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GPCR
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN13936 | TUG-891 | 1374516-07-0 | TUG-891 is a selective agonist of long chain free fatty acid LCFA receptor 4 GPR120 |
| CSN17794 | TUG-770 | 1402601-82-4 | TUG-770 is a highly potent free fatty acid receptor 1 FFA1GPR40 agonist with EC50 of 6 nM for hFFA1 |
| CSN13717 | TGR5 Receptor Agonist | 1197300-24-5 | TGR5 receptor agonist a potent TGR5 GPCR19 agonist showed improved potency in the U2-OS cell assay pEC50 68 and in melanophore cells pEC50 75 |
| CSN15825 | TAK-875 Hemihydrate | 1374598-80-7 | TAK-875 is a selective GPR40 agonist with EC50 of 14 nM in human GPR40 expressing CHO cell line 400-fold more potent than oleic acid |
| CSN13586 | TAK-875 | 1000413-72-8 | TAK-875 is a potent selective and orally bioavailable GPR40 agonist with EC50 of 0072 M |
| CSN21268 | SB-568849 | 395679-53-5 | SB-568849 is a melanin-concentrating hormone receptor 1 MCH R1 antagonist with a pKi of 77 |
| CSN16413 | PSN632408 | 857652-30-3 | PSN632408 is an optimized agonist of GPR119 receptors that shows similar potency to OEA at both recombinant mouse and human GPR119 receptors exhibiting EC50 values of 56 and 79 M respectively |
| CSN22483 | PBI-4050 | 1254472-97-3 | PBI-4050 acts as an agonist for GPR40 and as an antagonist or inverse agonist for GPR84. |
| CSN17281 | NIBR189 | 1599432-08-2 | NIBR189 is a small molecule antagonist of the Epstein-Barr virus-induced gene 2 (EBI2 GPR183) receptor with IC50 of 16 nM (Binding) and 11 nM (Functional). |
| CSN21271 | NGD-4715 | 476322-70-0 | NGD-4715 is a selective and orally active melanin-concentrating hormone receptor 1 MCHR1 antagonist |
| CSN22253 | Monosodium Taurocholate | 145-42-6 | Monosodium taurocholate is an agonist of GPBAR1 and is potential of the treatment of type 2 diabetes and obesity in rats |
| CSN20277 | ML-290 | 1482500-76-4 | ML290 is a biased allosteric agonist at the relaxin receptor RXFP1 possessing a signalling profile indicative of vasodilator and anti-fibrotic properties |
| CSN16921 | MK-6892 | 917910-45-3 | MK-6892 is a highly potential GPR109A agonist with Ki value of 40 nM |
| CSN18472 | MK-0354 | 851776-28-8 | MK-0354 is a partial agonist of GPR109a receptor for hGPR109a mGPR109a with EC50 of 165108 M showed no activation of GPR109b |
| CSN21282 | MCHr1 Antagonist 2 | 863115-70-2 | MCHr1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1 with an IC50 of 65 nM also inhibits hERG with an IC50 of 40 nM in IMR-32 cells |
| CSN21217 | MCH-1 Antagonist 1 | 1039825-68-7 | MCH-1 antagonist 1 is a potent melanin concentrating hormone MCH-1 antagonist with a Ki of 26 nM MCH-1 antagonist 1 also inhibits CYP3A4 with an IC50 of 10 M |
| CSN16084 | MBX-2982 | 1037792-44-1 | MBX-2982 is a selective orally-available GPR119 agonist for the treatment of type 2 tiabetes |
| CSN11273 | Latanoprost | 130209-82-4 | Latanoprost is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure |
| CSN18985 | INT-777 R-Enantiomer | 1198786-98-9 | INT-777 R-enantiomer is the R-enantiomer of INT-777 with EC50 of 479 M for TGR5 and less potent than INT-777 |
| CSN17039 | INT-777 | 1199796-29-6 | INT-777 is a potent and selective TGR5 agonist with remarkable in vivo activity EC50082 M |
| CSN12659 | GW9508 | 885101-89-3 | GW9508 is selective FFA1 GPR40 agonist with pEC50 of 732 and stimulates insulin secretion in a glucose-sensitive manner |
| CSN13558 | GSK1292263 | 1032823-75-8 | GSK1292263 is an agonist of GPR119 receptor that is used to treat type 2 diabetes |
| CSN22421 | GPR84 Antagonist 8 | 1445846-30-9 | GPR84 antagonist 8 is a selective GPR84 antagonist. |
| CSN16256 | GPR40 Activator 2 | 1312787-30-6 | GPR40 activator 2 is a potent GPR40 activator |
