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ERK
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN17855 | XMD17-109 | 1435488-37-1 | XMD17-109 is a specific ERK-5 inhibitor with an EC50 42 M in HEK293 cells |
| CSN25710 | TMCB | 905105-89-7 | TMCB is a dual-kinase inhibitor of both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) with IC50s of 0.50 μM. |
| CSN13154 | Tauroursodeoxycholate Sodium | 35807-85-3 | Tauroursodeoxycholate sodium can suppress ERK via PKC-mediated MKP-1 induction thus inhibiting neointimal hyperplasia of smooth muscle cells |
| CSN11353 | Magnolin | 31008-18-1 | Magnolin, a natural product isolated and purified from the flowers of Magnolia biondii Pamp., reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. |
| CSN14412 | Hirsutenone | 41137-87-5 | Hirsutenone, a natural product isolated and purified from the eaves of Alnus nepalensis, exhibits anti-cancer effect against prostate cancer through a direct physical inhibition of Akt1/2, attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity, and may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone showed potent PL(pro) inhibitory activity with IC50 value of 4.1µM. |
| CSN26645 | SKI V | 24418-86-8 | for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity[1][2]. |
| CSN18045 | DEL-22379 | 181223-80-3 | DEL-22379 inhibits ERK dimerization with IC50 of 05 M |
| CSN21221 | AG-126 | 118409-62-4 | AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 M. |
| CSN27671 | ASTX029 | 2095719-92-7 |
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