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IGF-1R
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN18544 | XL228 | 898280-07-4 | XL228 is a protein kinase inhibitor targeting IGF1R the Aurora kinases FGFR1-3 ABL and SRC family kinases |
| CSN13582 | PQ401 | 196868-63-0 | PQ401 a selective insulin-like growth factor-1 receptor blocker is a diarylurea compound that inhibits IGF1R autophosphorylation with IC50 1 M |
| CSN16148 | Picropodophyllin | 477-47-4 | Picropodophyllotoxin is an orally active insulin-like growth factor-1 receptor (IGF-1R) inhibitor with IC50 of 1 nM, and exhibits little effect towards IR, FGFR, PDGFR and EGFR, and exerts no effects on microtubules and DNA topoisomerase II. |
| CSN18292 | NVP-AEW541 | 475489-16-8 | NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM 27-fold greater selectivity for IGF-1R than InsR |
| CSN16546 | NVP-ADW742 | 475488-23-4 | NVP-ADW742 is an selective IGF-1R inhibitor with IC50 of 0.17 M, 16-fold more potent against IGF-1R than InsR and shows little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit. |
| CSN15820 | NT157 | 1384426-12-3 | NT157 treatment resulted in dose-dependent inhibition of IGF1R activation, suppression of IRS protein expression, inhibition of IGF1-induced AKT activation, but increased ERK activation in NT157-treated cells in vitro. |
| CSN16044 | Linsitinib | 867160-71-2 | Linsitinib is highly potent orally efficacious and highly selective dual ATP-competitive inhibitor of IGF-1R IC50 35 nM and insulin receptor IC5075 nM |
| CSN17454 | GSK1904529A | 1089283-49-7 | GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM being 100-fold selective for IGF-1RInsR than Akt12 Aurora ABB-Raf CDK2 EGFR etc |
| CSN16594 | GSK1838705A | 1116235-97-2 | GSK1838705A is a potent small-molecule IGF-IR the insulin receptor and anaplastic lymphoma kinase ALK inhibitor with IC50 of 20 16 and 05 nM respectively |
| CSN18056 | Ginsenoside Rg5 | 186763-78-0 | Ginsenoside Rg5 is a natural product isolated and purified from the roots of Panax ginseng C. A. Mey. showing anti-inflammatory effect. |
| CSN15865 | BMS-754807 | 1001350-96-4 | BMS-754807 is a potent and reversible inhibitor of IGF-1RInsR with IC50 of 18 nM17 nM less potent to Met Aurora AB TrkAB and Ron and shows little activity to Flt3 Lck MK2 PKA PKC etc |
| CSN21409 | AZ7550 Mesylate | N/A | AZ7550 Mesylate is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 16 M |
| CSN13710 | AG1024 | 65678-07-1 | AG1024 inhibits IGF-1R autophosphorylation with IC50 of 7 M, less potent to IR with IC50 of 57 M. |
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