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IKK

IKK

Cat. No. Product Name CAS No. Information
CSN16939 WS6 1421227-53-3 WS6 is a small molecule that promotes β cell proliferation in rodent and human primary islets with EC50 of 0.28 μM (R7T1 cell viability). WS6 also stimulates α cell proliferation in human pancreatic islets. WS6 appears to act by inhibiting IKKε and blocking the ability of EBP1 to suppress E2F-medtiated transcription.
CSN15918 WS3 1421227-52-2 WS3 is an Erb3 binding protein-1 (EBP1) and IB kinase pathway modulator, its a non-specific proliferative molecule and promotes cell proliferation with EC50 of 28 nM.
CSN13432 TPCA-1 507475-17-4 TPCA-1 is a selective and potent IKK- inhibitor with IC50 value of 17.9 nM.
CSN20031 (Z)-Orantinib 210644-62-5 SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFR, VEGFR2 (Flk-1KDR), FGFR1 activity in vitro (IC50 0.01, 0.1, 3.9, and 3.8 M, respectively) and PDGFVEGFbFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target serthr kinases Aurora A, Aurora B, TBK1 (NAKT2K), and AMPK (IC50 0.85, 0.047, 1.4, and 1.8 M, respectively), as well as non-receptor TKs Lyn and Yes (IC50 4.3 and 5.8 M, respectively).
CSN16524 SC-514   354812-17-2 SC514 is a potent, reversible, ATP-competitive and highly selective IKK-(IKK-2) inhibitor with IC50 value ranging in 3-12 M.
CSN17016 Resveratrol   501-36-0 Resveratrol is one of the numerous polyphenolic compounds found in several vegetal sources, has a wide spectrum of targets with IC50 of 0.8, 1, 3.3 and 5 M for Adenylyl cyclase, IKK, DNA polymerase and , respectively.
CSN26927 Resveratrol analog 2 915378-82-4 Resveratrol analog 2 is an analog of Resveratrol (HY-16561). Resveratrol is a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties[1].
CSN25345 TBK1/IKKε-IN-5 1893397-65-3 QUN97653 is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively.
CSN18270 PS-1145 431898-65-6 PS-1145 is an IkappaB kinase (IKK) inhibitor with IC50 of 88 nM.
CSN23053 PS-1145 dihydrochloride 1049743-58-9 PS 1145 2HCl is a selective IκB kinase (IKK) inhibitor with IC50 of 100 nM.
CSN12718 PHA 408 503555-55-3 PHA-408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50 40 nM).
CSN23035 (Rac)-PF-184 1187460-81-6 PF-184 is a potent and selective IKKβ inhibitor with IC50 of 37 nM.
CSN17538 MRT67307 1190378-57-4 MRT67307 is a dual inhibitor of the IKKe and TBK-1.
CSN19224 MRT67307 hydrochloride 2095432-39-4 MRT67307 HCl is a potent and dual IKKε and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively.
CSN13105 MLN120B 783348-36-7 MLN120B is a potent and effective IKKbeta inhibitor.
CSN18625 LY2409881 946518-61-2 LY2409881 is a selective inhibitor of IKK2 with IC50 of 30 nM and IC50 for IKK1 and other common kinases is at least one log higher.
CSN16201 LY2409881 trihydrochloride   946518-60-1 LY2409881 3HCl is a selective inhibitor of IKK2 with IC50 of 30 nM and IC50 for IKK1 and other common kinases is at least one log higher.
CSN16069 IMD-0354 978-62-1 IMD-0354 is a synthetic selective NF-kB inhibitor and blocks IB phosphorylation in NF-B pathway.
CSN16345 TBK1/IKKε-IN-2 1292310-49-6 IKK-IN-1 is a potent IKK inhibitor. It inhibits the in-situ K -mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM.
CSN18487 GSK319347A 862812-98-4 IKK-3 inhibitor is a potent and selective inhibitor of IKK-epsilon kinase with IC50 of 40 nM and is inactive at IKK- and IKK-.
CSN16585 IKK 16 873225-46-8 IKK 16 is a selective IB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
CSN22855 IKK 16 hydrochloride 1186195-62-9 IKK 16 HCl is a selective inhibitor of IκB kinase (IKK) with IC50s of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively.
CSN24084 GSK8612 2361659-62-1 GSK8612 is a potent and highly selective Tank-binding Kinase-1 (TBK1) inhibitor with pIC50 of 6.8 for recombinant TBK1.
CSN27231 GS143   916232-21-8 GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup­presses NF-κB activation and transcription of target genes and does not inhibit proteasome activity. GS143 has anti-asthma effect .
CSN12711 BX795   702675-74-9 BX795 is a potent and selective dual inhibitor of TBK1PDK1 with IC50s of 2 nM6 nM respectively also inhibit Aurora B and IB kinase IKK
CSN16421 BMS-345541 hydrochloride 547757-23-3 BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 M and 4 M, respectively.
CSN16667 BMS-345541 445430-58-0 BMS-345541 dose-dependently inhibits the TNF-α-stimulated phosphorylation of IκBα in THP-1 monocytic cells with an IC50 of ~4 μM.
CSN18641 BI605906 960293-88-3 BI-605906, an inhibitor of IKK, inhibits IKK with an IC50 value of 380 nM when assayed at 0.1 mM ATP.
CSN26685 BAY-985 2409479-29-2 BAY-985 is a potent and selective TBK1/IKKε Inhibitor. BAY-985 inhibits the cellular phosphorylation of interferon regulatory factor 3 and displays antiproliferative efficacy in the melanoma cell line SK-MEL-2 but showed only weak antitumor activity in the SK-MEL-2 human melanoma xenograft model.
CSN16657 Bay 65-1942 (R form) 758683-21-5 Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKK kinase.
CSN18352 Bay 65-1942 free base 600734-02-9 Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKK kinase.
CSN16628 Bay 65-1942 hydrochloride 600734-06-3 Bay 65-1942 HCl is an ATP-competitive inhibitor that selectively targets IKKβ kinase.
CSN13625 BAY 11-7085 196309-76-9 BAY 11-7085 is an irreversible inhibitor of TNF-induced IB phosphorylation with IC50 of 10 M.
CSN13487 BAY 11-7082   19542-67-7 BAY 11-7082 is a NF-B inhibitor, inhibits TNF-induced IB phosphorylation with IC50 of 10 M in tumor cells. It also inhibits components of the ubiquitin system through inactivating the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13 and UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex).
CSN12997 Bardoxolone 218600-44-3 Bardoxolone is a nuclear regulator factor (Nrf-2) activator.
CSN17947 AZD3264 1609281-86-8 AZD3264 is an IkB-kinase IKK2 Inhibitor. IKK2 has been identified as one of the pathways to treat inflammatory conditions such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis.
CSN12359 Amlexanox   68302-57-8 Amlexanox is a selective inhibitor of TBK1 and IKK with IC50 values of 1-2 M.
CSN13573 ACHP Hydrochloride 406209-26-5 ACHP HCl is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM.
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