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IAP
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN16489 | UC-112 | 383392-66-3 | UC-112 is a potent IAP Inhibitor of apoptosis inhibitor and potently inhibits cell growth in two human melanoma A375 and M14 and two human prostate PC-3 and DU145 cancer cell lines IC5007-34 M |
| CSN18637 | SM-164 | 957135-43-2 | SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 056 nM and binds to cIAP-1 and cIAP-2 proteins with Ki values of 031 and 11 nM respectively |
| CSN17158 | LCL161 | 1005342-46-0 | LCL161 is an IAP inhibitor inhibits XIAP activity in HEK293 cell with IC50 of 35 nM also inhibits cIAP1 activity in MDA-MB-231 cell with IC50 of 04 nM |
| CSN18513 | GDC-0152 | 873652-48-3 | GDC-0152 is a potent inhibitor of IAPs and binds to the XIAP BIR3 domain the BIR domain of ML-IAP and the BIR3 domains of cIAP1 and cIAP2 with K i values of 28 14 17 and 43 nM respectively |
| CSN10903 | Embelin | 550-24-3 | Embelin, a quinone isolated from the Japanese Ardisia herb, is an inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 M in a cell-free assay. |
| CSN17869 | CUDC-427 | 1446182-94-0 | CUDC-427 is a small-molecule peptide mimetic of SMACDIABLO and directly antagonizes inhibitors of apoptosis proteins IAPs |
| CSN17381 | BV6 | 1001600-56-1 | BV6 is a small-molecule Smac mimetic which antagonizes IAP and induces autoubiquitination and subsequent proteasomal degradation of cIAP1 and cIAP2 |
| CSN19202 | BV-6 Trifluoroacetate | N/A | BV-6 trifluoroacetate is a SMAC mimetic dual cIAP and XIAP inhibitor |
| CSN17636 | Birinapant | 1260251-31-7 | Birinapant binds with XIAP and cIAP1 with K of 45 and <1 nM, respectively. |
| CSN17633 | AZD5582 | 1258392-53-8 | AZD5582 is a class of dimeric Smac mimetics as potent IAP antagonist and binds potently to the BIR3 domains of cIAP1 cIAP2 and XIAP IC50 15 21 and 15 nM respectively |
| CSN15873 | Xevinapant | 1071992-99-8 | AT406 is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs), AT-406 binds to XIAP, cIAP1, and cIAP2 proteins with K (i) of 66.4, 1.9, and 5.1 nM, respectively. |
| CSN20155 | XIAP/cIAP1 antagonist-1 | 1403898-55-4 | AT-IAP is a potent orally bioavailable dual antagonist of XIAP and cIAP1 which is functioning in anti-apoptotic and pro-survival signaling pathways |
| CSN21085 | ASTX660 | 1799328-86-1 | An orally bioavailable, non-peptidomimetic antagonist of both X chromosome-linked inhibitor of apoptosis protein (XIAP) and cellular IAP 1 (cIAP1), with potential antineoplastic and pro-apoptotic activities. |
| CSN28738 | cIAP1 ligand 2 | 2357114-70-4 |
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