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IGF-1R

IGF-1R

Cat. No. Product Name CAS No. Information
CSN18544 XL228 898280-07-4 XL228 is a protein kinase inhibitor targeting IGF1R the Aurora kinases FGFR1-3 ABL and SRC family kinases
CSN13582 PQ401 196868-63-0 PQ401 a selective insulin-like growth factor-1 receptor blocker is a diarylurea compound that inhibits IGF1R autophosphorylation with IC50 1 M
CSN16148 Picropodophyllin   477-47-4 Picropodophyllotoxin is an orally active insulin-like growth factor-1 receptor (IGF-1R) inhibitor with IC50 of 1 nM, and exhibits little effect towards IR, FGFR, PDGFR and EGFR, and exerts no effects on microtubules and DNA topoisomerase II.
CSN18292 NVP-AEW541 475489-16-8 NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM 27-fold greater selectivity for IGF-1R than InsR
CSN16546 NVP-ADW742 475488-23-4 NVP-ADW742 is an selective IGF-1R inhibitor with IC50 of 0.17 M, 16-fold more potent against IGF-1R than InsR and shows little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.
CSN16044 Linsitinib   867160-71-2 Linsitinib is highly potent orally efficacious and highly selective dual ATP-competitive inhibitor of IGF-1R IC50 35 nM and insulin receptor IC5075 nM
CSN17454 GSK1904529A 1089283-49-7 GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM being 100-fold selective for IGF-1RInsR than Akt12 Aurora ABB-Raf CDK2 EGFR etc
CSN16594 GSK1838705A 1116235-97-2 GSK1838705A is a potent small-molecule IGF-IR the insulin receptor and anaplastic lymphoma kinase ALK inhibitor with IC50 of 20 16 and 05 nM respectively
CSN15865 BMS-754807 1001350-96-4 BMS-754807 is a potent and reversible inhibitor of IGF-1RInsR with IC50 of 18 nM17 nM less potent to Met Aurora AB TrkAB and Ron and shows little activity to Flt3 Lck MK2 PKA PKC etc
CSN21409 AZ7550 Mesylate N/A AZ7550 Mesylate is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 16 M
CSN13710 AG1024 65678-07-1 AG1024 inhibits IGF-1R autophosphorylation with IC50 of 7 M, less potent to IR with IC50 of 57 M.
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