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IAP

IAP

Cat. No. Product Name CAS No. Information
CSN16489 UC-112 383392-66-3 UC-112 is a potent IAP Inhibitor of apoptosis inhibitor and potently inhibits cell growth in two human melanoma A375 and M14 and two human prostate PC-3 and DU145 cancer cell lines IC5007-34 M
CSN18637 SM-164 957135-43-2 SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 056 nM and binds to cIAP-1 and cIAP-2 proteins with Ki values of 031 and 11 nM respectively
CSN10903 Embelin   550-24-3 Embelin, a quinone isolated from the Japanese Ardisia herb, is an inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 M in a cell-free assay.
CSN17381 BV-6 1001600-56-1 BV6 is a small-molecule Smac mimetic which antagonizes IAP and induces autoubiquitination and subsequent proteasomal degradation of cIAP1 and cIAP2
CSN17633 AZD5582 1258392-53-8 AZD5582 is a class of dimeric Smac mimetics as potent IAP antagonist and binds potently to the BIR3 domains of cIAP1 cIAP2 and XIAP IC50 15 21 and 15 nM respectively
CSN15873 AT406 1071992-99-8 AT406 is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs), AT-406 binds to XIAP, cIAP1, and cIAP2 proteins with K (i) of 66.4, 1.9, and 5.1 nM, respectively.
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