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HIF
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN24188 | TP0463518 | 1558021-37-6 | TP0463518 is a potent HIF-PHD inhibitor with Ki value of 5.3 nM for PHD2, and also inhibited human PHD1/3 with IC50 values of 18 and 63 nM. |
| CSN18362 | THS-044 | 62054-67-5 | THS-044 binding stabilizes the HIF2 PAS-B folded state for regulating HIF2 activity in endogenous and clinical settings |
| CSN26249 | TC-S 7009 | 1422955-31-4 | TC-S 7009 is a potent and selective HIF-2α inhibitor with a Kd of 81 nM. TC-S 7009 disrupts HIF-2α-ARNT heterodimerization by binding to HIF-2α PAS-B domain, decreases DNA-binding activity, and reduces HIF-2α target gene expression. |
| CSN19042 | SYP-5 | 1384268-04-5 | SYP-5 is a HIF-1 inhibitor suppresses tumor cells invasion and angiogenesis |
| CSN18393 | PX-478 | 685898-44-6 | PX-478 target on HIF-1α, which can selectively inhibit the hypoxia-induced increase in HIF-1a protein. |
| CSN17993 | PT-2385 | 1672665-49-4 | PT2385 is an inhibitor of hypoxia inducible factor HIF-2 alpha with antineoplastic effect |
| CSN20370 | PHD-1 Inhibitor C54 | 2009344-53-8 | PHD-1 inhibitor C54 is a 4-1,2,4triazolo1,5-apyridin-5-ylbenzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1). It exhibits reasonable peripheral exposure but poor brain levels (Kp,uu 0.02 and BP 0.03). |
| CSN20369 | PHD-1 Inhibitor C53 | 2009345-20-2 | PHD-1 inhibitor C53 is a 4-1,2,4triazolo1,5-apyridin-5-ylbenzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1). It exhibits excellent peripheral exposure, but does not partition well into the brain (Kp,uu 0.39 and BP 0.21). |
| CSN20368 | PHD-1 Inhibitor C39 | 2009343-19-3 | PHD-1 inhibitor C39 is a 4-1,2,4triazolo1,5-apyridin-5-ylbenzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1) with high solubility and permeability. |
| CSN20367 | PHD-1-IN-1 | 2009343-14-8 | PHD-1 inhibitor C17 is an early lead compound of 4-1,2,4triazolo1,5-apyridin-5-ylbenzonitrile-based inhibitors of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1) showing a moderate rate of microsomal turnover in vitro. |
| CSN11613 | Ononin | 486-62-4 | Ononin is an isoflavonoid isolated and purified from the herb of Ononis natrix L., can inhibit the growth of pathogen such as Enterococcus sp., Enterobacter sp. |
| CSN11607 | Oltipraz | 64224-21-1 | Oltipraz can inhibit the insulin-activated HIF-1 (IC50 10 M) in a time-dependent manner. |
| CSN14672 | Moracin P | 102841-46-3 | Moracin P, a natural product isolated and purified from the root bark of Morus alba L., shows significant nitric oxide (NO) production inhibitory effects in RAW264.7 cells, exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia, and might protect neuronal cell death against the oxidative stress induced by oxygen-glucose deprivation(OGD), can enhance cell viability in dose-dependent manner against OGD-induced cell death in neuroblastoma SH-SY5Y cells. |
| CSN14671 | Moracin O | 123702-97-6 | Moracin O and moracin P exhibit potent in vitro inhibitory activity against hypoxia-inducible factor HIF-1 which is a key mediator during adaptation of cancer cells to tumour hypoxia |
| CSN16636 | ML228 | 1357171-62-0 | ML228 is an activator of the Hypoxia Inducible Factor HIF pathway and potently activate HIF in vitro as well as its downstream target VEGF |
| CSN19680 | MK-8617 | 1187990-87-9 | MK-8617 is a potent, selective, orally bioavailabl pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1−3 (HIF PHD1−3), inhibiting PHD1, 2, 3 with IC50s of 1.0, 1.0 and 14 nM, respectively. |
| CSN28806 | M1001 | 874590-32-6 | M1001 is the first HIF-2 allosteric agonist, capable of altering the conformation of Tyr281 of the HIF-2α PAS-B domain and enhancing the affinity of HIF-2α and ARNT for transcriptional activation. |
| CSN20474 | LW6 | 934593-90-5 | LW6 is an inhibitor of HIF-1 with IC50 of 4.4 μM. |
| CSN17251 | KC7F2 | 927822-86-4 | KC7F2 is a selective HIF-1 transcription inhibitor with IC50 of 20 M in a cell-based assay |
| CSN17541 | JNJ-42041935 | 1193383-09-3 | JNJ-42041935 is a selective inhibitor of prolyl hydroxylase (PHD) with the pKis of 7.91 0.04, 7.29 0.05, and 7.65 0.09 for PHD1, PHD2, and PHD3, respectively. |
| CSN24496 | IOX4 | 1154097-71-8 | IOX4 is a selective HIF-PHD2 inhibitor with IC50 value of 1.6nM. |
| CSN20256 | IDF-11774 | 1429054-28-3 | IDF-11774 is a hypoxia-inducible factor HIF-1 inhibitor which regulates cancer metabolism thereby suppressing tumor growth |
| CSN18038 | HIF-2α-IN-1 | 1799948-06-3 | HIF-2-IN-1 is a HIF-2 inhibitor has an IC50 of less than 500 nM in HIF-2 scintillation proximity assay |
| CSN20613 | Gsk360a | 931399-19-8 | GSK360A is an active HIF-PHD inhibitor with systemic and local effects by stabilizing HIF-1 signaling and can improve long-term ventricular function |
| CSN16866 | FG-2216 | 223387-75-5 | FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 39 M for PHD2 enzyme orally bioavailable and induced significant and reversible Epo induction in vivo |
| CSN22394 | Enarodustat | 1262132-81-9 | Enarodustat is a potent and orally active factor prolyl hydroxylase inhibitor with an EC50 of 022 M Enarodustat has entered clinical trial for renal anemia |
| CSN17599 | EL-102 | 1233948-61-2 | EL102 is an inhibitor of HIF1 Which can inhibit tubulin polymerisation and decreased microtubule stability |
| CSN10851 | DMOG | 89464-63-1 | DMOG (Dimethyloxalylglycine) is a prolyl 4-hydroxylase inhibitor with IC50 value of 2uM. |
| CSN23782 | Desidustat | 1616690-16-4 | Desidustat, an antianaemic drug, is a HIF hydroxylase inhibitor. |
| CSN16738 | Ciclopirox | 29342-05-0 | Ciclopirox inhibits iron-dependent enzymes PHD2 pIC50 58 and deoxyhypusine hydroxylase It is an antifungal and iron-chelating agent |
| CSN17588 | BAY 87-2243 | 1227158-85-1 | BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced HIF-1 activation |
| CSN67493 | TRC160334 | 1293289-69-6 | |
| CSN77481 | EZM0414 | 2411748-50-8 |
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