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Glucokinase
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN18191 | RO-28-1675 | 300353-13-3 | Ro 28-1675 is a potent allosteric GK activator with a SC15 value of 024 00019 M |
| CSN22238 | PF-04991532 | 1215197-37-7 | PF-04991532 is a potent, hepatoselective glucokinase activator with EC50s of 80 and 100 nM in human and rat, respectively. |
| CSN26253 | PF-04937319 | 1245603-92-2 | PF-04937319 is a glucokinase activator (GKA) with EC50 value of 154.4 μM, which is under development for the treatment of type 2 diametes mellitus. |
| CSN26447 | MK-0941 | 1137916-97-2 | MK-0941 mesylate is a glucokinase activator (GKA) potentially for the treatment of type 2 diabetes. MK-0941 led to improvements in glycemic control that were not sustained. MK-0941 was associated with an increased incidence of hypoglycemia and elevations in triglycerides and blood. |
| CSN16830 | Globalagliatin | 1234703-40-2 | LY2608204 is an activator of glucokinase GK with EC50 of 42 nM |
| CSN22830 | GKA50 | 851884-87-2 | GKA 50 is a potent glucokinase activator with EC50 of 33 nM. |
| CSN20177 | Dorzagliatin | 1191995-00-2 | Dorzagliatin is a glucokinase activator on glucose metabolism |
| CSN21071 | AMG-3969 | 1361224-53-4 | AMG-3969 is a glucokinase-GKRP disruptor with IC50 value of 343nM and potently reverses the inhibitory effect of GKRP on GK activity. |
| CSN19038 | AM-2394 | 1442684-77-6 | AM-2394 is a structurally distinct glucokinase activator GKA AM-2394 activates glucokinase GK with an EC50 of 60 nM |
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