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Glycine transporters (GlyTs) are plasmalemmal neurotransmitter transporters. They serve to terminate the signaling of glycine by mediating its reuptake from the synaptic cleft back into the presynaptic neurons. There are two glycine transporters: glycine transporter 1 (GlyT1) and glycine transporter 2 (GlyT2).
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN15699 | Sarcosine | 107-97-1 | Sarcosine is an NMDAR co-agonist at the glycine binding site. It is an intermediate and byproduct in glycine synthesis and degradation. |
| CSN23018 | Org 25543 HCl | 495076-64-7 | Org 25543 HCl is a potent and selective glycine transporter type 2 (GlyT2) inhibitor with IC50 of 16 nM for hGlyT2. |
| CSN23002 | NFPS | 405225-21-0 | NFPS is a selective, non-transportable inhibitor of GlyT1 with IC50s of 2.8 and 9.8 nM for hGlyT1, rGlyT1. |
| CSN19019 | LY2365109 HCl | 1779796-27-8 | LY2365109 is a selective inhibitor of GlyT1 with IC50 of 158 nM |
| CSN10295 | Amoxapine | 14028-44-5 | Amoxapine, a tricyclic dibenzoxazepine antidepressant, inhibits GLYT2a transport activity with IC50 of 92 μM. |
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