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GABA Receptor

GABA Receptor

Cat. No. Product Name CAS No. Information
CSN12085 Tiagabine HCl   145821-59-6 Tiagabine HCl is an inhibitor of gamma-aminobutyric acid (GABA) reuptake (IC50 = 67 nM in vivo) with anticonvulsant effect.
CSN11911 Securinine 5610-40-2 Securinine, a natural product isolated and purified from the leaves and twigs of Securinega suffruticosa with antifungal activity, induces apoptosis in human leukemia HL-60 cells, is a promising monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML).
CSN11714 Phytol   150-86-7 Phytol can activite PPAR and attenuate the inflammatory response by inhibiting neutrophil migration and oxidative stress. Phytol is isolated from the leaves of black tea and acts as an aromatic ingredient.
CSN23642 MRX-1024   348-67-4 MRX-1024 can inhibit the activation of GABAA receptor and exhibit relieving effect on hearing loss It can used as a chemoprotective agent
CSN18228 MRK-016 342652-67-9 MRK-016 is a functionally selective, inverse agonist at the benzodiazepine site of GABAA 5 receptors.
CSN25408 Isonipecotic acid 498-94-2 Isonipecotic acid is a specific GABAA receptor agonist.
CSN19501 Ginsenoside Rc 11021-14-0 Ginsenoside Rc is a steroid glycoside, and a triterpene saponin found exclusively in the plant genus Panax (ginseng) with properties that inhibit or prevent tumors growth.
CSN10697 Gelsemine 509-15-9 Gelsemine a natural indole alkaloid isolated from flowering plants of the genus Gelsemium with potent activity as an agonist of the mammalian glycine receptor, showing effect on pathwayssystems related to xenobiotic- or diet-induced oxidative stress, and in the treatment of anxiety and other conditions.
CSN25409 Ganaxolone 38398-32-2 Ganaxolone, also known as CCD 1042 and C1042, is a CNS-selective GABAA modulator that acts on well-characterized targets in the brain known to have anxiolytic and anticonvulsant effects. Ganaxolone protects against seizures in diverse animal models, including the pentylenetetrazol, 6 Hz and amygdala kindling models. Ganaxolone is a positive allosteric modulator of the action of the GABAA receptor and, unlike benzodiazepines, there does not appear to be tolerance to the anticonvulsant effects of ganaxolone.
CSN27585 N-Methyl-9H-pyrido[3,4-b]indole-3-carboxamide 78538-74-6 FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex .
CSN17574 DMCM HCl 1215833-62-7 DMCM HCl is benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity.
CSN12782 4-Aminobutyric Acid   56-12-2 4-Aminobutyric acid exhibits inhibitory activity on central nervous system (CNS). It is a natural neurotransmitter.
CSN23429 L-Glutamic Acid   56-86-0 (S)-Glutamic acid acts as an excitatory neurotransmitter in the central nervous system.
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