The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease. The ErbB protein family consists of 4 members: ErbB-1, also named epidermal growth factor receptor (EGFR); ErbB-2, also named HER2 in humans and neu in rodents; ErbB-3, also named HER3; ErbB-4, also named HER4.
|Cat. No.||Product Name||CAS No.||Information|
|CSN16204||Poziotinib (HM781-36B)||1092364-38-9||Poziotinib is an irreversible Pan-HER inhibitor with IC50s of 3/5/23 nM for HER1/HER2/HER4 respectively.|
|CSN13899||Dacomitinib||1110813-31-4||Dacomitinib is a potent, orally available, irreversible tyrosine kinase HER 1 (EGFR), HER2 and HER4 inhibitor with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively.|
|CSN15701||BMS-690514||859853-30-8||BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor EGFR HER2 and HER4 as well as the VEGF receptor kinases|
|CSN13724||AG490||133550-30-8||AG-490 is a broad-spectrum inhibitor that has several targets including EGFR (IC50 2 M), ErbB2 (IC50 13.5 M), STAT3 and JAK2.|
|CSN25738||AG-825||149092-50-2||AG 825 is a selective inhibitor of ErbB2 and the IC50 values are 0.15 and 19 μM for ErbB2 and ErbB1 respectively.|