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HMGCR

HMGCR

Cat. No. Product Name CAS No. Information
CSN19944 Swertiamarin   17388-39-5 Swertiamarine is a naturally occuring secoiridoid glycoside which could inhibit HMG-CoA reductase activity
CSN19036 SR12813 126411-39-0 SR-12813 is a pregnane X receptor PXR agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM
CSN11928 Simvastatin acid ammonium 139893-43-9 Simvastatin ammonium is an HMG-CoA reductase inhibitor
CSN11927 Simvastatin   79902-63-9 Simvastatin a specific and a lovastatin similar HMG-CoA reductase inhibitor with Ki value of 0.1-0.2 nM, used to treat hypercholesterolemia.
CSN11865 Rosuvastatin   287714-41-4 Rosuvastatin is a synthetic and highly effective statin-class HMG-CoA reductase inhibitor with IC50 of 11 nM
CSN12558 Rosuvastatin Calcium   147098-20-2 Rosuvastatin Calcium is a competitive and synthetic HMG-CoA reductase inhibitor with IC50 value of 11 nM
CSN12298 Pravastatin sodium 81131-70-6 Pravastatin Sodium is a competitive HMG-CoA reductase inhibitor with IC50 value of 56 M
CSN12933 Pravastatin 81093-37-0 Pravastatin is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 56 M
CSN11236 Pitavastatin 147511-69-1 Pitavastatin is a potent HMG-CoA reductase inhibitor and inhibits cholesterol synthesis from acetic acid with an IC50 of 58 nM in a human liver cancer cell line HepG2
CSN11738 Pitavastatin Calcium   147526-32-7 Pitavastatin Calcium is a potent and competitive inhibitor of HMG-CoA reductase with Ki value of 1.7nM, which can block cholesterol synthesis.
CSN22122 Monacolin J 79952-42-4 Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.
CSN11434 Mevastatin   73573-88-3 Mevastatin is the first discovered statin-class HMG-CoA reductase inhibitor used as a cholesterol-lowering agent isolated from Penicillium citinium
CSN19379 Meglutol 503-49-1 Meglutol is an antilipemic agent which lowers cholesterol triglycerides serum beta-lipoproteins and phospholipids and inhibits the activity of hydroxymethylglutarryl CoA reductases which is the rate limiting enzyme in the biosynthesis of cholesterol
CSN11335 Lovastatin   75330-75-5 Lovastatin is a HMG-CoA reductase used to treat high blood cholesterol and reduce the risk of cardiovascular disease, a naturally occuring fungal metabolite.
CSN13091 Fluvastatin sodium   93957-55-2 Fluvastatin Sodium is a synthetic indole-heptanoic-acid-derived inhibitor of hepatic HMG-CoA reductase with IC50 of 8 nM
CSN12947 Fluvastatin 93957-54-1 Fluvastatin inhibits HMG-CoA reductase activity with IC50 of 8 nM
CSN10667 Clinofibrate   30299-08-2 Clinofibrate is a HMG-CoA reductase inhibitor with IC50 value of 470 M which can reduce plasma cholesterol levels and shows antihyperlipidemic effects
CSN26676 Cerivastatin sodium 143201-11-0 Cerivastatin, also known as BAY-w-6228, and Rivastatin, is a statins used to lower cholesterol and prevent cardiovascular disease. It was marketed by the pharmaceutical company Bayer A.G. in the late 1990s. Cerivastatin was voluntarily withdrawn from the market worldwide in 2001, due to reports of fatal rhabdomyolysis. During postmarketing surveillance, 52 deaths were reported in patients using Cerivastatin, mainly from rhabdomyolysis and its resultant renal failure.
CSN27522 Atorvastatin lactone 125995-03-1 Atorvastatin lactone is a prodrug form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.
CSN12529 Atorvastatin 134523-00-5 Atorvastatin is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol
CSN12530 Atorvastatin hemicalcium salt   134523-03-8 Atorvastatin Hemicalcium is a potent HMG-CoA reductase inhibitor with IC50 value of 8 nM
CSN11493 alpha-Asarone   2883-98-9 alpha-Asarone is a naturally occuring inhibitor of both HMG-CoA reductase IC50 3 mM and certain isoforms of the cytochrome P450 superfamily of enzymes IC50 552 and 652 gml for CYP2D6 and CYP3A4 respectively with neuroprotective anti-oxidative anticonvulsive and cognitive enhancing action
CSN29521 (3S,5R)-Fluvastatin sodium 94061-81-1 (3S,5R)-Fluvastatin sodium ((3S,5R)-XU 62-320) is the (3S,5R)-enantiomer of Fluvastatin. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.
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