| CSN17674 | GPR40 Activator 1 | 1309435-60-6 | GPR40 activator 1 is a potent GPR40 activator for treatment of type 2 diabetes |
| CSN20435 | GPR4 Antagonist C39c | 1197879-16-5 | GPR4 antagonist C39c shows potent cellular activity and is efficacious in animal models of angiogenesis, inflammation and pain. |
| CSN17433 | GPR120 Modulator 2 | 1050506-87-0 | GPR120 modulator 2 is useful for modulating G protein-coupled receptor 120 GPR120 |
| CSN17432 | GPR120 Modulator 1 | 1050506-75-6 | GPR120 modulator 1 is useful for modulating G protein-coupled receptor 120 GPR120 |
| CSN22236 | GPR120 Agonist 2 | 1234844-11-1 | GPR120 Agonist 2 is a GPR120 agonist extracted from patent US 20110313003 A1 example 209 |
| CSN20374 | GPR119 Agonist C26 | 1353004-92-8 | GPR119 agonist C26 shows potent GPR119 agonistic activity EC50 42 nM Emax 117 with improved liver microsome clearance than other GPR119 agonists in the series and exerted 33 reduction in blood glucose AUC at a dose of 10 mgkg in an oral glucose tolerance test in C57BL6 N mice |
| CSN20362 | G-1 | 881639-98-1 | G-1 is a nonsteroidal high-affinity selective agonist of GPR30 that binds with a Ki value of 11 nM |
| CSN18981 | Etrasimod | 1206123-37-6 | Etrasimod is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor with an IC50 value of 1.88 nM in CHO cells. |
| CSN22390 | E6130 | 1427058-33-0 | E6130 is an orally available and highly selective CX3CR1 modulator, that may be effective for treatment of inflammatory bowel disease. |
| CSN20481 | DC260126 | 346692-04-4 | DC260126 is antagoniat of free fatty acid receptor 1 FFA1GPR40 and inhibits FFA-induced the increase of intracellular Ca2 level |
| CSN20443 | CYM 5541 | 945128-26-7 | CYM-5541 is an allosteric agonist of S1P3 with EC50 of 72 nM - 132 nM. |
| CSN20173 | CP-154526 | 157286-86-7 | CP-154526 is a selective non-peptide CRF1 receptor antagonist Ki values are 27 and 10000 nM for CRF1 and CRF2 receptors respectively CP-154526 blocks CRF-induced adenylate cyclase activation Ki 37 nM and attenuates activation of the HPA axis by CRF |
| CSN18454 | CID-16020046 | 834903-43-4 | CID-16020046 is a selective GPR55 LPI receptor antagonist with IC50 of 015 M |
| CSN22239 | BMS-819881 | 1197420-05-5 | BMS-819881 is a melaninconcentrating hormone receptor 1 MCHR1 antagonist which binds rat MCHR1 with a Ki of 7 nM BMS-819881 also is selective and potent for CYP3A4 activity with an EC50 of 13 M |
| CSN13564 | AR 231453 | 733750-99-7 | AR 231453 is a potent and selective small molecule agonist of GPR119 that enhances glucose-dependent insulin secretion and glucagon-like peptide 1 GLP-1 release used as an antidiabetic agent |
| CSN16029 | APD668 | 832714-46-2 | APD668 is a potent GPR119 agonist with EC50 of 27 nM and 33 nM for hGPR119 and ratGPR119 respectively |
| CSN18543 | APD597 | 897732-93-3 | APD597 is an agonist of GPR119 with EC50 of 46 nM and is used for the treatment of type 2 diabetes |
| CSN18497 | AMG-837 Sodium | 865231-45-4 | AMG-837 sodium is a potent GPR40 agonist EC5013 nM with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents |
| CSN13002 | AMG-837 | 865231-46-5 | AMG-837 is a potent GPR40 agonist EC5013 nM with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents |
| CSN22344 | AM-1638 | 1142214-62-7 | AM-1638 is a potent and orally bioavailable GPR40FFA1 full agonist with an EC50 of 016 M |
| CSN16337 | 6-OAU | 83797-69-7 | 6-OAU is a surrogate agonist of GPR84 activating human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay. |
| CSN24479 | BAY-293 | 2244904-70-7 | |
| CSN22671 | AH 7614 | 6326-06-3 | |
| CSN22386 | Dihydromunduletone | 674786-20-0 | |
| CSN23709 | GW-803430 | 515141-51-2 |
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