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IKK
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN15918 | WS3 | 1421227-52-2 | WS3 is an Erb3 binding protein-1 (EBP1) and IB kinase pathway modulator, its a non-specific proliferative molecule and promotes cell proliferation with EC50 of 28 nM. |
| CSN13432 | TPCA-1 | 507475-17-4 | TPCA-1 is a selective and potent IKK- inhibitor with IC50 value of 17.9 nM. |
| CSN16524 | SC514 | 354812-17-2 | SC514 is a potent, reversible, ATP-competitive and highly selective IKK-(IKK-2) inhibitor with IC50 value ranging in 3-12 M. |
| CSN25345 | QUN97653 | 1893397-65-3 | QUN97653 is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively. |
| CSN16069 | IMD-0354 | 978-62-1 | IMD-0354 is a synthetic selective NF-kB inhibitor and blocks IB phosphorylation in NF-B pathway. |
| CSN16345 | IKKε-IN-1 | 1292310-49-6 | IKK-IN-1 is a potent IKK inhibitor. It inhibits the in-situ K -mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM. |
| CSN22855 | IKK 16 HCl | 1186195-62-9 | IKK 16 HCl is a selective inhibitor of IκB kinase (IKK) with IC50s of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively. |
| CSN27231 | GS143 | 916232-21-8 | GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit proteasome activity. GS143 has anti-asthma effect . |
| CSN12711 | BX795 | 702675-74-9 | BX795 is a potent and selective dual inhibitor of TBK1PDK1 with IC50s of 2 nM6 nM respectively also inhibit Aurora B and IB kinase IKK |
| CSN16657 | BAY 65-1942 R Form | 758683-21-5 | Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKK kinase. |
| CSN18352 | BAY 65-1942 | 600734-02-9 | Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKK kinase. |
| CSN13625 | BAY 11-7085 | 196309-76-9 | BAY 11-7085 is an irreversible inhibitor of TNF-induced IB phosphorylation with IC50 of 10 M. |
| CSN13487 | BAY 11-7082 | 19542-67-7 | BAY 11-7082 is a NF-B inhibitor, inhibits TNF-induced IB phosphorylation with IC50 of 10 M in tumor cells. It also inhibits components of the ubiquitin system through inactivating the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13 and UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex). |
| CSN12997 | Bardoxolone | 218600-44-3 | Bardoxolone is a nuclear regulator factor (Nrf-2) activator. |
| CSN17947 | AZD3264 | 1609281-86-8 | AZD3264 is an IkB-kinase IKK2 Inhibitor. IKK2 has been identified as one of the pathways to treat inflammatory conditions such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis. |
| CSN12359 | Amlexanox | 68302-57-8 | Amlexanox is a selective inhibitor of TBK1 and IKK with IC50 values of 1-2 M. |
| CSN13573 | ACHP HCl | 406209-26-5 | ACHP HCl is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM. |
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