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Immunology/Inflammation

Cat. No. Product Name CAS No. Information
CSN21951 Indobufen 63610-08-2 Indobufen is a platelet aggregation inhibitor and a reversible cyclooxygenase inhibitor. It has been used in studying the supportive care and prevention of Atrial Fibrillation.
CSN17716 E-6446 2HCl 1345675-25-3 E-6446 2HCl is an antagonist of TLRs and suppresses DNA stimulation in cancer cells with IC50 of 10 nM.
CSN16703 Nadifloxacin 124858-35-1 Nadifloxacin is a fluoroquinolone broad-spectrum antibacterial, working by inhibiting the enzyme DNA gyrase and thus inhibiting the bacterial multiplication.
CSN12237 Zileuton 111406-87-2 Zileuton is a reversible 5-lipoxygenase inhibitor with IC50 value of 0.5 M in rat basophilic leukemia-1 (RBL-1) cells. It also potently inhibited leukotriene B4 production with an IC50 value of 0.6 M in purified human peripheral blood polymorphonuclear leukocytes (PMNL).
CSN17031 (S)-(+)-Ibuprofen 51146-56-6 (S)-(+)-Ibuprofen, the S-enantiomer of ibuprofen, is capable of inhibiting cyclooxygenase (COX) at clinically relevant concentrations, R(-)-ibuprofen is not a COX inhibitor. S(+)-Ibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways
CSN23394 Amodiaquine 2HCl 69-44-3 Amodiaquine 2HCl is a 4-aminoquinoline similar to chloroquine with both anti-malarial and anti-inflammatory effect used to treat malaria.
CSN18467 cGAMP 849214-04-6 cGAMP, an endogenous second messenger, can induce the formation of cytokines and promote innate immune response. It also acts as an activator of STING with antitumor activity.
CSN22337 Adavivint 1467093-03-3 Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCFLEF-reporter assay in SW480 colon cancer cells.
CSN15947 TAK-242 243984-11-4 TAK-242, a small-molecule-specific inhibitor of Toll-like receptor (TLR)4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4.
CSN17706 BMS-5 1338247-35-0 BMS-5 is a highly selective and potent inhibitor of both LIMK 1 and 2 with IC50 values of 7 and 8 nM, respectively.
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