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Cat. No. Product Name CAS No. Information
CSN25739 ZK 164015 177583-70-9 ZK 164015 is an antagonist of estrogen receptor. It inhibits 17β-estradiol stimulation of luciferase activity with IC50 of 0.025 μM.
CSN16637 Tectoridin   611-40-5 Tectoridin, an isoflavone, is a natural product isolated and purified from the rhizomes of belamcanda chinensis (L.) DC. with anti-inflammatory activities.
CSN11817 Quinestrol   152-43-2 Quinestrol is a synthetic estrogen which is used in hormone replacement therapy.
CSN19099 MGL-3196 920509-32-6 MGL-3196 is a selective thyroid hormone receptor agonist with EC50s of 0.21 and 3.74 M for TR and TR respectively.
CSN11387 Mestranol 72-33-3 Mestranol is an agonist of estrogen receptor. It is used as contraceptives.
CSN12274 Liquiritigenin 578-86-9 Liquiritigenin is an estrogenic compound which fuctions as a selective agonist of the estrogen receptor ER and an partial agonist of ER. It also has choleretic effect. Liquiritigenin is a flavanone extracted from glycyrrhiza uralensis with antitumour action.
CSN12271 L-Thyroxine   51-48-9 L-Thyroxine is an iodine-containing hormone produced from thyroglobulin in the thyroid follicular cells.
CSN22842 GSK 4716 101574-65-6 GSK4716 is an agonist of ERR with IC50 of 2 M with similar potency as the protein ligand PGC-1
CSN19421 Genistin   529-59-9 Genistin is a isoflavone which has a role in blocking cell cycle and inducing apoptosis. It is also a modulator of estrogen receptor. Genistin can be isolated from the seeds of glycine max (L.) merr. and used as negative control of genistein.
CSN10938 Estropipate   7280-37-7 Estropipate, deriving from estrogen, is used to treat symptoms of menopause and to prevent osteoporosis.
CSN25302 Estrogen receptor modulator 1 63676-22-2 Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. It has been found to be both estrogenic and antiproliferative in ER-positive endocrine-resistant breast cancer cell lines that overexpress protein kinase C alpha (PKCα).
CSN10935 Estradiol Benzoate   50-50-0 Estradiol benzoate is an estradiol analog which binds to the human, murine and chicken ER with IC50 of 22-28 nM.
CSN24698 ERRα degrader ligand 4a 2306388-57-6 ERRα degrader ligand 4a block the protein-protein interaction of ERRα with PGC-1α coactivator with IC50 value of 5.67nM in a TR-FRET assay.
CSN27511 ERRα antagonist-1 1072145-33-5 ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1.
CSN22143 ERB-196 550997-55-2 ERB-196 is a nonsteroidal selective estrogen receptor- (ER) agonist.
CSN12284 Equol   531-95-3 Equol, a non-steroidal estrogen, is a selective agonist of ER. It is produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora.
CSN27510 Dihydroresveratrol 58436-28-5 Dihydroresveratrol, a potent phytoestrogen, is a hormone receptor modulator. Dihydroresveratrol exhibits proliferative effects in androgen-independent prostate and breast cancer cells at picomolar and nanomolar concentrations.
CSN10623 Chlorotrianisene   569-57-3 Chlorotrianisene, a synthetic and non-steroidal estrogen, is a modulator of estrogen receptor.
CSN12352 Calycosin 20575-57-9 Calycosin, a phytoestrogen, is a partial agonist of ER and a calcium channel blocker. It also shows prevention of reperfusion injury. Calycosin can be isolated and purified from the herb of Astragalus membranaceus Bge. var. mongholicus with anti-oxidative activity.
CSN21522 Bifluranol 34633-34-6 Bifluranol is a synthetic nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol that has been used as an antiandrogen in the United Kingdom in the treatment of benign prostatic hyperplasia.
CSN18837 Bazedoxifene HCl 198480-56-7 Bazedoxifene is a third generation selective estrogen receptor modulator (SERM).
CSN10382 Bazedoxifene Acetate 198481-33-3 Bazedoxifene acetate can selectively modulate estrogen receptor (SERM), the IC50 values are 26 nM and 99 nM for ER and ER respectively.
CSN22351 Arzoxifene HCl 182133-27-3 Arzoxifene HCl is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol.
CSN28406 ARV-471 2614417-52-4 ARV-471 is the first-clinical-entered ERα PROTAC degrader with DC50 of ~1nM. It degrades clinically-relevant ESR1 variants (Y537S and D538G) and inhibits growth of cell lines expressing those variants.
CSN22335 Acolbifene 182167-02-8 Acolbifene (EM652) is a fourth-generation selective estrogen receptor antagonist with a LC50 value of 223 nM.
CSN22663 AC 186 1421854-16-1 AC 186 is a potent and selective ERβ agonist with EC50 of 6 nM.
CSN22105 4-Hydroxytamoxifen 68047-06-3 4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.
CSN17211 α-Estradiol 57-91-0 -Estradiol is an endogenous estrogen receptor ligand (Ki values are 0.2 and 1.2 nM for ER and ER receptors respectively).
CSN22628 (R,R)-THC 138090-06-9 (R,R)-THC is a selective estrogen receptor ligand that agonist at ERα receptor (Ki = 9.0 nM) and antagonist at ERβ receptor (Ki = 3.6 nM).
CSN21921 (R)-Equol 221054-79-1 (R)-Equol is an agonist of both ERα and ERβ with Kis of 27.4 and 15.4 nM, respectively.
CSN26189 Afimoxifene   68392-35-8
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