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ERK

ERK

Cat. No. Product Name CAS No. Information
CSN16763 XMD8-92 1234480-50-2 XMD8-92 is an inhibitor of ERK5BMK1 The Kd values for BMK1 DCAMKL2 PLK4 and TNK1 are 80 nM 190 nM 600 nM and 890 nM respectively
CSN17855 XMD17-109 1435488-37-1 XMD17-109 is a specific ERK-5 inhibitor with an EC50 42 M in HEK293 cells
CSN18540 VX-11e 896720-20-0 VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Signal-Regulated Kinase) and is antitumor agent.
CSN15784 Ulixertinib 869886-67-9 Ulixertinib is a potent and reversible ERK1ERK2 inhibitor with IC50 of 0.3 nM for ERK2.
CSN23392 Ulixertinib HCl   1956366-10-1 Ulixertinib HCl the salt of ulixertinib is a reversible inhibitor of ERK1ERK2 It can inhibit cell proliferation
CSN13154 Tauroursodeoxycholate Sodium   35807-85-3 Tauroursodeoxycholate sodium can suppress ERK via PKC-mediated MKP-1 induction thus inhibiting neointimal hyperplasia of smooth muscle cells
CSN13643 SCH772984 942183-80-4 SCH772984 is a specific inhibitor of ERK12 with IC50 of 4 nM and 1 nM respectively
CSN17141 Pluripotin 839707-37-8 Pluripotin is a dual inhibitor of extracellular signal-regulated kinase 1 ERK1 MAPK3 and RasGAP It maintains embryonic stem cell ESC self-renewal
CSN11644 Pachymic Acid 29070-92-6 Pachymic acid is a lanostrane-type triterpenoid, which possesses anti-emetic, anti-inflammatory, and anti-cancer properties.
CSN18836 Mogrol 88930-15-8 Mogrol is a natural product isolated and purified from the fruit of Siraitia grosvenorii Swingle and a potential AMPK activator.
CSN21082 MK-8353 1184173-73-6 MK-8353 also known as SCH900353 is a potent and orally active ERK12 inhibitor and anticancer drug candidate currently being developed by Schering-Plough MK-8353 exhibited comparable potency with SCH772984 across various preclinical cancer models
CSN11353 Magnolin 31008-18-1 Magnolin, a natural product isolated and purified from the flowers of Magnolia biondii Pamp., reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro.
CSN20623 LY3214996 1951483-29-6 LY3214996 can inhibit ERK1 and ERK2 with IC50s of 5 nM
CSN24745 Longdaysin 1353867-91-0 Longdaysin is the inhibitor of Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. Longdaysin inhibits CK1α, CK1δ, CDK7 and ERK2 with IC50 values of 5.6µM, 8.8µM, 29µM and 52µM, respectively.
CSN22441 KO-947 1695533-89-1 KO-947 is a potent and selective inhibitor of ERK12 kinases with potential clinical utility in MAPK pathway dysregulated tumors
CSN14412 Hirsutenone 41137-87-5 Hirsutenone, a natural product isolated and purified from the eaves of Alnus nepalensis, exhibits anti-cancer effect against prostate cancer through a direct physical inhibition of Akt1/2, attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity, and may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone showed potent PL(pro) inhibitory activity with IC50 value of 4.1µM.
CSN16271 GDC-0994 1453848-26-4 GDC-0994 is a selective inhibitor of ERK1/2 with IC50 value of 6.1 nM and 3.1 nM.
CSN19017 GDC-0994 HCl 2070009-58-2 GDC-0994 hydrochloride is highly selective for ERK1 and ERK2 with biochemical potency of 11 nM and 03 nM respectively
CSN13064 FR 180204 865362-74-9 FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2 with Ki value of 031 M and 014 M respectively and has IC50 values of 051 and 033 M in enzymatic assays against ERK1 and ERK2 respectively
CSN24288 ERK5-IN-2 1888305-96-1 ERK5-IN-2 is a selective ERK5 inhibitor with IC50 value of 0.82 μM.
CSN17601 ERK5-IN-1 1234479-76-5 ERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 019 M and enzymatic IC50 values of 0087 M and of LRRK2G2019S with enzymatic IC50 values of 0026M
CSN18045 DEL-22379 181223-80-3 DEL-22379 inhibits ERK dimerization with IC50 of 05 M
CSN13519 Corynoxeine 630-94-4 Corynoxeine is a potent ERK12 inhibitor of key PDGF-BB-induced VSMC proliferation and is a useful and prospective compound in the prevention and treatment for vascular diseases
CSN22365 CC-90003 1621999-82-3 CC-90003 is an irreversible inhibitor of ERK 12 with antitumor activity
CSN20512 Cafestol 469-83-0 Cafestol is a bioactive substance isolated and extracted from coffee with potential medical uses.
CSN24804 BCI-215 1245792-67-9 BCI-215 is a hyperactivator of fibroblast growth factor signaling that is devoid of developmental toxicity and restores defective MAPK activity caused by overexpression of DUSP1 and DUSP6 in mammalian cells. BCI-215 induced rapid and sustained phosphorylation of extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) in the absence of reactive oxygen species, and its toxicity was partially rescued by inhibition of p38 but not JNK or ERK.
CSN21094 AZD0364   2097416-76-5 AZD0364 is an ERK1 andor ERK2 kinase for the treatment of cancer
CSN22695 AX 15836 2035509-96-5 AX 15836 is a potent and selective ERK5 inhibitor with IC50 of 8 nM.
CSN19016 APS-2-79 2002381-25-9 APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site
CSN21221 AG-126   118409-62-4 AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 M.
CSN20372 ADA-07 N/A ADA-07 a T-LAK cell-originated protein kinase TOPK inhibitor is a promising chemopreventive or potential therapeutic agent against SUV-induced skin carcinogenesis that acts by specifically targeting TOPK
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