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HSP
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN27850 | YUM70 | 423145-35-1 | YUM70 is a GRP78 inhibitor with IC50 value of 1.5μM and resulted in ER stress-mediated apoptosis. It inhibited pancreatic cancer cell growth in vitro and showed in vivo efficacy in a pancreatic cancer xenograft model with no toxicity to normal tissues. |
| CSN20345 | TRC051384 | 867164-40-7 | TRC051384 is a inducer of Hsp70 |
| CSN20344 | TRC051384 HCl | 1333327-56-2 | TRC051384 HCl is a potent inducer of HSP70 which can induce HSP70B mRNA expression. |
| CSN12051 | Teprenone | 6809-52-5 | Teprenone is used as an anti-ulcer drug, a cardioprotective agent, a hepatoprotective agent, a nephroprotective agent, a neuroprotective agent and a Hsp70 inducer. |
| CSN22232 | Pimitespib | 1260533-36-5 | TAS-116 is a potent and selective HSP90 inhibitor with Kis of 347 nM 213 nM respectively |
| CSN18943 | PU-H 71 HCl | 2095432-24-7 | PU-H71 HCl is a potent Hsp90 inhibitor with IC50 of 50 nM. |
| CSN32496 | PEN-866 | 1472614-83-7 | PEN-866 is a novel esterase-cleavable conjugate of an HSP90i and a topoisomerase I inhibitor. |
| CSN12794 | Palmitic acid | 57-10-3 | Palmitic acid, a natural product isolated and purified from the herbs of Atractylodes macrocephala Koidz., induces down-regulation of APOM expression and anxiety-like behavior in mice while increasing amygdala-based serotonin metabolism. Palmitic acid has a significant impact on proliferation and differentiation of NSCs in vitro and may be useful for elucidating the role of SFAs in regulating NSCs fate in physiological and pathological settings.Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. |
| CSN32424 | (2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone (S)-2-hydroxypropanoate | 1019889-35-0 | Onalespib lactate is a second-generation, potent and selective HSP90 Inhibitor. |
| CSN21425 | MKT-077 | 147366-41-4 | MKT-077 FJ-776 is a water-soluble rhodacyanine dye with antitumor activity It can bind to Hsp70 family member mortalin-2 and inhibit its interactions with p53 |
| CSN22600 | JG-98 | 1456551-16-8 | JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor which shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages. |
| CSN32437 | Icapamespib | 1000999-96-1 | Icapamespib is a heat shock protein 90 (HSP90) inhibitor. |
| CSN22089 | HSP70-IN-1 | 1268273-90-0 | HSP70-IN-1 is a heat shock protein (HSP) inhibitor. |
| CSN26677 | HM03 | 500565-15-1 | HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity[1]. |
| CSN19076 | HA15 | 1609402-14-3 | HA15 is a molecule that targets specifically BiPGRP78HSPA5. HA15 displays anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors. |
| CSN24783 | Grp94 Inhibitor-1 | 2234897-35-7 | Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α[1]. |
| CSN13554 | Eupalinolide B | 877822-41-8 | Eupalinolide A is a natural product isolated and purified from the herbs of Eupatorium lindleyanum DC. |
| CSN22799 | EC144 | 911397-80-3 | EC 144 is a high affinity, potent and selective Hsp90 inhibitor with Ki of 0.2 nM and IC50 of 1.1 nM. |
| CSN13532 | Dihydroberberine | 483-15-8 | Dihydroberberine, a natural product isolated and purified from the tubers of Corydalis decumbens (Thunb.) Pers., has anti-tumor activity. Dihydroberberine improves in vivo efficacy in terms of counteracting increased adiposity, tissue triglyceride accumulation, and insulin resistance in high-fat-fed rodents, thus is potential therapeutic reagents for type 2 diabetes treatment. |
| CSN18944 | Debio 0932 | 1061318-81-7 | Debio 0932 is a heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L). |
| CSN27185 | Col003 | 328565-16-8 | Col003 is a cell penetrant, selective and potent inhibitor of the interaction of Hsp47 with collagen. Col003 is the cleavage product of AK778.It competitively inhibited the interaction and caused the inhibition of collagen secretion by destabilizing the collagen triple helix. |
| CSN19190 | CH5138303 | 959763-06-5 | CH5138303 is an orally available Hsp90 inhibitor with Kd of 048 nM |
| CSN22743 | CCT018159 | 171009-07-7 | CCT 018159 is a novel inhibitor of heat shock protein 90 (Hsp90) ATPase activity with IC50 of 5.7 μM. |
| CSN22011 | Bimoclomol | 130493-03-7 | Bimoclomol is a heat shock protein coinducer, used for treatment of cardiovascular diseases. |
| CSN12421 | Luminespib | 747412-49-3 | AUY922 is a highly potent HSP90 inhibitor for HSP90 with IC50 of 13 nM 21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1. |
| CSN26679 | AMP-PCP | 3469-78-1 | AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90[1]. |
| CSN17209 | Tanespimycin | 75747-14-7 | 17-AAG is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. |
| CSN27737 | HSP27 inhibitor J2 | 2133499-85-9 | |
| CSN28855 | KBU2046 | 1143863-69-7 | |
| CSN33105 | DDO-5936 | 2355377-13-6 | |
| CSN41771 | AMP-PCP disodium | 7414-56-4 | |
| CSN42078 | Conglobatin | 72263-05-9 | |
| CSN50103 | KU-32 | 956498-70-7 | |
| CSN73281 | SNX-0723 | 1073969-18-2 |
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