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Histone Methyltransferase

Histone Methyltransferase

Cat. No. Product Name CAS No. Information
CSN18843 UNC3866 1872382-47-2 UNC3866 is a high-affinity CBX4 and CBX7 inhibitor with Ki values of 94 and 97 nM respectively
CSN23170 TP 064 2080306-20-1 TP-064 is a potent and selective PRMT4 inhibitor. The in vitro activity of TP-064 includes inhibition of PRMT4 with IC50 < 10nM for methylation of H3 (1-25) and greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In cellular assays, TP-064 inhibits the methylation of MED12 with IC50 = 43 nM.
CSN23150 TC-E 5003 17328-16-4 TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor.
CSN18955 SGC2085   1821908-48-8 SGC2085 is a selectivel and potent CARM1 inhibitor with IC50 value of 50 nM
CSN27839 NSD2-PWWP1 antagonist 3f 1210906-48-1 NSD2-PWWP1 antagonist 3f can bind to the NSD2-PWWP1 domain with Kd value of 3.4μM and abrogates histone H3K36me2 binding to the PWWP1 domain in cells.
CSN18048 MS023 1831110-54-3 MS023 is a potent and selective chemical probe for Type I PRMTs with IC50 values of 30 119 83 8 and 8 nM for PRMTs 1346and 8 respectively MS023 is active in cells
CSN18954 MS049 1502816-23-0 MS 049 is a potent selective and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM respectively
CSN23320 GSK3326595 1616392-22-3 GSK3326595 is a potent specific and reversible PRMT5 inhibitor which can decrease the levels of both monomethylated and dimethylated arginine residues in histones H2A H3 and H4
CSN22899 GSK2807 Trifluoroacetate 2245255-66-5 GSK2807 Trifluoroacetate is a SMYD3 SAM-competitive inhibitor with Ki of 14 nM
CSN22826 Furamidine 2HCl 55368-40-6 Furamidine 2HCl is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 9.4 μM.
CSN18855 EPZ020411 HCl 2070015-25-5 EPZ020411 HCl is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has > 10 fold selectivity for PRMT6 over PRMT1 and PRMT8.
CSN13909 EPZ-6438   1403254-99-8 EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity with Ki value of 2.5±0.5 nM.
CSN12600 AMI-1 20324-87-2 AMI-1 is an inhibitor of protein arginine N-methyltransferases (PRMTs) with IC50 of 8.8 M for PRMT1 via blocking peptide-substrate binding.
CSN27520 AMI-1 free acid 134-47-4 AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding.
CSN19081 A-196 1982372-88-2 A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50s of 25 and 144 nM respectively
CSN17152 3-Deazaneplanocin A 102052-95-9 3-Deazaneplanocin A is an attractive epigenetic anticancer agent through the inhibition of the cellular enhancer of zeste homolog 2 (EZH2) protein.
CSN13890 3-Deazaneplanocin A HCl 120964-45-6 3-Deazaneplanocin A HCl is a cyclopentanyl analog of 3-deazaadenosine that potently interferes with SAH, a component of the methionine cycle, which causes cellular SAH levels to increase, thus repressing the activity of S-adenosyl-l-methionine–dependent histone lysine methyltransferase activity.
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