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|Cat. No.||Product Name||CAS No.||Information|
|CSN12515||Losartan Potassium||124750-99-8||Losartan Potassium is the potassium salt form of Losartan, which is a compeitive AT1 receptor inhibitor with IC50 value of 20 nM.|
|CSN13680||ABT-199||1257044-40-8||ABT-199 is a highly potent inhibitor of Bcl-2, re-engineered from ABT-263. It has subnanomolar affinity (Ki<0.010 nM, analysis by TR–FRET assay), which is over three orders of magnitude to Bcl-XL (Ki=48nM) and Bcl-W (Ki=245 nM).|
|CSN16807||Imatinib Mesylate||220127-57-1||Imatinib Mesylate is the mesylate form of Imatinib. Imatinib is a multiple target inhibitor with IC50 values of 100nM, 100nM, 38nM, 25nM and 25nM for PDGFR, c-kit, v-Abl, c-abl and bcr-abl, respectively, usually used for treatment of chronic myelogenous leukemia.|
|CSN13702||Salicin||138-52-3||Salicin is a non-selective COX-1 and COX-2 inhibitor, it is a phenol β-glycosid isolated and purified from the peel of Salix alba L.and shows anti-inflammatory effects.|
|CSN11280||Lenalidomide||191732-72-6||Lenalidomide, a thalidomide analog, is a TNF-α secretion inhibitor with IC50 of 13 nM.|
|CSN12073||Thalidomide||50-35-1||Thalidomide interacts directly with the protein cereblon (CRBN; IC50 = 8.5 nM), a ubiquitously-expressed E3 ligase. And binding of thalidomide analogs to CRBN-DNA damage binding protein-1 complexes (CRBN-DDB1-Cul4A complex) account for the immunomodulatory and antiproliferative effects of these compounds.|
|CSN13185||Pomalidomide||19171-19-8||Pomalidomide inhibits lipopolysaccharide (LPS) stimulated TNF-alpha release in human PBMC and in human whole blood with IC50 values of 13 nM and 25 nM, respectively. Pomalidomide inhibits the growth of T regulatory cells which is stimulated by IL-2 with an IC50 of ~1 μM. Treatment with Pomalidomide (6.4 nM-10 μM) increases the production of IL-2 in human peripheral blood T cells, and is slightly more potent in the CD4+ subset than in the CD8+ subset. Pomalidomide is significantly more potent than CC-5013 at elevating IL-2, IL-5, and IL-10 levels, but only slightly more potent than CC-5013 at elevating IFN-γ levels. Pomalidomide enhances SEE and Raji cells induced AP-1 transcriptional activity in Jurkat cells in a dose-dependent manner, with a maximal enhancement of 4-fold at 1 μM. Exposure of Raji cells to various concentrations of Pomalidomide (2.5-40 μg/mL) for 48 hours leads to a significant decrease in cell proliferation and DNA synthesis. There is a reduction of ~40% compared to vehicle-treated controls.|
|CSN16132||Mycophenolate mofetil||128794-94-5||Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively.|
|CSN12842||Dopamine HCl||62-31-7||Dopamine hydrochloride works as a catecholamine neurotransmitter and a dopamine receptors agonist. It can treat various types of shock clinically.|
|CSN10805||Diethylstilbestrol||56-53-1||Diethylstilbestrol is a synthetic nonsteroidal estrogen that produces all the pharmacological and therapeutic effects of natural estradiol. It is mainly used for functional hemorrhage caused by estrogen hypoxia and hormonal imbalance, amenorrhea.|
|CSN17329||Daidzein||486-66-8||Daidzein can act as an inhibitor of tyrosine kinase and an activator of estrogen receptor. It is inactive analogue of genistein.|
|CSN17077||Y15||4506-66-5||Y15 is a selective FAK inhibitor.|
|CSN12374||Tripelennamine HCl||154-69-8||Tripelennamine hydrochloride, a H1-receptor antagonist, is a psychoactive drug and member of the pyridine andethylenediamine classes that is used as an antipruritic and first-generation antihistamine.|
|CSN13892||Epacadostat||1204669-58-8||Epacadostat is a selective IDO1 inhibitor with IC50 value of ~10nM with little activity against the related enzymes IDO2 or TDO.|
|CSN16720||Fingolimod HCl||162359-56-0||Dinotefuran is the third generation of neonicotinoid group,which works through inhibiting nAchRs.|
|CSN19486||Paclitaxel||33069-62-4||Paclitaxel can stabilize the microtubule formation through interacting with β-tubulin and then promoting the polymerization and assembly of it.|
|CSN10001||Levofloxacin||100986-85-4||Adenosine is a nucleoside that is composed of adenine and d-ribose and plays many important biological roles in addition to being components of DNA and RNA.|
|CSN16581||Campathecin||7689-03-4||Camptothecin is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231.|
|CSN16761||Sunitinib||557795-19-4||Sunitinib is a multiple RTKs inhibitor with IC50 values of 2nM and 80nM for VEGFR2 and PDGFRβ, respectively, also shows inhibition against KIT and FLT3 receptor.|
|CSN19418||Retinoic acid||302-79-4||Oridonin, a diterpenoid purified from Rabdosia rubescens, is an antitumor agent.|
|CSN11410||Methyl Gallate||99-24-1||Methyl gallate, a natural product isolated and purified from the herbs of Sapium sebiferum, is a reverse transcriptase inhibitor.|
|CSN10424||Caffeic Acid||331-39-5||Caffeic acid is a hydroxycinnamic acid, a naturally occurring organic compound isolated and purified from the herb of Boehmeria siamensis Craib., with antioxidant, antineoplastic, anti-HIV, choleretic, hepatotropic, and is a strong inhibitor of neutrophil elastase.|
|CSN11247||Kanamycin Sulfate||25389-94-0||Kanamycin Sulfate is an antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil and is effective as a bacteriocidal agent by inhibiting ribosomal translocation and eliciting miscoding. It is usually used in cloning selection.|
|CSN15946||Doxycycline Hyclate||24390-14-5||Doxycycline Hyclate is a broad-spectrum antibiotic used to treat infections caused by bacteria, including pneumonia and other respiratory tract infections, and an MMP inhibitor.|
|CSN16742||Carbenicillin Disodium||4800-94-6||Carbenicillin Disodium is a broad-spectrum, semi-synthetic penicillin antibiotic.|
|CSN12629||Coenzyme Q10||303-98-0||Coenzyme Q10 is a component of the electron transport chain and participates in aerobic cellular respiration.|
|CSN10452||Biotin NHS||35013-72-0||Biotin NHS is a membrane-permeable compound for labeling intracellular proteins by forming irreversible amide bonds.|