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IAP

IAP

Cat. No. Product Name CAS No. Information
CSN16489 UC-112 383392-66-3 UC-112 is a potent IAP Inhibitor of apoptosis inhibitor and potently inhibits cell growth in two human melanoma A375 and M14 and two human prostate PC-3 and DU145 cancer cell lines IC5007-34 M
CSN18637 SM-164 957135-43-2 SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 056 nM and binds to cIAP-1 and cIAP-2 proteins with Ki values of 031 and 11 nM respectively
CSN17158 LCL161 1005342-46-0 LCL161 is an IAP inhibitor inhibits XIAP activity in HEK293 cell with IC50 of 35 nM also inhibits cIAP1 activity in MDA-MB-231 cell with IC50 of 04 nM
CSN18513 GDC-0152 873652-48-3 GDC-0152 is a potent inhibitor of IAPs and binds to the XIAP BIR3 domain the BIR domain of ML-IAP and the BIR3 domains of cIAP1 and cIAP2 with K i values of 28 14 17 and 43 nM respectively
CSN10903 Embelin   550-24-3 Embelin, a quinone isolated from the Japanese Ardisia herb, is an inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 M in a cell-free assay.
CSN17869 CUDC-427 1446182-94-0 CUDC-427 is a small-molecule peptide mimetic of SMACDIABLO and directly antagonizes inhibitors of apoptosis proteins IAPs
CSN17381 BV-6 1001600-56-1 BV6 is a small-molecule Smac mimetic which antagonizes IAP and induces autoubiquitination and subsequent proteasomal degradation of cIAP1 and cIAP2
CSN19202 BV-6 Trifluoroacetate N/A BV-6 trifluoroacetate is a SMAC mimetic dual cIAP and XIAP inhibitor
CSN17633 AZD5582 1258392-53-8 AZD5582 is a class of dimeric Smac mimetics as potent IAP antagonist and binds potently to the BIR3 domains of cIAP1 cIAP2 and XIAP IC50 15 21 and 15 nM respectively
CSN15873 AT406 1071992-99-8 AT406 is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs), AT-406 binds to XIAP, cIAP1, and cIAP2 proteins with K (i) of 66.4, 1.9, and 5.1 nM, respectively.
CSN20155 AT-IAP 1403898-55-4 AT-IAP is a potent orally bioavailable dual antagonist of XIAP and cIAP1 which is functioning in anti-apoptotic and pro-survival signaling pathways
CSN21085 ASTX660 1799328-86-1
CSN17636 Birinapant 1260251-31-7
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