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Histamine Receptor

Histamine Receptor

Cat. No. Product Name CAS No. Information
CSN25848 Zolantidine dimaleate 104076-39-3 Zolantidine dimaleate is a selective and brain penetrating H2 receptor antagonist.
CSN25862 VUF 8430 dihydrobromide 100130-32-3 VUF 8430 dihydrobromide is a full agonist of histamine H4 receptor with pKi of 7.5 and pEC50 of 7.3.
CSN26513 SUN 1334H 607736-84-5 SUN-1334H is a histamine H1 receptor antagonist potentially for the treatment of allergic conjunctivitis and allergic rhinitis
CSN24554 SEN12333 874450-44-9 SEN 12333 is a selective agonist of α7 nicotinic acetylcholine receptor (nAChR) with EC50 and Ki of 1.6 μM, 260 nM in rat. It also displays functional antagonism at histamine H3 receptors (IC50 = 103 nM).
CSN21826 Rocastine 91833-77-1 Rocastine is a selective antagonist of nonsedative H1 antagonist for antihistamines.
CSN26180 PU02   313984-77-9 PU-02 is an antagonist of serotonin (5-HT) receptor subtype 5-HT3.
CSN17113 Promethazine hydrochloride   58-33-3 Promethazine HCl is the effective antagonist of the H1 receptor and moderate antagonist of mACh receptor.
CSN25855 Nα-Methylhistamine 2HCl 16503-22-3 Nα-Methylhistamine dihydrochloride is H2R agonist that acts directly on histamine H(2) receptors (H2Rs) in animals to stimulate acid secretion and it dose dependently stimulated cAMP productions in CHO-H2R cells.
CSN21744 Niperotidine 84845-75-0 Niperotidine is an antagonist of histamine H2-receptor.
CSN11531 Nedocromil 69049-73-6 Nedocromil is an inhaled anti-inflammatory agent for the preventive management of asthma.
CSN11809 Mepyramine maleate   59-33-6 Mepyramine maleate is an antagonist of histamine H1 receptor.
CSN14575 Marmin 14957-38-1 Marmin, a natural product isolated and purified from the herbs of Citrus maxima with potent anti-ulcer, antibacterial, fungicidal, and algicidal properties, can inhibit contraction of the guinea-pig tracheal smooth muscle, especially by interfering histamine receptor, inhibiting the histamine release from mast, inhibiting intracellular Ca2+ release from the intracellular store and the Ca2+ influx through voltage-dependent Ca2+ channels, is potential to develop as antihistamine agents, especially as histamine H1 receptor antagonists by interacting with amino acid residues, Asp107, Lys179, Lys191, Asn198, and Trp428 of histamine H1 receptor, shows a cell-growth inhibitory effect against L1210 and K562 in vitro.
CSN25565 LML134 1542135-76-1 LML134 is an orally active and high selective Histamine 3 receptor (H3R) inverse agonist with Kis of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg. LML134 penetrates the brain rapidly, leading to high H3R occupancy, and disengages its target with a fast kinetic profile. LML134 has the potential for excessive sleep disorders.
CSN25273 JNJ-5207852 398473-34-2 JNJ-5207852 is a novel, non-imidazole histamine H3 receptor antagonist, with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor.
CSN22061 JNJ-39758979 1046447-90-8 JNJ-39758979 is a selective, high-affinity histamine H4 receptor antagonist with Ki of 12.5 nM.
CSN25851 Impentamine dihydrobromide 149629-70-9 Impentamine dihydrobromide is highly selective antagonist of histamine H3 receptor with pA2 of 8.4.
CSN25847 Ici162,846 84545-30-2 ICI 162,846 is a potent histamine H2 receptor antagonist.
CSN25852 GT-2016 152241-24-2 GT 2016 is a high affinity antagonist of H3 receptor with Ki of 43.8 nM.
