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HDAC
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN11991 | Vorinostat | 149647-78-9 | Vorinostat is an HDAC1/3 inhibitor with IC50 of ~10 nM. |
| CSN22526 | Tucidinostat | 1616493-44-7 | Tucidinostat is an inhibitor of HDACenzymes class I (HDAC123) and class IIb (HDAC10) inhibitor withIC50s of 95, 160, 67 and 78 nM, espectively. |
| CSN24808 | 7-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)-N-hydroxyheptanamide hydrochloride | 1793059-58-1 | Tinostamustine is an alkylatlng histone-deacetylase inhibitor (HDACi) fusion molecule. It is a functional pan-histone-deacetylase inhibitor and is assumed to potentiate the alkylating activity of the compound and/or may help to overcome resistance to other therapeutic agents. |
| CSN16416 | Theophylline | 58-55-9 | Theophylline is a natural product present in tea and cocoa working as a phosphodiesterase inhibitor adenosine receptor blocker and histone deacetylase activator |
| CSN22927 | TH34 | 2196203-96-8 | TH34 is a potent HDAC6/8/10 inhibitor that induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. |
| CSN24467 | SIS17 | 2374313-54-7 | SIS17 is a specific HDAC11 inhibitor with IC50 value of 0.83μM for inhibition of the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2. |
| CSN23627 | Sinapinic acid | 530-59-6 | Sinapinic Acid inhibits collagen-induced human platelet aggregation by up to 70 in vitro with IC50 of 103 mM is a phenylpropanoid hydroxycinnamic acid with diverse biological activities |
| CSN13496 | Romidepsin | 128517-07-7 | Romidepsin is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively. |
| CSN18493 | Resminostat | 864814-88-0 | Resminostat is a potent inhibitor of HDAC136 (IC5043-72 nM) and less potent to HDAC8 with IC50 of 877 nM. |
| CSN24148 | N-Hydroxy-2-(4-(naphthalen-2-ylsulfonyl)piperazin-1-yl)pyrimidine-5-carboxamide | 604769-01-9 | R306465 is a hydroxamate-based histone deacetylase (HDAC) inhibitor with broad-spectrum antitumour activity against solid and haematological malignancies in preclinical models. |
| CSN21402 | Pomiferin | 572-03-2 | Pomiferin, a flavonoid from the fruits of Maclura pomifera, acts as an potential inhibitor of HDAC, with an IC50 of 1.05 M, and also potently inhibits mTOR (IC50, 6.2 M). |
| CSN16486 | Pimelic Diphenylamide 106 | 937039-45-7 | Pimelic diphenylamide 106 is an inhibitor of class I HDAC with IC50 for HDAC1, HDAC2, and HDAC3 of 150 nM, 760nM, and 370 nM, respectively. |
| CSN18939 | Pimelic Diphenylamide 106 (analog) | 2070015-24-4 | Pimelic diphenylamide 106 Analog is an analog of Pimelic Diphenylamide 106 with unknown biological activity. Pimelic Diphenylamide 106 is a class I HDAC inhibitor, demonstrating no activity against class II HDACs. 106 is a slow, tight-binding inhibitor of HDACs 1, 2, and 3 with preference toward HDAC3 with Ki of approximately 14 nm, 15 times lower than the Ki for HDAC1. |
| CSN15819 | Abexinostat | 783355-60-2 | PCI-24781 is a pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM, modest potent to HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. |
| CSN12908 | Panobinostat | 404950-80-7 | Panobinostat is a broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. |
| CSN23161 | HDAC6-IN-7 | 956154-63-5 | NCT-14b is a selective HDAC6 inhibitor. It inhibits cell growth of α-positive MCF-7 breast cancer cells treated with estrogen but not untreated cells. |
| CSN32427 | Nanatinostat | 1256448-47-1 | Nanatinostat is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC). |
| CSN27756 | MPI_5a | 1259296-46-2 | MPI-5a is an effective and selective inhibitor of HDAC6 with IC50 value of 36nM. |
| CSN16017 | Mocetinostat | 726169-73-9 | Mocetinostat is an inhibitor of HDAC1 (IC50 0.15 M), HDAC2 (IC50 0.29 M) and HDAC3 (IC50 1.66 M). |
