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JAK
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN18177 | ZM39923 | 273727-89-2 | ZM39923 is a Janus kinase inhibitor with IC50 of 10 nM |
| CSN13641 | XL019 | 945755-56-6 | XL019 is a selective and potent JAK2 inhibitor with IC50 value of 22 nM with less potency to JAK1 JAK3 FLT3 and PDGFR with IC50 values of 1343 nM 2142 nM 1397 nM and 1254 nM respectively |
| CSN13436 | WP1066 | 857064-38-1 | WP1066 is a dual inhibitor for both JAK2 and STAT3 with IC50 value of 230 M and 243 M respectively |
| CSN18107 | WHI-P97 | 211555-05-4 | WHI-P97 is a rationally designed potent inhibitor of JAK-3 |
| CSN16224 | WHI-P154 | 211555-04-3 | WHI-P154 is a specific inhibitor of JAK3 with IC50 value of 18 M almost shows no activity against JAK1 or JAK2 |
| CSN18721 | Upadacitinib | 1310726-60-3 | Upadacitinib is a selective JAK1 inhibitor with an IC50 of 43 nM. |
| CSN12405 | TG 101348 | 936091-26-8 | TG 101348 is an inhibitor of JAK2 with an IC of 6 nM and also inhibits related kinases FLT3, RET, and JAK3 with less potent activity, having IC values of 25, 17 and 169 nM, respectively. |
| CSN15697 | Solcitinib | 1206163-45-2 | Solcitinib is a highly selective JAK1 inhibitor with IC50 value of 9.8 nM, with much less potency against JAK1 and JAK2 with IC50 values 100nM. |
| CSN20642 | SD1029 | 118372-34-2 | SD1029 is a cell-permeable xanthenedione compound that acts as a JAK2-selective inhibitor |
| CSN18612 | S-Ruxolitinib | 941685-37-6 | S-Ruxolitinib is the first potent, selective, JAK12 inhibitor to enter the clinic with IC50 of 3.3 nM2.8 nM, 130-fold selectivity for JAK12 versus JAK3. |
| CSN17456 | Ruxolitinib Sulfate | 1092939-16-6 | Ruxolitinib sulfate is the first potent, selective, JAK12 inhibitor to enter the clinic with IC50 of 3.3 nM2.8 nM, 130-fold selectivity for JAK12 versus JAK3. |
| CSN13499 | Ruxolitinib Phosphate | 1092939-17-7 | Ruxolitinib phosphate is a potent and selective JAK12 inhibitor to enter the clinic with IC50 of 3.3 nM2.8 nM, 130-fold selectivity for JAK12 versus JAK3. |
| CSN12394 | Ruxolitinib | 941678-49-5 | Ruxolitinib is the first potent, selective, JAK12 inhibitor to enter the clinic with IC50 of 3.3 nM2.8 nM, 130-fold selectivity for JAK12 versus JAK3. |
| CSN16800 | Pyridone 6 | 457081-03-7 | Pyridone 6 is a potent and selective inhibitor of JAK1 (IC5015 nM, murine JAK1), JAK2 (IC501 nM), JAK3 (Ki5 nM), and Tyk2 (IC501 nM) displaying significantly weaker affinities(130 nM to 10 mM) for other protein tyrosine kinases. |
| CSN19685 | PF-956980 | 1262832-74-5 | PF-956980 is a FGF1 receptor antagonist, a PDGF receptor modulator, an Flt3 tyrosine kinase modulator, and a VEGF antagonist used as immunosuppressive agent. |
| CSN19687 | PF-06263276 | 1421502-62-6 | PF-06263276 is a potent and selective pan-JAK inhibitor which is suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin. |
| CSN16871 | Peficitinib | 944118-01-8 | Peficitinb is an oral Janus kinase (JAK) inhibitor. Peficitinib inhibits JAK1, JAK2, JAK3 and Tyk2 enzyme activities with IC50s of 3.9, 5.0, 0.71 and 4.8 nM, respectively, and has moderate selectivity for JAK3 inhibition. |
| CSN13490 | Pacritinib | 937272-79-2 | Pacritinib is a macrocyclic multiple inhibitor of JAK2 V617F JAK2 FLT3 D835Y and FLT3 with IC50 values of 19 nM 23 nM 6 nM and 22 nM respectively |
| CSN19239 | Oclacitinib | 1640292-55-2 | Oclacitinib is a potent JAK inhibitor with IC50 value ranging in 10-99 nM for JAK family members, most potent against JAK1 with IC50 value of 10 nM. |
| CSN17137 | NVP-BSK805 | 1092499-93-8 | NVP-BSK805 is a selective JAK2 and JAK2V617F mutant inhibitor with IC50 value of 048 nM with 20-fold selectivity over TYK2 JAK3 and JAK1 IC50 values of 108 187 and 316 nM respectively |
| CSN16932 | NSC 42834 | 195371-52-9 | NSC 42834 a specific inhibitor of Jak2 inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity |
| CSN13153 | CYT387 | 1056634-68-4 | Momelotinib is a selective and potent ATP-competitive JAK12 inhibitor with IC50 values of 11nM and 18nM, respectively, with less potency against JAK3 with IC50 value of 155 nM. |
