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Immunology/Inflammation

Cat. No. Product Name CAS No. Information
CSN12289 QNZ 545380-34-5 QNZ can inhibit the activation of NF-κB and the production of TNF-α with IC50 of 11 nM and 7 nM, respectively.
CSN21951 Indobufen 63610-08-2 Indobufen is a platelet aggregation inhibitor and a reversible cyclooxygenase inhibitor. It has been used in studying the supportive care and prevention of Atrial Fibrillation.
CSN17716 E-6446 2HCl 1345675-25-3 E-6446 2HCl is an antagonist of TLRs and suppresses DNA stimulation in cancer cells with IC50 of 10 nM.
CSN16703 Nadifloxacin 124858-35-1 Nadifloxacin is a fluoroquinolone broad-spectrum antibacterial, working by inhibiting the enzyme DNA gyrase and thus inhibiting the bacterial multiplication.
CSN12237 Zileuton 111406-87-2 Zileuton is a reversible 5-lipoxygenase inhibitor with IC50 value of 0.5 M in rat basophilic leukemia-1 (RBL-1) cells. It also potently inhibited leukotriene B4 production with an IC50 value of 0.6 M in purified human peripheral blood polymorphonuclear leukocytes (PMNL).
CSN17031 (S)-(+)-Ibuprofen 51146-56-6 (S)-(+)-Ibuprofen, the S-enantiomer of ibuprofen, is capable of inhibiting cyclooxygenase (COX) at clinically relevant concentrations, R(-)-ibuprofen is not a COX inhibitor. S(+)-Ibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways
CSN23394 Amodiaquine 2HCl 69-44-3 Amodiaquine 2HCl is a 4-aminoquinoline similar to chloroquine with both anti-malarial and anti-inflammatory effect used to treat malaria.
CSN21261 CU-CPT-9a 2165340-32-7 CU-CPT9b is a selective inhibitor of TLR8 with IC50 and Kd of 0.7 nM and 21 nM.
CSN21112 Licogliflozin 1291094-73-9 Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor
CSN18340 R112 575474-82-7 R112, an ATP-competitive inhibitor, can inhibit Syk kinase with Ki of 96 nM.
CSN18467 cGAMP 849214-04-6 cGAMP, an endogenous second messenger, can induce the formation of cytokines and promote innate immune response. It also acts as an activator of STING with antitumor activity.
CSN22337 Adavivint 1467093-03-3 Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCFLEF-reporter assay in SW480 colon cancer cells.
CSN18411 BAY 61-3606 732983-37-8 BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
CSN18539 Imiquimod Maleate 896106-16-4 Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas.
CSN17529 Zileuton Sodium 118569-21-4 Zileuton sodium is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.
CSN19006 ML RR-S2 CDA Ammonium 1638750-96-5 ML RR-S2 CDA ammonium is an inducer of STING (stimulator of interferon genes). ML RR-S2 CDA has enhanced binding affinity to STING and activate all known human STING alleles.
CSN18646 Imiquimod HCl 99011-78-6 Imiquimod HCl is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas.
CSN15947 TAK-242 243984-11-4 TAK-242, a small-molecule-specific inhibitor of Toll-like receptor (TLR)4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4.
CSN16863 ML RR-S2 CDA 1638241-89-0 ML RR-S2 CDA is a highly active cyclic-di-nucleotide immune stimulators that activate DCs via the cytoplamtic receptor STING (Stimulator of Interferon Genes).
CSN13939 PF-4840154 1332708-14-1 PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively.
CSN17706 BMS-5 1338247-35-0 BMS-5 is a highly selective and potent inhibitor of both LIMK 1 and 2 with IC50 values of 7 and 8 nM, respectively.
CSN22143 ERB-196 550997-55-2 ERB-196 is a nonsteroidal selective estrogen receptor- (ER) agonist.
CSN19226 STA-21 111540-00-2 STA-21 is a selective STAT3 inhibitor.
CSN21351 MD2-IN-1 111797-22-9 MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 M for the recombinant human MD2 (rhMD2).
CSN22347 AN-3485 1213827-99-6 AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM.
CSN24268 Mitoquinone mesylate 845959-50-4 Mitoquinone Mesylate is a ubiquinone derivative, TPP-based and mitochondrially targeted antioxidant, preventing lipid peroxidation-induced apoptosis and protecting mitochondria from oxidative damage.
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