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FGFR

FGFR

Cat. No. Product Name CAS No. Information
CSN18656 Sulfatinib   1308672-74-3 Sulfatinib is an inhbitor of KDR and FGFR1 with IC50 values of 0.021 M and 0.053 M respectively. It also shows inhibition of hERG (IC50 6.8 M).
CSN15810 SSR128129E 848318-25-2 SSR128129E is an allosteric modulator of FGFR by binding to the extracellular FGFR domain
CSN18466 SSR128129E Free Acid 848463-13-8 SSR128129E free acid is a multi-FGFR blocker with allosteric properties and inhibits FGFR signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding
CSN20388 PRN1371 1802929-43-6 PRN1371 is an irreversible covalent FGFR inhibitor used for the treatment of solid tumor
CSN12916 PD173074 219580-11-7 PD173074 is a potent FGFR1 inhibitor with IC50 of 25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM 1000-fold selective for FGFR1 than PDGFR and c-Src
CSN13927 PD166866   192705-79-6 PD 166866 is a selective FGFR tyrosine kinase inhibitor with an IC50 of 524 nM
CSN19223 NSC 12 102586-30-1 NSC 12 is an orally available pan-FGF trap able to inhibit FGF2FGFR interaction and endowed with promising antitumor activity
CSN16111 LY2874455 1254473-64-7 LY2874455 is a pan-FGFR inhibitor with IC50 of 28 nM 26 nM 64 nM and 6 nM for FGFR1 FGFR2 FGFR3 and FGFR4 respectively and also inhibits VEGFR2 activity with IC50 of 7 nM
CSN18841 H3B-6527 1702259-66-2 H3B-6527 acts as a selective FGFR4 inhibitor IC50 12 nM over FGFR1-3
CSN13938 FIIN-3 1637735-84-2 FIIN-3 is an irreversible inhibitor of FGFR1-4 with IC50s of 13 21 31 and 35 nM respectively
CSN13937 FIIN-2 1633044-56-0 FIIN-2 is an irreversible inhibitor of FGFR1-4 with IC50 values of 31 43 27 and 45 nM respectively
CSN18853 FGFR4-IN-1 1708971-72-5 FGFR4-IN-1 is a potent inhibiotr of FGFR4 with IC50 of 07 nM
CSN20012 FGFR4 Inhibitor C(-)-11 2020395-38-2 FGFR4 inhibitor C--11 is a highly potent FGFR4 inhibitor with selectivity over FGFR1 with good stability and CYP inhibition
CSN19155 FGFR-IN-1 1448169-71-8 FGFR-IN-1 is a potent and highly selective FGFR inhibitor used for antitumor treatment
CSN19757 FGF401 1708971-55-4 FGF401 an inhibitor of human fibroblast growth factor receptor 4 FGFR4 IC50 11 nM has potential antineoplastic activity
CSN17720 Erdafitinib 1346242-81-6 Erdafitinib inhibits FGFR1 pIC50 9 FGFR2 pIC50 85 FGFR3 pIC50 85 and FGFR4 pIC50 825 and it is a quinoxaline derivative compound
CSN20555 Derazantinib 1234356-69-4 Derazantinib is a fibroblast growth factor receptor FGFR inhibitor that has antitumor activity
CSN21245 ARQ-087 2HCl 1821329-75-2 Derazantinib ARQ-087 is an ATP competitive tyrosine kinase inhibitor exhibits potent activity against FGFR1-3 chondrocytes with IC50s of 45 18 and 45 nM respectively
CSN17224 CH5183284     1265229-25-1 CH5183284 is a selective and orally available FGFR inhibitor with IC50 of 9.3 nM, 7.6 nM, 22 nM, and 290 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.
CSN13925 BLU9931 1538604-68-0 BLU9931 is an inhibitor of FGFR4 with IC50 of 3 nM and is less potent for FGFR1/2/3 (IC50 > 150 nM).
CSN18780 BLU-554 1707289-21-1 BLU-554 is a selective inhibitor of FGFR4 with the IC50 of 5 nM
CSN17679 NVP-BGJ398 Phosphate 1310746-10-1 BGJ398 Phosphate is a selective and potent inhibitor of FGFRs with IC50 values of 1nM for FGFR11-3 and 60nM for FGFR4, as well as 4.9nM for FGFR3-K650E mutant.
CSN16144 BGJ398   872511-34-7 BGJ-398 is a selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively and > 40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes.
CSN12890 AZD4547   1035270-39-3 AZD4547 is a selective FGFR inhibitor targeting FGFR123 with IC50 of 02 nM25 nM18 nM with weaker activity against FGFR4 VEGFR2 KDR and little activity observed against IGFR CDK2 and p38
CSN19705 ASP5878 1453208-66-6 ASP5878 is a selective FGFR inhibitor to treat FGFR3-dependent urothelial cancer with or without chemoresistance
CSN22608 Alofanib   1612888-66-0 Alofanib is a selective and allosteric inhibitor of FGFR2 with potential antitumor activity
CSN18610 ACTB-1003 939805-30-8 ACTB-1003 is a potent inhibitor of FGFR1 with IC50 10 nM in FGFR-1 biochemical assay
CSN22818 FIIN 1 HCl 1256152-35-8
CSN23024 PD 161570 192705-80-9
CSN23858 PF-05231023 1037589-69-7
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