Welcome to CSNpharm! For Research Use Only!

Guanylate Cyclase

Guanylate Cyclase

Cat. No. Product Name CAS No. Information
CSN19707 Vericiguat 1350653-20-1 Vericiguat targets soluble guanylate cyclase sGC and is used for treating heart failure
CSN15708 Riociguat 625115-55-1 Riociguat acts as stimulator of soluble guanylate cyclase sGC that is used to treat ipulmonary hypertension
CSN25656 Praliciguat 1628730-49-3 Praliciguat is a novel, orally available sGC stimulator. It suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH.
CSN25839 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one 41443-28-1 ODQ is a selective and irreversible inhibitor of nitric oxide-sensitive guanylyl cyclase.
CSN26373 NS-2028 204326-43-2 NS-2028 is a potent soluble guanylyl cyclase (sGC) inhibitor with Ki of 8 nM. NS-2028 inhibits sGC activity in homogenates of mouse cerebellum and neuronal NO synthase with IC50 values of 17 nM and 20 nM[1]. NS-2028 is commonly used in the research of nitric oxide signaling pathways, it inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM)[1]. NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability[2].
CSN12227 YC-1   170632-47-0 Lificiguat is an acivator of guanylyl cyclase sGC and can bind to the heme-containing domain of the subunit with Kd of 06 M - 11 M
CSN18217 Cinaciguat 329773-35-5 Cinaciguat is the first of a class of soluble guanylate cyclase sGC activators in clinical development for acute decompensated heart failure
CSN15709 BAY 41-2272 256376-24-6 BAY 41-2272 is an activator of guanylate cyclases (sGC).
<< PREV 1 NEXT >>