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HER2

HER2

Cat. No. Product Name CAS No. Information
CSN16336 XL647 781613-23-8 XL647 or tesevatinib inhibits EGFR, HER2, VEGFR and EphB4 with potential antineoplastic activity.
CSN16032 Varlitinib 845272-21-1 Varlitinib is a selective and potent ErbB1 EGFR and ErbB2 HER2 inhibitor with IC50 of 7 nM and 2 nM respectively
CSN12170 Tyrphostin AG 879 148741-30-4 Tyrphostin AG 879 potently inhibits HER2ErbB2 with IC50 of 1 M 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR
CSN16247 TAK-285 871026-44-7 TAK-285 is a dual HER2 and EGFR HER1 inhibitor with IC50 of 17 nM and 23 nM 10-fold selectivity for HER12 than HER4 less potent to MEK15 c-Met Aurora B Lck CSK etc
CSN16204 Poziotinib 1092364-38-9 Poziotinib is an irreversible Pan-HER inhibitor with IC50s of 3/5/23 nM for HER1/HER2/HER4 respectively.
CSN20576 Neratinib Maleate 915942-22-2 Neratinib maleate is an orally available irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR respectively
CSN12420 Neratinib   698387-09-6 Neratinib is an orally available irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR respectively
CSN11482 Mubritinib 366017-09-6 Mubritinib is a potent and selective inhibitor of HER2ErbB2 with IC50 of 6 nM with no inhibition on EGFR FGFR PDGFR and etc
CSN11269 Lapatinib Ditosylate   388082-77-7 Lapatinib ditosylate is a potent EGFR and ErbB2 inhibitor with IC50 of 108 and 92 nM respectively
CSN18606 Irbinitinib 937263-43-9 Irbinitinib is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold selective for HER2 versus EGFR.
CSN22156 Epertinib 908305-13-5 Epertinib is a potent oral reversible and selective tyrosine kinase inhibitor of EGFR HER2 and HER4 with IC50s of 148 nM 715 nM and 249 nM respectively Epertinib shows potent antitumor activity
CSN13899 Dacomitinib   1110813-31-4 Dacomitinib is a potent, orally available, irreversible tyrosine kinase HER 1 (EGFR), HER2 and HER4 inhibitor with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively.
CSN12702 CP-724714 (Random Configuration) 537705-08-1 CP-724714 is a potent selective inhibitor of HER2ErbB2 with IC50 of 10 nM 640-fold selectivity against EGFR InsR IRG-1R PDGFR VEGFR2 Abl Src c-Met etc in cell-free assays
CSN18252 CP-724714 383432-38-0 CP-724714 is a potent selective inhibitor of HER2ErbB2 with IC50 of 10 nM 640-fold selectivity against EGFR InsR IRG-1R PDGFR VEGFR2 Abl Src c-Met etc
CSN10535 Canertinib 2HCl 289499-45-2 Canertinib 2HCl, an irreversible quinazoline-based HER family tyrosine kinase inhibitor, inhibits EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM respectively. Phase II.
CSN15701 BMS-690514 859853-30-8 BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor EGFR HER2 and HER4 as well as the VEGF receptor kinases
CSN18515 BMS-599626 HCl 873837-23-1 BMS-599626 is an inhibitor of HER1 IC50 20 nM and HER2 IC50 30 nM
CSN15811 AZD8931   848942-61-0 AZD8931 is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM respectively.
CSN18835 AST-1306 p-Toluenesulfonic Acid 1050500-29-2 AST-1306 p-toluenesulfonic acid is an irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790ML858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.
CSN16578 AST-1306 897383-62-9 AST-1306 is an irreversible inhibitor of EGFR and ErbB2 with IC50 of 05 nM and 3 nM also effective in mutation EGFR T790ML858R more potent to ErbB2-overexpressing cells 3000-fold selective for ErbB family than other kinases
CSN17153 ARRY-380 Analog 937265-83-3 ARRY-380 analog is a potent and selective HER2 inhibitor with IC50 of 8 nM equipotent against truncated p95-HER2 500-fold selective for HER2 versus EGFR
CSN12703 Afatinib   850140-72-6 Afatinib E-isomer is an irreversible inhibitor of dual EGFR and HER2 that shows obvious activitives of EGFR wt EGFR L858R EGFR L858RT790M and HER2 with IC50 of 05 nM 04 nM 10 nM and 14 nM respectively
CSN12809 AC480 714971-09-2 AC480 is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM 8-fold less potent to HER4 100-fold to VEGFR2 c-Kit Lck MET etc
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