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FLT3

FLT3

Cat. No. Product Name CAS No. Information
CSN15695 UNC2025   1429881-91-3 UNC2025 is an inhibitor of Mer and Flt3 with IC50 of 08 nM and 074 nM respectively
CSN19156 UNC2025 HCl 2070015-17-5 UNC2025 HCl is a potent and orally bioavailable MerFlt3 dual inhibitor with IC50 of 08074 nM for MerFlt3
CSN13941 TCS 359 301305-73-7 TCS 359 a 2-acylaminothiophene-3-carboxamide is a potent inhibitor of FLT3 with IC50 of 42 nM
CSN12033 Tandutinib   387867-13-2 Tandutinib is an antagonist of FLT3 with IC50 of 0.22 M and can also inhibit PDGFR and c-Kit thereby inhibiting cellular proliferation and inducing apoptosis.
CSN20533 SU-5614   1055412-47-9 SU-5614 is an inhibitor of FLT3 In BaF3 and AML cell lines expressing a constitutively activated FLT3 SU-5614 exhibits significant cell growth inhibition and cell cycle arrest
CSN13100 Quizartinib   950769-58-1 Quizartinib is a second-generation FLT3 inhibitor for Flt3 ITDWT with IC50 of 11 nM42 nM being 10-fold selective for Flt3 than KIT PDGFR PDGFR RET and CSF-1R
CSN17304 KW-2449 1000669-72-6 KW-2449 is a multiple-targeted inhibitor mostly for Flt3 with IC50 of 66 nM modestly potent to FGFR1 Bcr-Abl and Aurora A and showing little effect on PDGFR IGF-1R EGFR
CSN13926 Gilteritinib 1254053-43-4 Gilteritinib is a potent FLT3AXL inhibitor with IC50 of 029 nM 1 nM respectively and shows potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations
CSN13783 G-749 1457983-28-6 G-749 is a FLT3 inhibitor that showed potent and sustained inhibition of the FLT3 wild type and mutants with IC50s of 04063575 nM for Wt Flt3D835YMV4-11Molm-14 respectively
CSN16867 FLT3-IN-2 923562-23-6 FLT3-IN-2 is a FLT3 inhibitor with IC50 of 1 M
CSN21240 FLT3-IN-1 Succinate 1702864-11-6 FLT3-IN-1 Succinate is a potent FLT3 inhibitor extracted from patent WO2015056683A1 compound example A
CSN21235 FLT3-IN-1 1472797-69-5 FLT3-IN-1 is a potent FLT3 inhibitor extracted from patent WO2015056683A1 compound example A
CSN16265 SKLB4771 1370256-78-2 FLT3-IN-1 is a potent and selective Flt3 inhibitor with IC50 of 10 nM and against FLT3-ITD-expressing MV4-11 cells with IC50 of 6 nM
CSN20591 Famitinib 1044040-56-3 Famitinib a structural analogue of sunitinib is a multi-targeted receptor tyrosine kinase inhibitor which is potential for treatment of renal cell carcinoma gastrointestinal stromal tumours pancreatic cancer and nasopharyngeal carcinoma
CSN16610 ENMD-2076 Tartrate 1453868-32-0 ENMD-2076 tartrate has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 186 nM 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2KDR and VEGFR3 FGFR1 and FGFR2 and PDGFR
CSN18598 ENMD-2076 934353-76-1 ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 186 nM 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2KDR and VEGFR3 FGFR1 and FGFR2 and PDGFR
CSN16257 BPR1J-097 1327167-19-0 BPR1J-097 is a small molecule FLT-3 inhibitor IC50117 nM with promising in vivo anti-tumour activities inhibiting FLT-3 D835Y with an IC50 of 3 nM
CSN21227 Gilteritinib Hemifumarate 1254053-84-3
CSN22654 5'-Fluoroindirubinoxime 861214-33-7
CSN22754 CHMFL-FLT3-122 1839150-56-9
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