RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis. Specifically demethylates N6-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes.
|MUN36378 is a FTO inhibitor for treatment of leukemia, extractd from patent WO 2018157842.
|FB23-2 is a FTO inhibitor. It directly binds to FTO and selectively inhibits FTO's m6A demethylase activity.