| CSN24175 | JAK/HDAC-IN-1 | 2284621-75-4 | JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor with improved antiproliferative and proapoptotic activities over SAHA and ruxolitinib in several hematological cell lines. |
| CSN16577 | Givinostat hydrochloride monohydrate | 732302-99-7 | ITF2357 HCl H2O is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM, respectively. |
| CSN16989 | HDAC-IN-7 | 743420-02-2 | HDAC-IN-7 is an analogue of Chidamide. Chidamide is a class I HDAC inhibitor with IC50s of 95/160/67/733 nM for HDAC1/2/3/8, also inhibiting HDAC10/11 (IC50=78/432 nM) and showing no inhibition on HDAC4/5/7/9/6 (IC50> 30 μM). |
| CSN26516 | HDAC-IN-4 | 1252003-13-6 | HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC50s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity[1]. |
| CSN18301 | Givinostat | 497833-27-9 | Givinostat is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM,respectively. |
| CSN12566 | Gallic acid | 149-91-7 | Gallic acid is an organic acid that found in a variety of foods and herbs with effective antioxidant activity. |
| CSN11480 | Entinostat | 209783-80-2 | Entinostat strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM. |
| CSN51392 | Elevenostat | 1454902-97-6 | Elevenostat is a putative specific inhibitor of HDAC11, which has been shown to deacetylate the transcription factor FoxP3 in T cells. |
| CSN18820 | Crotonoside | 1818-71-9 | Crotonoside is a naturally occurring active isomer of guanosine found in the seeds of Croton tiglium, which could reduce the blood pressure in rabbits and cats. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the treatment of AML. |
| CSN13794 | Citarinostat | 1316215-12-9 | Citarinostat selectively inhibits HDAC6 with IC50 of 4 nM. It can also inhibit HDAC3 (IC50 76 nM). |
| CSN12488 | Tacedinaline | 112522-64-2 | CI-994 is an inhibitor of HDAC1 with IC50 of 0.57 M with anti-tumor effect. It can cause G1 cell cycle arrest. |
| CSN20569 | BRD3308 | 1550053-02-5 | BRD3308 is a highly selective inhibitor of histone deacetylase 3 (HDAC3) with an IC50 value of 65 nM for HDAC3 vs. |
| CSN24145 | BRD 4354 ditrifluoroacetate | 2444837-63-0 | BRD 4354 Ditrifluoroacetate is an inhibitor of HDAC5 and HDAC9 with IC50s of 0.85 and 1.88 μM respectively. |
| CSN21754 | Biphenyl-4-sulfonyl chloride | 1623-93-4 | Biphenyl-4-sulfonyl chloride is an inhibitor of HDAC and it has synthetic applications in palladium-catalyzed desulfitative C-arylation. |
| CSN11550 | Belinostat (PXD101) | 414864-00-9 | Belinostat is a HDAC inhibitor with IC50 of 27 nM in a cell-free assay, with activity demonstrated in cisplatin-resistant tumors. |
| CSN13429 | AR-42 | 935881-37-1 | AR-42 is an inhibitor of HDAC with IC50 30 nM. |
| CSN23643 | 4-Phenylbutyric acid | 1821-12-1 | 4-Phenylbutanoic acid is an inhibitor of HDAC which can regulate gene transcription with anti-tumor and neuroprotective effects |
| CSN19518 | 4-Hydroxybenzoic acid | 99-96-7 | 4-Hydroxybenzoic acid, a natural product isolated and purified from the herbs of Rhodiola crenulata, positively regulates the expression of gum cluster to promote EPS production in PXO99A, and its derivatives have potential to as pan-HDAC inhibitors with anticancer properties. |
| CSN29552 | 1-Naphthohydroxamic acid | 6953-61-3 | 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity, But it can induce tubulin acetylation. |
| CSN19744 | (R)-Sulforaphane | 142825-10-3 | (R)-Sulforaphane, a natural product isolated and purified from brocoli, is a promising potential chemopreventitive agent in bladder cancer. |
| CSC21754 | Biphenyl-4-sulfonyl chloride | 1623-93-4 | |
| CSN68780 | Sulforaphane | 4478-93-7 | |
| CSN29070 | Pivanex | 122110-53-6 | |
| CSN34624 | RTS-V5 | 2285346-31-6 | |
| CSN36392 | Biotinyl tyramide | 41994-02-9 | |
| CSN84963 | HDAC6-IN-6 | 2413603-10-6 | |
| CSN85088 | HDAC6-IN-5 | 2413603-15-1 |
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