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HIF

HIF

Cat. No. Product Name CAS No. Information
CSN18362 THS-044 62054-67-5 THS-044 binding stabilizes the HIF2 PAS-B folded state for regulating HIF2 activity in endogenous and clinical settings
CSN19042 SYP-5 1384268-04-5 SYP-5 is a HIF-1 inhibitor suppresses tumor cells invasion and angiogenesis
CSN18393 PX-478 Dihydrobromide 685898-44-6 PX-478 target on HIF-1α, which can selectively inhibit the hypoxia-induced increase in HIF-1a protein.
CSN17993 PT-2385 1672665-49-4 PT2385 is an inhibitor of hypoxia inducible factor HIF-2 alpha with antineoplastic effect
CSN17994 PT-2385 R-Enantiomer 1672666-67-9 PT-2385 R-enantiomer is the R-enantiomer of PT-2385 which is a potent HIF-2 inhibitor and is a potential anticancer agent
CSN20370 PHD-1 Inhibitor C54 2009344-53-8 PHD-1 inhibitor C54 is a 4-1,2,4triazolo1,5-apyridin-5-ylbenzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1). It exhibits reasonable peripheral exposure but poor brain levels (Kp,uu 0.02 and BP 0.03).
CSN20369 PHD-1 Inhibitor C53 2009345-20-2 PHD-1 inhibitor C53 is a 4-1,2,4triazolo1,5-apyridin-5-ylbenzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1). It exhibits excellent peripheral exposure, but does not partition well into the brain (Kp,uu 0.39 and BP 0.21).
CSN20368 PHD-1 Inhibitor C39 2009343-19-3 PHD-1 inhibitor C39 is a 4-1,2,4triazolo1,5-apyridin-5-ylbenzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1) with high solubility and permeability.
CSN20367 PHD-1 Inhibitor C17 2009343-14-8 PHD-1 inhibitor C17 is an early lead compound of 4-1,2,4triazolo1,5-apyridin-5-ylbenzonitrile-based inhibitors of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1) showing a moderate rate of microsomal turnover in vitro.
CSN11607 Oltipraz 64224-21-1 Oltipraz can inhibit the insulin-activated HIF-1 (IC50 10 M) in a time-dependent manner.
CSN14671 Moracin O 123702-97-6 Moracin O and moracin P exhibit potent in vitro inhibitory activity against hypoxia-inducible factor HIF-1 which is a key mediator during adaptation of cancer cells to tumour hypoxia
CSN16636 ML228 1357171-62-0 ML228 is an activator of the Hypoxia Inducible Factor HIF pathway and potently activate HIF in vitro as well as its downstream target VEGF
CSN19680 MK-8617   1187990-87-9 MK-8617 is a potent, selective, orally bioavailabl pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1−3 (HIF PHD1−3), inhibiting PHD1, 2, 3 with IC50s of 1.0, 1.0 and 14 nM, respectively.
CSN20474 LW6 934593-90-5 LW6 is an inhibitor of HIF-1 with IC50 of 4.4 μM.
CSN17251 KC7F2   927822-86-4 KC7F2 is a selective HIF-1 transcription inhibitor with IC50 of 20 M in a cell-based assay
CSN17541 JNJ-42041935 1193383-09-3 JNJ-42041935 is a selective inhibitor of prolyl hydroxylase (PHD) with the pKis of 7.91 0.04, 7.29 0.05, and 7.65 0.09 for PHD1, PHD2, and PHD3, respectively.
CSN16064 IOX2   931398-72-0 IOX2 is a selective inhibitor of the hypoxia inducible factor HIF Prolyl-Hydroxylases PHD and active in cells with IC50 value of 21 nM for PHD2ELGN-1 and no inhibition at FIH20uM
CSN20256 IDF-11774 1429054-28-3 IDF-11774 is a hypoxia-inducible factor HIF-1 inhibitor which regulates cancer metabolism thereby suppressing tumor growth
CSN18038 HIF-2α-IN-1 1799948-06-3 HIF-2-IN-1 is a HIF-2 inhibitor has an IC50 of less than 500 nM in HIF-2 scintillation proximity assay
CSN20613 GSK360A 931399-19-8 GSK360A is an active HIF-PHD inhibitor with systemic and local effects by stabilizing HIF-1 signaling and can improve long-term ventricular function
CSN16866 FG-2216 223387-75-5 FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 39 M for PHD2 enzyme orally bioavailable and induced significant and reversible Epo induction in vivo
CSN22394 Enarodustat 1262132-81-9 Enarodustat is a potent and orally active factor prolyl hydroxylase inhibitor with an EC50 of 022 M Enarodustat has entered clinical trial for renal anemia
CSN17599 EL-102 1233948-61-2 EL102 is an inhibitor of HIF1 Which can inhibit tubulin polymerisation and decreased microtubule stability
CSN20491 Echinomycin 512-64-1 Echinomycin is a highly potent and selective HIF-1 inhibitor IC50 294 pM which selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-B
CSN10851 DMOG     89464-63-1 DMOG (Dimethyloxalylglycine) is a prolyl 4-hydroxylase inhibitor with IC50 value of 2uM.
CSN16738 Ciclopirox   29342-05-0 Ciclopirox inhibits iron-dependent enzymes PHD2 pIC50 58 and deoxyhypusine hydroxylase It is an antifungal and iron-chelating agent
CSN17588 BAY 87-2243     1227158-85-1 BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced HIF-1 activation
CSN19253 2-Methoxyestradiol     362-07-2 2-methoxyestradiol is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration.
CSN23782 Desidustat 1616690-16-4
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