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HIF

HIF

Cat. No. Product Name CAS No. Information
CSN18362 THS-044 62054-67-5 THS-044 binding stabilizes the HIF2 PAS-B folded state for regulating HIF2 activity in endogenous and clinical settings
CSN17993 PT-2385 1672665-49-4 PT2385 is an inhibitor of hypoxia inducible factor HIF-2 alpha with antineoplastic effect
CSN11613 Ononin 486-62-4 Ononin is an isoflavonoid isolated and purified from the herb of Ononis natrix L., can inhibit the growth of pathogen such as Enterococcus sp., Enterobacter sp.
CSN11607 Oltipraz 64224-21-1 Oltipraz can inhibit the insulin-activated HIF-1 (IC50 10 M) in a time-dependent manner.
CSN14672 Moracin P 102841-46-3 Moracin P, a natural product isolated and purified from the root bark of Morus alba L., shows significant nitric oxide (NO) production inhibitory effects in RAW264.7 cells, exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia, and might protect neuronal cell death against the oxidative stress induced by oxygen-glucose deprivation(OGD), can enhance cell viability in dose-dependent manner against OGD-induced cell death in neuroblastoma SH-SY5Y cells.
CSN14671 Moracin O 123702-97-6 Moracin O and moracin P exhibit potent in vitro inhibitory activity against hypoxia-inducible factor HIF-1 which is a key mediator during adaptation of cancer cells to tumour hypoxia
CSN16866 FG-2216 223387-75-5 FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 39 M for PHD2 enzyme orally bioavailable and induced significant and reversible Epo induction in vivo
CSN10851 DMOG   89464-63-1 DMOG (Dimethyloxalylglycine) is a prolyl 4-hydroxylase inhibitor with IC50 value of 2uM.
CSN16738 Ciclopirox   29342-05-0 Ciclopirox inhibits iron-dependent enzymes PHD2 pIC50 58 and deoxyhypusine hydroxylase It is an antifungal and iron-chelating agent
CSN19253 2-Methoxyestradiol   362-07-2 2-methoxyestradiol is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration.
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