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HSP

HSP

Cat. No. Product Name CAS No. Information
CSN12051 Teprenone   6809-52-5 Teprenone is used as an anti-ulcer drug, a cardioprotective agent, a hepatoprotective agent, a nephroprotective agent, a neuroprotective agent and a Hsp70 inducer.
CSN11740 Platycodin D 58479-68-8 Platycodin D is a natural product isolated and purified from the root of Platycodon grandiflorum., which may stimulate TNF- synthesis or inhibit degradation of TNF- mRNA, and is an Hsp90 inhibitor which disrupting the co-chaperone interaction of Hsp90cell division cycle protein 37 (Cdc37) and subsequently degrading multiple Hsp90 client proteins without the feedback increase of Hsp70.
CSN17514 PF-04929113 Mesylate 1173111-67-5 PF-04929113 mesylate is a potent and selective Hsp90 inhibitor with an IC50 of median 50 nM
CSN17387 ML346 100872-83-1 ML346 is an activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay
CSN21425 MKT-077   147366-41-4 MKT-077 FJ-776 is a water-soluble rhodacyanine dye with antitumor activity It can bind to Hsp70 family member mortalin-2 and inhibit its interactions with p53
CSN18942 KRIBB11 342639-96-7 KRIBB11 is an inhibitor of heat shock factor HSF inhibitor with IC50 of 12 M
CSN17321 KNK437   218924-25-5 KNK437 is a pan-HSP inhibitor which inhibits the synthesis of inducible HSPs including HSP105 HSP72 and HSP40
CSN22600 JG98 1456551-16-8 JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor which shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages.
CSN13532 Dihydroberberine 483-15-8 Dihydroberberine, a natural product isolated and purified from the tubers of Corydalis decumbens (Thunb.) Pers., has anti-tumor activity. Dihydroberberine improves in vivo efficacy in terms of counteracting increased adiposity, tissue triglyceride accumulation, and insulin resistance in high-fat-fed rodents, thus is potential therapeutic reagents for type 2 diabetes treatment.
CSN20998 DehydropachyMic acid 77012-31-8 Dehydropachymic acid is extracted from the root of wolfiporia cocos (Schw.) Ryv. with antiinflammatory activity.
CSN17209 17-AAG 75747-14-7 17-AAG is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells.
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