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GABA Receptor
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN17779 | Vigabatrin HCl | 1391054-02-6 | Vigabatrin HCl is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase. |
| CSN24498 | TP003 | 628690-75-5 | TP003 is a GABAA receptor partial agonist that demonstrates affinity for the benzodiazepine site. |
| CSN12084 | Tiagabine | 115103-54-3 | Tiagabine is an anti-convulsive medication and a selective gamma-aminobutyric acid (GABA) reuptake inhibitor. |
| CSN12085 | Tiagabine HCl | 145821-59-6 | Tiagabine HCl is an inhibitor of gamma-aminobutyric acid (GABA) reuptake (IC50 = 67 nM in vivo) with anticonvulsant effect. |
| CSN12077 | Thiocolchicoside | 602-41-5 | Thiocolchicoside is a small molecule muscle relaxant and anti-inflammatory agent, shown to function as a competitive GABAA (gamma-aminobutyric acid type A) receptor antagonist. |
| CSN11911 | Securinine | 5610-40-2 | Securinine, a natural product isolated and purified from the leaves and twigs of Securinega suffruticosa with antifungal activity, induces apoptosis in human leukemia HL-60 cells, is a promising monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML). |
| CSN19979 | Sanggenon D | 81422-93-7 | Sanggenon D, a natural product isolated and purified from the root bark of Morus alba L. |
| CSN20452 | Ro 15-3890 | 84378-44-9 | Ro 15-3890 is an antagonist of benzodiazepine receptor It is a main metabolite of Ro 15-1788 flumazenil |
| CSN10515 | Progabide | 62666-20-0 | Progabide is an analog and prodrug of gamma-aminobutyric acid It is commonly used in the treatment of epilepsy with agonistic activity for both the GABAA and GABAB receptors Progabide has been investigated for many diseases besides epilepsy including Parkinsons disease schizophrenia clinical depression and anxiety disorder with varying success |
| CSN21797 | Pipequaline | 77472-98-1 | Pipequaline is a partial agonist of benzodiazepine receptor (Ki = 78 nM) with anxiolytic activity. |
| CSN11714 | Phytol | 150-86-7 | Phytol can activite PPAR and attenuate the inflammatory response by inhibiting neutrophil migration and oxidative stress. Phytol is isolated from the leaves of black tea and acts as an aromatic ingredient. |
| CSN23337 | Phenibut | 1078-21-3 | Phenibut, a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects. |
| CSN11488 | Nefiracetam | 77191-36-7 | Nefiracetam is a neuronal systems enhancer for Ro 5-4864-induced convulsions. Nefiracetam has GABAergic, cholinergic, and monoaminergic properties. |
| CSN15900 | NCS-382 Sodium | 131733-92-1 | NCS-382 sodium is a -hydroxybutyric acid antagonist, anticonvulsant. |
| CSN18228 | MRK-016 | 342652-67-9 | MRK-016 is a functionally selective, inverse agonist at the benzodiazepine site of GABAA 5 receptors. |
| CSN19855 | MK 0343 | 233275-76-8 | MK 0343 is a selective partial agonist of GABAA3 1 5 and 2 with Ki values of 021 nM-040 nM It displays anxiolytic activity in rodent and primate models |
| CSN24055 | Loreclezole | 117857-45-1 | Loreclezole is a subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. |
| CSN19849 | Loreclezole HCl | 2227372-56-5 | Loreclezole HCl is a subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. |
| CSN17671 | L-655,708 | 130477-52-0 | L-655708 is a potent 5 subunit-selective GABAA receptor inverse agonist Ki 045 nM |
| CSN20905 | Kavain | 3155-48-4 | Kavain is a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors. |
| CSN21680 | Hypotaurine | 300-84-5 | Hypotaurine, a analog of cystamine, is the precursor for taurine synthesis and can act as an antioxidant and singlet oxygen scavenger. it also acts as an endogenous neurotransmitter via action on the glycine receptors. |
