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The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease. The ErbB protein family consists of 4 members: ErbB-1, also named epidermal growth factor receptor (EGFR); ErbB-2, also named HER2 in humans and neu in rodents; ErbB-3, also named HER3; ErbB-4, also named HER4.

ErbB

Cat. No. Product Name CAS No. Information
CSN16204 Poziotinib 1092364-38-9 Poziotinib is an irreversible Pan-HER inhibitor with IC50s of 3/5/23 nM for HER1/HER2/HER4 respectively.
CSN25737 JNJ 28871063 HCl 944342-90-9 JNJ 28871063 hydrochloride is a selective ErbB receptor family inhibitor with IC50 values of 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively.
CSN22156 Epertinib 908305-13-5 Epertinib is a potent oral reversible and selective tyrosine kinase inhibitor of EGFR HER2 and HER4 with IC50s of 148 nM 715 nM and 249 nM respectively Epertinib shows potent antitumor activity
CSN13899 Dacomitinib   1110813-31-4 Dacomitinib is a potent, orally available, irreversible tyrosine kinase HER 1 (EGFR), HER2 and HER4 inhibitor with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively.
CSN15701 BMS-690514 859853-30-8 BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor EGFR HER2 and HER4 as well as the VEGF receptor kinases
CSN25738 AG 825 149092-50-2 AG 825 is a selective inhibitor of ErbB2 and the IC50 values are 0.15 and 19 μM for ErbB2 and ErbB1 respectively.
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