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HSP

HSP

Cat. No. Product Name CAS No. Information
CSN16304 XL888 1149705-71-4 XL888 is a specific and ATP-competitive Hsp90 inhibitor with IC50 of 24 nM
CSN13596 VER-50589 747413-08-7 VER-50589 is an isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM
CSN18335 VER-49009 558640-51-0 VER-49009 is a pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM
CSN13116 VER-155008 1134156-31-2 VER-155008 is a potent Hsp70 family inhibitor with IC50 of 05 M 26 M and 26 M in cell-free assays for HSP70 HSC70 and GRP78 respectively 100-fold selectivity over HSP90
CSN20345 TRC051384 867164-40-7 TRC051384 is a inducer of Hsp70
CSN20344 TRC051384 HCl   1333327-56-2 TRC051384 HCl is a potent inducer of HSP70 which can induce HSP70B mRNA expression.
CSN12051 Teprenone   6809-52-5 Teprenone is used as an anti-ulcer drug, a cardioprotective agent, a hepatoprotective agent, a nephroprotective agent, a neuroprotective agent and a Hsp70 inducer.
CSN22232 TAS-116 1260533-36-5 TAS-116 is a potent and selective HSP90 inhibitor with Kis of 347 nM 213 nM respectively
CSN16517 SNX-2112 908112-43-6 SNX-2112 is a potent synthetic heat shock protein 90 HSP90 inhibitor with an IC50 of 092 M for K562 cells
CSN18481 Retaspimycin 857402-23-4 Retaspimycin is a small-molecule inhibitor of heat shock protein 90 HSP90 with antiproliferative and antineoplastic activities
CSN18482 Retaspimycin HCl 857402-63-2 Retaspimycin HCl is the HCl salt of a small-molecule inhibitor of heat shock protein 90 (HSP90) with antiproliferative and antineoplastic activities.
CSN15760 PU-WS13 1454619-14-7 PU-WS13 is a potent Grp94-specific Hsp90 inhibitor of the purine scaffold class
CSN16046 PU-H 71 873436-91-0 PU-H71 is a potent Hsp90 inhibitor with IC50 of 50 nM
CSN18943 PU-H 71 HCl 2095432-24-7 PU-H71 HCl is a potent Hsp90 inhibitor with IC50 of 50 nM.
CSN11740 Platycodin D 58479-68-8 Platycodin D is a natural product isolated and purified from the root of Platycodon grandiflorum., which may stimulate TNF- synthesis or inhibit degradation of TNF- mRNA, and is an Hsp90 inhibitor which disrupting the co-chaperone interaction of Hsp90cell division cycle protein 37 (Cdc37) and subsequently degrading multiple Hsp90 client proteins without the feedback increase of Hsp70.
CSN17514 PF-04929113 Mesylate 1173111-67-5 PF-04929113 mesylate is a potent and selective Hsp90 inhibitor with an IC50 of median 50 nM
CSN16541 PF-04929113 908115-27-5 PF-04929113 is a potent and selective HSP90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM
CSN15852 HSP990 934343-74-5 NVP-HSP990 is a potent and selective HSP90 inhibitor for HSP90 with IC50 of 06 nM08 nM
CSN17190 NVP-BEP800 847559-80-2 NVP-BEP800 is a fully synthetic HSP90 inhibitor with IC50 of 58 nM exhibits 70-fold selectivity against Hsp90 family members Grp94 and Trap-1
CSN16765 NMS-E973 1253584-84-7 NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of 10 nM for Hsp90 binding no activiy against a panel of 52 diverse protein kinases
CSN17387 ML346 100872-83-1 ML346 is an activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay
CSN21425 MKT-077   147366-41-4 MKT-077 FJ-776 is a water-soluble rhodacyanine dye with antitumor activity It can bind to Hsp70 family member mortalin-2 and inhibit its interactions with p53
CSN22959 Macbecin I 73341-72-7 Macbecin I is a Hsp90 inhibitor with IC50 of 2 μM.
