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ERK

ERK

Cat. No. Product Name CAS No. Information
CSN17855 XMD17-109 1435488-37-1 XMD17-109 is a specific ERK-5 inhibitor with an EC50 42 M in HEK293 cells
CSN25710 TMCB 905105-89-7 TMCB is a dual-kinase inhibitor of both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) with IC50s of 0.50 μM.
CSN13154 Tauroursodeoxycholate Sodium   35807-85-3 Tauroursodeoxycholate sodium can suppress ERK via PKC-mediated MKP-1 induction thus inhibiting neointimal hyperplasia of smooth muscle cells
CSN11353 Magnolin 31008-18-1 Magnolin, a natural product isolated and purified from the flowers of Magnolia biondii Pamp., reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro.
CSN14412 Hirsutenone 41137-87-5 Hirsutenone, a natural product isolated and purified from the eaves of Alnus nepalensis, exhibits anti-cancer effect against prostate cancer through a direct physical inhibition of Akt1/2, attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity, and may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone showed potent PL(pro) inhibitory activity with IC50 value of 4.1µM.
CSN26645 SKI V 24418-86-8 for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity[1][2].
CSN18045 DEL-22379 181223-80-3 DEL-22379 inhibits ERK dimerization with IC50 of 05 M
CSN21221 AG-126   118409-62-4 AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 M.
CSN27671 ASTX029   2095719-92-7
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