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Glycine transporters (GlyTs) are plasmalemmal neurotransmitter transporters. They serve to terminate the signaling of glycine by mediating its reuptake from the synaptic cleft back into the presynaptic neurons. There are two glycine transporters: glycine transporter 1 (GlyT1) and glycine transporter 2 (GlyT2).

Glycine transporter

Cat. No. Product Name CAS No. Information
CSN15699 Sarcosine   107-97-1 Sarcosine is an NMDAR co-agonist at the glycine binding site. It is an intermediate and byproduct in glycine synthesis and degradation.
CSN23018 Org 25543 HCl 495076-64-7 Org 25543 HCl is a potent and selective glycine transporter type 2 (GlyT2) inhibitor with IC50 of 16 nM for hGlyT2.
CSN23002 NFPS 405225-21-0 NFPS is a selective, non-transportable inhibitor of GlyT1 with IC50s of 2.8 and 9.8 nM for hGlyT1, rGlyT1.
CSN19019 LY2365109 HCl 1779796-27-8 LY2365109 is a selective inhibitor of GlyT1 with IC50 of 158 nM
CSN22951 LY 2365109 HCl 868265-28-5 LY 2365109 HCl is a potent and selective glycine transporter 1 (GlyT1) inhibitor with IC50 of 15.8 nM.
CSN22690 ASP 2535 374886-51-8 ASP 2535 is a potent and selective GlyT1 inhibitor with IC50 of 92 nM.
CSN22675 ALX 5407 HCl 200006-08-2 ALX 5407 HCl is a selective non-transportable inhibitor of the glycine transporter GlyT1 with IC50 of 3 nM for human GlyT1c.
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