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HIF

HIF

Cat. No. Product Name CAS No. Information
CSN24188 TP0463518 1558021-37-6 TP0463518 is a potent HIF-PHD inhibitor with Ki value of 5.3 nM for PHD2, and also inhibited human PHD1/3 with IC50 values of 18 and 63 nM.
CSN18362 THS-044 62054-67-5 THS-044 binding stabilizes the HIF2 PAS-B folded state for regulating HIF2 activity in endogenous and clinical settings
CSN19042 SYP-5 1384268-04-5 SYP-5 is a HIF-1 inhibitor suppresses tumor cells invasion and angiogenesis
CSN18393 PX-478 2HCl 685898-44-6 PX-478 target on HIF-1α, which can selectively inhibit the hypoxia-induced increase in HIF-1a protein.
CSN17993 PT-2385   1672665-49-4 PT2385 is an inhibitor of hypoxia inducible factor HIF-2 alpha with antineoplastic effect
CSN17994 PT-2385 R-Enantiomer 1672666-67-9 PT-2385 R-enantiomer is the R-enantiomer of PT-2385 which is a potent HIF-2 inhibitor and is a potential anticancer agent
CSN20370 PHD-1 Inhibitor C54 2009344-53-8 PHD-1 inhibitor C54 is a 4-1,2,4triazolo1,5-apyridin-5-ylbenzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1). It exhibits reasonable peripheral exposure but poor brain levels (Kp,uu 0.02 and BP 0.03).
CSN20369 PHD-1 Inhibitor C53 2009345-20-2 PHD-1 inhibitor C53 is a 4-1,2,4triazolo1,5-apyridin-5-ylbenzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1). It exhibits excellent peripheral exposure, but does not partition well into the brain (Kp,uu 0.39 and BP 0.21).
CSN20368 PHD-1 Inhibitor C39 2009343-19-3 PHD-1 inhibitor C39 is a 4-1,2,4triazolo1,5-apyridin-5-ylbenzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1) with high solubility and permeability.
CSN20367 PHD-1 Inhibitor C17 2009343-14-8 PHD-1 inhibitor C17 is an early lead compound of 4-1,2,4triazolo1,5-apyridin-5-ylbenzonitrile-based inhibitors of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1) showing a moderate rate of microsomal turnover in vitro.
CSN11613 Ononin 486-62-4 Ononin is an isoflavonoid isolated and purified from the herb of Ononis natrix L., can inhibit the growth of pathogen such as Enterococcus sp., Enterobacter sp.
CSN11607 Oltipraz 64224-21-1 Oltipraz can inhibit the insulin-activated HIF-1 (IC50 10 M) in a time-dependent manner.
CSN14672 Moracin P 102841-46-3 Moracin P, a natural product isolated and purified from the root bark of Morus alba L., shows significant nitric oxide (NO) production inhibitory effects in RAW264.7 cells, exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia, and might protect neuronal cell death against the oxidative stress induced by oxygen-glucose deprivation(OGD), can enhance cell viability in dose-dependent manner against OGD-induced cell death in neuroblastoma SH-SY5Y cells.
CSN14671 Moracin O 123702-97-6 Moracin O and moracin P exhibit potent in vitro inhibitory activity against hypoxia-inducible factor HIF-1 which is a key mediator during adaptation of cancer cells to tumour hypoxia
CSN16636 ML228 1357171-62-0 ML228 is an activator of the Hypoxia Inducible Factor HIF pathway and potently activate HIF in vitro as well as its downstream target VEGF
CSN19680 MK-8617   1187990-87-9 MK-8617 is a potent, selective, orally bioavailabl pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1−3 (HIF PHD1−3), inhibiting PHD1, 2, 3 with IC50s of 1.0, 1.0 and 14 nM, respectively.
CSN20474 LW6 934593-90-5 LW6 is an inhibitor of HIF-1 with IC50 of 4.4 μM.
CSN17251 KC7F2   927822-86-4 KC7F2 is a selective HIF-1 transcription inhibitor with IC50 of 20 M in a cell-based assay
CSN17541 JNJ-42041935 1193383-09-3 JNJ-42041935 is a selective inhibitor of prolyl hydroxylase (PHD) with the pKis of 7.91 0.04, 7.29 0.05, and 7.65 0.09 for PHD1, PHD2, and PHD3, respectively.
CSN24496 IOX4 1154097-71-8 IOX4 is a selective HIF-PHD2 inhibitor with IC50 value of 1.6nM.
CSN16064 IOX2   931398-72-0 IOX2 is a selective inhibitor of the hypoxia inducible factor HIF Prolyl-Hydroxylases PHD and active in cells with IC50 value of 21 nM for PHD2ELGN-1 and no inhibition at FIH20uM
CSN20256 IDF-11774 1429054-28-3 IDF-11774 is a hypoxia-inducible factor HIF-1 inhibitor which regulates cancer metabolism thereby suppressing tumor growth
CSN18038 HIF-2α-IN-1 1799948-06-3 HIF-2-IN-1 is a HIF-2 inhibitor has an IC50 of less than 500 nM in HIF-2 scintillation proximity assay
CSN20613 GSK360A 931399-19-8 GSK360A is an active HIF-PHD inhibitor with systemic and local effects by stabilizing HIF-1 signaling and can improve long-term ventricular function
CSN16866 FG-2216 223387-75-5 FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 39 M for PHD2 enzyme orally bioavailable and induced significant and reversible Epo induction in vivo
CSN22394 Enarodustat 1262132-81-9 Enarodustat is a potent and orally active factor prolyl hydroxylase inhibitor with an EC50 of 022 M Enarodustat has entered clinical trial for renal anemia
CSN17599 EL-102 1233948-61-2 EL102 is an inhibitor of HIF1 Which can inhibit tubulin polymerisation and decreased microtubule stability
CSN20491 Echinomycin 512-64-1 Echinomycin is a highly potent and selective HIF-1 inhibitor IC50 294 pM which selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-B
CSN10851 DMOG   89464-63-1 DMOG (Dimethyloxalylglycine) is a prolyl 4-hydroxylase inhibitor with IC50 value of 2uM.
CSN23782 Desidustat 1616690-16-4 Desidustat, an antianaemic drug, is a HIF hydroxylase inhibitor.
CSN16738 Ciclopirox   29342-05-0 Ciclopirox inhibits iron-dependent enzymes PHD2 pIC50 58 and deoxyhypusine hydroxylase It is an antifungal and iron-chelating agent
CSN17588 BAY 87-2243   1227158-85-1 BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced HIF-1 activation
CSN19253 2-Methoxyestradiol   362-07-2 2-methoxyestradiol is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration.
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