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GABA Receptor
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN17779 | Vigabatrin HCl | 1391054-02-6 | Vigabatrin HCl is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase. |
| CSN12084 | Tiagabine | 115103-54-3 | Tiagabine is an anti-convulsive medication and a selective gamma-aminobutyric acid (GABA) reuptake inhibitor. |
| CSN12085 | Tiagabine HCl | 145821-59-6 | Tiagabine HCl is an inhibitor of gamma-aminobutyric acid (GABA) reuptake (IC50 = 67 nM in vivo) with anticonvulsant effect. |
| CSN11911 | Securinine | 5610-40-2 | Securinine, a natural product isolated and purified from the leaves and twigs of Securinega suffruticosa with antifungal activity, induces apoptosis in human leukemia HL-60 cells, is a promising monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML). |
| CSN19979 | Sanggenon D | 81422-93-7 | Sanggenon D, a natural product isolated and purified from the root bark of Morus alba L. |
| CSN26143 | Pivagabine | 69542-93-4 | Pivagabine has a highly significant therapeutic potential in clinical conditions characterized by manifestations of psychological distress due to an inadequate management of stressful events. |
| CSN21797 | Pipequaline | 77472-98-1 | Pipequaline is a partial agonist of benzodiazepine receptor (Ki = 78 nM) with anxiolytic activity. |
| CSN11714 | Phytol | 150-86-7 | Phytol can activite PPAR and attenuate the inflammatory response by inhibiting neutrophil migration and oxidative stress. Phytol is isolated from the leaves of black tea and acts as an aromatic ingredient. |
| CSN11488 | Nefiracetam | 77191-36-7 | Nefiracetam is a neuronal systems enhancer for Ro 5-4864-induced convulsions. Nefiracetam has GABAergic, cholinergic, and monoaminergic properties. |
| CSN15900 | NCS-382 Sodium | 131733-92-1 | NCS-382 sodium is a -hydroxybutyric acid antagonist, anticonvulsant. |
| CSN18228 | MRK-016 | 342652-67-9 | MRK-016 is a functionally selective, inverse agonist at the benzodiazepine site of GABAA 5 receptors. |
| CSN24055 | Loreclezole | 117857-45-1 | Loreclezole is a subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. |
| CSN20905 | Kavain | 3155-48-4 | Kavain is a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors. |
| CSN25408 | Isonipecotic acid | 498-94-2 | Isonipecotic acid is a specific GABAA receptor agonist. |
| CSN21680 | Hypotaurine | 300-84-5 | Hypotaurine, a analog of cystamine, is the precursor for taurine synthesis and can act as an antioxidant and singlet oxygen scavenger. it also acts as an endogenous neurotransmitter via action on the glycine receptors. |
| CSN19501 | Ginsenoside Rc | 11021-14-0 | Ginsenoside Rc is a steroid glycoside, and a triterpene saponin found exclusively in the plant genus Panax (ginseng) with properties that inhibit or prevent tumors growth. |
| CSN10697 | Gelsemine | 509-15-9 | Gelsemine a natural indole alkaloid isolated from flowering plants of the genus Gelsemium with potent activity as an agonist of the mammalian glycine receptor, showing effect on pathwayssystems related to xenobiotic- or diet-induced oxidative stress, and in the treatment of anxiety and other conditions. |
| CSN25409 | Ganaxolone | 38398-32-2 | Ganaxolone, also known as CCD 1042 and C1042, is a CNS-selective GABAA modulator that acts on well-characterized targets in the brain known to have anxiolytic and anticonvulsant effects. Ganaxolone protects against seizures in diverse animal models, including the pentylenetetrazol, 6 Hz and amygdala kindling models. Ganaxolone is a positive allosteric modulator of the action of the GABAA receptor and, unlike benzodiazepines, there does not appear to be tolerance to the anticonvulsant effects of ganaxolone. |
| CSN27585 | FG-7142 | 78538-74-6 | FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex . |
| CSN21616 | Doxefazepam | 40762-15-0 | Doxefazepam is a benzodiazepine medication with anxiolyti and anticonvulsant properties. It is used therapeutically as a hypnotic. |
| CSN17574 | DMCM HCl | 1215833-62-7 | DMCM HCl is benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity. |
| CSN21600 | Deramciclane | 120444-71-5 | Deramciclane is an antagonist of 5-HT2A and inverse agonist of 5-HT2C receptor. It also functions as a GABA reuptake inhibitor. |
| CSN25691 | CL 218872 | 66548-69-4 | CL 218872 is an agonist of benzodiazepine which displaying selectivity for α1 subunit-containing GABAA receptors with Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively. |
| CSN25694 | CGS 20625 | 111205-55-1 | CGS 20625 is selective and partial agonist for the benzodiazepine binding site of the GABAA receptor. It has anxiolytic activity. |
| CSN23521 | 6-Methyl-2-phenyl-4H-chromen-4-one | 29976-75-8 | 6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. |
| CSN23331 | 6-Hydroxyflavone | 6665-83-4 | 6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. 6-Hydroxyflavone exhibits inhibitory effect towards bovine hemoglobin (BHb) glycation. 6-Hydroxyflavone can activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation. 6-Hydroxyflavone inhibits the LPS-induced NO production[1] [2]. |
| CSN22026 | 6,2'-Dihydroxyflavone | 92439-20-8 | 6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor. |
| CSN23335 | 5-methoxyflavone | 42079-78-7 | 5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors. |
| CSN12782 | 4-Aminobutyric Acid | 56-12-2 | 4-Aminobutyric acid exhibits inhibitory activity on central nervous system (CNS). It is a natural neurotransmitter. |
| CSN25114 | 3,4,5-Trimethoxycinnamic acid | 90-50-6 | 3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex. |
| CSN23429 | L-Glutamic Acid | 56-86-0 | (S)-Glutamic acid acts as an excitatory neurotransmitter in the central nervous system. |
| CSN17026 | (R)-Baclofen | 69308-37-8 | (R)-Baclofen is a derivative of gamma-aminobutyric acid with the selective activation of GABAB receptor that is used to treat spasticity. |
| CSN27656 | GABAA receptor agent 1 | 1571-87-5 |
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