively
CSN16932 NSC 42834 195371-52-9 NSC 42834 a specific inhibitor of Jak2 inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity
CSN13153 CYT387   1056634-68-4 Momelotinib is a selective and potent ATP-competitive JAK12 inhibitor with IC50 values of 11nM and 18nM, respectively, with less potency against JAK3 with IC50 value of 155 nM.
CSN13502 LY2784544 1229236-86-5 LY2784544 is a potent selective and ATP-competitive inhibitor of JAK2 with IC50 value of 3 nM for both JAK2 and JAK2V617F as well as inhibits FLT3 with IC50 value of 4 nM less potent to JAK1 and JAK3 with IC50 values of 198 nM and 48 nM respectively with additional minor inhibition of STAT3
CSN11286 Lestaurtinib 111358-88-4 Lestaurtinib is a tyrosine kinase inhibitor structurally related to staurosporine. This semisynthetic derivative of the indolocarbazole K252a was investigated by Cephalon as a treatment for various types of cancer.
CSN16118 JANEX-1 202475-60-3 JANEX-1 is a cell-permeable reversible potent ATP-competitive and specific inhibitor of JAK3 IC50 78 M and has no effect on JAK1 JAK2 or ZapSyk or SRC tyrosine kinases
CSN18043 JAK3-IN-1 1805787-93-2 JAK3-IN-1 is a potent JAK3 inhibitor with IC50 of 48 nM also inhibits JAK1 IC50 896 nM and JAK2 IC50 1050 nM
CSN22435 JAK-IN-1 1334673-53-8 JAK-IN-1 is a JAK123 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively. JAK-IN-1 shows improved selectivity for JAK3 over JAK1.
CSN20267 JAK Inhibitor C35 1400687-19-5 JAK inhibitor C6 is a potent dual JAK13 inhibitor providing exceptional biochemical potency against JAK1 and JAK3 while maintaining good selectivity against JAK2 and Tyk2.
CSN22434 JAK Inhibitor 1 2096999-92-5 JAK inhibitor 1 is an inhibitor of JAK extracted from patent US20170121327A1, compound example 283.
CSN17204 Itacitinib 1334298-90-6 Itacitinib is an oral selective JAK1 tyrosine kinase inhibitor, which is potential for the treatment of rheumatoid arthritis, myelofibrosis, rheumatoid arthritis and plaque psoriasis.
CSN13689 GLPG0634 Analog 1206101-20-3 GLPG0634 analog is a pan JAK inhibitor with IC50s of 50-200 nM for JAK1JAK2JAK3.
CSN18801 FLLL32   1226895-15-3 FLLL32 is a potent JAK2STAT3 inhibitor with IC50 of 5 M
CSN15694 Filgotinib 1206161-97-8 Filgotinib is a selective JAK12 inhibitor with IC50 values of 1028nM, with less potency against JAK3 and TYK2 with IC50 values of 810 nM and 116 nM, respectively.
CSN21229 Delgocitinib 1263774-59-9 Delgocitinib is a novel and specific JAK inhibitor with IC50s of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, respectively.
CSN13843 Decernotinib 944842-54-0 Decernotinib is a selective JAK3 inhibitor with Ki value of 2.5nM, with 4-fold selectivity over JAK1, JAK2, and TYK2 with Ki values of 11nM, 13nM and 13nM, respectively.
CSN17436 CYT387 Sulfate 1056636-06-6 CYT387 sulfate is an ATP-competitive inhibitor of JAK1JAK2 with IC50 of 11 nM18 nM, 10-fold selectivity versus JAK3.
CSN13905 Cerdulatinib 1198300-79-6 Cerdulatinib is a multiple tyrosine kinase inhibitor with IC50 values of 12 nM6 nM8 nM and 0.5 nM, for JAK1JAK2JAK3 and TYK2, also shows potency against MST1, ARK5, MLK1, Fms. Syk, etc. with IC50 values ranging in 4-51 nM.
CSN19204 Cerdulatinib HCl 1369761-01-2 Cerdulatinib HCl is a dual JAKSYK inhibitor with IC50 of 12 nM6 nM8 nM0.5 nM and 32 nM for JAK1JAK2JAK3TYK2 and Syk, respectively. It also inhibits other kinases with IC50 less than 200 nM.
CSN15836 CEP-33779 1257704-57-6 CEP-33779 is a highly selective JAK2 inhibitor with IC50 value of 1.8 nM, with much less potency against JAK1 and TYK2 with 40- and 800-fold IC50 values.
CSN17535 Baricitinib Phosphate 1187595-84-1 Baricitinib Phosphate can selectively inhibit JAK12 inhibitor with IC50 values of 5.9 nM and 5.7 nM.
CSN13692 Baricitinib   1187594-09-7 Baricitinib can selectively inhibit JAK12 inhibitor with IC50 values of 5.9 nM and 5.7 nM.
CSN13663 AZD1480 935666-88-9 AZD1480 is a selective ATP-competitive JAK12 inhibitor with IC50 value of 13 and 04nM respectively as well as shows inhibitory effect on JAK3 and Tyk2
CSN17120 AZ 960 905586-69-8 AZ 960 is a potent ATP-competitive JAK inhibitor with IC50 values of 3 nM and 9nM for JAK2 and JAK3 respectively
CSN22692 Atiprimod 2HCl 130065-61-1
CSN23211 ZM 449829 4452-06-6
CSN23034 PF 06551600 Malonate 2140301-97-7
CSN23010 NSC 33994 82058-16-0
CSN23146 TC JL 37 1258294-34-6
CSN23158 TCS 21311 1260181-14-3
CSN23767 JAK3-IN-6 1443235-95-7
<< PREV 1 2 3 NEXT >>