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GABA Receptor

GABA Receptor

Cat. No. Product Name CAS No. Information
CSN17779 Vigabatrin HCl 1391054-02-6 Vigabatrin HCl is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.
CSN12084 Tiagabine 115103-54-3 Tiagabine is an anti-convulsive medication and a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
CSN12085 Tiagabine HCl   145821-59-6 Tiagabine HCl is an inhibitor of gamma-aminobutyric acid (GABA) reuptake (IC50 = 67 nM in vivo) with anticonvulsant effect.
CSN11911 Securinine 5610-40-2 Securinine, a natural product isolated and purified from the leaves and twigs of Securinega suffruticosa with antifungal activity, induces apoptosis in human leukemia HL-60 cells, is a promising monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML).
CSN19979 Sanggenon D 81422-93-7 Sanggenon D, a natural product isolated and purified from the root bark of Morus alba L.
CSN26143 Pivagabine 69542-93-4 Pivagabine has a highly significant therapeutic potential in clinical conditions characterized by manifestations of psychological distress due to an inadequate management of stressful events.
CSN21797 Pipequaline 77472-98-1 Pipequaline is a partial agonist of benzodiazepine receptor (Ki = 78 nM) with anxiolytic activity.
CSN11714 Phytol   150-86-7 Phytol can activite PPAR and attenuate the inflammatory response by inhibiting neutrophil migration and oxidative stress. Phytol is isolated from the leaves of black tea and acts as an aromatic ingredient.
CSN11488 Nefiracetam   77191-36-7 Nefiracetam is a neuronal systems enhancer for Ro 5-4864-induced convulsions. Nefiracetam has GABAergic, cholinergic, and monoaminergic properties.
CSN15900 NCS-382 Sodium 131733-92-1 NCS-382 sodium is a -hydroxybutyric acid antagonist, anticonvulsant.
CSN18228 MRK-016 342652-67-9 MRK-016 is a functionally selective, inverse agonist at the benzodiazepine site of GABAA 5 receptors.
CSN24055 Loreclezole 117857-45-1 Loreclezole is a subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors.
CSN20905 Kavain 3155-48-4 Kavain is a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors.
CSN25408 Isonipecotic acid 498-94-2 Isonipecotic acid is a specific GABAA receptor agonist.
CSN21680 Hypotaurine 300-84-5 Hypotaurine, a analog of cystamine, is the precursor for taurine synthesis and can act as an antioxidant and singlet oxygen scavenger. it also acts as an endogenous neurotransmitter via action on the glycine receptors.
CSN19501 Ginsenoside Rc 11021-14-0 Ginsenoside Rc is a steroid glycoside, and a triterpene saponin found exclusively in the plant genus Panax (ginseng) with properties that inhibit or prevent tumors growth.
CSN10697 Gelsemine 509-15-9 Gelsemine a natural indole alkaloid isolated from flowering plants of the genus Gelsemium with potent activity as an agonist of the mammalian glycine receptor, showing effect on pathwayssystems related to xenobiotic- or diet-induced oxidative stress, and in the treatment of anxiety and other conditions.
CSN25409 Ganaxolone 38398-32-2 Ganaxolone, also known as CCD 1042 and C1042, is a CNS-selective GABAA modulator that acts on well-characterized targets in the brain known to have anxiolytic and anticonvulsant effects. Ganaxolone protects against seizures in diverse animal models, including the pentylenetetrazol, 6 Hz and amygdala kindling models. Ganaxolone is a positive allosteric modulator of the action of the GABAA receptor and, unlike benzodiazepines, there does not appear to be tolerance to the anticonvulsant effects of ganaxolone.
CSN27585 FG-7142   78538-74-6 FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex .
CSN21616 Doxefazepam 40762-15-0 Doxefazepam is a benzodiazepine medication with anxiolyti and anticonvulsant properties. It is used therapeutically as a hypnotic.
CSN17574 DMCM HCl 1215833-62-7 DMCM HCl is benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity.
CSN21600 Deramciclane 120444-71-5 Deramciclane is an antagonist of 5-HT2A and inverse agonist of 5-HT2C receptor. It also functions as a GABA reuptake inhibitor.
CSN25691 CL 218872 66548-69-4 CL 218872 is an agonist of benzodiazepine which displaying selectivity for α1 subunit-containing GABAA receptors with Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively.
CSN25694 CGS 20625 111205-55-1 CGS 20625 is selective and partial agonist for the benzodiazepine binding site of the GABAA receptor. It has anxiolytic activity.
CSN23521 6-Methyl-2-phenyl-4H-chromen-4-one 29976-75-8 6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.
CSN23331 6-Hydroxyflavone 6665-83-4 6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. 6-Hydroxyflavone exhibits inhibitory effect towards bovine hemoglobin (BHb) glycation. 6-Hydroxyflavone can activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation. 6-Hydroxyflavone inhibits the LPS-induced NO production[1] [2].
CSN22026 6,2'-Dihydroxyflavone 92439-20-8 6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor.
CSN23335 5-methoxyflavone 42079-78-7 5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors.
CSN12782 4-Aminobutyric Acid   56-12-2 4-Aminobutyric acid exhibits inhibitory activity on central nervous system (CNS). It is a natural neurotransmitter.
CSN25114 3,4,5-Trimethoxycinnamic acid 90-50-6 3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex.
CSN23429 L-Glutamic Acid   56-86-0 (S)-Glutamic acid acts as an excitatory neurotransmitter in the central nervous system.
CSN17026 (R)-Baclofen   69308-37-8 (R)-Baclofen is a derivative of gamma-aminobutyric acid with the selective activation of GABAB receptor that is used to treat spasticity.
CSN27656 GABAA receptor agent 1   1571-87-5
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