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HDAC
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN11991 | Vorinostat | 149647-78-9 | Vorinostat is an HDAC1/3 inhibitor with IC50 of ~10 nM. |
| CSN17250 | UF010 | 537672-41-6 | UF010 is a selective inhibitor of HDAC3 2 1 and 8 with IC50s of 006 M 01 M 05 M and 15 M respectively |
| CSN22526 | Tucidinostat | 1616493-44-7 | Tucidinostat is an inhibitor of HDACenzymes class I (HDAC123) and class IIb (HDAC10) inhibitor withIC50s of 95, 160, 67 and 78 nM, espectively. |
| CSN17162 | Tubastatin A | 1252003-15-8 | Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM and is selective1000-fold more against all other isozymes except HDAC857-fold more |
| CSN15899 | TMP269 | 1314890-29-3 | TMP269 is an inhibitor of class IIa HDAC with IC50 of 157 nM 97 nM 43 nM and 23 nM for HDAC4 HDAC5 HDAC7 and HDAC9 respectively |
| CSN22927 | TH34 | 2196203-96-8 | TH34 is a potent HDAC6/8/10 inhibitor that induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. |
| CSN19743 | Sulforaphane Racemate | 4478-93-7 | Sulforaphane a natural product isolated and purified from the seeds of Brassica oleracea L var botrytis L with neuroprotective anti-inflammatory and antitumor effects inhibits TPA-induced NF-B activation and COX-2 expression in MCF-10A cells by blocking two distinct signaling pathways mediated by ERK12-IKK and NAK-IKK |
| CSN11945 | Sodium Butyrate | 156-54-7 | Sodium butyrate is a histone deacetylase HDAC inhibitor with IC50s are 03 mM 04 mM 03 mM for HDAC1 2 and 7 respectively |
| CSN24467 | SIS17 | 2374313-54-7 | SIS17 is a specific HDAC11 inhibitor with IC50 value of 0.83μM for inhibition of the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2. |
| CSN23627 | Sinapinic Acid | 530-59-6 | Sinapinic Acid inhibits collagen-induced human platelet aggregation by up to 70 in vitro with IC50 of 103 mM is a phenylpropanoid hydroxycinnamic acid with diverse biological activities |
| CSN13123 | Scriptaid | 287383-59-9 | Scriptaid is an inhibitor of HDAC with greater effect on acetylated H4 |
| CSN13835 | Santacruzamate A | 1477949-42-0 | Santacruzamate A is an inhibitor of HDAC2 with IC50 of 119 pM |
| CSN13496 | Romidepsin | 128517-07-7 | Romidepsin is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively. |
| CSN18796 | RGFP966 Racemate | 1396841-57-8 | RGFP966 Racemate is the racemate form of HDAC3 inhibitor RGFP966. |
| CSN13881 | Remodelin | 949912-58-7 | Remodelin is a potent and selective inhibitor of the acetyl-transferase protein NAT10 |
| CSN24148 | R306465 | 604769-01-9 | R306465 is a hydroxamate-based histone deacetylase (HDAC) inhibitor with broad-spectrum antitumour activity against solid and haematological malignancies in preclinical models. |
| CSN13125 | PTACH | 848354-66-5 | PTACH is a SAHA-based inhibitor of human HDAC PTACH exerts potent growth inhibition against various human cancer cells with EC50 values ranging from 1 to 10 M |
| CSN21402 | Pomiferin | 572-03-2 | Pomiferin, a flavonoid from the fruits of Maclura pomifera, acts as an potential inhibitor of HDAC, with an IC50 of 1.05 M, and also potently inhibits mTOR (IC50, 6.2 M). |
| CSN16486 | Pimelic Diphenylamide 106 | 937039-45-7 | Pimelic diphenylamide 106 is an inhibitor of class I HDAC with IC50 for HDAC1, HDAC2, and HDAC3 of 150 nM, 760nM, and 370 nM, respectively. |
| CSN18939 | Pimelic Diphenylamide 106 Analog | 2070015-24-4 | Pimelic diphenylamide 106 Analog is an analog of Pimelic Diphenylamide 106 with unknown biological activity. Pimelic Diphenylamide 106 is a class I HDAC inhibitor, demonstrating no activity against class II HDACs. 106 is a slow, tight-binding inhibitor of HDACs 1, 2, and 3 with preference toward HDAC3 with Ki of approximately 14 nm, 15 times lower than the Ki for HDAC1. |
| CSN16819 | PCI-34051 | 950762-95-5 | PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM in a cell-free assay It has greater than 200-fold selectivity over HDAC1 and 6 more than 1000-fold selectivity over HDAC2 3 and 10 |
| CSN15819 | PCI-24781 | 783355-60-2 | PCI-24781 is a pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM, modest potent to HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. |
| CSN12908 | Panobinostat | 404950-80-7 | Panobinostat is a broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. |
