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Histone Demethylase

Histone Demethylase

Cat. No. Product Name CAS No. Information
CSN21075 NCGC00244536 2003260-55-5 NCGC00244536 is a selective inhibitor of KDM4A with IC50 of 10 nM
CSN27531 L-2-Hydroxyglutaric acid disodium 63512-50-5 L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively.
CSN29559 JMJD7-IN-1 311316-96-8 JMJD7-IN-1 is a potent JMJD7 inhibitor with IC50 value of 6.62μM.
CSN13708 JIB-04   199596-05-9 JIB-04 is a selective inhibitor of jumonji histone demethylase with IC50s of 2303408554454351100 and 290 nM for JARID1AJMJD2EJMJD3JMJD2AJMJD2BJMJD2C and JMJD2D respectively
CSN12941 IOX1   5852-78-8 IOX1 is the broad-spectrum inhibitor of 2OG oxygenases and its IC50 for KDM4AKDM3A and KDM4CKDM6BKDM2AKDM4E are 0601 M and 06 M16 M18 M23 M
CSN23888 GSK 467 1628332-52-4 GSK467 is a selective KDM5 inhibitor with Ki of 10 nM. It has no measurable inhibitory effects toward other JmJ family members.
CSN19181 GSK-J4 HCl   1797983-09-5 GSK-J4 HCl is selective inhibitor of jumonji H3K27 demethylase. It can attenuate lipopolysaccharide (LPS)-induced proinflammatory cytokine production.
CSN17785 GSK-J2 1394854-52-4 GSK-J2 is a pyridine regio-isomer of GSK-J1 which poorly inhibits JMJD3 IC50 100 M making it an appropriate negative control for in vitro studies involving GSK-J1 and is a selective inhibitor for human H3K27me3 demethylases
CSN19243 CPI-455 HCl   2095432-28-1 CPI-455 HCl is an inhibitor of KDM5 It can elevate global levels of H3K4 trimethylation H3K4me3 and decrease the number of DTPs in multiple cancer cell line models
CSN23733 Corin 1808113-09-8 Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1.
CSN17765 CBB1007 1379573-92-8 CBB1007 is a cell-permeable amidino-guanidinium compound that acts as a potent reversible and substrate competitive LSD1 selective inhibitor IC50 527 M for hLSD1
CSN21279 AS-8351   796-42-9 AS8351 is a selective inhibitor of histone demethylase KDM5B JARID1B via competing for the chelated iron KDM5B needs and it can act as an iron chelator
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