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HSP

HSP

Cat. No. Product Name CAS No. Information
CSN16304 XL888 1149705-71-4 XL888 is a specific and ATP-competitive Hsp90 inhibitor with IC50 of 24 nM
CSN13596 VER-50589 747413-08-7 VER-50589 is an isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM
CSN18335 VER-49009 558640-51-0 VER-49009 is a pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM
CSN13116 VER-155008 1134156-31-2 VER-155008 is a potent Hsp70 family inhibitor with IC50 of 05 M 26 M and 26 M in cell-free assays for HSP70 HSC70 and GRP78 respectively 100-fold selectivity over HSP90
CSN20344 TRC051384 HCl   1333327-56-2 TRC051384 is an inducer of heat shock protein Hsp70 it reduces stroke-associated neuronal injury and increases survival in a rat model of transient ischemic stroke and activates heat shock factor-1 and results in elevated chaperone and anti-inflammatory activity
CSN20345 TRC051384 867164-40-7 TRC051384 is a inducer of Hsp70
CSN12051 Teprenone   6809-52-5 Teprenone is used as an anti-ulcer drug, a cardioprotective agent, a hepatoprotective agent, a nephroprotective agent, a neuroprotective agent and a Hsp70 inducer.
CSN22232 TAS-116 1260533-36-5 TAS-116 is a potent and selective HSP90 inhibitor with Kis of 347 nM 213 nM respectively
CSN16517 SNX-2112 908112-43-6 SNX-2112 is a potent synthetic heat shock protein 90 HSP90 inhibitor with an IC50 of 092 M for K562 cells
CSN18481 Retaspimycin 857402-23-4 Retaspimycin is a small-molecule inhibitor of heat shock protein 90 HSP90 with antiproliferative and antineoplastic activities
CSN18482 Retaspimycin HCl 857402-63-2 Retaspimycin hydrochloride is the hydrochloride salt of a small-molecule inhibitor of heat shock protein 90 HSP90 with antiproliferative and antineoplastic activities
CSN15760 PU-WS13 1454619-14-7 PU-WS13 is a potent Grp94-specific Hsp90 inhibitor of the purine scaffold class
CSN16046 PU-H 71 873436-91-0 PU-H71 is a potent Hsp90 inhibitor with IC50 of 50 nM
CSN18943 PU-H 71 HCl 2095432-24-7 PU-H71 hydrochloride is a potent Hsp90 inhibitor with IC50 of 50 nM
CSN17514 PF-04929113 Mesylate 1173111-67-5 PF-04929113 mesylate is a potent and selective Hsp90 inhibitor with an IC50 of median 50 nM
CSN16541 PF-04929113 908115-27-5 PF-04929113 is a potent and selective HSP90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM
CSN15852 HSP990 934343-74-5 NVP-HSP990 is a potent and selective HSP90 inhibitor for HSP90 with IC50 of 06 nM08 nM
CSN17190 NVP-BEP800 847559-80-2 NVP-BEP800 is a fully synthetic HSP90 inhibitor with IC50 of 58 nM exhibits 70-fold selectivity against Hsp90 family members Grp94 and Trap-1
CSN16765 NMS-E973 1253584-84-7 NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of 10 nM for Hsp90 binding no activiy against a panel of 52 diverse protein kinases
CSN17387 ML346 100872-83-1 ML346 is an activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay
CSN21425 MKT-077   147366-41-4 MKT-077 FJ-776 is a water-soluble rhodacyanine dye with antitumor activity It can bind to Hsp70 family member mortalin-2 and inhibit its interactions with p53
CSN16562 KW-2478 819812-04-9 KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 38 nM
CSN18942 KRIBB11 342639-96-7 KRIBB11 is an inhibitor of heat shock factor HSF inhibitor with IC50 of 12 M
CSN17321 KNK437   218924-25-5 KNK437 is a pan-HSP inhibitor which inhibits the synthesis of inducible HSPs including HSP105 HSP72 and HSP40
CSN11085 Geldanamycin 30562-34-6 Geldanamycin is a natural existing HSP90 inhibitor with Kd of 12 M
CSN15732 Ganetespib 888216-25-9 Ganetespib is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells
CSN12347 Elesclomol 488832-69-5 Elesclomol an inhibitor of HSP90 is a potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells
CSN18944 Debio 0932 1061318-81-7 Debio 0932 is a heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L).
CSN19190 CH5138303 959763-06-5 CH5138303 is an orally available Hsp90 inhibitor with Kd of 048 nM
CSN13441 BIIB021   848695-25-0 BIIB021 is an orally available fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 17 nM and 38 nM respectively
CSN12421 Luminespib 747412-49-3 AUY922 is a highly potent HSP90 inhibitor for HSP90 with IC50 of 13 nM 21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1.
CSN16920 Onalespib 912999-49-6 AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells displays a long duration of anti-tumor activity
CSN18941 Apoptozole   1054543-47-3 Apoptozole is an inhibitor of heat shock protein 70 HSP70 and Hsc70 It induces caspase-dependent apoptosis
CSN16172 Alvespimycin 467214-20-6 Alvespimycin is a potent, water-soluble HSP90 inhibitor with IC50 of 62 nM.
CSN18284 Alvespimycin HCl 467214-21-7 Alvespimycin hydrochloride is a potent, water-soluble HSP90 inhibitor with IC50 of 62 nM.
CSN17209 17-AAG 75747-14-7 17-AAG is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells.
CSN18562 17-AAG HCl 911710-03-7 17-AAG hydrochloride is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells.
CSN22743 CCT 018159 171009-07-7
CSN22828 Gedunin 2753-30-2
CSN22959 Macbecin I 73341-72-7
CSN22799 EC 144 911397-80-3
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