CSN16562 KW-2478 819812-04-9 KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 38 nM
CSN18942 KRIBB11 342639-96-7 KRIBB11 is an inhibitor of heat shock factor HSF inhibitor with IC50 of 12 M
CSN15324 Kongensin A 885315-96-8 Kongensin A, a natural product isolated and purified from the herbs of Croton cascarilloides, is an effective heat shock protein 90 (HSP90) inhibitor that has potential anti-necroptosis and anti-inflammation applications.
CSN17321 KNK437   218924-25-5 KNK437 is a pan-HSP inhibitor which inhibits the synthesis of inducible HSPs including HSP105 HSP72 and HSP40
CSN22600 JG98 1456551-16-8 JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor which shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages.
CSN22089 HSP70-IN-1 1268273-90-0 HSP70-IN-1 is a heat shock protein (HSP) inhibitor.
CSN19076 HA15   1609402-14-3 HA15 is a molecule that targets specifically BiPGRP78HSPA5. HA15 displays anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.
CSN24783 Grp94 Inhibitor-1 2234897-35-7 Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α[1].
CSN11085 Geldanamycin 30562-34-6 Geldanamycin is a natural existing HSP90 inhibitor with Kd of 12 M
CSN15732 Ganetespib 888216-25-9 Ganetespib is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells
CSN13554 Eupalinolide B 877822-41-8 Eupalinolide A is a natural product isolated and purified from the herbs of Eupatorium lindleyanum DC.
CSN12347 Elesclomol 488832-69-5 Elesclomol an inhibitor of HSP90 is a potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells
CSN22799 EC 144 911397-80-3 EC 144 is a high affinity, potent and selective Hsp90 inhibitor with Ki of 0.2 nM and IC50 of 1.1 nM.
CSN13532 Dihydroberberine 483-15-8 Dihydroberberine, a natural product isolated and purified from the tubers of Corydalis decumbens (Thunb.) Pers., has anti-tumor activity. Dihydroberberine improves in vivo efficacy in terms of counteracting increased adiposity, tissue triglyceride accumulation, and insulin resistance in high-fat-fed rodents, thus is potential therapeutic reagents for type 2 diabetes treatment.
CSN27185 Col003   328565-16-8 Col003 is a cell penetrant, selective and potent inhibitor of the interaction of Hsp47 with collagen. Col003 is the cleavage product of AK778.It competitively inhibited the interaction and caused the inhibition of collagen secretion by destabilizing the collagen triple helix.
CSN19190 CH5138303 959763-06-5 CH5138303 is an orally available Hsp90 inhibitor with Kd of 048 nM
CSN22743 CCT 018159 171009-07-7 CCT 018159 is a novel inhibitor of heat shock protein 90 (Hsp90) ATPase activity with IC50 of 5.7 μM.
CSN22011 Bimoclomol 130493-03-7 Bimoclomol is a heat shock protein coinducer, used for treatment of cardiovascular diseases.
CSN13441 BIIB021   848695-25-0 BIIB021 is an orally available fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 17 nM and 38 nM respectively
CSN12421 Luminespib 747412-49-3 AUY922 is a highly potent HSP90 inhibitor for HSP90 with IC50 of 13 nM 21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1.
CSN16920 Onalespib 912999-49-6 AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells displays a long duration of anti-tumor activity
CSN18941 Apoptozole   1054543-47-3 Apoptozole is an inhibitor of heat shock protein 70 HSP70 and Hsc70 It induces caspase-dependent apoptosis
CSN16172 Alvespimycin 467214-20-6 Alvespimycin is a potent, water-soluble HSP90 inhibitor with IC50 of 62 nM.
CSN18284 Alvespimycin HCl 467214-21-7 Alvespimycin HCl is a potent, water-soluble HSP90 inhibitor with IC50 of 62 nM.
CSN17209 17-AAG 75747-14-7 17-AAG is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells.
CSN18562 17-AAG HCl 911710-03-7 17-AAG HCl is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells.
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