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HSP
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN16304 | XL888 | 1149705-71-4 | XL888 is a specific and ATP-competitive Hsp90 inhibitor with IC50 of 24 nM |
| CSN13596 | VER-50589 | 747413-08-7 | VER-50589 is an isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM |
| CSN18335 | VER-49009 | 558640-51-0 | VER-49009 is a pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM |
| CSN13116 | VER-155008 | 1134156-31-2 | VER-155008 is a potent Hsp70 family inhibitor with IC50 of 05 M 26 M and 26 M in cell-free assays for HSP70 HSC70 and GRP78 respectively 100-fold selectivity over HSP90 |
| CSN20345 | TRC051384 | 867164-40-7 | TRC051384 is a inducer of Hsp70 |
| CSN20344 | TRC051384 HCl | 1333327-56-2 | TRC051384 HCl is a potent inducer of HSP70 which can induce HSP70B mRNA expression. |
| CSN12051 | Teprenone | 6809-52-5 | Teprenone is used as an anti-ulcer drug, a cardioprotective agent, a hepatoprotective agent, a nephroprotective agent, a neuroprotective agent and a Hsp70 inducer. |
| CSN22232 | TAS-116 | 1260533-36-5 | TAS-116 is a potent and selective HSP90 inhibitor with Kis of 347 nM 213 nM respectively |
| CSN16517 | SNX-2112 | 908112-43-6 | SNX-2112 is a potent synthetic heat shock protein 90 HSP90 inhibitor with an IC50 of 092 M for K562 cells |
| CSN18481 | Retaspimycin | 857402-23-4 | Retaspimycin is a small-molecule inhibitor of heat shock protein 90 HSP90 with antiproliferative and antineoplastic activities |
| CSN18482 | Retaspimycin HCl | 857402-63-2 | Retaspimycin HCl is the HCl salt of a small-molecule inhibitor of heat shock protein 90 (HSP90) with antiproliferative and antineoplastic activities. |
| CSN15760 | PU-WS13 | 1454619-14-7 | PU-WS13 is a potent Grp94-specific Hsp90 inhibitor of the purine scaffold class |
| CSN16046 | PU-H 71 | 873436-91-0 | PU-H71 is a potent Hsp90 inhibitor with IC50 of 50 nM |
| CSN18943 | PU-H 71 HCl | 2095432-24-7 | PU-H71 HCl is a potent Hsp90 inhibitor with IC50 of 50 nM. |
| CSN11740 | Platycodin D | 58479-68-8 | Platycodin D is a natural product isolated and purified from the root of Platycodon grandiflorum., which may stimulate TNF- synthesis or inhibit degradation of TNF- mRNA, and is an Hsp90 inhibitor which disrupting the co-chaperone interaction of Hsp90cell division cycle protein 37 (Cdc37) and subsequently degrading multiple Hsp90 client proteins without the feedback increase of Hsp70. |
| CSN17514 | PF-04929113 Mesylate | 1173111-67-5 | PF-04929113 mesylate is a potent and selective Hsp90 inhibitor with an IC50 of median 50 nM |
| CSN16541 | PF-04929113 | 908115-27-5 | PF-04929113 is a potent and selective HSP90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM |
| CSN15852 | HSP990 | 934343-74-5 | NVP-HSP990 is a potent and selective HSP90 inhibitor for HSP90 with IC50 of 06 nM08 nM |
| CSN17190 | NVP-BEP800 | 847559-80-2 | NVP-BEP800 is a fully synthetic HSP90 inhibitor with IC50 of 58 nM exhibits 70-fold selectivity against Hsp90 family members Grp94 and Trap-1 |
| CSN16765 | NMS-E973 | 1253584-84-7 | NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of 10 nM for Hsp90 binding no activiy against a panel of 52 diverse protein kinases |
| CSN17387 | ML346 | 100872-83-1 | ML346 is an activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay |
| CSN21425 | MKT-077 | 147366-41-4 | MKT-077 FJ-776 is a water-soluble rhodacyanine dye with antitumor activity It can bind to Hsp70 family member mortalin-2 and inhibit its interactions with p53 |
| CSN22959 | Macbecin I | 73341-72-7 | Macbecin I is a Hsp90 inhibitor with IC50 of 2 μM. |
| CSN16562 | KW-2478 | 819812-04-9 | KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 38 nM |
| CSN18942 | KRIBB11 | 342639-96-7 | KRIBB11 is an inhibitor of heat shock factor HSF inhibitor with IC50 of 12 M |
