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Hedgehog

Hedgehog

Cat. No. Product Name CAS No. Information
CSN12427 Vismodegib     879085-55-9 Vismodegib is an inhibitor of hedgehog pathway with IC50 of 3 nM and also inhibits P-gp IC50 30 M
CSN18358 Veratramine   60-70-8 Veratramine is a natually occuring alkaloid isolated from the rhizomes of Veratrum and can inhibit the Hh signaling-dependent proliferation of NIH3T3 cells for it is an analog of cyclopamine.
CSN17420 RU-SKI 43 1043797-53-0 RU-SKI 43 is a small molecule inhibitor of Hhat Hedgehog acyltransferase the enzyme responsible for the attachment of palmitate onto Shh
CSN10046 Mebendazole   31431-39-7 Mebendazole is an inhibitor of hedgehog and a broad spectrum antihelmintic for the treatment of nematode infestations.
CSN13124 JK184   315703-52-7 JK184 is a hedgehog Hh pathway inhibitor with IC50 of 30 nM in mammalian cells
CSN19162 Ciliobrevin A   302803-72-1 Ciliobrevin A inhibits hedgehog (Hh) signaling pathway with IC50 less than 10 M.
CSN22696 AY 9944 2HCl 366-93-8 AY 9944 2HCl is an inhibitor of hedgehog (Hh) signaling.
CSN25227 20(S)-Hydroxycholesterol 516-72-3 20(S)-Hydroxycholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein. It activates Hedgehog (Hh) signaling with EC50 value of ~ 3μM for induction of Hh reporter gene transcription in NIH 3T3 cells.
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