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Cat. No. Product Name CAS No. Information
CSN17912 ML355 1532593-30-8 ML355 is a selective 12-lipoxygenase inhibitor with an IC50 value of 0.34 M, with much less potency against 15-LO-1, 15-LO-2, and 5-LO (IC50s 9.7, 100, and 100 M).
CSN12289 QNZ 545380-34-5 QNZ can inhibit the activation of NF-B and the production of TNF-α with IC50 of 11 nM and 7 nM, respectively.
CSN22564 Thymopentin 69558-55-0 Thymopentin is an immunomodulatory peptide and an immunostimulant which can enhance the production of thymic T cells and may help restore immunocompetence in immunosuppressed subjects.
CSN21951 Indobufen 63610-08-2 Indobufen is a platelet aggregation inhibitor and a reversible cyclooxygenase inhibitor. It has been used in studying the supportive care and prevention of Atrial Fibrillation.
CSN13882 LDC1267 1361030-48-9 LDC1267 is a selective inhibitor of TAM and inhibits Tyro3, Axl and Mer with IC50 of 5 nM, 8 nM, 29 nM, respectively.
CSN23354 Compstatin 206645-99-0 Compstatin is a complement inhibitor which can bind C3 inhibiting proteolytic cleavage by C3 convertase with IC50 value of 28 M and activate classical and alternative complement pathways with IC50 values of 63 and 12 M, respectively.
CSN23312 Royal jelly acid 14113-05-4 Royal jelly acid is a naturally occuring unsaturated fatty acid found in royal jelly which can suppress both VEGF-induced human umbilical vein endothelial cells (HUVECs) proliferation and migration, and possesses effect on cholesterol-lowering, antiinflammatory, wound-healing and antibiotic.
CSN17716 E-6446 2HCl 1345675-25-3 E6446 dihydrochloride is an antagonist of TLRs and suppresses DNA stimulation in cancer cells with IC50 of 10 nM.
CSN23305 4-Methylesculetin 529-84-0 4-Methylesculetin is a coumarin derivative which showed anti-inflammatory activity and antioxidant property.
CSN23633 Bendazac 20187-55-7 Bendazac is an oxyacetic acid with multiple function, including possessing anti-inflammatory, anti-necrotic, choleretic, and anti-lipidemic characteristics and inhibiting the denaturation of proteins.
CSN23263 Clonixin 17737-65-4 Clonixin is a non steroidal anti inflammatory drug (NSAID) with analgesic properties.
CSN16703 Nadifloxacin 124858-35-1 Nadifloxacin is a fluoroquinolone broad-spectrum antibacterial, working by inhibiting the enzyme DNA gyrase and thus inhibiting the bacterial multiplication.
CSN22592 Actarit 18699-02-0 Actarit is acid active immunomodulator which can suppresse inflammation and nitric oxide production.
CSN12237 Zileuton 111406-87-2 Zileuton is a reversible 5-lipoxygenase inhibitor with IC50 value of 0.5 M in rat basophilic leukemia-1 (RBL-1) cells. It also potently inhibited leukotriene B4 production with an IC50 value of 0.6 M in purified human peripheral blood polymorphonuclear leukocytes (PMNL).
CSN17031 (S)-(+)-Ibuprofen 51146-56-6 S()-ibuprofen, the S-enantiomer of ibuprofen, is capable of inhibiting cyclooxygenase (COX) at clinically relevant concentrations, R(-)-ibuprofen is not a COX inhibitor. S()-Ibuprofen prevents neurodegeneration and cognitive decline in APPswePS1dE9 through multiple signaling pathways
CSN23394 Amodiaquine 2HCl 69-44-3 Amodiaquine 2HCl is a 4-aminoquinoline similar to chloroquine with both anti-malarial and anti-inflammatory effect used to treat malaria.
CSN23347 Methyl Ferulate 2309-07-1 Methyl Ferulate is a naturally-occurring phenolic with antioxidant activities and inhibits the release of pro-inflammatory cytokines, blocks the expression of COX-2, and reduces nitric oxide generation from LPS-stimulated macrophages.
CSN20789 4-Biphenylacetic acid 5728-52-9 4-Biphenylacetic acid is used in the synthesis of gastrosparing non-steroidal antiinflammatory drug as a potential non-steroidal antiinflammatory agent.
CSN24268 Mitoquinone Mesylate 845959-50-4 Mitoquinone Mesylate is a ubiquinone derivative, TPP-based and mitochondrially targeted antioxidant, preventing lipid peroxidation-induced apoptosis and protecting mitochondria from oxidative damage.
CSN16903 Lusutrombopag 1110766-97-6 Lusutrombopag is an agonist of thrombopoietin (TPO) receptor which is used for treatment of chronic liver disease.
