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HER2

HER2

Cat. No. Product Name CAS No. Information
CSN12170 Tyrphostin AG 879 148741-30-4 Tyrphostin AG 879 potently inhibits HER2ErbB2 with IC50 of 1 M 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR
CSN16247 TAK-285 871026-44-7 TAK-285 is a dual HER2 and EGFR HER1 inhibitor with IC50 of 17 nM and 23 nM 10-fold selectivity for HER12 than HER4 less potent to MEK15 c-Met Aurora B Lck CSK etc
CSN15811 AZD8931   848942-61-0 Sapitinib is a reversible ATP competitive inhibitor of EGFR ErbB2 and ErbB3 with IC50 of 4 nM 3 nM and 4 nM respectively
CSN20576 Neratinib Maleate 915942-22-2 Neratinib maleate is an orally available irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR respectively
CSN12420 Neratinib   698387-09-6 Neratinib is an orally available irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR respectively
CSN11482 Mubritinib 366017-09-6 Mubritinib is a potent and selective inhibitor of HER2ErbB2 with IC50 of 6 nM with no inhibition on EGFR FGFR PDGFR and etc
CSN11269 Lapatinib Ditosylate   388082-77-7 Lapatinib ditosylate is a potent EGFR and ErbB2 inhibitor with IC50 of 108 and 92 nM respectively
CSN18606 Irbinitinib 937263-43-9 Irbinitinib is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold selective for HER2 versus EGFR.
CSN12702 CP-724714 (Random Configuration) 537705-08-1 CP-724714 is a potent selective inhibitor of HER2ErbB2 with IC50 of 10 nM 640-fold selectivity against EGFR InsR IRG-1R PDGFR VEGFR2 Abl Src c-Met etc in cell-free assays
CSN18252 CP-724714 383432-38-0 CP-724714 is a potent selective inhibitor of HER2ErbB2 with IC50 of 10 nM 640-fold selectivity against EGFR InsR IRG-1R PDGFR VEGFR2 Abl Src c-Met etc
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