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Hedgehog

Hedgehog

Cat. No. Product Name CAS No. Information
CSN12427 Vismodegib     879085-55-9 Vismodegib is an inhibitor of hedgehog pathway with IC50 of 3 nM and also inhibits P-gp IC50 30 M
CSN18358 Veratramine   60-70-8 Veratramine is a natually occuring alkaloid isolated from the rhizomes of Veratrum and can inhibit the Hh signaling-dependent proliferation of NIH3T3 cells for it is an analog of cyclopamine.
CSN19183 SANT-1   304909-07-7 SANT-1 can directly bind to Smoothened Smo receptor with Kd of 12 nM It also exhibits inhibition of Smo agonist effects IC50 20 nM
CSN17420 RU-SKI 43 1043797-53-0 RU-SKI 43 is a small molecule inhibitor of Hhat Hedgehog acyltransferase the enzyme responsible for the attachment of palmitate onto Shh
CSN19164 RU-SKI 43 HCl 1782573-67-4 RU-SKI 43 hydrochloride is a small molecule inhibitor of Hhat Hedgehog acyltransferase the enzyme responsible for the attachment of palmitate onto Shh
CSN10046 Mebendazole   31431-39-7 Mebendazole is an inhibitor of hedgehog and a broad spectrum antihelmintic for the treatment of nematode infestations.
CSN13124 JK184   315703-52-7 JK184 is a hedgehog Hh pathway inhibitor with IC50 of 30 nM in mammalian cells
CSN20410 Hedgehog Inhibitor C15h 1616368-12-7 Hedgehog inhibitor C15h displays a potent hedgehog-inhibitory activity with an IC50 of 0050 nM
CSN19162 Ciliobrevin A   302803-72-1 Ciliobrevin A inhibits hedgehog (Hh) signaling pathway with IC50 less than 10 M.
CSN22696 AY 9944 2HCl 366-93-8
CSN23089 SANT-2 329196-48-7
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