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HSP

HSP

Cat. No. Product Name CAS No. Information
CSN27850 YUM70 423145-35-1 YUM70 is a GRP78 inhibitor with IC50 value of 1.5μM and resulted in ER stress-mediated apoptosis. It inhibited pancreatic cancer cell growth in vitro and showed in vivo efficacy in a pancreatic cancer xenograft model with no toxicity to normal tissues.
CSN20345 TRC051384 867164-40-7 TRC051384 is a inducer of Hsp70
CSN20344 TRC051384 HCl   1333327-56-2 TRC051384 HCl is a potent inducer of HSP70 which can induce HSP70B mRNA expression.
CSN12051 Teprenone   6809-52-5 Teprenone is used as an anti-ulcer drug, a cardioprotective agent, a hepatoprotective agent, a nephroprotective agent, a neuroprotective agent and a Hsp70 inducer.
CSN22232 Pimitespib 1260533-36-5 TAS-116 is a potent and selective HSP90 inhibitor with Kis of 347 nM 213 nM respectively
CSN18943 PU-H 71 HCl 2095432-24-7 PU-H71 HCl is a potent Hsp90 inhibitor with IC50 of 50 nM.
CSN32496 PEN-866 1472614-83-7 PEN-866 is a novel esterase-cleavable conjugate of an HSP90i and a topoisomerase I inhibitor.
CSN12794 Palmitic acid   57-10-3 Palmitic acid, a natural product isolated and purified from the herbs of Atractylodes macrocephala Koidz., induces down-regulation of APOM expression and anxiety-like behavior in mice while increasing amygdala-based serotonin metabolism. Palmitic acid has a significant impact on proliferation and differentiation of NSCs in vitro and may be useful for elucidating the role of SFAs in regulating NSCs fate in physiological and pathological settings.Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
CSN32424 (2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone (S)-2-hydroxypropanoate 1019889-35-0 Onalespib lactate is a second-generation, potent and selective HSP90 Inhibitor.
CSN21425 MKT-077   147366-41-4 MKT-077 FJ-776 is a water-soluble rhodacyanine dye with antitumor activity It can bind to Hsp70 family member mortalin-2 and inhibit its interactions with p53
CSN22600 JG-98 1456551-16-8 JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor which shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages.
CSN32437 Icapamespib 1000999-96-1 Icapamespib is a heat shock protein 90 (HSP90) inhibitor.
CSN22089 HSP70-IN-1 1268273-90-0 HSP70-IN-1 is a heat shock protein (HSP) inhibitor.
CSN26677 HM03 500565-15-1 HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity[1].
CSN19076 HA15   1609402-14-3 HA15 is a molecule that targets specifically BiPGRP78HSPA5. HA15 displays anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.
CSN24783 Grp94 Inhibitor-1 2234897-35-7 Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α[1].
CSN13554 Eupalinolide B 877822-41-8 Eupalinolide A is a natural product isolated and purified from the herbs of Eupatorium lindleyanum DC.
CSN22799 EC144 911397-80-3 EC 144 is a high affinity, potent and selective Hsp90 inhibitor with Ki of 0.2 nM and IC50 of 1.1 nM.
CSN13532 Dihydroberberine 483-15-8 Dihydroberberine, a natural product isolated and purified from the tubers of Corydalis decumbens (Thunb.) Pers., has anti-tumor activity. Dihydroberberine improves in vivo efficacy in terms of counteracting increased adiposity, tissue triglyceride accumulation, and insulin resistance in high-fat-fed rodents, thus is potential therapeutic reagents for type 2 diabetes treatment.
CSN18944 Debio 0932 1061318-81-7 Debio 0932 is a heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L).
CSN27185 Col003   328565-16-8 Col003 is a cell penetrant, selective and potent inhibitor of the interaction of Hsp47 with collagen. Col003 is the cleavage product of AK778.It competitively inhibited the interaction and caused the inhibition of collagen secretion by destabilizing the collagen triple helix.
CSN19190 CH5138303 959763-06-5 CH5138303 is an orally available Hsp90 inhibitor with Kd of 048 nM
CSN22743 CCT018159 171009-07-7 CCT 018159 is a novel inhibitor of heat shock protein 90 (Hsp90) ATPase activity with IC50 of 5.7 μM.
CSN22011 Bimoclomol 130493-03-7 Bimoclomol is a heat shock protein coinducer, used for treatment of cardiovascular diseases.
CSN12421 Luminespib 747412-49-3 AUY922 is a highly potent HSP90 inhibitor for HSP90 with IC50 of 13 nM 21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1.
CSN26679 AMP-PCP 3469-78-1 AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90[1].
CSN17209 Tanespimycin 75747-14-7 17-AAG is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells.
CSN27737 HSP27 inhibitor J2 2133499-85-9
CSN28855 KBU2046 1143863-69-7
CSN33105 DDO-5936 2355377-13-6
CSN41771 AMP-PCP disodium 7414-56-4
CSN42078 Conglobatin 72263-05-9
CSN50103 KU-32 956498-70-7
CSN73281 SNX-0723 1073969-18-2
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