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GPCR
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN23156 | TC-O 9311 | 444932-31-4 | TC-O 9311 is a potent orphan G protein-coupled receptor 139 (GPR139) agonist with an EC50 of 39 nM[1]. |
| CSN25253 | TC-G 1005 | 1415407-60-1 | TC-G 1005 is a TGR5 agonist with EC50 values of 0.72nM and 6.2nM for hTGR5 and mTGR5, respectively. It exhibited a significant dose-dependent glucagon-like peptide-1 (GLP-1) secretion effect. |
| CSN23214 | ZQ 16 | 376616-73-8 | Selective GPR84 agonist |
| CSN25229 | SBI-115 | 882366-16-7 | SBI-115 is a GPBAR1 (TGR5) antagonist. |
| CSN21268 | SB-568849 | 395679-53-5 | SB-568849 is a melanin-concentrating hormone receptor 1 MCH R1 antagonist with a pKi of 77 |
| CSN24134 | PMX 53 | 219639-75-5 | PMX 53 is a potent C5a receptor antagonist. |
| CSN22483 | PBI-4050 | 1254472-97-3 | PBI-4050 acts as an agonist for GPR40 and as an antagonist or inverse agonist for GPR84. |
| CSN17281 | NIBR189 | 1599432-08-2 | NIBR189 is a potent and selective EBI2 (GPR183) receptor antagonist with IC50 value of 11nM. |
| CSN27549 | NE 52-QQ57 | 1401728-56-0 | NE 52-QQ57 is a selective, and orally available GPR4 antagonist with an IC50 of 70 nM. NE 52-QQ57 has anti-inflammatory activity. |
| CSN22253 | Monosodium Taurocholate | 145-42-6 | Monosodium taurocholate is an agonist of GPBAR1 and is potential of the treatment of type 2 diabetes and obesity in rats |
| CSN24295 | ML401 | 1597489-14-9 | ML401 is a selective inhibitor of GPR183. |
| CSN18472 | MK-0354 | 851776-28-8 | MK-0354 is a partial agonist of GPR109a receptor for hGPR109a mGPR109a with EC50 of 165108 M showed no activation of GPR109b |
| CSN21727 | Melanin Concentrating Hormone, salmon | 87218-84-6 | Melanin concentrating hormone, a cyclic peptide originally isolated from chum salmon pituitaries, is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2. |
| CSN21282 | MCHr1 Antagonist 2 | 863115-70-2 | MCHr1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1 with an IC50 of 65 nM also inhibits hERG with an IC50 of 40 nM in IMR-32 cells |
| CSN23711 | MCHr1 Antagonist 1 | 391610-37-0 | MCHr1 antagonist 1 is a selective antagonist of MCH1 receptor with Kb of 1 nM and Ki of 4 nM at human MCHR1, may be used to reduce the body mass. |
| CSN21217 | MCH-1 Antagonist 1 | 1039825-68-7 | MCH-1 antagonist 1 is a potent melanin concentrating hormone MCH-1 antagonist with a Ki of 26 nM MCH-1 antagonist 1 also inhibits CYP3A4 with an IC50 of 10 M |
| CSN16084 | MBX-2982 | 1037792-44-1 | MBX-2982 is a selective orally-available GPR119 agonist for the treatment of type 2 tiabetes |
| CSN21714 | Lodoxamide | 53882-12-5 | Lodoxamide is an agonist of GPR35. |
| CSN23709 | GW-803430 | 515141-51-2 | GW 803430 is a selective melanin-concentrating hormone receptor 1 (MCH1) antagonist with IC50 of 9.3 nM. |
| CSN25330 | GSK1292263 HCl | 1032824-54-6 | GSK 1292263 HCl is a novel GPR119 receptor agonist that is currently under development for the treatment of type 2 diabetes. |
| CSN14893 | Grifolic Acid | 80557-12-6 | Grifolic acid, a natural product isolated and purified from the Cylindrocarpon ianthothele var. majus, with anti-tumour and anti-haemolytic activities. Grifolic acid is a glucose-6-phosphatase inhibitor and a selective partial GPR120 agonist, can induce ERK and Ca2i responses in cells expressing GPR120. |
| CSN22421 | GPR84 Antagonist 8 | 1445846-30-9 | GPR84 antagonist 8 is a selective GPR84 antagonist. |
