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IKK
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN16939 | WS6 | 1421227-53-3 | WS6 is a small molecule that promotes β cell proliferation in rodent and human primary islets with EC50 of 0.28 μM (R7T1 cell viability). WS6 also stimulates α cell proliferation in human pancreatic islets. WS6 appears to act by inhibiting IKKε and blocking the ability of EBP1 to suppress E2F-medtiated transcription. |
| CSN15918 | WS3 | 1421227-52-2 | WS3 is an Erb3 binding protein-1 (EBP1) and IB kinase pathway modulator, its a non-specific proliferative molecule and promotes cell proliferation with EC50 of 28 nM. |
| CSN13432 | TPCA-1 | 507475-17-4 | TPCA-1 is a selective and potent IKK- inhibitor with IC50 value of 17.9 nM. |
| CSN20031 | (Z)-Orantinib | 210644-62-5 | SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFR, VEGFR2 (Flk-1KDR), FGFR1 activity in vitro (IC50 0.01, 0.1, 3.9, and 3.8 M, respectively) and PDGFVEGFbFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target serthr kinases Aurora A, Aurora B, TBK1 (NAKT2K), and AMPK (IC50 0.85, 0.047, 1.4, and 1.8 M, respectively), as well as non-receptor TKs Lyn and Yes (IC50 4.3 and 5.8 M, respectively). |
| CSN16524 | SC-514 | 354812-17-2 | SC514 is a potent, reversible, ATP-competitive and highly selective IKK-(IKK-2) inhibitor with IC50 value ranging in 3-12 M. |
| CSN17016 | Resveratrol | 501-36-0 | Resveratrol is one of the numerous polyphenolic compounds found in several vegetal sources, has a wide spectrum of targets with IC50 of 0.8, 1, 3.3 and 5 M for Adenylyl cyclase, IKK, DNA polymerase and , respectively. |
| CSN26927 | Resveratrol analog 2 | 915378-82-4 | Resveratrol analog 2 is an analog of Resveratrol (HY-16561). Resveratrol is a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties[1]. |
| CSN25345 | TBK1/IKKε-IN-5 | 1893397-65-3 | QUN97653 is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively. |
| CSN18270 | PS-1145 | 431898-65-6 | PS-1145 is an IkappaB kinase (IKK) inhibitor with IC50 of 88 nM. |
| CSN23053 | PS-1145 dihydrochloride | 1049743-58-9 | PS 1145 2HCl is a selective IκB kinase (IKK) inhibitor with IC50 of 100 nM. |
| CSN12718 | PHA 408 | 503555-55-3 | PHA-408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50 40 nM). |
| CSN23035 | (Rac)-PF-184 | 1187460-81-6 | PF-184 is a potent and selective IKKβ inhibitor with IC50 of 37 nM. |
| CSN17538 | MRT67307 | 1190378-57-4 | MRT67307 is a dual inhibitor of the IKKe and TBK-1. |
| CSN19224 | MRT67307 hydrochloride | 2095432-39-4 | MRT67307 HCl is a potent and dual IKKε and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. |
| CSN13105 | MLN120B | 783348-36-7 | MLN120B is a potent and effective IKKbeta inhibitor. |
| CSN18625 | LY2409881 | 946518-61-2 | LY2409881 is a selective inhibitor of IKK2 with IC50 of 30 nM and IC50 for IKK1 and other common kinases is at least one log higher. |
| CSN16201 | LY2409881 trihydrochloride | 946518-60-1 | LY2409881 3HCl is a selective inhibitor of IKK2 with IC50 of 30 nM and IC50 for IKK1 and other common kinases is at least one log higher. |
| CSN16069 | IMD-0354 | 978-62-1 | IMD-0354 is a synthetic selective NF-kB inhibitor and blocks IB phosphorylation in NF-B pathway. |
| CSN16345 | TBK1/IKKε-IN-2 | 1292310-49-6 | IKK-IN-1 is a potent IKK inhibitor. It inhibits the in-situ K -mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM. |
| CSN18487 | GSK319347A | 862812-98-4 | IKK-3 inhibitor is a potent and selective inhibitor of IKK-epsilon kinase with IC50 of 40 nM and is inactive at IKK- and IKK-. |
| CSN16585 | IKK 16 | 873225-46-8 | IKK 16 is a selective IB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. |
| CSN22855 | IKK 16 hydrochloride | 1186195-62-9 | IKK 16 HCl is a selective inhibitor of IκB kinase (IKK) with IC50s of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively. |
| CSN24084 | GSK8612 | 2361659-62-1 | GSK8612 is a potent and highly selective Tank-binding Kinase-1 (TBK1) inhibitor with pIC50 of 6.8 for recombinant TBK1. |
| CSN27231 | GS143 | 916232-21-8 | GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit proteasome activity. GS143 has anti-asthma effect . |
| CSN12711 | BX795 | 702675-74-9 | BX795 is a potent and selective dual inhibitor of TBK1PDK1 with IC50s of 2 nM6 nM respectively also inhibit Aurora B and IB kinase IKK |
| CSN16421 | BMS-345541 hydrochloride | 547757-23-3 | BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 M and 4 M, respectively. |
| CSN16667 | BMS-345541 | 445430-58-0 | BMS-345541 dose-dependently inhibits the TNF-α-stimulated phosphorylation of IκBα in THP-1 monocytic cells with an IC50 of ~4 μM. |
| CSN18641 | BI605906 | 960293-88-3 | BI-605906, an inhibitor of IKK, inhibits IKK with an IC50 value of 380 nM when assayed at 0.1 mM ATP. |
| CSN26685 | BAY-985 | 2409479-29-2 | BAY-985 is a potent and selective TBK1/IKKε Inhibitor. BAY-985 inhibits the cellular phosphorylation of interferon regulatory factor 3 and displays antiproliferative efficacy in the melanoma cell line SK-MEL-2 but showed only weak antitumor activity in the SK-MEL-2 human melanoma xenograft model. |
| CSN16657 | Bay 65-1942 (R form) | 758683-21-5 | Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKK kinase. |
| CSN18352 | Bay 65-1942 free base | 600734-02-9 | Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKK kinase. |
| CSN16628 | Bay 65-1942 hydrochloride | 600734-06-3 | Bay 65-1942 HCl is an ATP-competitive inhibitor that selectively targets IKKβ kinase. |
| CSN13625 | BAY 11-7085 | 196309-76-9 | BAY 11-7085 is an irreversible inhibitor of TNF-induced IB phosphorylation with IC50 of 10 M. |
| CSN13487 | BAY 11-7082 | 19542-67-7 | BAY 11-7082 is a NF-B inhibitor, inhibits TNF-induced IB phosphorylation with IC50 of 10 M in tumor cells. It also inhibits components of the ubiquitin system through inactivating the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13 and UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex). |
| CSN12997 | Bardoxolone | 218600-44-3 | Bardoxolone is a nuclear regulator factor (Nrf-2) activator. |
| CSN17947 | AZD3264 | 1609281-86-8 | AZD3264 is an IkB-kinase IKK2 Inhibitor. IKK2 has been identified as one of the pathways to treat inflammatory conditions such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis. |
| CSN12359 | Amlexanox | 68302-57-8 | Amlexanox is a selective inhibitor of TBK1 and IKK with IC50 values of 1-2 M. |
| CSN13573 | ACHP Hydrochloride | 406209-26-5 | ACHP HCl is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM. |
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