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| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN17912 | ML355 | 1532593-30-8 | ML355 is a selective 12-lipoxygenase inhibitor with an IC50 value of 0.34 M, with much less potency against 15-LO-1, 15-LO-2, and 5-LO (IC50s 9.7, 100, and 100 M). |
| CSN12289 | QNZ | 545380-34-5 | QNZ can inhibit the activation of NF-κB and the production of TNF-α with IC50 of 11 nM and 7 nM, respectively. |
| CSN21951 | Indobufen | 63610-08-2 | Indobufen is a platelet aggregation inhibitor and a reversible cyclooxygenase inhibitor. It has been used in studying the supportive care and prevention of Atrial Fibrillation. |
| CSN13882 | LDC1267 | 1361030-48-9 | LDC1267 is a selective inhibitor of TAM and inhibits Tyro3, Axl and Mer with IC50 of 5 nM, 8 nM, 29 nM, respectively. |
| CSN16059 | Fostamatinib disodium hexahydrate | 914295-16-2 | R788 Disodium is a Syk inhibitor with IC50 of 41 nM. It is the prodrug of metabolite R406 with immunomodulatory activity. |
| CSN17716 | E6446 dihydrochloride | 1345675-25-3 | E-6446 2HCl is an antagonist of TLRs and suppresses DNA stimulation in cancer cells with IC50 of 10 nM. |
| CSN12668 | R406 free base | 841290-80-0 | R406 is an inhibitor of Syk with IC50 of 41 nM. |
| CSN16703 | Nadifloxacin | 124858-35-1 | Nadifloxacin is a fluoroquinolone broad-spectrum antibacterial, working by inhibiting the enzyme DNA gyrase and thus inhibiting the bacterial multiplication. |
| CSN12237 | Zileuton | 111406-87-2 | Zileuton is a reversible 5-lipoxygenase inhibitor with IC50 value of 0.5 M in rat basophilic leukemia-1 (RBL-1) cells. It also potently inhibited leukotriene B4 production with an IC50 value of 0.6 M in purified human peripheral blood polymorphonuclear leukocytes (PMNL). |
| CSN17031 | (S)-(+)-Ibuprofen | 51146-56-6 | (S)-(+)-Ibuprofen, the S-enantiomer of ibuprofen, is capable of inhibiting cyclooxygenase (COX) at clinically relevant concentrations, R(-)-ibuprofen is not a COX inhibitor. S(+)-Ibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways |
| CSN23394 | Amodiaquine dihydrochloride | 69-44-3 | Amodiaquine 2HCl is a 4-aminoquinoline similar to chloroquine with both anti-malarial and anti-inflammatory effect used to treat malaria. |
| CSN16903 | Lusutrombopag | 1110766-97-6 | Lusutrombopag is an agonist of bioavailablethrombopoietin (TPO) receptor that is used to treat chronic liver disease. |
| CSN21243 | KI696 | 1799974-70-1 | KI696 is a high affinity probe that disrupts the Keap1NRF2 interaction. |
| CSN21187 | SSR240612 | 464930-42-5 | SSR240612 is a potent and selective non-peptide bradykinin B1 receptor antagonist with Kis of 0.48 nM and 0.73 nM for B1 kinin receptors of human fibroblast MRC5 and HEK cells expressing human B1 receptors, 481 nM and 358 nM for B2 receptors of guinea pig ileum membranes and CHO cells expressing human B1 receptor, respectively. |
| CSN21196 | GENZ-882706 | 2070864-35-4 | GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) inhibitor that intends to treat immune-mediated diseases and neurological diseases. |
| CSN21197 | ABBV-744 | 2138861-99-9 | ABBV-744 is an inhibitor of BDII-selective BET bromodomain that is being investigated to treat AML and metastic castration-resistant prostate cancer. |
| CSN21262 | CU-CPT9b | 2162962-69-6 | CU-CPT9a is a selective Toll-like receptor 8 (TLR8) inhibitor with IC50 of 0.5 nM. It can also suppress TNF- levels. |
| CSN21261 | CU-CPT-9a | 2165340-32-7 | CU-CPT9b is a selective inhibitor of TLR8 with IC50 and Kd of 0.7 nM and 21 nM. |
| CSN21112 | Licogliflozin | 1291094-73-9 | Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor |
| CSN18340 | R112 | 575474-82-7 | R112, an ATP-competitive inhibitor, can inhibit Syk kinase with Ki of 96 nM. |
| CSN18467 | cGAMP | 849214-04-6 | cGAMP, an endogenous second messenger, can induce the formation of cytokines and promote innate immune response. It also acts as an activator of STING with antitumor activity. |
