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HSP
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN16304 | XL888 | 1149705-71-4 | XL888 is a specific and ATP-competitive Hsp90 inhibitor with IC50 of 24 nM |
| CSN13596 | VER-50589 | 747413-08-7 | VER-50589 is an isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM |
| CSN18335 | VER-49009 | 558640-51-0 | VER-49009 is a pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM |
| CSN13116 | VER-155008 | 1134156-31-2 | VER-155008 is a potent Hsp70 family inhibitor with IC50 of 05 M 26 M and 26 M in cell-free assays for HSP70 HSC70 and GRP78 respectively 100-fold selectivity over HSP90 |
| CSN20344 | TRC051384 HCl | 1333327-56-2 | TRC051384 is an inducer of heat shock protein Hsp70 it reduces stroke-associated neuronal injury and increases survival in a rat model of transient ischemic stroke and activates heat shock factor-1 and results in elevated chaperone and anti-inflammatory activity |
| CSN20345 | TRC051384 | 867164-40-7 | TRC051384 is a inducer of Hsp70 |
| CSN12051 | Teprenone | 6809-52-5 | Teprenone is used as an anti-ulcer drug, a cardioprotective agent, a hepatoprotective agent, a nephroprotective agent, a neuroprotective agent and a Hsp70 inducer. |
| CSN22232 | TAS-116 | 1260533-36-5 | TAS-116 is a potent and selective HSP90 inhibitor with Kis of 347 nM 213 nM respectively |
| CSN16517 | SNX-2112 | 908112-43-6 | SNX-2112 is a potent synthetic heat shock protein 90 HSP90 inhibitor with an IC50 of 092 M for K562 cells |
| CSN18481 | Retaspimycin | 857402-23-4 | Retaspimycin is a small-molecule inhibitor of heat shock protein 90 HSP90 with antiproliferative and antineoplastic activities |
| CSN18482 | Retaspimycin HCl | 857402-63-2 | Retaspimycin hydrochloride is the hydrochloride salt of a small-molecule inhibitor of heat shock protein 90 HSP90 with antiproliferative and antineoplastic activities |
| CSN15760 | PU-WS13 | 1454619-14-7 | PU-WS13 is a potent Grp94-specific Hsp90 inhibitor of the purine scaffold class |
| CSN16046 | PU-H 71 | 873436-91-0 | PU-H71 is a potent Hsp90 inhibitor with IC50 of 50 nM |
| CSN18943 | PU-H 71 HCl | 2095432-24-7 | PU-H71 hydrochloride is a potent Hsp90 inhibitor with IC50 of 50 nM |
| CSN17514 | PF-04929113 Mesylate | 1173111-67-5 | PF-04929113 mesylate is a potent and selective Hsp90 inhibitor with an IC50 of median 50 nM |
| CSN16541 | PF-04929113 | 908115-27-5 | PF-04929113 is a potent and selective HSP90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM |
| CSN15852 | HSP990 | 934343-74-5 | NVP-HSP990 is a potent and selective HSP90 inhibitor for HSP90 with IC50 of 06 nM08 nM |
| CSN17190 | NVP-BEP800 | 847559-80-2 | NVP-BEP800 is a fully synthetic HSP90 inhibitor with IC50 of 58 nM exhibits 70-fold selectivity against Hsp90 family members Grp94 and Trap-1 |
| CSN16765 | NMS-E973 | 1253584-84-7 | NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of 10 nM for Hsp90 binding no activiy against a panel of 52 diverse protein kinases |
| CSN17387 | ML346 | 100872-83-1 | ML346 is an activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay |
| CSN21425 | MKT-077 | 147366-41-4 | MKT-077 FJ-776 is a water-soluble rhodacyanine dye with antitumor activity It can bind to Hsp70 family member mortalin-2 and inhibit its interactions with p53 |
| CSN16562 | KW-2478 | 819812-04-9 | KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 38 nM |
| CSN18942 | KRIBB11 | 342639-96-7 | KRIBB11 is an inhibitor of heat shock factor HSF inhibitor with IC50 of 12 M |
| CSN17321 | KNK437 | 218924-25-5 | KNK437 is a pan-HSP inhibitor which inhibits the synthesis of inducible HSPs including HSP105 HSP72 and HSP40 |
| CSN11085 | Geldanamycin | 30562-34-6 | Geldanamycin is a natural existing HSP90 inhibitor with Kd of 12 M |
| CSN15732 | Ganetespib | 888216-25-9 | Ganetespib is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells |
| CSN12347 | Elesclomol | 488832-69-5 | Elesclomol an inhibitor of HSP90 is a potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells |
| CSN18944 | Debio 0932 | 1061318-81-7 | Debio 0932 is a heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L). |
| CSN19190 | CH5138303 | 959763-06-5 | CH5138303 is an orally available Hsp90 inhibitor with Kd of 048 nM |
| CSN13441 | BIIB021 | 848695-25-0 | BIIB021 is an orally available fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 17 nM and 38 nM respectively |
| CSN12421 | Luminespib | 747412-49-3 | AUY922 is a highly potent HSP90 inhibitor for HSP90 with IC50 of 13 nM 21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1. |
| CSN16920 | Onalespib | 912999-49-6 | AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells displays a long duration of anti-tumor activity |
| CSN18941 | Apoptozole | 1054543-47-3 | Apoptozole is an inhibitor of heat shock protein 70 HSP70 and Hsc70 It induces caspase-dependent apoptosis |
| CSN16172 | Alvespimycin | 467214-20-6 | Alvespimycin is a potent, water-soluble HSP90 inhibitor with IC50 of 62 nM. |
| CSN18284 | Alvespimycin HCl | 467214-21-7 | Alvespimycin hydrochloride is a potent, water-soluble HSP90 inhibitor with IC50 of 62 nM. |
| CSN17209 | 17-AAG | 75747-14-7 | 17-AAG is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. |
| CSN18562 | 17-AAG HCl | 911710-03-7 | 17-AAG hydrochloride is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. |
| CSN22743 | CCT 018159 | 171009-07-7 | |
| CSN22828 | Gedunin | 2753-30-2 | |
| CSN22959 | Macbecin I | 73341-72-7 | |
| CSN22799 | EC 144 | 911397-80-3 |
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