| CSN17253 | NKL 22 | 537034-15-4 | NKL 22 is a HDAC inhibitor The value of IC 50 is 78 uM |
| CSN16017 | Mocetinostat | 726169-73-9 | Mocetinostat is an inhibitor of HDAC1 (IC50 0.15 M), HDAC2 (IC50 0.29 M) and HDAC3 (IC50 1.66 M). |
| CSN24175 | JAK/HDAC-IN-1 | 2284621-75-4 | JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor with improved antiproliferative and proapoptotic activities over SAHA and ruxolitinib in several hematological cell lines. |
| CSN16577 | ITF2357 HCl H2O | 732302-99-7 | ITF2357 HCl H2O is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM, respectively. |
| CSN20245 | HDAC Inhibitor C4j | 2098896-13-8 | HDAC inhibitor C4j is a potent HDAC inhibitor in the cellular HDAC assay revealed remarkable chemosensitizing properties and enhanced the cisplatin sensitivity of the cisplatin-resistant head-neck cancer cell line Cal27CisR by almost sevenfold Furthermore 4j almost completely reversed the cisplatin resistance in Cal27CisR |
| CSN20189 | HDAC Inhibitor C001 | 1609389-52-7 | HDAC inhibitor C001 is an inhibitor of HDACs with IC50 of 4 nM HDAC1 15 nM HDAC2 114 nM HDAC3 and can increase Gata2 expression which may be useful in treatment of Gata2-deficiency-associated diseases including leukemia and other blood cell disorders |
| CSN18301 | Givinostat | 497833-27-9 | Givinostat is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM,respectively. |
| CSN18083 | Givinostat HCl | 199657-29-9 | Givinostat HCl is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM, respectively. |
| CSN12566 | Gallic Acid | 149-91-7 | Gallic acid is an organic acid that found in a variety of foods and herbs with effective antioxidant activity. |
| CSN11480 | Entinostat | 209783-80-2 | Entinostat strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM. |
| CSN16783 | Divalproex Sodium | 76584-70-8 | Divalproex sodium is a HDAC inhibitor used in the treatment for epilepsy |
| CSN15774 | Dacinostat | 404951-53-7 | Dacinostat is a HDAC inhibitor with IC50 of 32 nM which can activate the p21 promoter. |
| CSN20226 | CM-272 | 1846570-31-7 | CM-272 is a potent selective and reversible dual small molecule against G9a and DNMTs activity |
| CSN13794 | Citarinostat | 1316215-12-9 | Citarinostat selectively inhibits HDAC6 with IC50 of 4 nM. It can also inhibit HDAC3 (IC50 76 nM). |
| CSN12488 | CI-994 | 112522-64-2 | CI-994 is an inhibitor of HDAC1 with IC50 of 0.57 M with anti-tumor effect. It can cause G1 cell cycle arrest. |
| CSN16989 | Chidamide | 743420-02-2 | Chidamide is a class I HDAC inhibitor with IC50s of 9516067733 nM for HDAC1238, also inhibiting HDAC1011 (IC5078432 nM) and showing no inhibition on HDAC45796 (IC50 30 M). |
| CSN13836 | CAY10603 | 1045792-66-2 | CAY10603 is a selective inhibitor of HDAC6 with IC50 of 2 pM |
| CSN24145 | BRD 4354 Ditrifluoroacetate | N/A | BRD 4354 Ditrifluoroacetate is an inhibitor of HDAC5 and HDAC9 with IC50s of 0.85 and 1.88 μM respectively. |
| CSN17249 | BML-210 | 537034-17-6 | BML-210 is the HDAC inhibitor and its mechanism of action has not been characterized |
| CSN21754 | Biphenyl-4-sulfonyl Chloride | 1623-93-4 | Biphenyl-4-sulfonyl chloride is an inhibitor of HDAC and it has synthetic applications in palladium-catalyzed desulfitative C-arylation. |
| CSN17264 | BG45 | 926259-99-6 | BG45 is a selective inhibitor for HDAC3 with IC50 of 289 nM |
| CSN11550 | Belinostat(Random Configuration) | 414864-00-9 | Belinostat is a HDAC inhibitor with IC50 of 27 nM in a cell-free assay, with activity demonstrated in cisplatin-resistant tumors. |
| CSN13429 | AR-42 | 935881-37-1 | AR-42 is an inhibitor of HDAC with IC50 30 nM. |
| CSN17328 | ACY-738 | 1375465-91-0 | ACY-738 inhibits HDAC6 with IC50 value of 17 nM |
| CSN19518 | 4-Hydroxybenzoic Acid | 99-96-7 | 4-Hydroxybenzoic acid, a natural product isolated and purified from the herbs of Rhodiola crenulata, positively regulates the expression of gum cluster to promote EPS production in PXO99A, and its derivatives have potential to as pan-HDAC inhibitors with anticancer properties. |
| CSN19744 | (R)-Sulforaphane | 142825-10-3 | (R)-Sulforaphane, a natural product isolated and purified from brocoli, is a promising potential chemopreventitive agent in bladder cancer. |
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