| CSN13502 | LY2784544 | 1229236-86-5 | LY2784544 is a potent selective and ATP-competitive inhibitor of JAK2 with IC50 value of 3 nM for both JAK2 and JAK2V617F as well as inhibits FLT3 with IC50 value of 4 nM less potent to JAK1 and JAK3 with IC50 values of 198 nM and 48 nM respectively with additional minor inhibition of STAT3 |
| CSN11286 | Lestaurtinib | 111358-88-4 | Lestaurtinib is a tyrosine kinase inhibitor structurally related to staurosporine. This semisynthetic derivative of the indolocarbazole K252a was investigated by Cephalon as a treatment for various types of cancer. |
| CSN16118 | JANEX-1 | 202475-60-3 | JANEX-1 is a cell-permeable reversible potent ATP-competitive and specific inhibitor of JAK3 IC50 78 M and has no effect on JAK1 JAK2 or ZapSyk or SRC tyrosine kinases |
| CSN18043 | JAK3-IN-1 | 1805787-93-2 | JAK3-IN-1 is a potent JAK3 inhibitor with IC50 of 48 nM also inhibits JAK1 IC50 896 nM and JAK2 IC50 1050 nM |
| CSN22435 | JAK-IN-1 | 1334673-53-8 | JAK-IN-1 is a JAK123 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively. JAK-IN-1 shows improved selectivity for JAK3 over JAK1. |
| CSN20267 | JAK Inhibitor C35 | 1400687-19-5 | JAK inhibitor C6 is a potent dual JAK13 inhibitor providing exceptional biochemical potency against JAK1 and JAK3 while maintaining good selectivity against JAK2 and Tyk2. |
| CSN22434 | JAK Inhibitor 1 | 2096999-92-5 | JAK inhibitor 1 is an inhibitor of JAK extracted from patent US20170121327A1, compound example 283. |
| CSN17204 | Itacitinib | 1334298-90-6 | Itacitinib is an oral selective JAK1 tyrosine kinase inhibitor, which is potential for the treatment of rheumatoid arthritis, myelofibrosis, rheumatoid arthritis and plaque psoriasis. |
| CSN13689 | GLPG0634 Analog | 1206101-20-3 | GLPG0634 analog is a pan JAK inhibitor with IC50s of 50-200 nM for JAK1JAK2JAK3. |
| CSN18801 | FLLL32 | 1226895-15-3 | FLLL32 is a potent JAK2STAT3 inhibitor with IC50 of 5 M |
| CSN15694 | Filgotinib | 1206161-97-8 | Filgotinib is a selective JAK12 inhibitor with IC50 values of 1028nM, with less potency against JAK3 and TYK2 with IC50 values of 810 nM and 116 nM, respectively. |
| CSN21229 | Delgocitinib | 1263774-59-9 | Delgocitinib is a novel and specific JAK inhibitor with IC50s of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, respectively. |
| CSN13843 | Decernotinib | 944842-54-0 | Decernotinib is a selective JAK3 inhibitor with Ki value of 2.5nM, with 4-fold selectivity over JAK1, JAK2, and TYK2 with Ki values of 11nM, 13nM and 13nM, respectively. |
| CSN17436 | CYT387 Sulfate | 1056636-06-6 | CYT387 sulfate is an ATP-competitive inhibitor of JAK1JAK2 with IC50 of 11 nM18 nM, 10-fold selectivity versus JAK3. |
| CSN13905 | Cerdulatinib | 1198300-79-6 | Cerdulatinib is a multiple tyrosine kinase inhibitor with IC50 values of 12 nM6 nM8 nM and 0.5 nM, for JAK1JAK2JAK3 and TYK2, also shows potency against MST1, ARK5, MLK1, Fms. Syk, etc. with IC50 values ranging in 4-51 nM. |
| CSN19204 | Cerdulatinib HCl | 1369761-01-2 | Cerdulatinib HCl is a dual JAKSYK inhibitor with IC50 of 12 nM6 nM8 nM0.5 nM and 32 nM for JAK1JAK2JAK3TYK2 and Syk, respectively. It also inhibits other kinases with IC50 less than 200 nM. |
| CSN15836 | CEP-33779 | 1257704-57-6 | CEP-33779 is a highly selective JAK2 inhibitor with IC50 value of 1.8 nM, with much less potency against JAK1 and TYK2 with 40- and 800-fold IC50 values. |
| CSN17535 | Baricitinib Phosphate | 1187595-84-1 | Baricitinib Phosphate can selectively inhibit JAK12 inhibitor with IC50 values of 5.9 nM and 5.7 nM. |
| CSN13692 | Baricitinib | 1187594-09-7 | Baricitinib can selectively inhibit JAK12 inhibitor with IC50 values of 5.9 nM and 5.7 nM. |
| CSN13663 | AZD1480 | 935666-88-9 | AZD1480 is a selective ATP-competitive JAK12 inhibitor with IC50 value of 13 and 04nM respectively as well as shows inhibitory effect on JAK3 and Tyk2 |
| CSN17120 | AZ 960 | 905586-69-8 | AZ 960 is a potent ATP-competitive JAK inhibitor with IC50 values of 3 nM and 9nM for JAK2 and JAK3 respectively |
| CSN22692 | Atiprimod 2HCl | 130065-61-1 | |
| CSN23211 | ZM 449829 | 4452-06-6 | |
| CSN23034 | PF 06551600 Malonate | 2140301-97-7 | |
| CSN23010 | NSC 33994 | 82058-16-0 | |
| CSN23146 | TC JL 37 | 1258294-34-6 | |
| CSN23158 | TCS 21311 | 1260181-14-3 | |
| CSN23767 | JAK3-IN-6 | 1443235-95-7 |
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