| CSN19501 | Ginsenoside Rc | 11021-14-0 | Ginsenoside Rc is a steroid glycoside, and a triterpene saponin found exclusively in the plant genus Panax (ginseng) with properties that inhibit or prevent tumors growth. |
| CSN12568 | Ginkgolide A | 15291-75-5 | Ginkgolide A is an antagonist of g-aminobutyric acid (GABA) with Ki of 14.5 M and also can activate PAF. It is purified from the leaves of ginkgo biloba tree. |
| CSN10697 | Gelsemine | 509-15-9 | Gelsemine a natural indole alkaloid isolated from flowering plants of the genus Gelsemium with potent activity as an agonist of the mammalian glycine receptor, showing effect on pathwayssystems related to xenobiotic- or diet-induced oxidative stress, and in the treatment of anxiety and other conditions. |
| CSN20431 | EVT-201 | 308239-86-3 | EVT-201 is a benzodiazepine derivative drug and partial positive allosteric modulator of the benzodiazepine site of the GABA receptor |
| CSN21616 | Doxefazepam | 40762-15-0 | Doxefazepam is a benzodiazepine medication with anxiolyti and anticonvulsant properties. It is used therapeutically as a hypnotic. |
| CSN17574 | DMCM HCl | 1215833-62-7 | DMCM HCl is benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity. |
| CSN21600 | Deramciclane | 120444-71-5 | Deramciclane is an antagonist of 5-HT2A and inverse agonist of 5-HT2C receptor. It also functions as a GABA reuptake inhibitor. |
| CSN17089 | Bemegride | 64-65-3 | Bemegride can stimulate central nervous system and release barbiturate poisoning |
| CSN19034 | Basmisanil | 1159600-41-5 | Basmisanil is a selective modulator of GABAA5 with negative allosteric regulation. |
| CSN25262 | AZD7325 | 942437-37-8 | AZD-7325 is a GABA-Aα2,3 selective receptor modulator. |
| CSN24752 | AZD6280 | 942436-93-3 | AZD-6280 is a selective GABAA Receptor α2/3 modulator, used for treatment of generalized anxiety disorder. |
| CSN10198 | Acamprosate Calcium | 77337-73-6 | Acamprosate calcium is an agonist of GABA receptor It can act as a modulator of glutamatergic systems and reduce alcohol consumption in animal models of alcohol addiction |
| CSN23521 | 6-Methyl-2-phenyl-4H-chromen-4-one | 29976-75-8 | 6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. |
| CSN23331 | 6-Hydroxyflavone | 6665-83-4 | 6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. 6-Hydroxyflavone exhibits inhibitory effect towards bovine hemoglobin (BHb) glycation. 6-Hydroxyflavone can activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation. 6-Hydroxyflavone inhibits the LPS-induced NO production[1] [2]. |
| CSN22026 | 6,2'-Dihydroxyflavone | 92439-20-8 | 6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor. |
| CSN23335 | 5-methoxyflavone | 42079-78-7 | 5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors. |
| CSN12782 | 4-Aminobutyric Acid | 56-12-2 | 4-Aminobutyric acid exhibits inhibitory activity on central nervous system (CNS). It is a natural neurotransmitter. |
| CSN10435 | (+)-Bicuculline | 485-49-4 | -Bicuculline is an antagonist of GABAA receptor with IC50 of 2 M and also shows inhibition of Ca2-activated potassium channels |
| CSN23429 | L-Glutamic Acid | 56-86-0 | (S)-Glutamic acid acts as an excitatory neurotransmitter in the central nervous system. |
| CSN17026 | (R)-Baclofen | 69308-37-8 | (R)-Baclofen is a derivative of gamma-aminobutyric acid with the selective activation of GABAB receptor that is used to treat spasticity. |
| CSN14755 | (-)-Corlumine | 79082-64-7 | (-)-Corlumine is a natural product isolated and purified from the herbs of Fumaria parviflora with spasmolytic and GABA antagonist activity. |
| CSN25408 | Isonipecotic acid | 498-94-2 | |
| CSN25410 | Saclofen | 125464-42-8 | |
| CSN25409 | Ganaxolone | 38398-32-2 |
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