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Histone Methyltransferase

Histone Methyltransferase

Cat. No. Product Name CAS No. Information
CSN17962 XY1   1624117-53-8 XY1 is a negative control of SGC 707 which works as a potent and selective allosteric inhibitor of PRMT3 while XY1 shows almost no activity
CSN23170 TP 064 2080306-20-1 TP-064 is a potent and selective PRMT4 inhibitor. The in vitro activity of TP-064 includes inhibition of PRMT4 with IC50 < 10nM for methylation of H3 (1-25) and greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In cellular assays, TP-064 inhibits the methylation of MED12 with IC50 = 43 nM.
CSN23150 TC-E 5003 17328-16-4 TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor.
CSN18955 SGC2085   1821908-48-8 SGC2085 is a selectivel and potent CARM1 inhibitor with IC50 value of 50 nM
CSN18048 MS023 1831110-54-3 MS023 is a potent and selective chemical probe for Type I PRMTs with IC50 values of 30 119 83 8 and 8 nM for PRMTs 1346and 8 respectively MS023 is active in cells
CSN18954 MS049 1502816-23-0 MS 049 is a potent selective and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM respectively
CSN23320 GSK3326595 1616392-22-3 GSK3326595 is a potent specific and reversible PRMT5 inhibitor which can decrease the levels of both monomethylated and dimethylated arginine residues in histones H2A H3 and H4
CSN22899 GSK2807 Trifluoroacetate 2245255-66-5 GSK2807 Trifluoroacetate is a SMYD3 SAM-competitive inhibitor with Ki of 14 nM
CSN22826 Furamidine 2HCl 55368-40-6 Furamidine 2HCl is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 9.4 μM.
CSN12600 AMI-1 20324-87-2 AMI-1 is an inhibitor of protein arginine N-methyltransferases (PRMTs) with IC50 of 8.8 M for PRMT1 via blocking peptide-substrate binding.
CSN27520 AMI-1 free acid 134-47-4 AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding.
CSN17152 3-Deazaneplanocin A 102052-95-9 3-Deazaneplanocin A is an attractive epigenetic anticancer agent through the inhibition of the cellular enhancer of zeste homolog 2 (EZH2) protein.
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