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Cat. No. Product Name CAS No. Information
CSN17912 ML355 1532593-30-8 ML355 is a selective 12-lipoxygenase inhibitor with an IC50 value of 0.34 M, with much less potency against 15-LO-1, 15-LO-2, and 5-LO (IC50s 9.7, 100, and 100 M).
CSN12289 QNZ 545380-34-5 QNZ can inhibit the activation of NF-κB and the production of TNF-α with IC50 of 11 nM and 7 nM, respectively.
CSN21951 Indobufen 63610-08-2 Indobufen is a platelet aggregation inhibitor and a reversible cyclooxygenase inhibitor. It has been used in studying the supportive care and prevention of Atrial Fibrillation.
CSN13882 LDC1267 1361030-48-9 LDC1267 is a selective inhibitor of TAM and inhibits Tyro3, Axl and Mer with IC50 of 5 nM, 8 nM, 29 nM, respectively.
CSN16059 Fostamatinib 2Na 6H2O 914295-16-2 R788 Disodium is a Syk inhibitor with IC50 of 41 nM. It is the prodrug of metabolite R406 with immunomodulatory activity.
CSN17716 E-6446 2HCl 1345675-25-3 E-6446 2HCl is an antagonist of TLRs and suppresses DNA stimulation in cancer cells with IC50 of 10 nM.
CSN12668 R406 841290-80-0 R406 is an inhibitor of Syk with IC50 of 41 nM.
CSN16703 Nadifloxacin 124858-35-1 Nadifloxacin is a fluoroquinolone broad-spectrum antibacterial, working by inhibiting the enzyme DNA gyrase and thus inhibiting the bacterial multiplication.
CSN12237 Zileuton 111406-87-2 Zileuton is a reversible 5-lipoxygenase inhibitor with IC50 value of 0.5 M in rat basophilic leukemia-1 (RBL-1) cells. It also potently inhibited leukotriene B4 production with an IC50 value of 0.6 M in purified human peripheral blood polymorphonuclear leukocytes (PMNL).
CSN17031 (S)-(+)-Ibuprofen 51146-56-6 (S)-(+)-Ibuprofen, the S-enantiomer of ibuprofen, is capable of inhibiting cyclooxygenase (COX) at clinically relevant concentrations, R(-)-ibuprofen is not a COX inhibitor. S(+)-Ibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways
CSN23394 Amodiaquine 2HCl 69-44-3 Amodiaquine 2HCl is a 4-aminoquinoline similar to chloroquine with both anti-malarial and anti-inflammatory effect used to treat malaria.
CSN24268 Mitoquinone mesylate 845959-50-4 Mitoquinone Mesylate is a ubiquinone derivative, TPP-based and mitochondrially targeted antioxidant, preventing lipid peroxidation-induced apoptosis and protecting mitochondria from oxidative damage.
CSN16903 Lusutrombopag 1110766-97-6 Lusutrombopag is an agonist of bioavailablethrombopoietin (TPO) receptor that is used to treat chronic liver disease.
CSN21243 KI696 1799974-70-1 KI696 is a high affinity probe that disrupts the Keap1NRF2 interaction.
CSN21226 CU-CPT-8m 125079-83-6
CSN21113 (5R)-5-Hydroxytriptolide 583028-68-6 (5R)-5-Hydroxytriptolide is obtained from Triptolide (T815600) which is Diterpenoid triepoxide with immunosuppressant and antitumor properties.
CSN21196 GENZ-882706 2070864-35-4 GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) inhibitor that intends to treat immune-mediated diseases and neurological diseases.
CSN21197 ABBV-744 2138861-99-9 ABBV-744 is an inhibitor of BDII-selective BET bromodomain that is being investigated to treat AML and metastic castration-resistant prostate cancer.
CSN21262 CU-CPT-9b 2162962-69-6 CU-CPT9a is a selective Toll-like receptor 8 (TLR8) inhibitor with IC50 of 0.5 nM. It can also suppress TNF- levels.
CSN21261 CU-CPT-9a 2165340-32-7 CU-CPT9b is a selective inhibitor of TLR8 with IC50 and Kd of 0.7 nM and 21 nM.
