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FGFR

FGFR

Cat. No. Product Name CAS No. Information
CSN33144 Tasurgratinib 1622204-21-0 Tasurgratinib is a novel selective inhibitor of fibroblast growth factor receptors, that displays potent anti-tumor activity.
CSN18656 Sulfatinib   1308672-74-3 Sulfatinib is an inhbitor of KDR and FGFR1 with IC50 values of 0.021 M and 0.053 M respectively. It also shows inhibition of hERG (IC50 6.8 M).
CSN15810 SSR128129E 848318-25-2 SSR128129E is an allosteric modulator of FGFR by binding to the extracellular FGFR domain
CSN18466 SSR128129E Free Acid 848463-13-8 SSR128129E free acid is a multi-FGFR blocker with allosteric properties and inhibits FGFR signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding
CSN26937 Rogaratinib 1443530-05-9 Rogaratinib is a potent and selective fibroblast growth factor receptor (FGFR) inhibitor.
CSN20388 PRN1371 1802929-43-6 PRN1371 is an irreversible covalent FGFR inhibitor used for the treatment of solid tumor
CSN12916 PD173074 219580-11-7 PD173074 is a potent FGFR1 inhibitor with IC50 of 25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM 1000-fold selective for FGFR1 than PDGFR and c-Src
CSN13927 PD166866   192705-79-6 PD 166866 is a selective FGFR tyrosine kinase inhibitor with an IC50 of 524 nM
CSN23024 PD 161570 192705-80-9 PD 161570 is a selective FGFR inhibitor with IC50 of 40 nM.
CSN25230 ODM-203 1430723-35-5 ODM-203 is a selective inhibitor of FGFR and VEGFR with IC50 values of 11, 16, 6, 35nM for recombinant FGFR1-4 and 26, 9, 5nM for VEGFR1-3, respectively.
CSN22060 MRX-2843 1429882-07-4 MRX-2843 is an orally available small-molecule inhibitor of both MERTK and FLT3.
CSN16111 LY2874455 1254473-64-7 LY2874455 is a pan-FGFR inhibitor with IC50 of 28 nM 26 nM 64 nM and 6 nM for FGFR1 FGFR2 FGFR3 and FGFR4 respectively and also inhibits VEGFR2 activity with IC50 of 7 nM
CSN18841 H3B-6527 1702259-66-2 H3B-6527 acts as a selective FGFR4 inhibitor IC50 12 nM over FGFR1-3
CSN13938 FIIN-3 1637735-84-2 FIIN-3 is an irreversible inhibitor of FGFR1-4 with IC50s of 13 21 31 and 35 nM respectively
CSN13937 FIIN-2 1633044-56-0 FIIN-2 is an irreversible inhibitor of FGFR1-4 with IC50 values of 31 43 27 and 45 nM respectively
CSN22818 FIIN 1 HCl 1779796-29-0 FIIN 1 HCl is a potent, irreversible FGFR inhibitor with Kds of 2.8, 5.4, 6.9 and 120 nM for FGFR1, FGFR3, FGFR2 and FGFR4 respectively.
CSN18853 FGFR4-IN-1 1708971-72-5 FGFR4-IN-1 is a potent inhibiotr of FGFR4 with IC50 of 07 nM
CSN19155 FGFR-IN-1 1448169-71-8 FGFR-IN-1 is a potent and highly selective FGFR inhibitor used for antitumor treatment
CSN19757 FGF401 1708971-55-4 FGF401 an inhibitor of human fibroblast growth factor receptor 4 FGFR4 IC50 11 nM has potential antineoplastic activity
CSN17720 Erdafitinib 1346242-81-6 Erdafitinib inhibits FGFR1 pIC50 9 FGFR2 pIC50 85 FGFR3 pIC50 85 and FGFR4 pIC50 825 and it is a quinoxaline derivative compound
CSN20555 Derazantinib 1234356-69-4 Derazantinib is a fibroblast growth factor receptor FGFR inhibitor that has antitumor activity
CSN21245 ARQ-087 2HCl 1821329-75-2 Derazantinib ARQ-087 is an ATP competitive tyrosine kinase inhibitor exhibits potent activity against FGFR1-3 chondrocytes with IC50s of 45 18 and 45 nM respectively
CSN17224 CH5183284   1265229-25-1 CH5183284 is a selective and orally available FGFR inhibitor with IC50 of 9.3 nM, 7.6 nM, 22 nM, and 290 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.
CSN13925 BLU9931 1538604-68-0 BLU9931 is an inhibitor of FGFR4 with IC50 of 3 nM and is less potent for FGFR1/2/3 (IC50 > 150 nM).
CSN18780 BLU-554 1707289-21-1 BLU-554 is a selective inhibitor of FGFR4 with the IC50 of 5 nM
CSN17679 NVP-BGJ398 Phosphate 1310746-10-1 BGJ398 Phosphate is a selective and potent inhibitor of FGFRs with IC50 values of 1nM for FGFR11-3 and 60nM for FGFR4, as well as 4.9nM for FGFR3-K650E mutant.
CSN16144 BGJ398 872511-34-7 BGJ-398 is a selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively and > 40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes.
CSN19705 ASP5878 1453208-66-6 ASP5878 is a selective FGFR inhibitor to treat FGFR3-dependent urothelial cancer with or without chemoresistance
CSN26650 ARQ 069 1314021-57-2 and 1.23 μM, respectively). ARQ 069 inhibits FGFR1/FGFR2 autophosphorylation (IC50s of 2.8 and 1.9 μM, respectively) through a mechanism in a non-ATP competitive dependent manner[1].
CSN22608 Alofanib   1612888-66-0 Alofanib is a selective and allosteric inhibitor of FGFR2 with potential antitumor activity
CSN18610 ACTB-1003 939805-30-8 ACTB-1003 is a potent inhibitor of FGFR1 with IC50 10 nM in FGFR-1 biochemical assay
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