| CSN15324 | Kongensin A | 885315-96-8 | Kongensin A, a natural product isolated and purified from the herbs of Croton cascarilloides, is an effective heat shock protein 90 (HSP90) inhibitor that has potential anti-necroptosis and anti-inflammation applications. |
| CSN17321 | KNK437 | 218924-25-5 | KNK437 is a pan-HSP inhibitor which inhibits the synthesis of inducible HSPs including HSP105 HSP72 and HSP40 |
| CSN22600 | JG98 | 1456551-16-8 | JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor which shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages. |
| CSN22089 | HSP70-IN-1 | 1268273-90-0 | HSP70-IN-1 is a heat shock protein (HSP) inhibitor. |
| CSN19076 | HA15 | 1609402-14-3 | HA15 is a molecule that targets specifically BiPGRP78HSPA5. HA15 displays anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors. |
| CSN24783 | Grp94 Inhibitor-1 | 2234897-35-7 | Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α[1]. |
| CSN11085 | Geldanamycin | 30562-34-6 | Geldanamycin is a natural existing HSP90 inhibitor with Kd of 12 M |
| CSN15732 | Ganetespib | 888216-25-9 | Ganetespib is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells |
| CSN13554 | Eupalinolide B | 877822-41-8 | Eupalinolide A is a natural product isolated and purified from the herbs of Eupatorium lindleyanum DC. |
| CSN12347 | Elesclomol | 488832-69-5 | Elesclomol an inhibitor of HSP90 is a potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells |
| CSN22799 | EC 144 | 911397-80-3 | EC 144 is a high affinity, potent and selective Hsp90 inhibitor with Ki of 0.2 nM and IC50 of 1.1 nM. |
| CSN13532 | Dihydroberberine | 483-15-8 | Dihydroberberine, a natural product isolated and purified from the tubers of Corydalis decumbens (Thunb.) Pers., has anti-tumor activity. Dihydroberberine improves in vivo efficacy in terms of counteracting increased adiposity, tissue triglyceride accumulation, and insulin resistance in high-fat-fed rodents, thus is potential therapeutic reagents for type 2 diabetes treatment. |
| CSN27185 | Col003 | 328565-16-8 | Col003 is a cell penetrant, selective and potent inhibitor of the interaction of Hsp47 with collagen. Col003 is the cleavage product of AK778.It competitively inhibited the interaction and caused the inhibition of collagen secretion by destabilizing the collagen triple helix. |
| CSN19190 | CH5138303 | 959763-06-5 | CH5138303 is an orally available Hsp90 inhibitor with Kd of 048 nM |
| CSN22743 | CCT 018159 | 171009-07-7 | CCT 018159 is a novel inhibitor of heat shock protein 90 (Hsp90) ATPase activity with IC50 of 5.7 μM. |
| CSN22011 | Bimoclomol | 130493-03-7 | Bimoclomol is a heat shock protein coinducer, used for treatment of cardiovascular diseases. |
| CSN13441 | BIIB021 | 848695-25-0 | BIIB021 is an orally available fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 17 nM and 38 nM respectively |
| CSN12421 | Luminespib | 747412-49-3 | AUY922 is a highly potent HSP90 inhibitor for HSP90 with IC50 of 13 nM 21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1. |
| CSN16920 | Onalespib | 912999-49-6 | AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells displays a long duration of anti-tumor activity |
| CSN18941 | Apoptozole | 1054543-47-3 | Apoptozole is an inhibitor of heat shock protein 70 HSP70 and Hsc70 It induces caspase-dependent apoptosis |
| CSN16172 | Alvespimycin | 467214-20-6 | Alvespimycin is a potent, water-soluble HSP90 inhibitor with IC50 of 62 nM. |
| CSN18284 | Alvespimycin HCl | 467214-21-7 | Alvespimycin HCl is a potent, water-soluble HSP90 inhibitor with IC50 of 62 nM. |
| CSN17209 | 17-AAG | 75747-14-7 | 17-AAG is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. |
| CSN18562 | 17-AAG HCl | 911710-03-7 | 17-AAG HCl is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. |
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