CSN21112 Licogliflozin 1291094-73-9 Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor
CSN18340 R112 575474-82-7 R112, an ATP-competitive inhibitor, can inhibit Syk kinase with Ki of 96 nM.
CSN18467 cGAMP 849214-04-6 cGAMP, an endogenous second messenger, can induce the formation of cytokines and promote innate immune response. It also acts as an activator of STING with antitumor activity.
CSN16893 Secalciferol 55721-11-4 Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid which is involved in bone ossification.
CSN13630 GS-9620 1228585-88-3 GS-9620 is a selective agonist of Toll-like receptor 7 (TLR-7) in chimpanzees and has anti-HBV infection activity.
CSN22337 Adavivint 1467093-03-3 Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCFLEF-reporter assay in SW480 colon cancer cells.
CSN11294 Lexacalcitol 131875-08-6 Lexacalcitol is over 100 times more active than 1alpha, 25-dihydroxyvitamin D3 1alpha,25-(OH)2D3, as judged by in vitro antiproliferative and cell differentiating assays.
CSN10950 Toll-like Receptor Modulator 926927-42-6 Toll-like receptor modulator is a quinazolinone-derived regulator of both Toll-like receptor and -secretase.
CSN18411 BAY 61-3606 732983-37-8 BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
CSN18539 Imiquimod Maleate 896106-16-4 Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas.
CSN17529 Zileuton Sodium 118569-21-4 Zileuton sodium is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.
CSN18895 C 87 332420-90-3 C 87 is a small-moleculeTNF inhibitor and potently inhibits TNF-induced cytotoxicity with an IC50 of 8.73 M.
CSN19006 ML RR-S2 CDA Ammonium 1638750-96-5 ML RR-S2 CDA ammonium is an inducer of STING (stimulator of interferon genes). ML RR-S2 CDA has enhanced binding affinity to STING and activate all known human STING alleles.
CSN18646 Imiquimod HCl 99011-78-6 Imiquimod HCl is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas.
CSN15947 TAK-242 243984-11-4 TAK-242, a small-molecule-specific inhibitor of Toll-like receptor (TLR)4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4.
CSN18399 STING Agonist-1 702662-50-8 STING agonist-1 is a human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses.
CSN13939 PF-4840154 1332708-14-1 PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively.
CSN17582 E-6446 1219925-73-1 E-6446 is a synthetic antagonist for nucleic acid-sensing TLRs and potently suppresses DNA stimulation of HEKTLR9 cells with IC50 of 10 nM.
CSN17706 BMS-5 1338247-35-0 BMS-5 is a highly selective and potent inhibitor of both LIMK 1 and 2 with IC50 values of 7 and 8 nM, respectively.
CSN16532 BAY 61-3606 2HCl 648903-57-5 BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki 7.5 nM).
CSN15818 Fostamatinib 901119-35-5 Fostamatinib, a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.
CSN22143 ERB-196 550997-55-2 ERB-196 is a nonsteroidal selective estrogen receptor- (ER) agonist.
CSN19150 RO9021 1446790-62-0 RO9021 potently inhibits SYK kinase activity with an average IC50 of 5.6 nM and suppresses B-cell receptor signaling.
CSN19750 MEDI9197 1359993-59-1 MEDI9197 is an imidazoquinoline analogue toll-like receptor (TLR) agonist that can be used for cancer immunotherapy based on its efficacy toward a variety of tumors.
CSN20419 GSK2245035 Maleate 1325212-97-2 GSK2245035 maleate is a selective Toll-like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties which displays extraordinary IFN inducing potency and IFNTNF selectivity.
CSN20548 Selepressin 876296-47-8 Selepressin is a potent, selective vasopressin V1a receptor agonist potentially for the treatment of septic shock.
CSN21351 MD2-IN-1 111797-22-9 MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 M for the recombinant human MD2 (rhMD2).
CSN21399 Saikogenin A 5092-09-1 Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor.
CSN22347 AN-3485 1213827-99-6 AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM.
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