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Guanylate Cyclase
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN19707 | Vericiguat | 1350653-20-1 | Vericiguat targets soluble guanylate cyclase sGC and is used for treating heart failure |
| CSN15708 | Riociguat | 625115-55-1 | Riociguat acts as stimulator of soluble guanylate cyclase sGC that is used to treat ipulmonary hypertension |
| CSN21165 | Plecanatide | 467426-54-6 | Plecanatide is an oral guanylate cyclase C agonist acting locally in the gastrointestinal tract it is approved in January 2017 by the FDA for the treatment of chronic idiopathic constipation CIC |
| CSN16037 | Linaclotide | 851199-59-2 | Linaclotide is a 14-amino acid peptide indicated for the treatment of adults with CC and IBS-C and an agonist of guanylate cyclase C |
| CSN12227 | Lificiguat | 170632-47-0 | Lificiguat is an acivator of guanylyl cyclase sGC and can bind to the heme-containing domain of the subunit with Kd of 06 M - 11 M |
| CSN18217 | Cinaciguat | 329773-35-5 | Cinaciguat is the first of a class of soluble guanylate cyclase sGC activators in clinical development for acute decompensated heart failure |
| CSN18983 | Cinaciguat HCl | 646995-35-9 | Cinaciguat hydrochloride is a potent soluble guanylate cyclase GC activator with EC50 of 15 nM in platelets |
| CSN21294 | BM121307 | 137213-91-3 | BM121307 is a guanylate cyclase activator that was in phase I development for the treatment of ischaemic heart disorders The research has been discontinued |
| CSN15709 | BAY 41-2272 | 256376-24-6 | BAY 41-2272 is an activator of guanylate cyclases (sGC). |
| CSN19827 | Ataciguat | 254877-67-3 | Ataciguat is a potent guanylate cyclase activator potentially for the treatment of aortic valve stenosis |
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