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FAK

FAK

Cat. No. Product Name CAS No. Information
CSN17077 Y15   4506-66-5 Y15 is a small molecule FAK phosphorylation inhibitor which specifically block phosphorylation of Y397-FAK and total phosphorylation of FAK.
CSN23200 Y 11 1086639-59-9 Y11 is a small molecule inhibitor targeting Y397 site of FAK. Y11 significantly and specifically decreased FAK autophosphorylation, directly bound to the N-terminal domain of FAK. In addition, Y11 decreased Y397-FAK autophosphorylation, inhibited viability and clonogenicity of colon SW620 and breast BT474 cancer cells and increased detachment and apoptosis in vitro. Moreover, Y11 significantly decreased tumor growth in the colon cancer cell mouse xenograft model. Finally, tumors from the Y11-treated mice demonstrated decreased Y397-FAK autophosphorylation and activation of poly (ADP ribose) polymerase and caspase-3.
CSN20842 Solanesol   13190-97-1 Solanesol is a C45 isoprenoid alcohol, it is the most abundant lipid in tobacco leaves and may be an important precursor of the tumorigenic polynuclear aromatic hydrocarbons of smoke.
CSN16593 PND-1186   1061353-68-1 PND-1186 is a potent FAK inhibitor with IC50 of 1.5 nM.
CSN16483 PF-573228 869288-64-2 PF-573228 is a potent and selective FAK inhibitor with IC50 of 4 nM for inhibiton of purified recombinant catalytic fragment of FAK and inhibits FAK phosphorylation on Tyr397 with an IC50 of 30-100 nM
CSN16016 PF-562271 717907-75-0 PF-562271 is a potent ATP-competitive reversible inhibitor of FAK with IC50 of 15 nM 10-fold less potent for Pyk2 than FAK and 100-fold selectivity against other protein kinases except for some CDKs
CSN19192 PF-562271 HCl 939791-41-0 PF-562271 HCl is the HCl salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and > 100-fold selectivity against other protein kinases, except for some CDKs.
CSN13737 PF-562271 Besylate 939791-38-5 PF-562271 besylate is a potent ATP-competitive reversible inhibitor of FAK with IC50 of 15 nM 10-fold less potent for Pyk2 than FAK and 100-fold selectivity against other protein kinases except for some CDKs
CSN13426 PF-431396   717906-29-1 PF-431396 is dual focal adhesion kinase FAK and proline-rich tyrosine kinase 2 PYK2 inhibitor IC50 values are 2 and 11 nM respectively PF-431396 has a Kd value of 445 nM for BRD4
CSN13117 NVP-TAE 226   761437-28-9 NVP-TAE 226 is a potent FAK inhibitor with IC50 of 55 nM modestly potent to Pyk2 IC5035 nM and 10- to 100-fold less potent against InsR IGF-1R ALK and c-Met
CSN18810 GSK2256098 1224887-10-8 GSK2256098 is a focal adhesion kinase-1 FAK inhibitor with potential antiangiogenic and antineoplastic activities
CSN17445 Defactinib 1073154-85-4 Defactinib is a potent FAK phosphorylation inhibitor and overcomes YB-1mediated paclitaxel resistance by an AKT-dependent pathway.
CSN17446 Defactinib HCl 1073160-26-5 Defactinib HCl is a potent FAK phosphorylation inhibitor and overcomes YB-1–mediated paclitaxel resistance by an AKT-dependent pathway.
CSN16269 CTX-0294885 1439934-41-4 CTX-0294885 is a bisanilino pyrimidine and exhibits inhibitory activity against a broad range of kinases in vitro, further developed into a Sepharose-supported kinase capture reagent.
CSN16907 CEP-37440 1391712-60-9 CEP-37440 is a potent and selective Dual FAKALK inhibitor with IC50 s of 23 nM FAK and 120 nM ALK cellular IC50 in 75 human plasma
CSN23887 BI-4464 1227948-02-8 BI-4464 is a ATP competitive inhibitor of focal adhesion tyrosine kinase (PTK2/FAK) with IC50 of 17 nM.
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