| CSN13630 | Vesatolimod | 1228585-88-3 | GS-9620 is a selective agonist of Toll-like receptor 7 (TLR-7) in chimpanzees and has anti-HBV infection activity. |
| CSN22337 | Adavivint | 1467093-03-3 | Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCFLEF-reporter assay in SW480 colon cancer cells. |
| CSN11294 | Lexacalcitol | 131875-08-6 | Lexacalcitol is over 100 times more active than 1alpha, 25-dihydroxyvitamin D3 1alpha,25-(OH)2D3, as judged by in vitro antiproliferative and cell differentiating assays. |
| CSN10950 | Toll-like receptor modulator | 926927-42-6 | Toll-like receptor modulator is a quinazolinone-derived regulator of both Toll-like receptor and -secretase. |
| CSN18411 | BAY 61-3606 | 732983-37-8 | BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. |
| CSN18539 | Imiquimod maleate | 896106-16-4 | Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas. |
| CSN17529 | Zileuton sodium | 118569-21-4 | Zileuton sodium is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation. |
| CSN18895 | C 87 | 1609281-56-2 | C 87 is a small-moleculeTNF inhibitor and potently inhibits TNF-induced cytotoxicity with an IC50 of 8.73 M. |
| CSN19006 | ADU-S100 ammonium salt | 1638750-96-5 | ML RR-S2 CDA ammonium is an inducer of STING (stimulator of interferon genes). ML RR-S2 CDA has enhanced binding affinity to STING and activate all known human STING alleles. |
| CSN18646 | Imiquimod hydrochloride | 99011-78-6 | Imiquimod HCl is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas. |
| CSN15947 | Resatorvid | 243984-11-4 | TAK-242, a small-molecule-specific inhibitor of Toll-like receptor (TLR)4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4. |
| CSN16863 | ADU-S100 | 1638241-89-0 | ML RR-S2 CDA is a highly active cyclic-di-nucleotide immune stimulators that activate DCs via the cytoplamtic receptor STING (Stimulator of Interferon Genes). |
| CSN18399 | STING agonist-1 | 702662-50-8 | STING agonist-1 is a human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. |
| CSN13939 | PF-4840154 | 1332708-14-1 | PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively. |
| CSN17582 | E6446 | 1219925-73-1 | E-6446 is a synthetic antagonist for nucleic acid-sensing TLRs and potently suppresses DNA stimulation of HEKTLR9 cells with IC50 of 10 nM. |
| CSN17706 | BMS-5 | 1338247-35-0 | BMS-5 is a highly selective and potent inhibitor of both LIMK 1 and 2 with IC50 values of 7 and 8 nM, respectively. |
| CSN16532 | BAY 61-3606 dihydrochloride | 648903-57-5 | BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki 7.5 nM). |
| CSN15818 | Fostamatinib | 901119-35-5 | Fostamatinib, a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM. |
| CSN22143 | ERB-196 | 550997-55-2 | ERB-196 is a nonsteroidal selective estrogen receptor- (ER) agonist. |
| CSN19150 | RO9021 | 1446790-62-0 | RO9021 potently inhibits SYK kinase activity with an average IC50 of 5.6 nM and suppresses B-cell receptor signaling. |
| CSN19226 | Ochromycinone | 111540-00-2 | STA-21 is a selective STAT3 inhibitor. |
| CSN19750 | Telratolimod | 1359993-59-1 | MEDI9197 is an imidazoquinoline analogue toll-like receptor (TLR) agonist that can be used for cancer immunotherapy based on its efficacy toward a variety of tumors. |
| CSN20419 | GSK2245035 Maleate | 1325212-97-2 | GSK2245035 maleate is a selective Toll-like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties which displays extraordinary IFN inducing potency and IFNTNF selectivity. |
| CSN21351 | MD2-IN-1 | 111797-22-9 | MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 M for the recombinant human MD2 (rhMD2). |
| CSN22347 | AN-3485 | 1213827-99-6 | AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM. |
| CSN24268 | Mitoquinone mesylate | 845959-50-4 | Mitoquinone Mesylate is a ubiquinone derivative, TPP-based and mitochondrially targeted antioxidant, preventing lipid peroxidation-induced apoptosis and protecting mitochondria from oxidative damage. |
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