| CSN24786 | GPR40 agonist 4 | 2102196-57-4 | GPR40 agonist 4 is a potent free fatty acid receptor 1 (FFA1/ GPR40) agonist with a pEC50 of 7.54. |
| CSN16256 | GPR40 Activator 2 | 1312787-30-6 | GPR40 activator 2 is a potent GPR40 activator |
| CSN20435 | GPR4 Antagonist C39c | 1197879-16-5 | GPR4 antagonist C39c shows potent cellular activity and is efficacious in animal models of angiogenesis, inflammation and pain. |
| CSN21935 | GPR120-IN-1 | 1599477-75-4 | GPR120-IN-1 is a selective Gpr120 agonist with a logEC50 of −7.62. |
| CSN17433 | GPR120 Modulator 2 | 1050506-87-0 | GPR120 modulator 2 is useful for modulating G protein-coupled receptor 120 GPR120 |
| CSN17432 | GPR120 Modulator 1 | 1050506-75-6 | GPR120 modulator 1 is useful for modulating G protein-coupled receptor 120 GPR120 |
| CSN22236 | GPR120 Agonist 2 | 1234844-11-1 | GPR120 Agonist 2 is a GPR120 agonist extracted from patent US 20110313003 A1 example 209 |
| CSN12484 | Ginsenoside Rb2 | 11021-13-9 | Ginsenoside Rb2 is a 20 (S)-protopanaxadiol glycoside extracted from ginseng, shows potent antioxidant and anticancer biological activities. |
| CSN18981 | Etrasimod | 1206123-37-6 | Etrasimod is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor with an IC50 value of 1.88 nM in CHO cells. |
| CSN22390 | E6130 | 1427058-33-0 | E6130 is an orally available and highly selective CX3CR1 modulator, that may be effective for treatment of inflammatory bowel disease. |
| CSN22386 | Dihydromunduletone | 674786-20-0 | Dihydromunduletone is a selective adhesion G protein–coupled receptor antagonist (aGPR) with an IC50 of ~21 μM. |
| CSN25392 | Deoxycholic acid sodium salt | 302-95-4 | Deoxycholic acid sodium salt is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity. |
| CSN10769 | Deoxycholic Acid | 83-44-3 | Deoxycholic Acid is a proinflammatory agent and used in a study to investigate dose-dependent anti-inflammatory effect of ursodeoxycholic acid in experimental colitis. |
| CSN20443 | CYM 5541 | 945128-26-7 | CYM-5541 is an allosteric agonist of S1P3 with EC50 of 72 nM - 132 nM. |
| CSN18454 | CID-16020046 | 834903-43-4 | CID-16020046 is a selective GPR55 LPI receptor antagonist with IC50 of 015 M |
| CSN22239 | BMS-819881 | 1197420-05-5 | BMS-819881 is a melaninconcentrating hormone receptor 1 MCHR1 antagonist which binds rat MCHR1 with a Ki of 7 nM BMS-819881 also is selective and potent for CYP3A4 activity with an EC50 of 13 M |
| CSN16029 | APD668 | 832714-46-2 | APD668 is a potent GPR119 agonist with EC50 of 27 nM and 33 nM for hGPR119 and ratGPR119 respectively |
| CSN18497 | AMG-837 Sodium | 865231-45-4 | AMG-837 sodium is a potent GPR40 agonist EC5013 nM with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents |
| CSN20400 | AEZS-108 | 139570-93-7 | AEZS-108 is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R). |
| CSN16337 | 6-OAU | 83797-69-7 | 6-OAU is a surrogate agonist of GPR84 activating human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay. |
| CSN25407 | 4-CMTB | 300851-67-6 | 4-CMTB is a selective free fatty acid receptor 2 (FFA2/GPR43) agonist and a positive allosteric modulator (pEC50=6.38). |
| CSN25414 | 3-chloro-5-hydroxybenzoic Acid | 53984-36-4 | 3-chloro-5-hydroxybenzoic Acid is a selective GPR81 agonist that exhibited favorable in vivo effects on lipolysis in a mouse model of obesity. |
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