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GABA Receptor
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN25776 | TPMPA | 182485-36-5 | TPMPA is an antagonist of GABAA-ρ1 (ρ1 GABAC) receptor. |
| CSN25782 | SCH 50911 | 733717-87-8 | SCH 50911 is a selective antagonist of GABAB with IC50 of 1.1 μM. |
| CSN19979 | Sanggenon D | 81422-93-7 | Sanggenon D, a natural product isolated and purified from the root bark of Morus alba L. |
| CSN26143 | Pivagabine | 69542-93-4 | Pivagabine has a highly significant therapeutic potential in clinical conditions characterized by manifestations of psychological distress due to an inadequate management of stressful events. |
| CSN26654 | Pipequaline HCl | 80221-58-5 | Pipequaline, also known as PK-8165, is an anxiolytic drug that was never marketed. It possesses a novel chemical structure that is not closely related to other drugs of this type. The drug has a similar pharmacological profile to the benzodiazepine family of drugs, but with mainly anxiolytic properties and very little sedative, amnestic or anticonvulsant effects, and so is classified as a nonbenzodiazepine anxiolytic. Pipequaline acts as a non-selective GABAA receptor partial agonist. While its profile of anxiolytic effects without sedation would appear to have potential medical applications, pipequaline has never been developed for medical use and is currently only used in scientific research. |
| CSN21797 | Pipequaline | 77472-98-1 | Pipequaline is a partial agonist of benzodiazepine receptor (Ki = 78 nM) with anxiolytic activity. |
| CSN25770 | PHP 501 trifluoroacetate | 1236105-75-1 | PHP 501 trifluoroacetate is a potent GABAA antagonist with IC50 value of 0.024 μM in human α1β2γ2 GABAA-expressing tsA201 cells. |
| CSN25780 | Phaclofen | 114012-12-3 | Phaclofen is a selective GABAB antagonist. |
| CSN25774 | Ocinaplon | 96604-21-6 | Ocinaplon is a modulator of GABAA receptors with anxiolytic activity. It displays modest selectivity for GABAA α1 receptors and partial agonist activity at α2-, α3- and α5-containing receptors. |
| CSN15900 | NCS-382 Sodium | 131733-92-1 | NCS-382 sodium is a -hydroxybutyric acid antagonist, anticonvulsant. |
| CSN18228 | MRK-016 | 342652-67-9 | MRK-016 is a functionally selective, inverse agonist at the benzodiazepine site of GABAA 5 receptors. |
| CSN24055 | Loreclezole | 117857-45-1 | Loreclezole is a subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. |
| CSN20905 | Kavain | 3155-48-4 | Kavain is a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors. |
| CSN25408 | Isonipecotic acid | 498-94-2 | Isonipecotic acid is a specific GABAA receptor agonist. |
| CSN25772 | Isoguvacine HCl | 68547-97-7 | Isoguvacine hydrochloride is a specific agonist of GABAA receptor. |
| CSN21680 | Hypotaurine | 300-84-5 | Hypotaurine, a analog of cystamine, is the precursor for taurine synthesis and can act as an antioxidant and singlet oxygen scavenger. it also acts as an endogenous neurotransmitter via action on the glycine receptors. |
| CSN27656 | GABAA receptor agent 1 | 1571-87-5 | GABAA receptor agent 1 is a high affinity ligand for GABAA receptor, with potent anticonvulsant activity. |
| CSN27585 | FG-7142 | 78538-74-6 | FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex . |
| CSN21616 | Doxefazepam | 40762-15-0 | Doxefazepam is a benzodiazepine medication with anxiolyti and anticonvulsant properties. It is used therapeutically as a hypnotic. |
| CSN17574 | DMCM HCl | 1215833-62-7 | DMCM HCl is benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity. |
| CSN21600 | Deramciclane | 120444-71-5 | Deramciclane is an antagonist of 5-HT2A and inverse agonist of 5-HT2C receptor. It also functions as a GABA reuptake inhibitor. |
| CSN25691 | CL 218872 | 66548-69-4 | CL 218872 is an agonist of benzodiazepine which displaying selectivity for α1 subunit-containing GABAA receptors with Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively. |
| CSN25694 | CGS 20625 | 111205-55-1 | CGS 20625 is selective and partial agonist for the benzodiazepine binding site of the GABAA receptor. It has anxiolytic activity. |
| CSN25779 | CGP 55845 HCl | 149184-22-5 | CGP 55845 hydrochloride is a selective antagonist of GABAB receptor with IC50 of 5 nM. |
| CSN25778 | CGP 54626 HCl | 149184-21-4 | CGP 54626 hydrochloride is a potent and selective antagonist of GABAB receptor with IC50 of 4 nM. |
| CSN25777 | (3-Aminopropyl)(ethyl)phosphinic acid | 123691-29-2 | CGP 36216 hydrochloride is a selective antagonist of GABAB receptors with IC50 of 43 µM. |
| CSN25262 | AZD7325 | 942437-37-8 | AZD-7325 is a GABA-Aα2,3 selective receptor modulator. |
| CSN24752 | AZD6280 | 942436-93-3 | AZD-6280 is a selective GABAA Receptor α2/3 modulator, used for treatment of generalized anxiety disorder. |
| CSN23521 | 6-Methyl-2-phenyl-4H-chromen-4-one | 29976-75-8 | 6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. |
| CSN23331 | 6-Hydroxyflavone | 6665-83-4 | 6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. 6-Hydroxyflavone exhibits inhibitory effect towards bovine hemoglobin (BHb) glycation. 6-Hydroxyflavone can activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation. 6-Hydroxyflavone inhibits the LPS-induced NO production[1] [2]. |
| CSN22026 | 6,2'-Dihydroxyflavone | 92439-20-8 | 6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor. |
| CSN23335 | 5-methoxyflavone | 42079-78-7 | 5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors. |
| CSN25114 | 3,4,5-Trimethoxycinnamic acid | 90-50-6 | 3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex. |
| CSN25781 | 2-Hydroxysaclofen | 117354-64-0 | 2-Hydroxysaclofen is a selective antagonist of GABAB receptors. |
| CSN23429 | L-Glutamic Acid | 56-86-0 | (S)-Glutamic acid acts as an excitatory neurotransmitter in the central nervous system. |
| CSN25868 | Rac-bhff | 123557-91-5 | (R,S)-BHFF is a potent allosteric modulator of GABAB receptor that increases the potency and efficacy of GABA. |
| CSN26652 | (-)-Bicuculline methochloride | 53552-05-9 | (-)-Bicuculline methochloride (l-Bicuculline methochloride) is a potent GABAA receptor antagonist. (-)-Bicuculline methochloride blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons[1]. |
| CSN26323 | (+)-Kavain | 500-64-1 | (+)-Kavain is a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors with EC50 values of 25 and 59 µM in the presence and absence of 300 µM kavain, respectively. |
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