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HMGCR
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN19944 | Swertiamarin | 17388-39-5 | Swertiamarine is a naturally occuring secoiridoid glycoside which could inhibit HMG-CoA reductase activity |
| CSN19036 | SR12813 | 126411-39-0 | SR-12813 is a pregnane X receptor PXR agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM |
| CSN11928 | Simvastatin acid ammonium | 139893-43-9 | Simvastatin ammonium is an HMG-CoA reductase inhibitor |
| CSN11927 | Simvastatin | 79902-63-9 | Simvastatin a specific and a lovastatin similar HMG-CoA reductase inhibitor with Ki value of 0.1-0.2 nM, used to treat hypercholesterolemia. |
| CSN11865 | Rosuvastatin | 287714-41-4 | Rosuvastatin is a synthetic and highly effective statin-class HMG-CoA reductase inhibitor with IC50 of 11 nM |
| CSN12558 | Rosuvastatin Calcium | 147098-20-2 | Rosuvastatin Calcium is a competitive and synthetic HMG-CoA reductase inhibitor with IC50 value of 11 nM |
| CSN12298 | Pravastatin sodium | 81131-70-6 | Pravastatin Sodium is a competitive HMG-CoA reductase inhibitor with IC50 value of 56 M |
| CSN12933 | Pravastatin | 81093-37-0 | Pravastatin is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 56 M |
| CSN11236 | Pitavastatin | 147511-69-1 | Pitavastatin is a potent HMG-CoA reductase inhibitor and inhibits cholesterol synthesis from acetic acid with an IC50 of 58 nM in a human liver cancer cell line HepG2 |
| CSN11738 | Pitavastatin Calcium | 147526-32-7 | Pitavastatin Calcium is a potent and competitive inhibitor of HMG-CoA reductase with Ki value of 1.7nM, which can block cholesterol synthesis. |
| CSN22122 | Monacolin J | 79952-42-4 | Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase. |
| CSN11434 | Mevastatin | 73573-88-3 | Mevastatin is the first discovered statin-class HMG-CoA reductase inhibitor used as a cholesterol-lowering agent isolated from Penicillium citinium |
| CSN19379 | Meglutol | 503-49-1 | Meglutol is an antilipemic agent which lowers cholesterol triglycerides serum beta-lipoproteins and phospholipids and inhibits the activity of hydroxymethylglutarryl CoA reductases which is the rate limiting enzyme in the biosynthesis of cholesterol |
| CSN11335 | Lovastatin | 75330-75-5 | Lovastatin is a HMG-CoA reductase used to treat high blood cholesterol and reduce the risk of cardiovascular disease, a naturally occuring fungal metabolite. |
| CSN13091 | Fluvastatin sodium | 93957-55-2 | Fluvastatin Sodium is a synthetic indole-heptanoic-acid-derived inhibitor of hepatic HMG-CoA reductase with IC50 of 8 nM |
| CSN12947 | Fluvastatin | 93957-54-1 | Fluvastatin inhibits HMG-CoA reductase activity with IC50 of 8 nM |
| CSN10667 | Clinofibrate | 30299-08-2 | Clinofibrate is a HMG-CoA reductase inhibitor with IC50 value of 470 M which can reduce plasma cholesterol levels and shows antihyperlipidemic effects |
| CSN26676 | Cerivastatin sodium | 143201-11-0 | Cerivastatin, also known as BAY-w-6228, and Rivastatin, is a statins used to lower cholesterol and prevent cardiovascular disease. It was marketed by the pharmaceutical company Bayer A.G. in the late 1990s. Cerivastatin was voluntarily withdrawn from the market worldwide in 2001, due to reports of fatal rhabdomyolysis. During postmarketing surveillance, 52 deaths were reported in patients using Cerivastatin, mainly from rhabdomyolysis and its resultant renal failure. |
| CSN27522 | Atorvastatin lactone | 125995-03-1 | Atorvastatin lactone is a prodrug form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. |
| CSN12529 | Atorvastatin | 134523-00-5 | Atorvastatin is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol |
| CSN12530 | Atorvastatin hemicalcium salt | 134523-03-8 | Atorvastatin Hemicalcium is a potent HMG-CoA reductase inhibitor with IC50 value of 8 nM |
| CSN11493 | alpha-Asarone | 2883-98-9 | alpha-Asarone is a naturally occuring inhibitor of both HMG-CoA reductase IC50 3 mM and certain isoforms of the cytochrome P450 superfamily of enzymes IC50 552 and 652 gml for CYP2D6 and CYP3A4 respectively with neuroprotective anti-oxidative anticonvulsive and cognitive enhancing action |
| CSN29521 | (3S,5R)-Fluvastatin sodium | 94061-81-1 | (3S,5R)-Fluvastatin sodium ((3S,5R)-XU 62-320) is the (3S,5R)-enantiomer of Fluvastatin. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. |
| CSN75676 | S-2E | 155730-92-0 |
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