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FAK is a tyrosine kinase overexpressed in cancer cells and plays an important role in the progression of tumors to a malignant phenotype.
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN28454 | PROTAC FAK degrader 1 | 2301916-69-6 | PROTAC FAK degrader 1 is a selective and potent PROTAC targeting on Fak with DC50 value of 3nM. It was generated by linking defactinib and VHL ligand. |
| CSN28517 | FC-11 | 2271035-37-9 | FC-11 is a potent FAK-targeting PROTAC. FC-11 showed a rapid and reversible FAK degradation with a picomolar of DC50 in various cell lines in vitro, which imply that FAK-PROTACs could be useful as expand tools for studying functions of FAK in biological system and as potential therapeutic agents. |
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