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Glutamate transporters are a family of neurotransmitter transporter proteins that move glutamate – the principal excitatory neurotransmitter – across a membrane. The family of glutamate transporters is composed of two primary subclasses: the excitatory amino acid transporter (EAAT) family and vesicular glutamate transporter (VGLUT) family. In the brain, EAATs remove glutamate from the synaptic cleft and extrasynaptic sites via glutamate reuptake into glial cells and neurons, while VGLUTs move glutamate from the cell cytoplasm into synaptic vesicles. Glutamate transporters also transport aspartate and are present in virtually all peripheral tissues, including the heart, liver, testes, and bone. They exhibit stereoselectivity for L-glutamate but transport both L-aspartate and D-aspartate.

Glutamate transporter

Cat. No. Product Name CAS No. Information
CSN22753 Chicago Sky Blue 6B 2610-05-1 Chicago Sky Blue 6B is a potent inhibitor of L-glutamate uptake into synaptic vesicles and also inhibits macrophage migration inhibitory factor (MIF) with IC50 of 0.81 μM.
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