CSN21243 KI696 1799974-70-1 KI696 is a high affinity probe that disrupts the Keap1NRF2 interaction.
CSN21226 CU-CPT-8m 125079-83-6
CSN21113 (5R)-5-Hydroxytriptolide 583028-68-6 (5R)-5-Hydroxytriptolide is obtained from Triptolide (T815600) which is Diterpenoid triepoxide with immunosuppressant and antitumor properties.
CSN21187 SSR240612 464930-42-5 SSR240612 is a potent and selective non-peptide bradykinin B1 receptor antagonist with Kis of 0.48 nM and 0.73 nM for B1 kinin receptors of human fibroblast MRC5 and HEK cells expressing human B1 receptors, 481 nM and 358 nM for B2 receptors of guinea pig ileum membranes and CHO cells expressing human B1 receptor, respectively.
CSN21196 GENZ-882706 2070864-35-4 GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) inhibitor that intends to treat immune-mediated diseases and neurological diseases.
CSN21197 ABBV-744 2138861-99-9 ABBV-744 is an inhibitor of BDII-selective BET bromodomain that is being investigated to treat AML and metastic castration-resistant prostate cancer.
CSN21262 CU-CPT-9b 2162962-69-6 CU-CPT9a is a selective Toll-like receptor 8 (TLR8) inhibitor with IC50 of 0.5 nM. It can also suppress TNF- levels.
CSN21261 CU-CPT-9a 2165340-32-7 CU-CPT9b is a selective inhibitor of TLR8 with IC50 and Kd of 0.7 nM and 21 nM.
CSN21112 Licogliflozin 1291094-73-9 Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor
CSN16893 Secalciferol 55721-11-4 Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid which is involved in bone ossification.
CSN13630 GS-9620 1228585-88-3 GS-9620 is a selective agonist of Toll-like receptor 7 (TLR-7) in chimpanzees and has anti-HBV infection activity.
CSN22337 Adavivint 1467093-03-3 Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCFLEF-reporter assay in SW480 colon cancer cells.
CSN11294 Lexacalcitol 131875-08-6 Lexacalcitol is over 100 times more active than 1alpha, 25-dihydroxyvitamin D3 1alpha,25-(OH)2D3, as judged by in vitro antiproliferative and cell differentiating assays.
CSN10950 Toll-like Receptor Modulator 926927-42-6 Toll-like receptor modulator is a quinazolinone-derived regulator of both Toll-like receptor and -secretase.
CSN18539 Imiquimod Maleate 896106-16-4 Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas.
CSN17529 Zileuton Sodium 118569-21-4 Zileuton sodium is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.
CSN18895 C 87 332420-90-3 C 87 is a small-moleculeTNF inhibitor and potently inhibits TNF-induced cytotoxicity with an IC50 of 8.73 M.
CSN18646 Imiquimod HCl 99011-78-6 Imiquimod hydrochloride is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas.
CSN15947 TAK-242 243984-11-4 TAK-242, a small-molecule-specific inhibitor of Toll-like receptor (TLR)4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4.
CSN13939 PF-4840154 1332708-14-1 PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively.
CSN17582 E-6446 1219925-73-1 E-6446 is a synthetic antagonist for nucleic acid-sensing TLRs and potently suppresses DNA stimulation of HEKTLR9 cells with IC50 of 10 nM.
CSN17706 BMS-5 1338247-35-0 BMS-5 is a highly selective and potent inhibitor of both LIMK 1 and 2 with IC50 values of 7 and 8 nM, respectively.
CSN22143 ERB-196 550997-55-2 ERB-196 is a nonsteroidal selective estrogen receptor- (ER) agonist.
CSN19750 MEDI9197 1359993-59-1 MEDI9197 is an imidazoquinoline analogue toll-like receptor (TLR) agonist that can be used for cancer immunotherapy based on its efficacy toward a variety of tumors.
CSN20419 GSK2245035 Maleate 1325212-97-2 GSK2245035 maleate is a selective Toll-like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties which displays extraordinary IFN inducing potency and IFNTNF selectivity.
CSN20548 Selepressin 876296-47-8 Selepressin is a potent, selective vasopressin V1a receptor agonist potentially for the treatment of septic shock.
CSN21351 MD2-IN-1 111797-22-9 MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 M for the recombinant human MD2 (rhMD2).
CSN21399 Saikogenin A 5092-09-1 Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor.
CSN22347 AN-3485 1213827-99-6 AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM.
CSN23754 NFAT Inhibitor 249537-73-3 NFAT Inhibitor is a high-affinity calcineurin-binding peptide that inhibits NFAT (Nuclear Factor of Activated T cells) activation and NFAT-dependent expression of endogenous cytokine genes in T cells.
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