CSN22023 FRG8701 108498-50-6 FRG-8701 is a new Histamine H2-receptor antagonist with IC50 of ranging from 0.25 to 0.43 μM.
CSN21734 Minocromil 85118-44-1 FPL59360, a anti-asthmatic compound, is histamine I receptor antagonist that prevents exercise-induced asthma.
CSN24500 Emedastine 87233-61-2 Emedastine is a potent, high affinity histamine H1-receptor-selective antagonist with Ki of 1.3 ±0.1 nM for H1-receptors while considerably weaker at H2- (Ki = 49,067 ± 11,113 nM) and H3-receptors (Ki = 12,430 ± 1,282 nM).
CSN25845 Dimaprit dihydrochloride 23256-33-9 Dimaprit dihydrochloride is a selective H2 agonist with central effects upon systemic administration.
CSN20584 Clobenpropit dihydrobromide 145231-35-2 Clobenpropit hydrobromide is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier, inhibiting histamine binding in rat brain.
CSN26664 Cimetidine sulfoxide 54237-72-8 Cimetidine sulfoxide (Cimetidine sulphoxide) is a sulfoxide metabolite of Cimetidine. Cimetidine is a histamine H2-receptor antagonist. Cimetidine has the potential for peptic ulcer disease and upper gastrointestinal haemorrhage treatment[1].
CSN26201 Chloropyramine hydrochloride 6170-42-9 Chloropyramine hydrochloride is a histamine receptor H1 antagonist which can also inhibit the biochemical function of VEGFR-3. Chloropyramine hydrochloride may be useful in the treatment of invasive breast cancer.
CSN25269 Bromodiphenhydramine hydrochloride 1808-12-4 Bromazine hydrochloride is an antagonist of histamine H1 receptor.
CSN24556 AR-R17779 hydrochloride 178419-42-6 AR-R 17779 hydrochloride is a selective alpha7 nicotinic agonist with Ki value of 190 nM for rat.
CSN25846 Amthamine dihydrobromide 142457-00-9 Amthamine dihydrobromide is a highly selective agonist of H2 receptor.
CSN25843 Aminopotentidine 140873-26-3 Aminopotentidine is antagonist of H2 with KB value of 220 nM.
CSN21455 Acrivastine 87848-99-5 Acrivastine, an H1-receptor antagonist, is a second-generation antihistamine.
CSN24555 A 844606 861119-08-6 A 844606 is a selective α7 nicotinic acetylcholine receptor (nAChR) partial agonist with EC50 values are 1.4 and 2.2 μM at human and rat receptors, respectively.
CSN10156 Nepetin 520-11-6 6-Methoxyluteolin is a natural product isolated and purified from the flower of Chrysanthemum zawadskii var. latilobum with antioxidant activity and is also a potent inhibitor of histamine release and calcium influx via down-regulation of the FcRI chain.
CSN26178 4I 930478-88-9 5-HT3 antagonist-4i is a 5-HT3 receptor antagonist which modulates the serotonergic system.
CSN25863 4-Methylhistamine dihydrochloride 36376-47-3 4-Methylhistamine dihydrochloride is a high affinity agonist of H4 receptor with Ki of 7 nM.
CSN25840 2-(Pyridin-2-yl)ethanamine dihydrochloride 3343-39-3 2-Pyridylethylamine dihydrochloride is an agonist of histamine H1 receptor that produces vasoconstriction.
CSN24562 (S)-(+)-Dimethindene maleate 136152-65-3 (S)-(+)-Dimethindene maleate is a subtype-selective M2 muscarinic receptor antagonist with pKi of 7.78 and is also a H1 histamine receptor antagonist with pKi of 7.48.
CSN25856 (R)-(-)-α-Methylhistamine dihydrobromide 868698-49-1 (R)-(-)-α-Methylhistamine dihydrobromide is a very potent agonist of H3 receptor with Kd of 50.3 nM that crosses the blood-brain barrier and inhibits histamine synthesis and release at nanomolar concentrations.
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